摘要:
The present invention relates to novel antibiotics TKR1912-I having the following formula I and TKR1912-II having the following formula II or pharmacologically acceptable salts thereof, which are useful as a remedy for fungal infections, as well as a process for producing them and a microorganism capable of producing them.
摘要:
Novel antibiotics useful as a remedy for fungal infections and a process for producing antibiotic TKR1912-I or pharmacologically acceptable salts thereof, which substances have such plysicochemical properties that (1) the mass spectrum thereof according to FAB-MS has a peak of m/z of 559 [M+H].sup.+ ; (2) the molecule bears 26 carbon atoms and no nitrogen atom; (3) the ultraviolet absorption spectrum thereof in methianol shows a terminal absorptions; (4) the main absorption wavenumbers of the infrared absorption spectrum according to the KBr method are 3430, 2920, 2850, 1740, and 1190 cm.sup.-1 ; and (5) they are soluble in methanol, chloroform, and water, but are sparingly soluble in hexane.
摘要:
The object of the present invention is to provide a novel bioactive substance of value as a therapeutic agent for mycosis, and the like.This invention relates to the bioactive substance TKR1785 of the following general formula (A): ##STR1## (wherein R represents --CH(CH.sub.3).sub.2 or --CH(CH.sub.3)C.sub.2 H.sub.5).
摘要:
To provide a method for detecting a cancer cell in a resected specimen by determining a change in an expression level of at least one of cancer-associated genes selected from genes of which cDNA is a DNA comprising a nucleotide sequence as shown in any one of SEQ ID NOs: 1 to 16 and 66 to 68 in Sequence Listing, or a DNA capable of hybridizing with a nucleic acid consisting of a nucleotide sequence as shown in any one of SEQ ID NOs: 1 to 16 and 66 to 68 in Sequence Listing under stringent conditions; as well as a kit for detecting cancer by the above method, and the like.
摘要翻译:本发明提供一种检测切除标本中癌细胞的方法,该方法是通过确定选自cDNA为包含SEQ ID NO中任一项所示核苷酸序列的DNA的基因中的至少一种癌症相关基因的表达水平的变化, ID NO:序列表中的1至16和66至68,或能够与序列表中SEQ ID NO:1至16和66至68中任一个所示核苷酸序列组成的核酸杂交的DNA 严格条件; 以及通过上述方法检测癌症的试剂盒等。
摘要:
A method for transferring a gene into a fat cell or progenitor fat cell comprising the step of infecting the fat cell or progenitor cell with a retrovirus vector having a foreign gene in the presence of a substance having both of a retrovirus-binding site and a target cell-binding site in the molecule or a mixture of a substance having a retrovirus-binding site and a substance having a target cell-binding site, the target cell-binding site having a region that can bind to VLA-5 and/or a region that can bind to VLA-4.
摘要:
A polypeptide having a high fidelity DNA polymerase activity and thus being useful as a genetic engineering reagent; a gene encoding this polypeptide; a method of producing the polypeptide; and a method of amplifying a nucleic acid by using the polypeptide.
摘要:
Disclosed are: polypeptides for TCR α-chain and β-chain which are restricted to HLA-A*0201 for Aur-A and are derived from a CTL; and nucleic acids encoding the polypeptides. The nucleic acids can impart a cytotoxic activity against a cell capable of presenting an HLA-A*0201 molecule and an Aur-A207-215 peptide thereon to a T cell, and are therefore useful for the treatment of cancer in which Aur-A is expressed.
摘要:
Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.
摘要:
A method for preparing a γδ T cell population, characterized in that the method includes the step of culturing a cell population containing γδ T cells, in the presence of (a) fibronectin, a fibronectin fragment or a mixture thereof and (b) an activating factor of γδ T cells. According to the present invention, a method for preparing a γδ T cell population is provided. The γδ T cell population obtained by the method is suitably used in, for example, immunotherapy. Therefore, the method of the present invention is expected to greatly contribute to a medical field.
摘要:
To provide a means of controlling the function of Flt3. A composition for inhibiting the function of human Flt3, a method of inducing apoptosis by using the composition, and a kit for the method.