摘要:
The present invention relates to a compound formula (I) wherein X1 is bond or —O—CH2—, (II) or (III) R1 is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s), and B is hydrogen; halogen; lower alkyl; lower alkoxycarbonyl; cyclo(lower)alkyl; or a heterocyclic group, naphthyl, 1,2,3,4-tetrahydronaphthyl, benzyl or phenyl, each of which may be substituted with one or two substituent(s), or a salt thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiures or urinary incontinence.
摘要:
The present invention relates to a compound formula [I] wherein R1 and R5 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, x is bond, -o-o, —O—CH2—, etc., y is in which Z is bond, —O—(CH2)m— (in which m is 1 to 4), etc., R3 is lower alkanoyl, carboxy, lower alkoxycarbonyl, etc., and R4 is hydrogen, halogen, hydroxy, phenoxy, lower alkyl, lower alkoxy, etc., and n is 0, 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
摘要:
The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases inflammatory diseases, and allergic diseases. The compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
摘要:
The sharing of language models is disclosed. In one embodiment, a language model service is provided that is shareable among handlers for input devices. The service includes a pre-processing mode of operation, and a correction mode of operation. In the former mode, the language model service is designed to receive a range within a document from a handler for an input device, and in response provide advice regarding text under consideration by the handler to insert within the document at the range, based on the context of the document within the range. In the latter mode, the language model service is designed to supervise correction over a range of text within a document, in which a number of different handlers for a number of different input devices were initially responsible for insertion of the text, such that the service solicits suggestions from the handlers, and based thereon determines text corrections. The corrections can then be made by the handlers, or by the service.
摘要:
An airbag device provided with an airbag and inflator integrally covering the head and side sections of an occupant seated in a vehicle seat. The airbag, includes, during expansion and deployment, a head protecting chamber that covers the head of the occupant and side protecting chambers that cover the side sections of the occupant, and is stowed in a rolled state, for example, from a first side of the backrest of the vehicle seat to the second side over the upper portion. An additional folding part is provided on the outer periphery of the airbag extending from the attachment end side to the backrest so as to cover at least a part of the outer periphery of the airbag on the side opposite to the seated occupant.
摘要:
With the curtain air bag system according to this aspect, if the vehicle ends up rolling over, the main deployment portion receives a supply of gas and consequently inflates and deploys in a curtain shape. Also, the auxiliary deployment portion inflates and deploys by receiving a supply of gas from this main deployment portion via the gas passage. The head of an occupant seated in the front seat is protected against a rollover by the main deployment portion and the auxiliary deployment portion. Here, with the curtain air bag system described above, the upper end portion of the auxiliary deployment portion is connected to the front pillar via the connecting portion. Therefore, it is possible to prevent or effectively suppress the upper end of the auxiliary deployment portion from becoming offset in the vehicle width direction with respect to the front pillar when protecting the head of an occupant, which improves occupant head protection performance forward of the seat.
摘要:
A commanding system for a computer. The system includes a memory storing a binding table that connects input to associated action, at least one binding in the binding table including an interface binding. The system also includes a processor in data communication with the memory, the processor programmed to query each binding in the binding table, receive the interface binding associated with the binding; and generate a command interface based on the interface binding. The command interface is dynamically generated based on the information provided by the interface binding. Examples of command interfaces include toolbars and menus.
摘要:
A commanding system for a computer. An input sequence can be received from an input device, and the commanding system can be used to connect the input to an associated action. Commanding can be provided by a plurality of nodes that represent elements of control and application levels. The nodes can be arranged in a hierarchical structure, and each node can include a table of bindings. A service can be attached to one or more of the nodes at run-time to provide additional commanding functionality. For example, a service can modify or supplement the binding entries provided in the table of bindings associated with a given node.
摘要:
A remote monitoring system for elevator has a plurality of remote monitors for individually monitoring the running states of a plurality of elevators installed in a building, transmits running state data from the remote monitoring system via a communal public telephone line to a communal monitoring center, and allows communication between interphones, provided in the carriages of the elevators, and the monitoring center via the public telephone line. Each of the plurality of remote monitors comprises a memory unit which stores incoming time data of different incoming times, the remote monitor performing incoming controls after independently determining call signals from the monitoring center, based on the incoming time data stored in the memory unit. Furthermore, a first switching unit cuts off the auxiliary power when there has been no irregularity in the monitoring information of the elevator after the operating power has been supplied for a fixed period of time from an auxiliary power instead of the main power when the main power fails; and a second switching unit is driven by power from an interphone battery, and re-injects the auxiliary power when an emergency call button has been pressed.
摘要:
A commanding system for a computer. An input sequence can be received from an input device, and the commanding system can be used to connect the input to an associated action. Commanding can be provided by a plurality of nodes that represent elements of control and application levels. The nodes can be arranged in a hierarchical structure, and each node can include a table of bindings. A service can be attached to one or more of the nodes at run-time to provide additional commanding functionality. For example, a service can modify or supplement the binding entries provided in the table of bindings associated with a given node.