摘要:
Novel erythromycin B derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each hydrogen or methyl, and the pharmaceutically acceptable acid addition salts thereof are disclosed. They exhibit excellent in vivo antibacterial activity against Gram-positive bacteria.
摘要:
Novel erythromycin A derivatives of the formula ##STR1## wherein R is hydrogen or methyl, and the pharmaceutically acceptable acid addition salts thereof are disclosed. They exhibit excellent antibacterial activity against erythromycin resistant bacteria, Gram-positive bacteria and Mycoplasma species.
摘要:
Erythromycin derivatives represented by the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a hydroxy group, R.sup.3 is a hydrogen atom, a lower alkanoyl group, an alkoxycarbonyl group or an alkylsuccinyl group, and the salts thereof are disclosed. These compounds have antibacterial activity.
摘要:
A microorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant Streptococcus aureus (MRSA), consequently these are useful as the therapeutic agents for infectious disease caused by MRSA as well as infectious diseases caused by multidrug including β-lactam antibiotics resistant bacteria. Further, similarly, since the novel K04-0144D substance isolated from the cultured liquid has the action for enhancing the effect of β-lactam antibiotics, which are utilized as the antibacterial agents, in combination with them, it is useful as the therapeutic agent for infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug including β-lactam antibiotics resistant bacteria.
摘要:
An image detecting apparatus has an edit function with good operability and compatibility. When a chapter mark key on a remote control is pressed while an image reproducing system including an MPEG video decoder, a video signal post-processing circuit, a combining circuit, and an NTSC encoder is reproducing image data recorded on a recording medium, a CPU obtains information for identifying the image being reproduced and displayed, and then records the information on the recording medium. With reference to the image provided with a chapter mark, a still image generating circuit displays reduced still images, for example, so that a target image can be specified. Reproduction and editing can be performed with reference to the specified image.
摘要:
A microorganism belonging to the genus Streptomyces and being capable of producing substance K01-0509-A1 and/or substance K01-0509-A2 is cultured in a medium. Then, the substance K01-0509-A1 and/or the substance K01-0509-A2 having been thus accumulated in the liquid culture medium are collected from the medium. It is expected that the obtained substances are efficacious as drugs which are selectively effective on pathogenic gram-negative bacteria having the type III secretion system.
摘要:
An contour correcting circuit for correcting the contour without deterioration of image quality of the video signal, comprising a first HPF for extracting the high frequency signal component of the video signal supplied from an input terminal Tin, a second HPF for differentiating the output of the first HPF additionally, and a correlator for synthesizing the output signals of the output and the inverted output of said first HPF, and the output of the second HPF to form a signal having a predetermined signal waveform, wherein the correlator forms a signal waveform of the preshoot portion and overshoot portion with the first order differential output which is relatively static at the inflection point of the video signal, synthesizes a second order differential waveform so as to be a sharp signal waveform at the middle portion, and performs sharpness processing of the video signal by use of the contour correction signal.
摘要:
In examining the progress of patients before and after a cataract operation, the morphology of cornea endothelium cells used in medical treatment, may be determined from a cornea endothelium cell image with less labor. Center points of two-dimensionally continuous cells of a cornea endothelium cell image are entered into a computer, and peripheral points obtained by determining peripheral points which are center points of the cells within a specified distance from one center point are sorted clockwise. If an angle formed by successive two peripheral points and the center point is less than a specified angle, the greater of the two peripheral points in distance from the center point is excluded from the peripheral points. If a distance between the first point and the third point of the obtained successive three peripheral points is shorter than a distance between the center point and the second point, the second point is excluded from the peripheral points, and average distances between the peripheral points and the center point are determined. A perpendicular line that proportionally divides a distance between a center point and its peripheral points by their average distances to the peripheral points is determined for each of the successive peripheral points, and intersection points of the resulting perpendicular lines are determined as vertices of the cells. Thus, morphological data are computed from the obtained vertices.
摘要:
To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.