Antibiotics TKR1912-I and TKR1912-II and process for producing the same
    2.
    发明授权
    Antibiotics TKR1912-I and TKR1912-II and process for producing the same 失效
    抗生素TKR1912-II及其制备方法

    公开(公告)号:US6068839A

    公开(公告)日:2000-05-30

    申请号:US913250

    申请日:1998-07-10

    CPC分类号: C12P1/00 C12P1/02

    摘要: Novel antibiotics useful as a remedy for fungal infections and a process for producing antibiotic TKR1912-I or pharmacologically acceptable salts thereof, which substances have such plysicochemical properties that (1) the mass spectrum thereof according to FAB-MS has a peak of m/z of 559 [M+H].sup.+ ; (2) the molecule bears 26 carbon atoms and no nitrogen atom; (3) the ultraviolet absorption spectrum thereof in methianol shows a terminal absorptions; (4) the main absorption wavenumbers of the infrared absorption spectrum according to the KBr method are 3430, 2920, 2850, 1740, and 1190 cm.sup.-1 ; and (5) they are soluble in methanol, chloroform, and water, but are sparingly soluble in hexane.

    摘要翻译: PCT No.PCT / JP96 / 00565 Sec。 371日期:1998年7月10日 102(e)1998年7月10日PCT 1996年3月8日PCT公布。 公开号WO96 / 28456 日期1996年9月19日新型抗生素可用作真菌感染的治疗方法和生产抗生素TKR1912-I或其药理学上可接受的盐的方法,该物质具有以下特性:(1)根据FAB-MS的质谱具有 m / z峰为559 [M + H] +; (2)分子具有26个碳原子,不含氮原子; (3)甲基酚中的紫外吸收光谱显示终端吸收; (4)KBr法红外吸收光谱的主要吸收波数分别为3430,2920,2850,1740和1190cm-1; 和(5)它们可溶于甲醇,氯仿和水,但微溶于己烷。

    Cancer-associated genes
    4.
    发明授权
    Cancer-associated genes 失效
    癌症相关基因

    公开(公告)号:US06670119B1

    公开(公告)日:2003-12-30

    申请号:US09377497

    申请日:1999-08-20

    IPC分类号: C12Q168

    摘要: To provide a method for detecting a cancer cell in a resected specimen by determining a change in an expression level of at least one of cancer-associated genes selected from genes of which cDNA is a DNA comprising a nucleotide sequence as shown in any one of SEQ ID NOs: 1 to 16 and 66 to 68 in Sequence Listing, or a DNA capable of hybridizing with a nucleic acid consisting of a nucleotide sequence as shown in any one of SEQ ID NOs: 1 to 16 and 66 to 68 in Sequence Listing under stringent conditions; as well as a kit for detecting cancer by the above method, and the like.

    摘要翻译: 本发明提供一种检测切除标本中癌细胞的方法,该方法是通过确定选自cDNA为包含SEQ ID NO中任一项所示核苷酸序列的DNA的基因中的至少一种癌症相关基因的表达水平的变化, ID NO:序列表中的1至16和66至68,或能够与序列表中SEQ ID NO:1至16和66至68中任一个所示核苷酸序列组成的核酸杂交的DNA 严格条件; 以及通过上述方法检测癌症的试剂盒等。

    Method for transfer of gene into fat cell or progenitor fat cell
    5.
    发明授权
    Method for transfer of gene into fat cell or progenitor fat cell 有权
    将基因转移到脂肪细胞或祖细胞脂肪细胞中的方法

    公开(公告)号:US08835177B2

    公开(公告)日:2014-09-16

    申请号:US11917853

    申请日:2006-06-12

    摘要: A method for transferring a gene into a fat cell or progenitor fat cell comprising the step of infecting the fat cell or progenitor cell with a retrovirus vector having a foreign gene in the presence of a substance having both of a retrovirus-binding site and a target cell-binding site in the molecule or a mixture of a substance having a retrovirus-binding site and a substance having a target cell-binding site, the target cell-binding site having a region that can bind to VLA-5 and/or a region that can bind to VLA-4.

    摘要翻译: 一种将基因转移到脂肪细胞或祖细胞脂肪细胞中的方法,包括在具有逆转录病毒结合位点和靶标的物质存在的情况下用具有外来基因的逆转录病毒载体感染所述脂肪细胞或祖细胞的步骤 分子中的细胞结合位点或具有逆转录病毒结合位点的物质与具有靶细胞结合位点的物质的混合物,所述靶细胞结合位点具有能够结合VLA-5的区域和/或 可以结合VLA-4的区域。

    METHOD FOR PRODUCING GAMMA DELTA T CELL POPULATION
    9.
    发明申请
    METHOD FOR PRODUCING GAMMA DELTA T CELL POPULATION 审中-公开
    生产GAMMA DELTA T细胞群体的方法

    公开(公告)号:US20110158954A1

    公开(公告)日:2011-06-30

    申请号:US12450017

    申请日:2008-03-04

    摘要: A method for preparing a γδ T cell population, characterized in that the method includes the step of culturing a cell population containing γδ T cells, in the presence of (a) fibronectin, a fibronectin fragment or a mixture thereof and (b) an activating factor of γδ T cells. According to the present invention, a method for preparing a γδ T cell population is provided. The γδ T cell population obtained by the method is suitably used in, for example, immunotherapy. Therefore, the method of the present invention is expected to greatly contribute to a medical field.

    摘要翻译: 一种制备γδT细胞群体的方法,其特征在于该方法包括在(a)纤连蛋白,纤连蛋白片段或其混合物存在下培养含有γδT细胞的细胞群的步骤,和(b)活化 γδT细胞因子。 根据本发明,提供了制备γδT细胞群体的方法。 通过该方法获得的γδT细胞群适用于例如免疫治疗。 因此,预期本发明的方法对医疗领域有很大贡献。