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公开(公告)号：US5801202A
公开(公告)日：1998-09-01
申请号：US817928
申请日：1997-05-30
申请人： Taketoshi Fujimori , Hiroshi Kusuoku , Akira Yamamuro , Yukihiro Yada , Kazuhiko Higuchi , Genji Imokawa , Naoki Kondo , Yoshinori Masukawa , Hajime Tokuda , Hisashi Tsujimura
发明人： Taketoshi Fujimori , Hiroshi Kusuoku , Akira Yamamuro , Yukihiro Yada , Kazuhiko Higuchi , Genji Imokawa , Naoki Kondo , Yoshinori Masukawa , Hajime Tokuda , Hisashi Tsujimura
IPC分类号： A61K8/41 , A61K31/13 , A61Q19/00 , C07C217/28 , C07D303/22 , A01K31/13
CPC分类号： A61K8/41 , A61Q19/00 , C07C217/28 , C07D303/22 , A61Q19/004 , A61Q5/006 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： Disclosed is an amine derivative represented by the following formula (1) or an acid addition salt thereof: ##STR1## wherein R.sup.1 represents a group ##STR2## a cyclopentyl group, cyclohexyl group, or a cycloheptyl group, R.sup.2 is a hydrogen atom or C1-C3 alkyl group which may be substituted by one or more hydroxyl groups, m is an integer falling in the range from 3 to 5 inclusive, and n is an integer falling in the range from 9 to 11 inclusive. Also, intermediates useful in the manufacture of the amine derivative (1), compositions for external application to the skin containing the amine derivative, and keratinization improvers containing the amine derivative as an active component are described. The compound (1) has excellent keratinization improving action, pigmentation preventing action, etc.
摘要翻译： PCT No.PCT / JP95 / 02284第 371日期1997年5月30日 102（e）日期1997年5月30日PCT提交1995年11月8日PCT公布。 公开号WO96 / 15098 日期：1996年5月23日公开是由下式（1）表示的胺衍生物或其酸加成盐：其中，R1表示环戊基，环己基或环庚基，R2表示 氢原子或可以被一个或多个羟基取代的C 1 -C 3烷基，m为3〜5的整数，n为9〜11的整数。 此外，描述了可用于制备胺衍生物（1）的中间体，外用于含有胺衍生物的皮肤的组合物，以及含有胺衍生物作为活性成分的角质化改进剂。 化合物（1）具有优异的角质化改善作用，防止着色作用等
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公开(公告)号：US09102987B2
公开(公告)日：2015-08-11
申请号：US12994571
申请日：2009-05-29
CPC分类号： C12Q1/6895 , C07K14/37 , C12Q2600/16
摘要： A method of detecting Paecilomyces variotii, containing identifying Paecilomyces variotii using a nucleic acid represented by the following nucleotide sequence (a) or (b): (a) a partial nucleotide sequence of a β-tubulin gene set forth in any one of SEQ ID NOS: 1 to 4 and 22 to 33, or a complementary sequence thereof; and (b) a nucleotide sequence which includes a nucleotide sequence set forth in any one of SEQ ID NOS: 1 to 4 and 22 to 33 which has a deletion, substitution, or addition of one to several nucleotides and can be used for detecting Paecilomyces variotii, or a complementary sequence thereof.
摘要翻译： 一种使用由下列核苷酸序列（a）或（b）表示的核酸，鉴别拟青霉的鉴别拟青霉的方法：（a）SEQ ID NO：1中任一项所示的＆bgr-微管蛋白基因的部分核苷酸序列 ID NOS：1至4和22至33或其互补序列; 和（b）包含SEQ ID NO：1至4和22至33中任一项所示的核苷酸序列的核苷酸序列，其具有一至几个核苷酸的缺失，取代或添加，并且可用于检测拟青霉 变异体或其互补序列。
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公开(公告)号：US20110136117A1
公开(公告)日：2011-06-09
申请号：US12994566
申请日：2009-05-28
CPC分类号： C12Q1/6895 , C12Q1/04 , C12Q2600/16 , G01N33/56961 , G01N2333/37 , G01N2333/38
摘要： A method of detecting a heat-resistant fungus, which has a step of identifying the heat-resistant fungus using the following nucleic acid (I) or (II):(I) a nucleic acid including a nucleotide sequence set forth in any one of SEQ ID NOS: 24 to 35 and 83 to 86, or a complementary sequence thereof; or(II) a nucleic acid including a nucleotide sequence resulting from a deletion, substitution, or addition of one to several nucleotides in the nucleotide sequence set forth in any one of SEQ ID NOS: 24 to 35 and 83 to 86 and being capable of detecting the heat-resistant fungus, or a complementary sequence thereof.
摘要翻译： 检测耐热真菌的方法，其具有使用以下核酸（I）或（II）鉴定所述耐热真菌的步骤：（I）包含以下任一项所述的核苷酸序列的核酸 SEQ ID NOS：24至35和83至86，或其互补序列; 或（II）包含在SEQ ID NO：24至35和83至86中任一项所示的核苷酸序列中缺失，取代或添加1至数个核苷酸而产生的核苷酸序列的核酸，并且能够 检测耐热真菌或其互补序列。
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4.发明授权Hair treatment composition comprising a lactam compound and a water-soluble macromolecule 失效包含内酰胺化合物和水溶性大分子的头发处理组合物
公开(公告)号：US6099828A
公开(公告)日：2000-08-08
申请号：US77876
申请日：1998-06-08
CPC分类号： A61K8/4913 , A61Q5/065 , A61Q5/12
摘要： A hair treatment composition comprising a compound of Formula (1): ##STR1## wherein R.sup.1, R.sup.2, m and n are as defined in the disclosure; and a water-soluble macromolecule.
摘要翻译： PCT No.PCT / JP97 / 03565 Sec。 371日期1998年6月8日第 102（e）日期1998年6月8日PCT 1997年10月6日PCT公布。 公开号WO98 / 15256 日本1998年4月16日一种包含式（1）化合物的头发处理组合物：其中R1，R2，m和n如本公开中所定义; 和水溶性高分子。
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公开(公告)号：US09074261B2
公开(公告)日：2015-07-07
申请号：US12994566
申请日：2009-05-28
IPC分类号： C12Q1/68 , C12Q1/04 , G01N33/569
CPC分类号： C12Q1/6895 , C12Q1/04 , C12Q2600/16 , G01N33/56961 , G01N2333/37 , G01N2333/38
摘要： A method of detecting a heat-resistant fungus, which has a step of identifying the heat-resistant fungus using the following nucleic acid (I) or (II): (I) a nucleic acid including a nucleotide sequence set forth in any one of SEQ ID NOS: 24 to 35 and 83 to 86, or a complementary sequence thereof; or (II) a nucleic acid including a nucleotide sequence resulting from a deletion, substitution, or addition of one to several nucleotides in the nucleotide sequence set forth in any one of SEQ ID NOS: 24 to 35 and 83 to 86 and being capable of detecting the heat-resistant fungus, or a complementary sequence thereof.
摘要翻译： 检测耐热真菌的方法，其具有使用以下核酸（I）或（II）鉴定所述耐热真菌的步骤：（I）包含以下任一项所述的核苷酸序列的核酸 SEQ ID NOS：24至35和83至86，或其互补序列; 或（II）包含在SEQ ID NO：24至35和83至86中任一项所示的核苷酸序列中缺失，取代或添加1至数个核苷酸而产生的核苷酸序列的核酸，并且能够 检测耐热真菌或其互补序列。
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公开(公告)号：US08748093B2
公开(公告)日：2014-06-10
申请号：US13128114
申请日：2009-11-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895
摘要： A method of detecting a fungus belonging to genus Geosmithia, including identifying a fungus belonging to genus Geosmithia using a nucleic acid represented by the nucleotide sequence defined in the following (a) or (b): (a) a partial nucleotide sequence of β-tubulin gene shown in any one of SEQ ID NOS: 1 to 3, or a complementary sequence thereof; (b) a nucleotide sequence including deletion, substitution, insertion or addition of one or several nucleotide(s) in the nucleotide sequence shown in any one of SEQ ID NOS: 1 to 3, or a complementary sequence thereof.
摘要翻译： 一种检测属于地缘硅藻属的真菌的方法，包括使用由以下（a）或（b）中定义的核苷酸序列表示的核酸鉴定属于地心属的真菌：（a）部分核苷酸序列＆bgr; - 如SEQ ID NO：1至3中任一项所示的 - 微管蛋白基因或其互补序列; （b）包含SEQ ID NO：1至3中任一项所示的核苷酸序列中的一个或多个核苷酸的缺失，取代，插入或添加的核苷酸序列或其互补序列。
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公开(公告)号：US20120129166A1
公开(公告)日：2012-05-24
申请号：US13128114
申请日：2009-11-11
CPC分类号： C12Q1/6895
摘要： A method of detecting a fungus belonging to genus Geosmithia, including identifying a fungus belonging to genus Geosmithia using a nucleic acid represented by the nucleotide sequence defined in the following (a) or (b): (a) a partial nucleotide sequence of β-tubulin gene shown in any one of SEQ ID NOS: 1 to 3, or a complementary sequence thereof; (b) a nucleotide sequence including deletion, substitution, insertion or addition of one or several nucleotide(s) in the nucleotide sequence shown in any one of SEQ ID NOS: 1 to 3, or a complementary sequence thereof.
摘要翻译： 一种检测属于地缘硅藻属的真菌的方法，包括使用由以下（a）或（b）中定义的核苷酸序列表示的核酸鉴定属于地心属的真菌：（a）部分核苷酸序列＆bgr; - 如SEQ ID NO：1至3中任一项所示的 - 微管蛋白基因或其互补序列; （b）包含SEQ ID NO：1至3中任一项所示的核苷酸序列中的一个或多个核苷酸的缺失，取代，插入或添加的核苷酸序列或其互补序列。
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公开(公告)号：US20110104699A1
公开(公告)日：2011-05-05
申请号：US12994571
申请日：2009-05-29
CPC分类号： C12Q1/6895 , C07K14/37 , C12Q2600/16
摘要： A method of detecting Paecilomyces variotii, containing identifying Paecilomyces variotii using a nucleic acid represented by the following nucleotide sequence (a) or (b): (a) a partial nucleotide sequence of a β-tubulin gene set forth in any one of SEQ ID NOS: 1 to 4 and 22 to 33, or a complementary sequence thereof; and (b) a nucleotide sequence which includes a nucleotide sequence set forth in any one of SEQ ID NOS: 1 to 4 and 22 to 33 which has a deletion, substitution, or addition of one to several nucleotides and can be used for detecting Paecilomyces variotii, or a complementary sequence thereof.
摘要翻译： 一种使用由下列核苷酸序列（a）或（b）表示的核酸，鉴别拟青霉的鉴别拟青霉的方法：（a）SEQ ID NO：1中任一项所示的＆bgr-微管蛋白基因的部分核苷酸序列 ID NOS：1至4和22至33或其互补序列; 和（b）包含SEQ ID NO：1至4和22至33中任一项所示的核苷酸序列的核苷酸序列，其具有一至几个核苷酸的缺失，取代或添加，并且可用于检测拟青霉 变异体或其互补序列。
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