摘要:
Disclosed is an amine derivative represented by the following formula (1) or an acid addition salt thereof: ##STR1## wherein R.sup.1 represents a group ##STR2## a cyclopentyl group, cyclohexyl group, or a cycloheptyl group, R.sup.2 is a hydrogen atom or C1-C3 alkyl group which may be substituted by one or more hydroxyl groups, m is an integer falling in the range from 3 to 5 inclusive, and n is an integer falling in the range from 9 to 11 inclusive. Also, intermediates useful in the manufacture of the amine derivative (1), compositions for external application to the skin containing the amine derivative, and keratinization improvers containing the amine derivative as an active component are described. The compound (1) has excellent keratinization improving action, pigmentation preventing action, etc.
摘要:
The present invention relates to an amine derivative represented by the following general formula (I) or (II): ##STR1## wherein R.sup.1 means a heteroatom-containing C.sub.1 -C.sub.40 hydrocarbon group which may have a ring structure, or the like; R.sup.2 -R.sup.5 each denote a C.sub.1 -C.sub.20 hydrocarbon group, hydrogen or the like; A.sup.1 represents ##STR2## or R.sup.15 --Z--.sup.16 --(CH.sub.2).sub.n --; B.sup.1 stands for hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen or the like; C.sup.1 denotes hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue or the like; a dermatologic preparation containing the same; and a process for producing the amine derivative. This amine derivative has excellent effects of smoothing or removing wrinkles and improving keratinization.
摘要:
A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.
摘要:
A composition for external skin care comprising an amine derivative represented by the following formula (1), ##STR1## wherein R.sup.1 is a linear, branched, or cyclic saturated or unsaturated hydrocarbon group having 4-40 carbon atoms, and R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are individually a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms, which may be substituted or unsubstituted by 1 or more hydroxy groups; or an acid addition salt thereof, in an amount from 0.0001 to less than 0.1% by weight; and a method of curing wrinkles and keratinization of the skin characterized by applying said amine derivative or its salt to the skin.
摘要:
The amide derivative of the present invention is one represented by the following general formula (I) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R.sup.1 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.2 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 3 to 39 carbon atoms; R.sup.3 represents a group containing at least one group represented by the formula: ##STR2## wherein R.sup.4 and R.sup.5 each represents a hydrogen atom or a straight-chain or branched or cyclic, saturated or unsaturated hydrocarbon group, or R.sup.4 and R.sup.5 may form a hydrocarbon group together; and X represents ##STR3##
摘要:
The amide derivative of the present invention is one represented by the following general formula (II) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R.sup.11 represents a straight-chain or branched hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.12 represents a straight-chain or branched hydrocarbon group carrying 1 to 39 carbon atoms; R.sup.13 represents a hydrogen atom or a hydrocarbon group carrying 1 to 6 carbon atoms; and R.sup.14 represents a hydrogen atom or a hydrocarbon group having a straight-chain, branched or cyclic structure and carrying 1 to 40 carbon atoms which may contain an oxygen atom.
摘要翻译:PCT No.PCT / JP93 / 01676 Sec。 371日期:1994年7月13日 102(e)日期1994年7月13日PCT 1993年11月16日PCT公布。 公开号WO94 / 12490 日期1994年6月9日本发明的酰胺衍生物为下述通式(II)所示的酰胺衍生物,本发明的皮肤病学制剂为含有所述酰胺衍生物的皮肤病学制剂。 (II)其中R11表示含有10〜40个碳原子的直链或支链烃基; R12表示带有1〜39个碳原子的直链或支链烃基; R 13表示氢原子或含有1〜6个碳原子的烃基; R 14表示氢原子或具有直链,支链或环状结构且含有可含有氧原子的1〜40个碳原子的烃基。
摘要:
The invention relates to a complexion-improving beauty composition comprising disintegrable granules and a blood circulation accelerator. The composition can synergistically exhibit a blood circulation-accelerating effect in a short period of time, is excellent in the effect of improving a complexion, and does not irritate the skin and eyes, thus being highly safe.
摘要:
A cosmetic method for obtaining substantial cosmetic effects through simple massaging by ordinary people by first massaging in the direction of arterial blood flow and then in the direction of venous blood flow, or by massaging the surface of the skin with the use of a cosmetic comprising disintegrating particles while the pulse, dermal vasculature, skin temperature, or dermal blood flow is in a stimulated, dilated, elevated, or stimulated state as opposed to a resting state, and by washing the skin with a cleanser or a detergent, and then using a skincare cosmetic, wherein massaging is done using a massaging cosmetic comprising disintegrating particles before the skincare cosmetic is used after washing with a cleanser or detergent. This allows effective skincare to be achieved.
摘要:
Light Lo is allowed to be applied on the skin S, the internal scattered light Li in the region from the surface of the skin S to the microcirculation system is detected preferably in at least three wavelength regions of 400 to nm, 500 to 600 nm, 600 to 800 nm, or 800 to 1500 nm, and the optical properties which are affected by blood circulation, such as skin color, spots, and discoloration are determined. With these optical properties, the surface state of the skin can be evaluated better.
摘要:
The autonomic nerve regulating agent of the present invention, which, has sedative action, sleep inducing action, and stress mitigating action in individuals, regardless of individual variation in sensitivity to or preference for fragrance, contains as an active ingredient a sesquiterpene alcohol with a boiling point of 250° C. or higher, particularly cedrol.