利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

86 条记录 (耗时 0.037 秒)

    Optical isolator, optical circuit, and rare-earth-doped fiber optical amplifier
    1.
    发明授权
    Optical isolator, optical circuit, and rare-earth-doped fiber optical amplifier 失效
    光隔离器，光电路和稀土掺杂光纤放大器

    公开(公告)号：US5283846A

    公开(公告)日：1994-02-01

    申请号：US898556

    申请日：1992-06-15

    申请人： Takashi Toyonaka ,  Shinji Tsuji ,  Makoto Haneda ,  Yuichi Ono

    发明人： Takashi Toyonaka ,  Shinji Tsuji ,  Makoto Haneda ,  Yuichi Ono

    IPC分类号： G02B27/28 ,  G02B6/42 ,  G02F1/09 ,  G02F1/35 ,  H01S3/06 ,  H01S3/067 ,  H01S3/07 ,  H01S3/10 ,  G02B6/32

    CPC分类号： H01S3/06754 ,  G02B6/4208 ,  G02F1/093 ,  G02F2203/06 ,  Y10S372/703

    摘要： In a polarization dependency type optical isolator comprising wedgelike polarizing prisms 3 and 5 and a Faraday rotator 4, the mode field diameters of an input side fiber 1 and an output side fiber 7 are the same as that of a transmission fiber and an erbium-doped fiber to be connected to them. The shape and other features of each lens are controlled so that the spot size of a parallel ray which is converted from an incident ray by an input side lens 2 is equal to the spot size of a parallel ray which is converted by an output side lens 6 when a reference beam is irradiated from the fiber 7. In a rare-earth-doped fiber optical amplifier using an optical isolator which is configured in a manner similar to this, the connecting portion of the fiber and the optical isolator can be spliced by fusion without increasing the insertion loss of the optical isolator in the forward direction and the connection loss due to a difference in the mode field diameter is reduced. Therefore, the noise figure decreases and the gain increases.

    摘要翻译： 在包括楔形偏振棱镜3和5以及法拉第旋转器4的偏振依赖型光隔离器中，输入侧光纤1和输出侧光纤7的模场直径与传输光纤和掺铒光纤的模场直径相同 光纤连接到它们。 控制每个透镜的形状和其它特征，使得通过输入侧透镜2从入射光线转换的平行光线的光斑尺寸等于由输出侧透镜转换的平行光线的光斑尺寸 6，当从光纤7照射参考光束时。在采用与此类似的方式配置的光隔离器的稀土掺杂光纤放大器中，光纤和光隔离器的连接部分可以被 融合而不增加光隔离器在正向上的插入损耗，并且由于模场直径差导致的连接损耗减小。 因此，噪声系数下降，增益增加。

    DOPAMINERGIC NEURON PROGENITOR CELL MARKER 187A5
    3.
    发明申请
    DOPAMINERGIC NEURON PROGENITOR CELL MARKER 187A5 有权
    多巴胺神经元细胞标记187A5

    公开(公告)号：US20120252021A1

    公开(公告)日：2012-10-04

    申请号：US13492733

    申请日：2012-06-08

    申请人： Yuichi Ono ,  Yoshimasa Sakamoto

    发明人： Yuichi Ono ,  Yoshimasa Sakamoto

    IPC分类号： C12Q1/68 ,  C07H21/00

    CPC分类号： C07K14/705 ,  A61K35/30 ,  A61K38/00 ,  C07K16/28 ,  C12Q1/6881 ,  C12Q2600/158 ,  G01N33/5058 ,  G01N33/5073 ,  G01N33/56966 ,  G01N2333/70571 ,  Y10S530/81

    摘要： An object of the present invention is to provide a probe, a primer, a primer set and an antibody for use in the detection or selection of a dopaminergic neuron progenitor cell. The present invention provides a probe, a primer and a primer set for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron proliferative progenitor cell, which can hybridize with a nucleotide sequence of a 187A5 gene, or a complementary sequence thereto, and an antibody for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron progenitor cell, which is capable of binding to a 187A5 protein.

    摘要翻译： 本发明的目的是提供用于检测或选择多巴胺能神经元祖细胞的探针，引物，引物组和抗体。 本发明提供了用于检测或选择中脑多巴胺能神经元祖细胞的探针，引物和引物组，优选多巴胺能神经元增殖祖细胞，其可以与187A5基因的核苷酸序列杂交，或 其互补序列，以及用于检测或选择能够结合187A5蛋白的中脑多巴胺能神经元祖细胞，优选多巴胺能神经元祖细胞的抗体。

    SPECIFIC MARKER Lmx1a ON DOPAMINERGIC NEURONS
    4.
    发明申请
    SPECIFIC MARKER Lmx1a ON DOPAMINERGIC NEURONS 有权
    特异性标记Lmx1a在多巴胺神经元上

    公开(公告)号：US20120178083A1

    公开(公告)日：2012-07-12

    申请号：US13352241

    申请日：2012-01-17

    申请人： Yuichi Ono ,  Yasuko Nakagawa ,  Tomoya Nakatani

    发明人： Yuichi Ono ,  Yasuko Nakagawa ,  Tomoya Nakatani

    IPC分类号： C12Q1/68 ,  C07K16/18 ,  G01N33/566

    CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6896 ,  G01N33/9413 ,  G01N2800/2835

    摘要： The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.

    摘要翻译： 本发明鉴定了在细胞周期退出至细胞周期后出现的细胞周期性增殖的多巴胺能神经元祖细胞中，在所有分化阶段的多巴胺能神经元中表达的Lmx1a基因。 当选择适合于帕金森病等神经变性疾病的移植治疗的细胞时，细胞中的Lmx1a表达可用作指示剂，并且可用作参与多巴胺能神经元分化诱导的筛选剂的标记。

    Method and apparatus for producing metal by electrolysis of molton salt
    5.
    发明申请
    Method and apparatus for producing metal by electrolysis of molton salt 审中-公开
    通过电解钼矿盐生产金属的方法和设备

    公开(公告)号：US20090211916A1

    公开(公告)日：2009-08-27

    申请号：US11631364

    申请日：2005-06-27

    申请人： Masanori Yamaguchi ,  Yuichi Ono ,  Susumu Kosemura ,  Eiji Nishimura

    发明人： Masanori Yamaguchi ,  Yuichi Ono ,  Susumu Kosemura ,  Eiji Nishimura

    IPC分类号： C25C3/00 ,  C25C7/00

    CPC分类号： C25C7/007 ,  C25C3/00 ,  C25C7/08

    摘要： A process for production of a metal includes a step of filling a metal chloride in an electrolysis vessel having positive and negative electrodes, a step of heating and fusing the metal chloride to make an electrolytic bath, and a step of electrolyzing the electrolytic bath to deposit metal on the negative electrode in a solid state. In addition, in an apparatus for production of a metal in which a metal chloride is filled in an electrolysis vessel having positive and negative electrodes, the metal chloride is heated and molten to make an electrolytic bath and the electrolytic bath is electrolyzed to deposit the metal on the negative electrode in a solid state, the electrolytic bath is divided into an electrolysis chamber and a dissolution chamber by a dividing wall, the positive electrode is arranged in the electrolysis chamber, the negative electrode is arranged to enable orbital movement in a circle through the electrolysis chamber and dissolution chamber, and the metal deposited on the negative electrode in the electrolysis chamber is separated and recovered in the dissolution chamber.

    摘要翻译： 金属的制造方法包括在具有正极和负极的电解容器中填充金属氯化物的步骤，对金属氯化物进行加热和熔融以形成电解槽的步骤，以及电解槽沉积步骤 金属在负极上固态。 另外，在具有正极和负极的电解容器中填充有金属氯化物的金属的制造装置中，对金属氯化物进行加热熔融，形成电解槽，电解槽被电解以沉积金属 在固态的负极上，通过分隔壁将电解槽分为电解室和溶解室，正极配置在电解室中，负极配置成能够以圆周方式轨道运动 电解室和溶解室，并且沉积在电解室中的负极上的金属在溶解室中分离回收。

    Lrp4/Corin DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKERS
    6.
    发明申请
    Lrp4/Corin DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKERS 有权
    Lrp4 / Corin DOPAMINERGIC神经元增殖型细胞标志物

    公开(公告)号：US20080280301A1

    公开(公告)日：2008-11-13

    申请号：US12110111

    申请日：2008-04-25

    申请人： Yuichi Ono ,  Yasuko Nakagawa ,  Yoshimasa Sakamoto

    发明人： Yuichi Ono ,  Yasuko Nakagawa ,  Yoshimasa Sakamoto

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such.According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.

    摘要翻译： 在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。 此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。 根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。 在细胞中使用Lrp4表达作为指标，可以进行分离。 的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

    Method of uniformizing dna fragment contents and subtraction method
    9.
    发明申请
    Method of uniformizing dna fragment contents and subtraction method 审中-公开
    dna片段内容均匀化和减法方法

    公开(公告)号：US20050175997A1

    公开(公告)日：2005-08-11

    申请号：US10481228

    申请日：2002-06-19

    申请人： Yuichi Ono ,  Toshio Imai

    发明人： Yuichi Ono ,  Toshio Imai

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6809 ,  C12Q2531/113 ,  C12Q2525/191 ,  C12Q2525/131

    摘要： A method of normalizing contents of DNA fragments in a sample among respective DNA fragments, comprising: preparing DNA fragments in which adaptors each comprising an oligodeoxyribonucleotide are attached to both ends of each DNA fragment in the sample to form restriction enzyme recognition sites that do not exist in the DNA fragments in the sample, and at least a part between the restriction enzyme recognition sites at both ends, including the restriction enzyme recognition sites, is double-stranded; denaturing the prepared double-stranded DNA fragments; hybridizing the denatured DNA fragments under a condition that a part of the DNA fragments remains single-stranded; cleaving the hybridized double-stranded DNA fragments with a restriction enzyme having a cleavage site exclusively in the adaptors; and performing PCR using the obtained DNA fragments as templates and using a primer having a nucleotide sequence complementary to a nucleotide sequence of the adaptors before the cleavage; and a subtraction method comprising performing normalization by the method.

    摘要翻译： 使各DNA片段中的样品中DNA片段的含量正常化的方法，包括：制备DNA片段，其中每个包含寡脱氧核糖核苷酸的衔接子连接到样品中每个DNA片段的两端，以形成不存在的限制酶识别位点 在样品中的DNA片段中，两端的限制酶识别位点（包括限制酶识别位点）之间的至少一部分是双链的; 使制备的双链DNA片段变性; 在一部分DNA片段保持单链的条件下使变性DNA片段杂交; 用具有切割位点的限制酶切割杂交的双链DNA片段，仅在适配器中; 并使用所获得的DNA片段作为模板并使用具有与切割前的衔接子的核苷酸序列互补的核苷酸序列的引物进行PCR; 以及减法方法，包括通过该方法执行归一化。

    Temperature sensitive type fluid fan coupling apparatus
    10.
    发明授权
    Temperature sensitive type fluid fan coupling apparatus 失效
    温度敏感型流体传感器联轴器

    公开(公告)号：US5125491A

    公开(公告)日：1992-06-30

    申请号：US716913

    申请日：1991-06-18

    申请人： Kazunori Takikawa ,  Yuichi Ono ,  Hiroshi Inoue

    发明人： Kazunori Takikawa ,  Yuichi Ono ,  Hiroshi Inoue

    IPC分类号： F16D35/02

    CPC分类号： F16D35/022

    摘要： Herein disclosed is a temperature sensitive type fluid fan coupling apparatus which comprises: a sealed container including a casing and a cover, the container being borne through a bearing on a rotating shaft, which has a drive disc fixed to its leading end, and having a cooling fan attached to its outer circumference; a partition dividing the inside of the sealed container into an oil sump and a torque transmission chamber housing the drive disc, a dam formed in a portion of such an inner circumference of the sealed container as faces the outer circumference of the drive disc, on which the oil is collected at the time of rotation; a circulation passage communicating with the dam and leading from the torque transmission chamber to the oil sump; a valve member fitted in the oil sump for opening an outflow adjusting orifice leading to the torque transmission chamber, if the ambient temperature exceeds a preset value, and closing the same if below the preset value; and a temperature sensing element mounted on the front face of the cover and associated with the valve member if deformed in accordance with the temperature change. Thus, the effective contact area of the oil at a torque transmission gap, which is formed between the opposed wall faces of the drive disc and the sealed container in the vicinity of the outside, is increased or decreased to control the torque transmission from the rotating shaft at the drive side to the sealed container at the driven side. The opening of the output adjusting orifice to be opened or closed by the valve member is formed to intersect the partition generally at a right angle.

    摘要翻译： 本发明公开了一种感温型流体风扇联接装置，其特征在于，包括：密封容器，其包括壳体和盖体，所述容器通过旋转轴上的轴承承载，所述轴承具有固定在其前端的驱动盘， 冷却风扇附在其外圆周上; 将密封容器的内部分割为油底壳的分隔件和容纳驱动盘的扭矩传递室，形成在密封容器的这样的内周的面向驱动盘的外周的部分的坝， 在旋转时收集油; 与坝连通并从扭矩传递室引导到油底壳的循环通道; 安装在油底壳中的阀构件，用于打开通向扭矩传递室的流出调节孔，如果环境温度超过预设值，并且如果低于预设值则将其关闭; 以及温度感测元件，其安装在所述盖的前表面上并且根据所述温度变化而变形时与所述阀构件相关联。 因此，在驱动盘的相对壁面与外部附近的密封容器之间形成的扭矩传递间隙处的油的有效接触面积增大或减小，以控制从旋转 驱动侧的轴在被驱动侧的密封容器。 由阀构件打开或关闭的输出调节孔的开口形成为大致直角地与隔板相交。