公开(公告)号：US20050090842A1

公开(公告)日：2005-04-28

申请号：US10998242

申请日：2004-11-24

申请人： Takayuki Suzuki ,  Pankaj Pasricha

发明人： Takayuki Suzuki ,  Pankaj Pasricha

IPC分类号： A61B1/018 ,  A61B1/273 ,  A61B17/04 ,  A61B17/06 ,  A61B17/28 ,  A61B17/10 ,  A61B17/12

CPC分类号： A61B17/0469 ,  A61B1/00098 ,  A61B1/00181 ,  A61B1/018 ,  A61B1/2736 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/29 ,  A61B2017/003 ,  A61B2017/00827 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/06042 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/2926

摘要： The holding device of the endoscope allows suspension of the tissue while it is held and fixed securely. Use of holding device with large distal ends will not damage tissue and allows holding and suspension of a large area. A needle pierces at least the proper muscularis, thereby forming a large protrusion including the proper muscularis of the stomach and the esophagus as artificial valve to prevent reflux effectively. The holding device, formed extending out of the distal end of the endoscope, can touch the tissue easily under observation of the endoscope. Treatment is simple, and takes a shorter time.

摘要翻译： 内窥镜的保持装置允许组织在被保持和固定的同时暂停。 使用具有大端部的保持装置不会损坏组织并允许保持和悬挂大面积。 针至少刺穿适当的肌层，从而形成包括胃和食道的适当肌层的大突起物作为人造瓣，以有效地防止反流。 从内窥镜的远端延伸出的保持装置能够在内窥镜的观察下容易地接触组织。 治疗简单，时间短。

公开(公告)号：US20080058589A1

公开(公告)日：2008-03-06

申请号：US11932445

申请日：2007-10-31

申请人： Takayuki Suzuki ,  Pankaj Pasricha

发明人： Takayuki Suzuki ,  Pankaj Pasricha

IPC分类号： A61B1/018

CPC分类号： A61B17/0469 ,  A61B1/00098 ,  A61B1/00181 ,  A61B1/018 ,  A61B1/2736 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/29 ,  A61B2017/003 ,  A61B2017/00827 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/06042 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/2926

摘要： The holding device of the endoscope allows suspension of the tissue while it is held and fixed securely. Use of the holding device with large distal ends will not damage tissue and allows holding and suspension of a large area. A needle pierces at least the proper muscularis, thereby forming a large protrusion including the proper muscularis of the stomach and the esophagus as artificial valve to prevent reflux effectively. The holding device, formed extending out of the distal end of the endoscope, can touch the tissue easily under observation of the endoscope. Treatment is simple, and takes a shorter time.

摘要翻译： 内窥镜的保持装置允许组织在被保持和固定的同时暂停。 使用具有大的远端的保持装置不会损坏组织并允许大面积的保持和悬挂。 针至少刺穿适当的肌层，从而形成包括胃和食道的适当肌层的大突起物作为人造瓣，以有效地防止反流。 从内窥镜的远端延伸出的保持装置能够在内窥镜的观察下容易地接触组织。 治疗简单，时间短。

公开(公告)号：US20060282100A1

公开(公告)日：2006-12-14

申请号：US11427836

申请日：2006-06-30

申请人： Pankaj Pasricha ,  Hideki Shimonaka ,  Koichi Kawashima ,  Takayuki Suzuki ,  Tsuyoshi Tsukagoshi ,  Yoshio Onuki

发明人： Pankaj Pasricha ,  Hideki Shimonaka ,  Koichi Kawashima ,  Takayuki Suzuki ,  Tsuyoshi Tsukagoshi ,  Yoshio Onuki

IPC分类号： A61B17/04

CPC分类号： A61B1/018 ,  A61B1/0014 ,  A61B17/00234 ,  A61B17/0467 ,  A61B17/0482 ,  A61B17/0485 ,  A61B17/06109 ,  A61B17/0643 ,  A61B17/068 ,  A61B17/29 ,  A61B2017/00269 ,  A61B2017/00827 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/0496 ,  A61B2017/061 ,  A61B2017/0647 ,  A61B2017/2905 ,  A61B2017/2906

摘要： An endoscopic instrument used to form an artificial valve for treating gastroesophageal reflux disease (GERD).

摘要翻译： 一种用于形成用于治疗胃食管反流病（GERD）的人造瓣膜的内窥镜仪器。

公开(公告)号：US20050251153A1

公开(公告)日：2005-11-10

申请号：US11099303

申请日：2005-04-05

申请人： Yuji Sakamoto ,  Yoshio Onuki ,  Koh Kimura ,  Satoshi Miyamoto ,  Pankaj Pasricha ,  Takayuki Suzuki ,  Koichi Kawashima

发明人： Yuji Sakamoto ,  Yoshio Onuki ,  Koh Kimura ,  Satoshi Miyamoto ,  Pankaj Pasricha ,  Takayuki Suzuki ,  Koichi Kawashima

IPC分类号： A61B17/06 ,  A61B1/00 ,  A61B17/00 ,  A61B17/04 ,  A61B17/10 ,  A61B17/24 ,  A61B17/28 ,  A61B17/30

CPC分类号： A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B2017/00469 ,  A61B2017/0406 ,  A61B2017/0417 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/2905 ,  A61B2017/306

摘要： A ligature and suture device for medical application that ligatures or sutures biomedical tissue that has been suctioned by a suction device using a suturing member. The ligature and suture device includes an insertion portion having a lumen into which an endoscope can be inserted, and a distal end portion that is connected to the lumen and in which at least one side aperture is provided, at least one hollow needle that is able to support inside itself the suturing member, and that is placed inside the insertion portion such that a tip of the hollow needle is able to move between a first position, which is on a base end side of the side aperture, and a second position, which is on a distal end side of the side aperture, an operating section that performs an operation to move the needle, and at least one pledget that can be penetrated by the needle, and that is placed in a vicinity of the distal end of the side aperture so as to be freely removable from the distal end portion.

摘要翻译： 用于医疗应用的结扎和缝合装置，其连接或缝合已由使用缝合构件的抽吸装置抽吸的生物医学组织。 连线和缝合装置包括具有内窥镜可被插入的内腔的插入部分和连接到内腔并且至少设置有至少一个侧孔的远端部分，至少一个中空针头能够 将其固定在缝合部件的内侧，并将其放置在插入部内，使得中空针头的前端能够在侧孔的基端侧的第一位置与第二位置之间移动， 位于所述侧孔的前端侧的操作部，所述操作部进行所述针的移动操作，以及至少一个能够被针刺入的毛发，并且被放置在所述针的前端的附近 从而能够从前端部自由地移除。

公开(公告)号：US11925609B2

公开(公告)日：2024-03-12

申请号：US16748974

申请日：2020-01-22

申请人： Pankaj Pasricha ,  Liansheng Liu

发明人： Pankaj Pasricha ,  Liansheng Liu

IPC分类号： A61B18/12 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04 ,  A61B18/18 ,  A61B18/20 ,  A61K31/165 ,  A61K31/167 ,  A61K31/357 ,  A61K31/36 ,  A61N7/00

CPC分类号： A61K31/167 ,  A61B18/20 ,  A61K31/165 ,  A61K31/357 ,  A61K31/36 ,  A61N7/00 ,  A61B2018/00434 ,  A61B2018/00494 ,  A61B18/02 ,  A61B18/04 ,  A61B18/12 ,  A61B18/18 ,  A61B18/1815 ,  A61N2007/003

摘要： Methods of treatment in subjects suffering from diabetes mellitus or obesity are provided. The methods comprise ablation of a region of the small intestine in the subject, in particular ablation of a region of the duodenum. The ablation may be a mechanical, electrical, thermal, radiative, or chemical ablation and may in some cases target a sensory nerve. The methods may, in some cases, comprise the step of administering an active agent directly to the small intestine in the subject, in particular administering the active agent directly to the duodenum.

公开(公告)号：US20170105781A1

公开(公告)日：2017-04-20

申请号：US15277704

申请日：2016-09-27

申请人： Pankaj Pasricha ,  Liansheng Liu

发明人： Pankaj Pasricha ,  Liansheng Liu

IPC分类号： A61B18/12 ,  A61B18/20 ,  A61N7/00 ,  A61B18/18

CPC分类号： A61B18/12 ,  A61B18/02 ,  A61B18/04 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/00434 ,  A61B2018/00494 ,  A61K31/165 ,  A61K31/357 ,  A61K31/36 ,  A61N7/00 ,  A61N2007/003

摘要： Methods of treatment in subjects suffering from diabetes mellitus or obesity are provided. The methods comprise ablation of a region of the small intestine in the subject, in particular ablation of a region of the duodenum. The ablation may be a mechanical, electrical, thermal, radiative, or chemical ablation and may in some cases target a sensory nerve. The methods may, in some cases, comprise the step of administering an active agent directly to the small intestine in the subject, in particular administering the active agent directly to the duodenum. The active agents useful in the treatments described herein include analgesic agents and, in particular, antinociceptive agents such as capsaicin, resiniferatoxin, and their analogues.

公开(公告)号：US20110066208A1

公开(公告)日：2011-03-17

申请号：US12865292

申请日：2009-01-30

申请人： Pankaj Pasricha ,  Jiande Chen

发明人： Pankaj Pasricha ,  Jiande Chen

IPC分类号： A61N1/36

CPC分类号： A61N1/36007

摘要： The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.

摘要翻译： 本公开是在需要的个体中治疗肥胖症的方法，包括将远端小肠或回肠中的刺激电极定位，并且在电刺激有效的脉冲或重复脉冲列中给予电刺激，至少在 部分地，刺激远端小肠或回肠的迷走神经传入和传出活动。 迷走神经传入和传出活动的刺激导致回肠制动器的调节。 具体地说，在脉冲串中提供电刺激。 此外，描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。 此外，本发明提供了一种饮食障碍的治疗方法，包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。 刺激电极通过腹腔镜，内窥镜或外科手段放置。

公开(公告)号：US20070150021A1

公开(公告)日：2007-06-28

申请号：US11681249

申请日：2007-03-02

申请人： Jiande Chen ,  Pankaj Pasricha

发明人： Jiande Chen ,  Pankaj Pasricha

IPC分类号： A61N1/36

CPC分类号： A61N1/36007

摘要： The present invention is directed to a method of stimulating the vagus nerve of a subject.

摘要翻译： 本发明涉及刺激受试者的迷走神经的方法。

公开(公告)号：US08326427B2

公开(公告)日：2012-12-04

申请号：US12836377

申请日：2010-07-14

申请人： Pankaj Pasricha ,  Jlande Chen

发明人： Pankaj Pasricha ,  Jlande Chen

IPC分类号： A61N1/00

CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/0517 ,  A61N1/0551

摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.

摘要翻译： 一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜，内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。

公开(公告)号：US20110015695A1

公开(公告)日：2011-01-20

申请号：US12836377

申请日：2010-07-14

申请人： Pankaj Pasricha ,  Jiande Chen

发明人： Pankaj Pasricha ,  Jiande Chen

IPC分类号： A61N1/05

CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/0517 ,  A61N1/0551

摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.

摘要翻译： 一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。 电极通过腹腔镜，内窥镜或外科手段放置。 胃肠道刺激激活迷走神经反射。 迷走神经反射的激活是通过胃和胰腺传入的。 胃肠道刺激也激活轴突反射。 轴突反射的激活是通过脊神经的二分支。 电刺激与内窥镜手术同时进行或立即进行内镜手术。 此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练 在激活烟碱受体。