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    Spiro compounds having stearoyl-CoA desaturase action
    2.
    发明授权
    Spiro compounds having stearoyl-CoA desaturase action 有权
    具有硬脂酰-CoA去饱和酶作用的螺环化合物

    公开(公告)号：US08575167B2

    公开(公告)日：2013-11-05

    申请号：US12449320

    申请日：2008-02-05

    申请人： Takahiko Taniguchi ,  Kenichi Miyata ,  Osamu Kubo

    发明人： Takahiko Taniguchi ,  Kenichi Miyata ,  Osamu Kubo

    IPC分类号： A61K31/50 ,  C07D401/00 ,  A61P3/04 ,  A61P3/06 ,  A61P7/12 ,  A61P9/12 ,  A61P9/04 ,  A61P9/00 ,  A61P9/10

    CPC分类号： C07D401/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/107 ,  C07D498/10

    摘要： The present invention aims to provide a novel SCD inhibitor.The present invention relate to SCD inhibitor comprising A compound represented by the formula (I) wherein R is an optionally substituted cyclic group or an optionally substituted carbamoyl group, provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl group; ring A is an optionally further substituted pyridazine ring; R1, R2, R3, R4, R11, R12, R13 and R14 are each independently a hydrogen atom or a substituent, or R1 and R11 in combination, R2 and R12 in combination, R3 and R13 in combination, or R4 and R14 in combination optionally form an oxo group, or R2 and R4 in combination optionally form a bond or an alkylene cross-linkage; m and n are each independently an integer of 0 to 2; ring B is an optionally substituted ring, provided that the two atoms constituting ring B, which are adjacent to the spiro carbon atom, are not oxygen atoms at the same time, or a salt thereof, or a prodrug thereof.

    摘要翻译： 本发明旨在提供一种新型的SCD抑制剂。 本发明涉及包含由式（I）表示的化合物的SCD抑制剂，其中R是任选取代的环状基团或任选取代的氨基甲酰基，条件是R不是任选取代的7-吡啶并[2,3-d] 嘧啶基; 环A是任选进一步取代的哒嗪环; R 1，R 2，R 3，R 4，R 11，R 12，R 13和R 14各自独立地为氢原子或取代基，或R 1和R 11组合，R 2和R 12组合，R 3和R 13组合，或R 4和R 14组合 任选地形成氧代基团，或者R 2和R 4组合任选地形成键或亚烷基交联; m和n各自独立地为0〜2的整数。 环B是任选取代的环，条件是与螺环碳原子相邻的构成环B的两个原子不是同时为氧原子，或其盐或其前药。

    SPIRO COMPOUND AND USE THEREOF
    3.
    发明申请
    SPIRO COMPOUND AND USE THEREOF 有权
    SPIRO化合物及其用途

    公开(公告)号：US20100069351A1

    公开(公告)日：2010-03-18

    申请号：US12449320

    申请日：2008-02-05

    申请人： Takahiko Taniguchi ,  Kenichi Miyata ,  Osamu Kubo

    发明人： Takahiko Taniguchi ,  Kenichi Miyata ,  Osamu Kubo

    IPC分类号： A61K31/397 ,  C07D237/02 ,  A61K31/50 ,  C07D265/12 ,  A61K31/537 ,  C07D239/72 ,  A61K31/527 ,  C07D245/04 ,  A61P3/00 ,  A61P9/00

    CPC分类号： C07D401/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/107 ,  C07D498/10

    摘要： The present invention aims to provide a novel SCD inhibitor.The present invention relate to SCD inhibitor comprising A compound represented by the formula (I) wherein R is an optionally substituted cyclic group or an optionally substituted carbamoyl group, provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl group; ring A is an optionally further substituted pyridazine ring; R1, R2, R3, R4, R11, R12, R13 and R14 are each independently a hydrogen atom or a substituent, or R1 and R11 in combination, R2 and R12 in combination, R3 and R13 in combination, or R4 and R14 in combination optionally form an oxo group, or R2 and R4 in combination optionally form a bond or an alkylene cross-linkage; m and n are each independently an integer of 0 to 2; ring B is an optionally substituted ring, provided that the two atoms constituting ring B, which are adjacent to the spiro carbon atom, are not oxygen atoms at the same time, or a salt thereof, or a prodrug thereof.

    摘要翻译： 本发明旨在提供一种新型的SCD抑制剂。 本发明涉及包含由式（I）表示的化合物的SCD抑制剂，其中R是任选取代的环状基团或任选取代的氨基甲酰基，条件是R不是任选取代的7-吡啶并[2,3-d] 嘧啶基; 环A是任选进一步取代的哒嗪环; R 1，R 2，R 3，R 4，R 11，R 12，R 13和R 14各自独立地为氢原子或取代基，或R 1和R 11组合，R 2和R 12组合，R 3和R 13组合，或R 4和R 14组合 任选地形成氧代基团，或者R 2和R 4组合任选地形成键或亚烷基交联; m和n各自独立地为0〜2的整数。 环B是任选取代的环，条件是与螺环碳原子相邻的构成环B的两个原子不是同时为氧原子，或其盐或其前药。

    Exhaust gas cleaning device of outboard motor unit
    4.
    发明授权
    Exhaust gas cleaning device of outboard motor unit 失效
    舷外马达单元排气净化装置

    公开(公告)号：US5855495A

    公开(公告)日：1999-01-05

    申请号：US684861

    申请日：1996-07-25

    申请人： Osamu Kubo

    发明人： Osamu Kubo

    IPC分类号： B63H20/24 ,  B63H21/32 ,  F01N3/28 ,  F01N13/12 ,  F02B61/04 ,  B63H21/38

    CPC分类号： F01N13/12 ,  F01N3/2882 ,  B63B2770/00 ,  F01N2590/021 ,  F02B61/045

    摘要： An exhaust gas cleaning device is provided for an outboard motor unit having an engine provided with a pair of cylinder rows arranged so as to provide a V-shape and a crank shaft arranged substantially in a perpendicular direction in a using state and having an exhaust expansion chamber on a side of a cylinder head of the engine. In the improvement, a catalyst is disposed below the engine and inside a space having substantially a triangle shape, in a plan view, defined by a central line of one of the cylinder rows, a central line of another one of the cylinder rows and a central line of the expansion exhaust chamber. The catalyst is also disposed, in an arrangement of the cylinder rows providing a V-shape having an angle of less than 90.degree., below the engine and inside a space having substantially a triangle shape, in a plan view, defined by an inner wall section of one of the cylinder rows, an inner wall section of another one of the cylinder rows and a wall section, facing the V-shape section of the cylinder rows, of the expansion exhaust chamber.

    摘要翻译： 本发明提供一种排气净化装置，用于具有发动机的发动机，该发动机设置有一对气缸排，所述发动机排列成在使用状态下提供基本上沿垂直方向设置的V形和曲轴，并具有排气膨胀 在发动机气缸盖的一侧的腔室。 在改进中，催化剂设置在发动机下方和具有基本上三角形形状的空间内，在平面图中，由气缸列之一的中心线，另一个气缸行的中心线和 膨胀排气室的中心线。 在平面图中，在由内壁限定的平面图中，催化剂也被设置为提供具有小于90°的角度的V形的气缸列的布置，在发动机下方和具有基本上三角形的空间内 气缸列中的一个的另一个的内壁部分和与气缸列的V形部分相对的膨胀排气室的壁部分。

    Electronic circuit device
    8.
    发明授权
    Electronic circuit device 失效
    电子电路装置

    公开(公告)号：US07371687B2

    公开(公告)日：2008-05-13

    申请号：US11475961

    申请日：2006-06-28

    申请人： Ryo Fujita ,  Osamu Kubo ,  Kouki Noguchi ,  Masaharu Kubo ,  Michihiro Mishima ,  Yasuhiko Takahashi

    发明人： Ryo Fujita ,  Osamu Kubo ,  Kouki Noguchi ,  Masaharu Kubo ,  Michihiro Mishima ,  Yasuhiko Takahashi

    IPC分类号： H01L23/52

    CPC分类号： G06F11/261 ,  G06F11/267 ,  G06F15/7867 ,  H01L25/18 ,  H01L2224/16225 ,  H01L2924/00014 ,  H01L2924/09701 ,  H01L2924/13091 ,  H01L2924/15192 ,  H01L2924/15311 ,  H01L2924/3011 ,  H01L2924/00 ,  H01L2224/0401

    摘要： An electronic circuit device has a high-density mount board (2), on which are disposed a microcomputer (3) and random access memory (7) which are connected to each other through an exclusive memory bus (12) for high-speed data transfer, a programmable device (8) which is a variable logic circuit represented by FPGA, and an electrically-rewritable nonvolatile memory (16) which can store the operation program of the microcomputer. The high-density mount board has external mounting pins on the bottom surface so that it can be mounted on a mother board in the same manner as a system on-chip multi-chip module. With an intended logic function being set on the programmable device, a hardware-based function to be realized by the electronic circuit device can be simulated. With an operation program being written to the nonvolatile memory, a software-based function to be realized can be simulated. Consequently, the device facilitates the debugging at early stages of system development, configures a prototype system, and contributes to the time reduction throughout the system development, prototype fabrication and large-scale production.

    摘要翻译： 电子电路装置具有高密度安装板（2），微型计算机（3）和随机存取存储器（7）设置在其上，通过用于高速数据的专用存储器总线（12）彼此连接 传输，由FPGA表示的可变逻辑电路的可编程器件（8）和可存储微型计算机的操作程序的电可重写非易失性存储器（16）。 高密度安装板在底面上具有外部安装销，使其可以以与系统片上多芯片模块相同的方式安装在母板上。 通过在可编程器件上设置预期的逻辑功能，可以模拟由电子电路器件实现的基于硬件的功能。 通过将操作程序写入非易失性存储器，可以模拟要实现的基于软件的功能。 因此，该设备便于系统开发初期的调试，配置原型系统，有助于整个系统开发，原型制作和大规模生产的时间缩短。

    Enterprise portfolio simulation system
    9.
    发明申请
    Enterprise portfolio simulation system 审中-公开
    企业投资组合模拟系统

    公开(公告)号：US20070005479A1

    公开(公告)日：2007-01-04

    申请号：US11477777

    申请日：2006-06-30

    申请人： Yuichi Ikeda ,  Shigeru Kawamoto ,  Osamu Kubo ,  Chihiro Fukui

    发明人： Yuichi Ikeda ,  Shigeru Kawamoto ,  Osamu Kubo ,  Chihiro Fukui

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/00 ,  G06Q40/06

    摘要： This enterprise portfolio simulation system includes the mechanisms of selecting companies having a large mutual influence from a company's own project portfolio, a business partner company, other competing companies, and still other companies giving an influence on the company's own project portfolio, the business partner company, and the other competing companies; configuring a company network with the own company, the business partner company, and the other competing companies; making each of the own company, the business partner company, and the other competing companies perform a reasonable intention decision while mutually giving an influence; and performing a numerical experiment of an economic activity.

    摘要翻译： 该企业投资组合模拟系统包括从公司自己的项目组合中选择具有较大相互影响力的公司的机制，业务合作伙伴公司，其他竞争公司以及影响公司自己的项目组合的其他公司的机制，业务伙伴公司 ，和其他竞争公司; 与自己的公司，业务伙伴公司和其他竞争公司配置公司网络; 使自己的公司，业务伙伴公司和其他竞争公司在相互影响的情况下进行合理的意图决策; 并进行经济活动的数值试验。

    Electronic circuit device
    10.
    发明申请
    Electronic circuit device 失效
    电子电路装置

    公开(公告)号：US20060244122A1

    公开(公告)日：2006-11-02

    申请号：US11475936

    申请日：2006-06-28

    申请人： Ryo Fujita ,  Osamu Kubo ,  Kouki Noguchi ,  Masaharu Kubo ,  Michihiro Mishima ,  Yasuhiko Takahashi

    发明人： Ryo Fujita ,  Osamu Kubo ,  Kouki Noguchi ,  Masaharu Kubo ,  Michihiro Mishima ,  Yasuhiko Takahashi

    IPC分类号： H01L23/52

    CPC分类号： G06F11/261 ,  G06F11/267 ,  G06F15/7867 ,  H01L25/18 ,  H01L2224/16225 ,  H01L2924/00014 ,  H01L2924/09701 ,  H01L2924/13091 ,  H01L2924/15192 ,  H01L2924/15311 ,  H01L2924/3011 ,  H01L2924/00 ,  H01L2224/0401

    摘要： An electronic circuit device has a high-density mount board (2), on which are disposed a microcomputer (3) and random access memory (7) which are connected to each other through an exclusive memory bus (12) for high-speed data transfer, a programmable device (8) which is a variable logic circuit represented by FPGA, and an electrically-rewritable nonvolatile memory (16) which can store the operation program of the microcomputer. The high-density mount board has external mounting pins on the bottom surface so that it can be mounted on a mother board in the same manner as a system on-chip multi-chip module. With an intended logic function being set on the programmable device, a hardware-based function to be realized by the electronic circuit device can be simulated. With an operation program being written to the nonvolatile memory, a software-based function to be realized can be simulated. Consequently, the device facilitates the debugging at early stages of system development, configures a prototype system, and contributes to the time reduction throughout the system development, prototype fabrication and large-scale production.

    摘要翻译： 电子电路装置具有高密度安装板（2），微型计算机（3）和随机存取存储器（7）设置在其上，通过用于高速数据的专用存储器总线（12）彼此连接 传输，由FPGA表示的可变逻辑电路的可编程器件（8）和可存储微型计算机的操作程序的电可重写非易失性存储器（16）。 高密度安装板在底面上具有外部安装销，使其可以以与系统片上多芯片模块相同的方式安装在母板上。 通过在可编程器件上设置预期的逻辑功能，可以模拟由电子电路器件实现的基于硬件的功能。 通过将操作程序写入非易失性存储器，可以模拟要实现的基于软件的功能。 因此，该设备便于系统开发初期的调试，配置原型系统，有助于整个系统开发，原型制作和大规模生产的时间缩短。