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41 条记录 (耗时 0.066 秒)

    Aromatic ring derivatives
    3.
    发明授权
    Aromatic ring derivatives 失效
    芳香环衍生物

    公开(公告)号：US06242474B1

    公开(公告)日：2001-06-05

    申请号：US09446619

    申请日：2000-03-21

    申请人： Noritsugu Yamasaki ,  Takafumi Imoto ,  Takahiro Hiramura ,  Osamu Onomura ,  Masahiro Nishikawa ,  Hiroshi Kayakiri ,  Yoshito Abe ,  Hitoshi Hamashima ,  Hitoshi Sawada

    发明人： Noritsugu Yamasaki ,  Takafumi Imoto ,  Takahiro Hiramura ,  Osamu Onomura ,  Masahiro Nishikawa ,  Hiroshi Kayakiri ,  Yoshito Abe ,  Hitoshi Hamashima ,  Hitoshi Sawada

    IPC分类号： A61K314164

    CPC分类号： C07D213/78 ,  C07C311/51 ,  C07D213/81 ,  C07D233/64 ,  C07D233/68 ,  C07D409/06

    摘要： Novel aromatic ring derivatives represented by formula (I) or their pharmaceutical acceptable salts are provided. wherein Nu represents a 5- or 6-membered aromatic ring; ch1 and ch2 each represents a cross-linking group; and A represents an aromatic ring. These compounds have blood sugar-depressing activity or PDE 5 inhibitory activity and are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin-resistance, polycystic ovary syndrome, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, hypertension, stenocardia, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, autoimmune diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, nephritis, cachexia, pancreatitis, restenosis after PTCA, etc.

    摘要翻译： 提供由式（I）表示的新颖芳环衍生物或其药学上可接受的盐。其中Nu表示5-或6-元芳环; ch1和ch2各自表示交联基团; 并且A代表芳香环。这些化合物具有抑制血糖的活性或PDE 5抑制活性，可用作治疗糖耐量异常，糖尿病，糖尿病并发症，胰岛素抵抗综合征，多囊卵巢综合症，高脂血症，动脉粥样硬化， 心血管疾病，高血糖症，高血压，心律失常，肺动脉高压，充血性心力衰竭，肾小球病，肾小管间质性疾病，肾衰竭，血管狭窄，远端血管病，脑中风，慢性可逆障碍，自身免疫性疾病，过敏性鼻炎，荨麻疹，青光眼，以肠蠕动为特征的疾病 疾病，阳ence，肾炎，恶病质，胰腺炎，PTCA后再狭窄等。

    Indole derivatives
    7.
    发明申请
    Indole derivatives 审中-公开
    吲哚衍生物

    公开(公告)号：US20050171185A1

    公开(公告)日：2005-08-04

    申请号：US11092398

    申请日：2005-03-29

    申请人： Noritsugu Yamasaki ,  Takafumi Imoto ,  Teruo Oku ,  Noriko Oku ,  Chikako Oku ,  Tomohito Oku ,  Hiroshi Kayakiri ,  Osamu Onomura ,  Takahiro Hiramura

    发明人： Noritsugu Yamasaki ,  Takafumi Imoto ,  Teruo Oku ,  Noriko Oku ,  Chikako Oku ,  Tomohito Oku ,  Hiroshi Kayakiri ,  Osamu Onomura ,  Takahiro Hiramura

    IPC分类号： C07D209/10 ,  C07D209/12 ,  C07D405/10 ,  C07D409/10 ,  C07D409/12 ,  A61K31/405 ,  C07D209/02 ,  C07D43/02

    CPC分类号： C07D405/10 ,  C07D209/10 ,  C07D209/12 ,  C07D409/10 ,  C07D409/12

    摘要： A novel indole derivative or a salt thereof is provided, which is represented by the formula: wherein R1 represents an aryl lower alkyl group, said aryl group may be substituted with one or more groups selected from the group consisting of a halogen atom, an aryl group, a heterocyclic group, an aryl lower alkyl group, an aryl lower alkenyl group, a halo-lower alkyl group, a lower cycloalkyl-lower alkoxy group, a lower cycloalkoxy-lower alkyl group, an aryl lower alkynyl group, an aryloxy lower alkyl group, an aryl lower alkoxy group, a lower alkylthio group, a lower alkoxy group, and an alkenyl group; and R2 represents a lower alkyl group, a lower alkenyl group, an aryl group, or a heterocyclic group, each of which may be substituted with a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aryl group. The compound of the present invention has blood sugar level-depressing activity and PDE5-inhibiting activity, and is useful as medicine.

    摘要翻译： 提供了一种新的吲哚衍生物或其盐，其由下式表示：其中R 1表示芳基低级烷基，所述芳基可以被一个或多个选自下组的基团取代： 由卤素原子，芳基，杂环基，芳基低级烷基，芳基低级烯基，卤代低级烷基，低级环烷基 - 低级烷氧基，低级环烷氧基 - 低级烷基， 芳基低级炔基，芳氧基低级烷基，芳基低级烷氧基，低级烷硫基，低级烷氧基和烯基; R 2表示低级烷基，低级烯基，芳基或杂环基，它们各自可以被氢原子，低级烷基，低级烯基 ，或芳基。 本发明的化合物具有血糖降低活性和PDE5抑制活性，作为药物有用。