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公开(公告)号:US20060252780A1
公开(公告)日:2006-11-09
申请号:US10554254
申请日:2004-04-23
申请人: Takao Nakajima , Kimihisa Ueno , Yuji Nomoto , Yuichi Matsumoto , Hiroshi Yano , Satoshi Nakanishi , Kotaro Takasaki , Hideaki Kusaka
发明人: Takao Nakajima , Kimihisa Ueno , Yuji Nomoto , Yuichi Matsumoto , Hiroshi Yano , Satoshi Nakanishi , Kotaro Takasaki , Hideaki Kusaka
IPC分类号: A61K31/519 , C07D487/14
CPC分类号: C07D487/14
摘要: A fused pyrimidine derivative is presented. The derivatie has an insulin secretion stimulating activity represented by Formula (I): {wherein R1 represents a hydrogen atom, lower alkyl, or the like; n represents an integer of 0 to 3; and X1 and X2 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like; and formula (II): represents formula (III): [wherein X—Y—Z represents R2C═CR3—NR4 (wherein R2, R3 and R4 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like)]}, or a pharmaceutically acceptable salt thereof.
摘要翻译: 提出了一种稠合的嘧啶衍生物。 衍生物具有由式(I)表示的胰岛素分泌刺激活性:其中R 1表示氢原子,低级烷基等; n表示0〜3的整数, X 1和X 2可以相同或不同,各自表示氢原子,低级烷基等; 和式(II):表示式(III):[其中XYZ表示R 2 C-CR 3 -NR 4(其中R' O 2,R 3和R 4可以相同或不同,各自表示氢原子,低级烷基等)]}, 或其药学上可接受的盐。
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公开(公告)号:US07718808B2
公开(公告)日:2010-05-18
申请号:US10584633
申请日:2004-12-24
申请人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
发明人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
IPC分类号: A61K31/427 , C07D417/14
CPC分类号: C07D417/06 , A61K31/427 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5383 , A61K31/541 , A61K31/542 , A61K31/551 , A61K31/553 , A61K31/695 , C07D417/04 , C07D417/14 , C07D491/048 , C07D491/10 , C07D498/04 , C07D513/04
摘要: (Wherein n is an integer of from 0 to 3; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R2 is halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, —COR8, or the like; R3 and R4 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, —COR12, or the like)For example, provided are adenosine A2A receptor antagonists comprising, as the active ingredient, a thiazole derivative represented by a general formula (I), or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译: 本发明提供的腺苷A 2A受体拮抗剂包含作为活性成分的由通式(I)表示的噻唑衍生物或其药学上可接受的盐:......(其中n为0-3的整数; R 1为取代或 取代或未取代的芳基,取代或未取代的脂环族杂环基或取代或未取代的芳族杂环基; R2为卤素,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的脂环族杂环基, 或未取代的芳族杂环基,-COR 8等; R 3和R 4可以相同或不同,各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳烷基,-COR 12等)。
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公开(公告)号:US08420827B2
公开(公告)日:2013-04-16
申请号:US12960937
申请日:2010-12-06
申请人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
发明人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
IPC分类号: A61K31/427 , C07D417/14
CPC分类号: C07D417/06 , A61K31/427 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5383 , A61K31/541 , A61K31/542 , A61K31/551 , A61K31/553 , A61K31/695 , C07D417/04 , C07D417/14 , C07D491/048 , C07D491/10 , C07D498/04 , C07D513/04
摘要: Wherein n is an integer of from 0 to 3; R1A is a 5-membered aromatic heterocyclic group containing at least one oxygen atom; R2A is —COR8 (wherein R8 is aryl); R3A is hydrogen or lower alkyl; and R12 represents cycloalkyl, aryl, aralkyl, alicyclic heterocyclic group, aromatic heterocyclic group, alicyclic hetocyclic-alkyl, or aromatic heterocyclic-alkyl, and R1A, R2A, R3A and R12 are individually optionally substituted.
摘要翻译: - 根据式(1A)的化合物,其中n为0至3的整数; R1A是含有至少一个氧原子的5元芳族杂环基; R2A是-COR8(其中R8是芳基); R3A是氢或低级烷基; R 12表示环烷基,芳基,芳烷基,脂环族杂环基,芳香族杂环基,脂环族环状烷基或芳香族杂环烷基,R1A,R2A,R3A,R12分别任选被取代,及其药学上可接受的盐。
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公开(公告)号:US07880013B2
公开(公告)日:2011-02-01
申请号:US12766986
申请日:2010-04-26
IPC分类号: A61K31/427 , C07D417/14
CPC分类号: C07D417/06 , A61K31/427 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5383 , A61K31/541 , A61K31/542 , A61K31/551 , A61K31/553 , A61K31/695 , C07D417/04 , C07D417/14 , C07D491/048 , C07D491/10 , C07D498/04 , C07D513/04
摘要: (Wherein n is an integer of from 0 to 3; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R2 is halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, —COR8, or the like; R3 and R4 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, —COR12, or the like)For example, provided are adenosine A2A receptor antagonists comprising, as the active ingredient, a thiazole derivative represented by a general formula (I), or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译: 本发明提供的腺苷A 2A受体拮抗剂包含作为活性成分的通式(I)所示的噻唑衍生物或其药学上可接受的盐等(其中,n为0〜3的整数,R1为 取代或未取代的环烷基,取代或未取代的芳基,取代或未取代的脂环族杂环基或取代或未取代的芳族杂环基; R2为卤素,取代或未取代的低级烷基,取代或未取代的芳基,取代或未取代的脂环族杂环基, 取代或未取代的芳族杂环基,-COR 8等; R 3和R 4可以相同或不同,各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳烷基,-COR 12等) 。
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公开(公告)号:US20070105919A1
公开(公告)日:2007-05-10
申请号:US10584633
申请日:2004-12-24
申请人: Takao Nakajima , Masamori Sugawara , Shin-ichi Ushida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
发明人: Takao Nakajima , Masamori Sugawara , Shin-ichi Ushida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
IPC分类号: A61K31/427
CPC分类号: C07D417/06 , A61K31/427 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5383 , A61K31/541 , A61K31/542 , A61K31/551 , A61K31/553 , A61K31/695 , C07D417/04 , C07D417/14 , C07D491/048 , C07D491/10 , C07D498/04 , C07D513/04
摘要: (Wherein n is an integer of from 0 to 3; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R2 is halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, —COR8, or the like; R3 and R4 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, —COR12, or the like) For example, provided are adenosine A2A receptor antagonists comprising, as the active ingredient, a thiazole derivative represented by a general formula (I), or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译: (其中n为0-3的整数; R 1是取代或未取代的环烷基,取代或未取代的芳基,取代或未取代的脂环族杂环基或取代或未取代的芳族杂环基; R 取代或未取代的芳基,取代或未取代的脂环族杂环基,取代或未取代的芳族杂环基,-COR 8或 R 3和R 4可以相同或不同,并且各自表示氢原子,取代或未取代的低级烷基,取代或未取代的芳烷基,-COR 3, 例如,提供了包含作为活性成分的由通式(I)表示的噻唑衍生物或腺苷A 2A受体拮抗剂的腺苷A 2A受体拮抗剂,或 药学上可接受的盐等。
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公开(公告)号:US20110105486A1
公开(公告)日:2011-05-05
申请号:US12960937
申请日:2010-12-06
申请人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
发明人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
IPC分类号: A61K31/541 , C07D277/38 , C07D417/14 , C07D401/14 , C07D213/89 , C07D413/14 , C07D279/12 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P25/28 , A61P25/00 , A61P3/10 , A61P25/12 , A61P25/24
CPC分类号: C07D417/06 , A61K31/427 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5383 , A61K31/541 , A61K31/542 , A61K31/551 , A61K31/553 , A61K31/695 , C07D417/04 , C07D417/14 , C07D491/048 , C07D491/10 , C07D498/04 , C07D513/04
摘要: Wherein n is an integer of from 0 to 3; R1A is a 5-membered aromatic heterocyclic group containing at least one oxygen atom; R2A is —COR8 (wherein R8 is aryl); R3A is hydrogen or lower alkyl; and R12 represents cycloalkyl, aryl, aralkyl, alicyclic heterocyclic group, aromatic heterocyclic group, alicyclic hetocyclic-alkyl, or aromatic heterocyclic-alkyl, and R1A, R2A, R3A and R12 are individually optionally substituted.
摘要翻译: 其中n为0至3的整数; R1A是含有至少一个氧原子的5元芳族杂环基; R2A是-COR8(其中R8是芳基); R3A是氢或低级烷基; R 12表示环烷基,芳基,芳烷基,脂环族杂环基,芳香族杂环基,脂环族环状烷基或芳香族杂环烷基,R1A,R2A,R3A,R12分别任意取代。
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公开(公告)号:US20100256361A1
公开(公告)日:2010-10-07
申请号:US12766986
申请日:2010-04-26
申请人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
发明人: Takao Nakajima , Masamori Sugawara , Shin-ichi Uchida , Tetsuji Ohno , Yuji Nomoto , Noriaki Uesaka , Yoshisuke Nakasato
IPC分类号: C07D417/14 , C07D413/14 , C07D498/04
CPC分类号: C07D417/06 , A61K31/427 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5383 , A61K31/541 , A61K31/542 , A61K31/551 , A61K31/553 , A61K31/695 , C07D417/04 , C07D417/14 , C07D491/048 , C07D491/10 , C07D498/04 , C07D513/04
摘要: (Wherein n is an integer of from 0 to 3; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, or a substituted or unsubstituted aromatic heterocyclic group; R2 is halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, —COR8, or the like; R3 and R4 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, —COR12, or the like)For example, provided are adenosine A2A receptor antagonists comprising, as the active ingredient, a thiazole derivative represented by a general formula (I), or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译: (其中n为0〜3的整数; R 1为取代或未取代的环烷基,取代或未取代的芳基,取代或未取代的脂环族杂环基或取代或未取代的芳香族杂环基; R2为卤素,取代或未取代的低级烷基 取代或未取代的芳基,取代或未取代的脂环族杂环基,取代或未取代的芳族杂环基,-COR 8等; R 3和R 4可以相同或不同,表示氢原子,取代或未取代的低级 烷基,取代或未取代的芳烷基,-COR 12等)例如,提供的是腺苷A 2A受体拮抗剂,其包含作为活性成分的由通式(I)表示的噻唑衍生物或其药学上可接受的盐,以及 类似。
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公开(公告)号:US09116111B2
公开(公告)日:2015-08-25
申请号:US14123234
申请日:2012-07-11
申请人: Takao Nakajima , Yasufumi Asao
发明人: Takao Nakajima , Yasufumi Asao
CPC分类号: G01N29/2418 , A61B5/0095 , G01H9/00 , G01H9/002 , G01N21/1702
摘要: There is used an acoustic signal receiving apparatus including a wavelength-tunable light source for irradiating measurement light, a controller for controlling a wavelength of the measurement light, a Fabry-Perot probe having a first mirror on a side where the measurement light enters, a second mirror on a side where an elastic wave from an object enters, and a spacer film positioned between the first and second mirrors and deforms in response to the elastic wave, an array photosensor for detecting a reflected light amount of the measurement light by the Fabry-Perot probe, and a signal processor for acquiring an intensity of the incident elastic wave based on a change in the reflected light amount. The controller sweeps the wavelength of the measurement light, and the signal processor determines the wavelength based on the reflected light amount at each wavelength subjected to the sweep.
摘要翻译: 使用包括用于照射测量光的波长可调光源的声信号接收装置,用于控制测量光的波长的控制器,在测量光进入的一侧具有第一反射镜的法布里 - 珀罗探头, 来自物体的弹性波的一侧的第二反射镜和位于第一和第二反射镜之间并且响应于弹性波而变形的间隔膜,用于通过法布里检测测量光的反射光量的阵列光电传感器 -Perot探针和用于基于反射光量的变化获取入射弹性波的强度的信号处理器。 控制器扫描测量光的波长,并且信号处理器基于经受扫描的每个波长处的反射光量确定波长。
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公开(公告)号:US08335448B2
公开(公告)日:2012-12-18
申请号:US12695337
申请日:2010-01-28
申请人: Takao Nakajima
发明人: Takao Nakajima
IPC分类号: G03G15/20
CPC分类号: G03G15/657 , G03G15/2028 , G03G2215/00413 , G03G2215/00945
摘要: An image forming apparatus includes a transfer unit configured to transfer a toner image to a sheet, a fixing unit configured to fix the toner image transferred to the sheet on the sheet, a conveyance unit disposed between the transfer unit and the fixing unit to convey the sheet, a moving unit configured to move the conveyance unit, and a control unit configured to controls the moving unit to move the conveyance unit so that a speed of a leading edge of the sheet conveyed from the transfer unit to the fixing unit is reduced, when the leading edge of the sheet reaches the fixing unit.
摘要翻译: 图像形成装置包括被配置为将调色剂图像转印到片材的转印单元,被配置为将转印到片材上的调色剂图像固定在片材上的定影单元,设置在转印单元和定影单元之间的输送单元, 移动单元,其构造成移动所述输送单元;以及控制单元,其被配置为控制所述移动单元移动所述输送单元,使得从所述转印单元传送到所述定影单元的所述纸张的前端的速度减小, 当纸张的前缘到达定影单元时。
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公开(公告)号:US20120207522A1
公开(公告)日:2012-08-16
申请号:US13371261
申请日:2012-02-10
申请人: Takao Nakajima
发明人: Takao Nakajima
IPC分类号: G03G15/20
CPC分类号: G03G15/161 , G03G15/1605 , G03G2215/0141
摘要: An area in which a sheet member and an intermediate transfer belt are in contact with each other is provided between an intersection between a guide surface of the second guide portion configured to guide a recording material toward the intermediate transfer belt and the intermediate transfer belt and a nip portion.
摘要翻译: 其中片状部件和中间转印带彼此接触的区域设置在构造成将记录材料向中间转印带引导的第二引导部分的引导表面与中间转印带之间的相交处和 压区部分。
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