公开(公告)号：US20080234774A1

公开(公告)日：2008-09-25

申请号：US11687957

申请日：2007-03-19

申请人： Tamara Colette Baynham ,  Quan Ni ,  Shelley Cazares ,  Kevin J. Stalsberg

发明人： Tamara Colette Baynham ,  Quan Ni ,  Shelley Cazares ,  Kevin J. Stalsberg

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684

摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of ventricular dyssynchrony or a patient's physiological response to ventricular dyssynchrony to control the delivery of cardioprotective pre-excitation pacing in closed-loop fashion.

摘要翻译： 心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。 这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。 本文描述了一种方法和系统，其使用心室不同步或患者对心室不同步的生理反应的测量来控制以闭环方式递送心脏保护性预激发起搏。

公开(公告)号：US07711420B2

公开(公告)日：2010-05-04

申请号：US11687957

申请日：2007-03-19

申请人： Tamara Colette Baynham ,  Quan Ni ,  Shelley M. Cazares ,  Kevin J. Stalsberg ,  Yi Zhang

发明人： Tamara Colette Baynham ,  Quan Ni ,  Shelley M. Cazares ,  Kevin J. Stalsberg ,  Yi Zhang

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684

摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of ventricular dyssynchrony or a patient's physiological response to ventricular dyssynchrony to control the delivery of cardioprotective pre-excitation pacing in closed-loop fashion.

摘要翻译： 心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。 这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。 本文描述了一种方法和系统，其使用心室不同步或患者对心室不同步的生理反应的测量来控制以闭环方式递送心脏保护性预激发起搏。

公开(公告)号：US09486628B2

公开(公告)日：2016-11-08

申请号：US13262434

申请日：2010-03-30

申请人： Mark A. Christopherson ,  Quan Ni ,  John Rondoni

发明人： Mark A. Christopherson ,  Quan Ni ,  John Rondoni

IPC分类号： A61B19/00 ,  A61N1/36 ,  A61N1/05

CPC分类号： A61N1/3601 ,  A61B5/0492 ,  A61B5/0826 ,  A61B5/4818 ,  A61B17/3468 ,  A61B2090/062 ,  A61N1/0504 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/0558

摘要： Systems and methods are described and illustrated for percutaneously implanting a stimulation lead for treating sleep-related disordered breathing.

摘要翻译： 描述和说明了用于经皮植入用于治疗与睡眠相关的无序呼吸的刺激引线的系统和方法。

公开(公告)号：US08900154B2

公开(公告)日：2014-12-02

申请号：US11136195

申请日：2005-05-24

申请人： Jeffrey E. Stahmann ,  Quan Ni ,  Jesse W. Hartley

发明人： Jeffrey E. Stahmann ,  Quan Ni ,  Jesse W. Hartley

IPC分类号： A61B5/08 ,  A61B5/053 ,  A61N1/362 ,  A61N1/05 ,  A61N1/365

CPC分类号： A61B5/0537 ,  A61B5/0538 ,  A61N1/3627 ,  A61N1/365 ,  A61N2001/0585

摘要： This patent document discusses, among other things, systems, devices, and methods for predicting an occurrence of impending thoracic fluid accumulation and in one example, invoking a responsive therapy, such as to prevent or minimize the consequences of the impending thoracic fluid accumulation. One example of the present systems, devices, and methods senses or receives at least one parameter that is statistically associated with impending thoracic fluid accumulation from a subject. Using such parameter(s), a probability of impending thoracic fluid accumulation is estimated. A list of parameters determines which values are recurrently sensed or received at various desired time intervals. Another example of the present systems, devices, and methods weights the sensed or received parameter value(s) to compute the probability estimate of impending thoracic fluid accumulation. A responsive preventive thoracic fluid accumulation therapy or other therapy is selected and activated using the probability estimate of impending thoracic fluid accumulation.

摘要翻译： 该专利文献尤其涉及用于预测即将到来的胸腔积液的发生的系统，装置和方法，并且在一个示例中，引用响应性治疗，例如防止或最小化即将到来的胸腔积液的后果。 本系统，装置和方法的一个示例感测或接收至少一个与来自受试者的即将到来的胸腔积液相关联的参数。 使用这样的参数，估计即将到来的胸腔积液的概率。 参数列表确定以各种期望的时间间隔反复感测或接收哪些值。 本系统，装置和方法的另一个例子对感测或接收的参数值进行加权，以计算即将到来的胸腔积液的概率估计。 使用即将到来的胸腔积液的概率估计来选择和激活反应性预防性胸腔积液治疗或其他治疗。

公开(公告)号：US08768466B2

公开(公告)日：2014-07-01

申请号：US12249856

申请日：2008-10-10

申请人： Yanting Dong ,  Xuan Wei ,  Ankur Garg ,  Quan Ni

发明人： Yanting Dong ,  Xuan Wei ,  Ankur Garg ,  Quan Ni

IPC分类号： A61N1/00 ,  A61N1/372 ,  G06F19/00 ,  A61N1/365

CPC分类号： A61N1/365 ,  A61N1/36585 ,  A61N1/37211 ,  A61N1/37264 ,  A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3481

摘要： A remote external interface for an implantable cardiac function management device is configured to be communicatively coupled to the implantable cardiac function management device via a network to a local external interface and via telemetry between the local external interface and the implantable cardiac function management device. The remote external interface includes a communication circuit and a processor circuit. The communication circuit is configured to communicate with the implantable cardiac function management device. The processor circuit is configured to perform an analysis of physiologic data received from the implantable cardiac function management device in response to operation of the implantable cardiac function management device using a plurality of therapy control parameter sets. The processor circuit can be further configured to select a particular therapy control parameter set using the analysis.

摘要翻译： 用于可植入心脏功能管理装置的远程外部接口被配置为通过网络通信地耦合到可植入心脏功能管理装置到本地外部接口并且经由本地外部接口和可植入心脏功能管理装置之间的遥测。 远程外部接口包括通信电路和处理器电路。 通信电路被配置为与可植入心脏功能管理装置进行通信。 处理器电路被配置为响应于使用多个治疗控制参数组的可植入心脏功能管理装置的操作来执行从可植入心脏功能管理装置接收的生理数据的分析。 处理器电路可以进一步配置为使用分析来选择特定的治疗控制参数集。

公开(公告)号：US20130231726A1

公开(公告)日：2013-09-05

申请号：US13600572

申请日：2012-08-31

申请人： Blake D. Johnson ,  Mark Christopherson ,  John Rondoni ,  Quan Ni

发明人： Blake D. Johnson ,  Mark Christopherson ,  John Rondoni ,  Quan Ni

IPC分类号： A61N1/05

CPC分类号： A61N1/0556 ,  A61N1/0558 ,  A61N1/3611 ,  A61N1/36135 ,  A61N1/37217

摘要： An electrode cuff includes a first elongate portion and a second elongate portion. The first elongate portion is configured to removably contact a length of a nerve while the second elongate portion extends outwardly at an angle relative to a first side edge of the first elongate portion to at least partially wrap about the nerve. The electrode cuff includes a first series of electrodes that is spaced apart longitudinally along the first elongate portion. A width of the second elongate portion is sized to fit between adjacent branches extending from a nerve.

公开(公告)号：US08401628B2

公开(公告)日：2013-03-19

申请号：US12478476

申请日：2009-06-04

申请人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

发明人： Dan Li ,  Allan C. Shuros ,  Quan Ni ,  Aaron R. McCabe ,  Yunlong Zhang ,  Jaeho Kim

IPC分类号： A61B5/024

CPC分类号： A61B5/0464 ,  A61B5/0215 ,  A61B5/0422 ,  A61B5/046 ,  A61N1/3622 ,  A61N1/3702

摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.

摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，其通信耦合 到心脏信号感测电路。 所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定 快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

公开(公告)号：US08323204B2

公开(公告)日：2012-12-04

申请号：US12403880

申请日：2009-03-13

申请人： Jeffrey E. Stahmann ,  John D. Hatlestad ,  Jesse W. Hartley ,  Quan Ni ,  Kent Lee

发明人： Jeffrey E. Stahmann ,  John D. Hatlestad ,  Jesse W. Hartley ,  Quan Ni ,  Kent Lee

IPC分类号： A61B5/08 ,  A61B5/02

CPC分类号： A61B5/0803 ,  A61B5/02405 ,  A61N1/3601

摘要： An event-based approach to collecting and organizing information associated with events affecting respiration is presented. The detection or prediction of an event affecting the respiration of a patient initiates acquisition of information associated with the event. The respiratory logbook system acquires information associated with the event during the event and during intervals proximate in time to the event. The information is organized as a respiratory log entry. The user can access the information by operating a user interface. The information may be presented in textual or graphical form.

摘要翻译： 提出了一种基于事件的方法来收集和组织与影响呼吸的事件相关的信息。 影响患者呼吸的事件的检测或预测启动与事件相关联的信息的获取。 呼吸记录系统在事件期间以及在时间上接近事件的间隔期间获取与事件相关联的信息。 信息被组织为呼吸日志条目。 用户可以通过操作用户界面访问信息。 信息可以以文本或图形形式呈现。

公开(公告)号：US08301234B2

公开(公告)日：2012-10-30

申请号：US13288105

申请日：2011-11-03

申请人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US08226570B2

公开(公告)日：2012-07-24

申请号：US11463076

申请日：2006-08-08

申请人： Yachuan Pu ,  Kent Lee ,  Jonathan Kwok ,  Quan Ni

发明人： Yachuan Pu ,  Kent Lee ,  Jonathan Kwok ,  Quan Ni

IPC分类号： A61B5/08

CPC分类号： A61B5/0816 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/4818 ,  A61N1/3627 ,  A61N1/36521

摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.

摘要翻译： 可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。 这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。 该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。 该警报可以通过远程监视来通知病人或看护者。 睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。