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    CONDENSED PYRIDINE COMPOUND
    6.
    发明申请
    CONDENSED PYRIDINE COMPOUND 审中-公开
    浓缩的吡啶化合物

    公开(公告)号：US20100105661A1

    公开(公告)日：2010-04-29

    申请号：US12522987

    申请日：2008-01-11

    申请人： Shohei Shirakami ,  Takayuki Inoue ,  Koichiro Mukoyoshi ,  Yutaka Nakajima ,  Hiroyuki Usuda ,  Hisao Hamaguchi ,  Yasuyuki Higashi ,  Keiko Hatanaka

    发明人： Shohei Shirakami ,  Takayuki Inoue ,  Koichiro Mukoyoshi ,  Yutaka Nakajima ,  Hiroyuki Usuda ,  Hisao Hamaguchi ,  Yasuyuki Higashi ,  Keiko Hatanaka

    IPC分类号： A61K31/55 ,  A61K31/501 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： The present invention provides a compound having excellent JAK3 inhibitory activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases, inflammatory diseases, and allergic diseases.As a result of investigations with respect to novel condensed heterocyclic derivatives, the inventors have verified that a condensed pyridine compound has excellent JAK3 inhibitory activity, thereby completing the present invention.More specifically, it has been verified that since the compound according to the present invention has inhibitory activity against JAK3, the compound is useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transduction (e.g., rejection during live organ/tissue transplantation, autoimmune diseases, asthma, atopic dermatitis, rheumatism, psoriasis and atherosclerotic disease), or diseases caused by abnormal cytokine signal transduction (e.g., cancer and leukemia).

    摘要翻译： 本发明提供了具有优异的JAK3抑制活性的化合物，可用作治疗和/或预防各种免疫疾病，包括自身免疫性疾病，炎症性疾病和过敏性疾病的药剂的活性成分。 作为关于新的稠合杂环衍生物的研究结果，本发明人证实了缩合的吡啶化合物具有优异的JAK3抑制活性，从而完成了本发明。 更具体地说，由于本发明的化合物对JAK3具有抑制活性，所以该化合物可用作治疗或预防由不良细胞因子信号转导引起的疾病（例如活体排斥）的药剂的有效成分 器官/组织移植，自身免疫疾病，哮喘，特应性皮炎，风湿病，牛皮癣和动脉粥样硬化疾病）或由细胞因子信号转导异常引起的疾病（例如癌症和白血病）。

    Language model sharing
    9.
    发明授权
    Language model sharing 失效
    语言模型共享

    公开(公告)号：US07035788B1

    公开(公告)日：2006-04-25

    申请号：US09557741

    申请日：2000-04-25

    申请人： Yutaka Nakajima ,  Yutaka Suzue ,  Kevin B. Gjerstad ,  Dong-Hui Zhang ,  Hiroaki Kanokogi ,  Benjamin M. Westbrook

    发明人： Yutaka Nakajima ,  Yutaka Suzue ,  Kevin B. Gjerstad ,  Dong-Hui Zhang ,  Hiroaki Kanokogi ,  Benjamin M. Westbrook

    IPC分类号： G06F17/27

    CPC分类号： G06F17/273 ,  G06F17/2715 ,  G06F17/2725 ,  G06F17/2765

    摘要： The sharing of language models is disclosed. In one embodiment, a language model service is provided that is shareable among handlers for input devices. The service includes a pre-processing mode of operation, and a correction mode of operation. In the former mode, the language model service is designed to receive a range within a document from a handler for an input device, and in response provide advice regarding text under consideration by the handler to insert within the document at the range, based on the context of the document within the range. In the latter mode, the language model service is designed to supervise correction over a range of text within a document, in which a number of different handlers for a number of different input devices were initially responsible for insertion of the text, such that the service solicits suggestions from the handlers, and based thereon determines text corrections. The corrections can then be made by the handlers, or by the service.

    摘要翻译： 披露了语言模型的共享。 在一个实施例中，提供可在输入设备的处理程序之间共享的语言模型服务。 该服务包括预处理操作模式和操作的校正模式。 在前一模式中，语言模型服务被设计为从输入设备的处理程序接收文档中的范围，并且作为响应，提供关于由处理程序考虑的文本的建议，以便在该范围内的文档内插入，基于 范围内文件的上下文。 在后一种模式中，语言模型服务被设计为对文档内的一系列文本进行校正，其中许多不同的输入设备的不同处理程序最初负责插入文本，使得服务 征求处理人员的意见，并据此确定文本更正。 然后可以由处理程序或服务进行更正。