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36 条记录 (耗时 0.053 秒)

    Fused pyrimidine derivatives
    1.
    发明申请
    Fused pyrimidine derivatives 审中-公开
    融合嘧啶衍生物

    公开(公告)号：US20060252780A1

    公开(公告)日：2006-11-09

    申请号：US10554254

    申请日：2004-04-23

    申请人： Takao Nakajima ,  Kimihisa Ueno ,  Yuji Nomoto ,  Yuichi Matsumoto ,  Hiroshi Yano ,  Satoshi Nakanishi ,  Kotaro Takasaki ,  Hideaki Kusaka

    发明人： Takao Nakajima ,  Kimihisa Ueno ,  Yuji Nomoto ,  Yuichi Matsumoto ,  Hiroshi Yano ,  Satoshi Nakanishi ,  Kotaro Takasaki ,  Hideaki Kusaka

    IPC分类号： A61K31/519 ,  C07D487/14

    CPC分类号： C07D487/14

    摘要： A fused pyrimidine derivative is presented. The derivatie has an insulin secretion stimulating activity represented by Formula (I): {wherein R1 represents a hydrogen atom, lower alkyl, or the like; n represents an integer of 0 to 3; and X1 and X2 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like; and formula (II): represents formula (III): [wherein X—Y—Z represents R2C═CR3—NR4 (wherein R2, R3 and R4 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like)]}, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 提出了一种稠合的嘧啶衍生物。 衍生物具有由式（I）表示的胰岛素分泌刺激活性：其中R 1表示氢原子，低级烷基等; n表示0〜3的整数， X 1和X 2可以相同或不同，各自表示氢原子，低级烷基等; 和式（II）：表示式（III）：[其中XYZ表示R 2 C-CR 3 -NR 4（其中R' O 2，R 3和R 4可以相同或不同，各自表示氢原子，低级烷基等）]}， 或其药学上可接受的盐。

    Fused purine derivatives
    2.
    发明授权
    Fused purine derivatives 失效
    融合嘌呤衍生物

    公开(公告)号：US07005430B2

    公开(公告)日：2006-02-28

    申请号：US10149423

    申请日：2000-12-22

    申请人： Kimihisa Ueno ,  Akira Ogawa ,  Yoshihisa Ohta ,  Yuji Nomoto ,  Kotaro Takasaki ,  Hideaki Kusaka ,  Hiroshi Yano ,  Chiharu Nakagawa ,  Satoshi Nakanishi

    发明人： Kimihisa Ueno ,  Akira Ogawa ,  Yoshihisa Ohta ,  Yuji Nomoto ,  Kotaro Takasaki ,  Hideaki Kusaka ,  Hiroshi Yano ,  Chiharu Nakagawa ,  Satoshi Nakanishi

    IPC分类号： C07D487/14 ,  C07D473/24 ,  C07D473/22 ,  A61K31/519 ,  A61P3/10

    CPC分类号： C07D487/14

    摘要： A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V1 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V2 represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X—Y-Z represents R1aN—C═O and R2 represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, —NR7R8, —CO2H, a lower alkoxycarbonyl group, —COHal, —CONR9R10 or —CHO, V2 may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

    摘要翻译： 由式（I）表示的稠合嘌呤衍生物：化学式id =“CHEM-US-00001”num =“000”

    Water pump for an internal combustion engine
    10.
    发明授权
    Water pump for an internal combustion engine 有权
    内燃机用水泵

    公开(公告)号：US06270314B1

    公开(公告)日：2001-08-07

    申请号：US09397149

    申请日：1999-09-16

    申请人： Yuji Nomoto

    发明人： Yuji Nomoto

    IPC分类号： F04D2916

    CPC分类号： F04D29/426 ,  F04D29/086 ,  F04D29/167

    摘要： A water pump for an internal combustion engine having a pump casing and a pump cover that forms a circulation cavity. A plate is positioned interface of the pump casing and the pump cover and divides the circulation cavity into an inlet passage and an outlet passage and has a seal portion that seals against the leakage between the inlet passage and the outlet passage of a gap of the interface of the pump casing and the pump cover.

    摘要翻译： 一种用于内燃机的水泵，其具有形成循环腔的泵壳体和泵盖。 板被定位在泵壳体和泵盖的界面上，并将循环腔分成入口通道和出口通道，并且具有密封部分，该密封部分密封入口通道和出口通道之间的界面间隙的泄漏 的泵壳和泵盖。