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29 条记录 (耗时 0.027 秒)

    Lactol derivatives, their production and use
    1.
    发明授权
    Lactol derivatives, their production and use 失效
    乳糖衍生物，其生产和使用

    公开(公告)号：US5496834A

    公开(公告)日：1996-03-05

    申请号：US300738

    申请日：1994-09-02

    申请人： Takashi Sohda ,  Yukio Fujisawa ,  Satoru Oi ,  Junji Mizoguchi

    发明人： Takashi Sohda ,  Yukio Fujisawa ,  Satoru Oi ,  Junji Mizoguchi

    IPC分类号： A61K38/00 ,  C07K5/06 ,  C07K5/078 ,  A61K31/44 ,  A61K31/35 ,  A61K31/40

    CPC分类号： C07K5/06139 ,  C07K5/06043 ,  A61K38/00

    摘要： The present invention provides novel compound of the formulas (Ia) or (I): ##STR1## wherein Q is one or two amino acid residues which may be substituted; R.sup.3 is a carboxyl group which may be esterified or an acyl group; A is an alkylene group; B is hydrogen or an alkyl group which may be substituted or an acyl group; or a salt thereof; ##STR2## wherein R.sup.1 and R.sup.2 may be the same or different and each is hydrogen or a hydrocarbon residue which may be substituted; R.sup.3, A and B have the same definitions as those shown above; m and n each is 0 or 1; provided that where both m and n are both equal to 0, R.sup.3 is a carboxyl group which may be esterified or an acyl group having not less than 7 carbon atoms; or a salt thereof.The compound (Ia) or (I) shows cathepsin L inhibitory and bone resorption inhibitory activities and are useful as a prophylactic/therapeutic agent for osteoporosis.

    摘要翻译： 本发明提供新的式（Ia）或（I）化合物：其中Q是一个或两个可被取代的氨基酸残基; R3是可被酯化的羧基或酰基; A是亚烷基; B是氢或可以被取代的烷基或酰基; 或其盐; （I）其中R 1和R 2可以相同或不同，各自为氢或可被取代的烃残基; R3，A和B具有与上述相同的定义; m和n各自为0或1; 条件是当m和n都等于0时，R 3是可被酯化的羧基或具有不少于7个碳原子的酰基; 或其盐。 化合物（Ia）或（I）表示组织蛋白酶L抑制和骨吸收抑制活性，可用作骨质疏松症的预防/治疗剂。

    Condensed thiadiazole derivative, method of its production, and use thereof
    2.
    发明授权
    Condensed thiadiazole derivative, method of its production, and use thereof 失效
    缩合噻二唑衍生物，其制备方法及其用途

    公开(公告)号：US5550138A

    公开(公告)日：1996-08-27

    申请号：US039579

    申请日：1993-03-23

    申请人： Takashi Sohda ,  Zen-ichi Terashita ,  Yu Momose ,  Yukio Fujisawa ,  Junji Mizoguchi

    发明人： Takashi Sohda ,  Zen-ichi Terashita ,  Yu Momose ,  Yukio Fujisawa ,  Junji Mizoguchi

    IPC分类号： C07D513/04 ,  A61K31/435

    CPC分类号： C07D513/04

    摘要： (1) a compound represented by the following formula (I): ##STR1## wherein R represents a hydrocarbon group or heterocyclic group which may be substituted; the ring A represents a pyridine ring having a substituent or a thiazole ring which may be substituted; or a pharmaceutically acceptable salt thereof, and a method of its production, and(2) an endothelin receptor antagonist, an cathepsin B inhibitor or a bone resorption suppressor having as an active ingredient a compound represented by the following formula (I'): ##STR2## wherein R has the same definition as in term (1); the ring A' represents a pyridine ring or thiazole ring which may be substituted; or a pharmaceutically acceptable salt thereof.

    摘要翻译： （1）由下式（I）表示的化合物：其中R表示可被取代的烃基或杂环基; 环A表示具有取代基的吡啶环或可被取代的噻唑环; 或其药学上可接受的盐及其制备方法，和（2）作为活性成分的下式（I'）表示的化合物的内皮素受体拮抗剂，组织蛋白酶B抑制剂或骨吸收抑制剂： （I'）其中R与术语（1）具有相同的定义; 环A'表示可被取代的吡啶环或噻唑环; 或其药学上可接受的盐。

    All digital switching regulator for use in power supplies, battery chargers, and DC motor control circuits
    9.
    发明授权
    All digital switching regulator for use in power supplies, battery chargers, and DC motor control circuits 失效
    用于电源，电池充电器和直流电机控制电路的所有数字开关稳压器

    公开(公告)号：US5675240A

    公开(公告)日：1997-10-07

    申请号：US495391

    申请日：1995-06-28

    申请人： Yukio Fujisawa ,  Isao Takinoue

    发明人： Yukio Fujisawa ,  Isao Takinoue

    IPC分类号： H02P7/29 ,  G05F1/575 ,  H02M3/155 ,  H02M3/157 ,  G05F1/40

    CPC分类号： H02M3/157 ,  G05F1/575

    摘要： A switching regulator is composed of digital circuits only. A switching regulator (30) comprises a driver (2) for directly controlling the operation of a switching transistor (1), and an OR gate (6) for determining the logic issued by the driver (2). An output terminal (Q) of an RS flip-flop (5) is connected to one input end of the OR gate (6), the output of a timer (40c) is applied to a set terminal (S) of the RS flip-flop (5), and the output of a comparator (4) is applied to a reset terminal (R1) through an OR gate (7). At a non-reverse input end of the comparator (4), a reference voltage (VE) is applied by a D/A convertor (40b), while a feedback voltage (VFB) is applied to a reverse input end. Accordingly, chopping of the switching transistor (1) is done on the basis of a rectangular pulse.

    摘要翻译： 开关稳压器仅由数字电路组成。 开关调节器（30）包括用于直接控制开关晶体管（1）的操作的驱动器（2）和用于确定由驱动器（2）发出的逻辑的或门（6）。 RS触发器（5）的输出端（Q）连接到或门（6）的一个输入端，定时器（40c）的输出被施加到RS翻转的设定端（S） （5），并且比较器（4）的输出通过或门（7）施加到复位端子（R1）。 在比较器（4）的非反相输入端，由D / A转换器（40b）施加参考电压（VE），而反馈电压（VFB）施加到反向输入端。 因此，开关晶体管（1）的斩波是基于矩形脉冲进行的。