公开(公告)号：US20090175929A1

公开(公告)日：2009-07-09

申请号：US12227201

申请日：2007-05-08

申请人： Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

发明人： Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

IPC分类号： A61K9/70 ,  A61K31/4353

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12 ,  A61K47/20 ,  C07D211/32

摘要： Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises an adhesive and a donepezil component (containing crystalline donepezil having type-B crystal polymorphism) and/or a salt thereof, wherein the donepezil component or the salt thereof is contained in an amount of 9 to 50% by mass relative to the total weight of the adhesive. The preparation (particularly, one having a non-aqueous adhesive layer) shows an excellent penetration of donepezil and/or a salt thereof into the skin, retains good stability of the active ingredient therein, and is remarkably reduced in local stimulation and adverse side effects.

摘要翻译： 公开了一种含多奈哌齐的透皮吸收制剂，其具有减少的副作用，并显示令人满意的治疗效果。 该制剂包含粘合剂和多奈哌齐组分（含有具有B型晶体多晶型的结晶多奈哌齐）和/或其盐，其中所述多奈哌齐组分或其盐的含量相对于所述组合物为9〜50质量％ 粘合剂的总重量。 该制剂（特别是具有非水性粘合剂层的制剂）显示出多奈哌齐和/或其盐对皮肤的渗透性优异，保持其中活性成分的良好稳定性，并且局部刺激和不良副作用显着降低 。

公开(公告)号：US08809615B2

公开(公告)日：2014-08-19

申请号：US12588721

申请日：2009-10-26

申请人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

发明人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

IPC分类号： B32B7/12 ,  B32B15/04 ,  C08G61/02 ,  C08J3/00 ,  A61K6/083 ,  A61K8/72 ,  C08L15/00 ,  A61K6/00 ,  C09J4/00 ,  C09J101/00 ,  C09J201/00 ,  A61F13/00 ,  A61F15/00 ,  A61L15/16 ,  A61K9/70 ,  B32B25/02

CPC分类号： A61L15/44 ,  A61F13/00 ,  A61F15/00 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K31/695 ,  A61L15/24 ,  A61L15/58 ,  A61L2300/216 ,  B32B7/12 ,  Y10T428/28 ,  Y10T428/2852 ,  Y10T442/2738 ,  Y10T442/3561

摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

摘要翻译： 一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯， 相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以 当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

公开(公告)号：US08455376B2

公开(公告)日：2013-06-04

申请号：US12227066

申请日：2007-08-01

申请人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

发明人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

IPC分类号： B32B25/02 ,  A61F13/00 ,  A61L15/16 ,  A61K9/70

CPC分类号： A61L15/44 ,  A61F13/00 ,  A61F15/00 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K31/695 ,  A61L15/24 ,  A61L15/58 ,  A61L2300/216 ,  B32B7/12 ,  Y10T428/28 ,  Y10T428/2852 ,  Y10T442/2738 ,  Y10T442/3561

摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

摘要翻译： 一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯， 相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以 当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

公开(公告)号：US07572227B2

公开(公告)日：2009-08-11

申请号：US11902350

申请日：2007-09-20

申请人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

发明人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

IPC分类号： A61B5/02

CPC分类号： A61B5/6838 ,  A61B5/02225 ,  A61B5/02241 ,  A61B5/6815 ,  A61B2562/0233

摘要： This invention provides a blood pressure measuring apparatus capable of stably measuring the blood pressure in even the tragus while suppressing the degree of invasion.An attaching portion (3) of the blood pressure measuring apparatus has an inner cuff (6), an outer cuff (7), and a holding member (10) which holds the inner cuff (6) and outer cuff (7), and the holding member has a “U” shape. The end portions of the holding member (10) where the inner cuff (6) and outer cuff (7) are arranged are almost parallel to each other, and the inner cuff (6) and outer cuff (7) oppose each other. An auxiliary member (80) which comes in contact with a predetermined position of the ear of a person to be measured and increases the attachment stability of the inner cuff (6) and outer cuff (7) at the tragus is attached to the holding member (10).

摘要翻译： 本发明提供能够在抑制入侵程度的同时稳定地测量耳屏中的血压的血压测量装置。 血压测量装置的安装部分（3）具有内箍（6），外箍（7）和保持内箍（6）和外箍（7）的保持构件（10），以及 保持构件具有“U”形状。 其中内侧袖带（6）和外侧袖口（7）的配置的保持构件（10）的端部大致平行，内侧袖带（6）与外侧袖口（7）相对。 与被测量人的耳朵的预定位置接触并且增加内耳套（6）和外袖带（7）在耳屏处的附着稳定性的辅助构件（80）附接到保持构件 （10）。

公开(公告)号：US20090149794A1

公开(公告)日：2009-06-11

申请号：US12227066

申请日：2007-08-01

申请人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

发明人： Kiyomi Tsuruda ,  Shinji Yamasoto ,  Kouki Shoho ,  Masaru Nakanishi

IPC分类号： A61F13/02

CPC分类号： A61L15/44 ,  A61F13/00 ,  A61F15/00 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/045 ,  A61K31/618 ,  A61K31/695 ,  A61L15/24 ,  A61L15/58 ,  A61L2300/216 ,  B32B7/12 ,  Y10T428/28 ,  Y10T428/2852 ,  Y10T442/2738 ,  Y10T442/3561

摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

摘要翻译： 一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯， 相对于该层的总质量，整个粘合剂制剂在40℃的温度和90％的相对湿度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24范围为3.0至60.0ng.hr/mL，以平均值±标准偏差计，水杨酸作为水杨酸甲酯的代谢物具有5000至13000ng.hr/mL的血浆AUC 0-24，以 当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

公开(公告)号：US20080091112A1

公开(公告)日：2008-04-17

申请号：US11902350

申请日：2007-09-20

申请人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

发明人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Koichiro Asama ,  Shinji Mino

IPC分类号： A61B5/021

CPC分类号： A61B5/6838 ,  A61B5/02225 ,  A61B5/02241 ,  A61B5/6815 ,  A61B2562/0233

摘要： This invention provides a blood pressure measuring apparatus capable of stably measuring the blood pressure in even the tragus while suppressing the degree of invasion. An attaching portion (3) of the blood pressure measuring apparatus has an inner cuff (6), an outer cuff (7), and a holding member (10) which holds the inner cuff (6) and outer cuff (7), and the holding member has a “U” shape. The end portions of the holding member (10) where the inner cuff (6) and outer cuff (7) are arranged are almost parallel to each other, and the inner cuff (6) and outer cuff (7) oppose each other. An auxiliary member (80) which comes in contact with a predetermined position of the ear of a person to be measured and increases the attachment stability of the inner cuff (6) and outer cuff (7) at the tragus is attached to the holding member (10).

摘要翻译： 本发明提供能够在抑制入侵程度的同时稳定地测量耳屏中的血压的血压测量装置。 血压测量装置的安装部分（3）具有内箍（6），外箍（7）和保持内箍（6）和外箍（7）的保持构件（10），以及 保持构件具有“U”形状。 其中内侧袖带（6）和外侧袖口（7）的配置的保持构件（10）的端部大致平行，内侧袖带（6）与外侧袖口（7）相对。 与被测量人的耳朵的预定位置接触并且增加内耳套（6）和外袖带（7）在耳屏处的附着稳定性的辅助构件（80）附接到保持构件 （10）。

公开(公告)号：US06214378B1

公开(公告)日：2001-04-10

申请号：US09230844

申请日：1999-03-08

申请人： Norifumi Tanida ,  Jun Aoki ,  Masaru Nakanishi

发明人： Norifumi Tanida ,  Jun Aoki ,  Masaru Nakanishi

IPC分类号： A61K948

CPC分类号： A61K9/4858 ,  A61K9/4891

摘要： This invention offers capsules for oral preparation which is useful for colon diseases such as colon cancer, ulcerative colitis, constipation and diarrhea and for systemic diseases such as osteoporosis and which does not undergo any change at all in stomach and in small intestine but firstly start to disintegrate upon arriving at large intestine and, at the same time, quickly release the drug therefrom wherein the capsule base therefor is hydroxypropylmethylcellulose (HPMC) or polyethyleneglycol-compounded HPMC, gelatin or agar and, on the surface of said capsule base in which powder or liquid containing a pharmacologically active substance is encapsulated, a double-coated structure comprising an inner layer consisting of a cationic copolymer and an outer layer consisting of anionic copolymer is formed.

摘要翻译： 本发明提供口服制剂用胶囊，其可用于结肠癌，溃疡性结肠炎，便秘和腹泻等结肠疾病，以及全身性疾病如骨质疏松症，并且在胃和小肠中均不发生任何变化，但首先开始 在到达大肠时分解，同时快速释放出药物，其中胶囊基为羟丙基甲基纤维素（HPMC）或聚乙二醇复合HPMC，明胶或琼脂，并且在所述胶囊基质的表面上，粉末或 含有药理活性物质的液体被包封，形成包含由阳离子共聚物和由阴离子共聚物组成的外层的内层的双层结构。

公开(公告)号：US5654004A

公开(公告)日：1997-08-05

申请号：US432202

申请日：1995-05-05

申请人： Minenobu Okayama ,  Masaru Nakanishi

发明人： Minenobu Okayama ,  Masaru Nakanishi

IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/30 ,  A61K9/32 ,  A61K9/50

CPC分类号： A61K9/5073 ,  A61K9/2018 ,  A61K9/2886

摘要： An oral pharmaceutical preparation releasable in the lower digestive tract, characterized by having a double-coated structure wherein a solid drug having a core containing an active ingredient is covered with both an inner coat made of a cationic polymer and an outer coat made of an anionic polymer.

摘要翻译： PCT No.PCT / JP93 / 01608 Sec。 371日期：1995年5月5日 102（e）日期1995年5月5日PCT 1993年11月5日PCT公布。 出版物WO94 / 10983 日期1994年5月26日可在下消化道中释放的口服药物制剂，其特征在于具有双层结构，其中具有含有活性成分的核心的固体药物被阳离子聚合物制成的内衣和外涂层 由阴离子聚合物制成。

公开(公告)号：US20090264774A1

公开(公告)日：2009-10-22

申请号：US12083060

申请日：2006-09-28

申请人： Akira Kondo ,  Shuichi Oonishi ,  Masaru Nakanishi ,  Takashi Watanabe ,  Hitoshi Ozawa

发明人： Akira Kondo ,  Shuichi Oonishi ,  Masaru Nakanishi ,  Takashi Watanabe ,  Hitoshi Ozawa

IPC分类号： A61B5/02

CPC分类号： A61B5/02241 ,  A61B5/6815 ,  A61B5/6838

摘要： The present invention enables making uniform contact with the tragus using inner and outer cuffs, each of said inner and outer cuffs being comprised of a cuff member 40 connected to a duct 4 and a cuff bladder 22 having a body 27 which is fixed onto said cuff member in an air-tight manner and can expand and contract, comprised in such manner in order to carry out accurate blood pressure measurement at any one given point in time without being affected by the pinch width of the tragus and depth to the tragus even with repeated mounting and removal from the ear auricle, and also comprised such that a lid 23 of said cuff bladder forms a pressing surface 25 in a shape of a protrusion.

摘要翻译： 本发明能够使用内外袖口与耳屏均匀接触，所述内箍和外袖口均包括连接到管道4的袖带件40和具有固定在所述袖带上的主体27的袖带囊22 会员以气密的方式进行扩张和收缩，包括以这种方式，以便在任何一个给定的时间点进行准确的血压测量，而不受耳屏的夹紧宽度和深度的影响，即使使用 从耳耳反复安装和移除，并且还包括使得所述袖带囊的盖23形成突起形状的按压表面25。

公开(公告)号：US20080091113A1

公开(公告)日：2008-04-17

申请号：US11902351

申请日：2007-09-20

申请人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Naoe Tatara ,  Shoichi Hayashida

发明人： Akira Kondo ,  Takashi Watanabe ,  Masaru Nakanishi ,  Shuichi Oonishi ,  Hitoshi Ozawa ,  Naoe Tatara ,  Shoichi Hayashida

IPC分类号： A61B5/021

CPC分类号： A61B5/6838 ,  A61B5/02208 ,  A61B5/02225 ,  A61B5/02241 ,  A61B5/6815 ,  A61B2562/0233

摘要： A blood pressure measurement apparatus which can install cuffs at a tragus that has differences between individuals is provided. Holding member 3 comprises; a shape part 52 to be installed in a space between an auticular concha and an antihelix, a first protrusion 54 extended from said shape part such that said first protrusion is directed towards the ear hole, a second protrusion 55 extended from said shape part such that said second protrusion is nearly right-angled with respect to said first protrusion and said second protrusion steps over the tragus, an integral member 50 having an ear hook part 51 that is extended from said shape part, said ear hook is integrally made with said integral member or made as an independent member, inner cuff 6 is supported at the end portion of the first protrusion, support member 15 is attached at the end portion of the second protrusion, cuffs 6,7 are attached to the support member through a clamping width adjustment part 11 that makes a clamping width adjustment against the tragus possible.

摘要翻译： 本发明提供一种血压测量装置，其能够在具有个体之间的差异的耳屏上安装袖带。 保持构件3包括： 一个形状部分52，安装在自由耳朵和反耳朵之间的空间中;一个从所述形状部分伸出的第一突出部分54，使得所述第一突起部朝向耳孔;第二突出部分55，其从所述形状部分伸出， 所述第二突出部相对于所述第一突出物几乎成直角，所述第二突出部越过耳屏，整体构件50具有从所述形状部分延伸的耳钩部分51，所述耳钩与所述积分 构件或制成独立构件，内箍6支撑在第一突起的端部，支撑构件15附接在第二突起的端部，袖带6,7通过夹紧宽度附接到支撑构件 调节部件11可以对耳屏进行夹紧宽度调整。