公开(公告)号：US20110237942A1

公开(公告)日：2011-09-29

申请号：US13072275

申请日：2011-03-25

申请人： Tamotsu Zako ,  Mizuo Maeda ,  Kohei Soga ,  Hidehiro Kishimoto ,  Hiroshi Hyodo ,  Masaaki Ito ,  Kazuhiro Kaneko

发明人： Tamotsu Zako ,  Mizuo Maeda ,  Kohei Soga ,  Hidehiro Kishimoto ,  Hiroshi Hyodo ,  Masaaki Ito ,  Kazuhiro Kaneko

IPC分类号： A61B6/00 ,  G01J1/58

CPC分类号： G01N21/6456 ,  A61B5/0071 ,  A61B5/0077 ,  A61B90/39 ,  A61B2090/3912 ,  A61B2090/3941 ,  A61B2090/3991 ,  G01N21/6428 ,  G01N2021/6439

摘要： This invention provides a novel bioimaging technique that can achieve a deep observation depth and a novel method for marking a lesion that allows clear recognition of the lesion from outside a living body. This invention also provides a bioimaging marker comprising a fluorescent material obtained by doping a ceramic with rare earths and the like and a bioimaging technique comprising detecting near-infrared fluorescence that can sufficiently penetrate a living body generated upon excitation of the marker with near-infrared excitation light.

摘要翻译： 本发明提供了一种可以实现深度观察深度的新型生物成像技术和用于标记病变的新方法，其允许从生物体外部清楚地识别病变。 本发明还提供一种生物成像标记物，其包含通过用稀土等掺杂陶瓷而获得的荧光材料，以及生物成像技术，其包括检测近红外荧光，所述近红外荧光可以充分穿透利用近红外激发的标记物激发时产生的活体 光。

公开(公告)号：US08809437B2

公开(公告)日：2014-08-19

申请号：US14002984

申请日：2011-03-03

申请人： Kohei Soga ,  Hiroshi Hyodo

发明人： Kohei Soga ,  Hiroshi Hyodo

IPC分类号： C08K3/22 ,  C01F17/00 ,  C08L53/00 ,  B01F17/00

CPC分类号： C08L53/005 ,  B01F17/0028 ,  B82Y30/00 ,  C01F17/0056 ,  C01F17/0068 ,  C01P2002/54 ,  C01P2004/64 ,  C01P2006/22

摘要： The present invention provides a method of producing a nanoparticle dispersion liquid, including: altering a surface of a nanoparticle in the presence of an ion by contacting a complex that includes the nanoparticle and a solid material present around the nanoparticle with a surface altering agent-containing liquid, that includes a surface altering agent for altering the surface of the nanoparticle and a solvent for dissolving the solid material and that has a viscosity of 1.10 mPa·s or more at 25° C.; and a dispersing step of dispersing the surface-altered nanoparticle in the solvent.

摘要翻译： 本发明提供一种制备纳米颗粒分散液的方法，包括：在离子存在下改变纳米颗粒的表面，通过使包含纳米颗粒的复合物和存在于纳米颗粒周围的固体材料与含有表面改性剂的物质接触 液体，其包括用于改变纳米颗粒的表面的表面改性剂和用于溶解固体材料的溶剂，并且在25℃下具有1.10mPa·s以上的粘度; 以及将表面改性的纳米粒子分散在溶剂中的分散步骤。

公开(公告)号：US4876204A

公开(公告)日：1989-10-24

申请号：US782356

申请日：1985-10-01

申请人： Kazushige Inoue ,  Hiroshi Yamamoto ,  Hiroshi Hyodo ,  Shinichi Kishimoto

发明人： Kazushige Inoue ,  Hiroshi Yamamoto ,  Hiroshi Hyodo ,  Shinichi Kishimoto

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00049 ,  G01N2035/00089 ,  G01N2035/00108 ,  G01N2035/00118 ,  G01N2035/1025 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165

摘要： An autonomous continuous analysis method and apparatus using Dip and Read type analytical implements. A series of operations of taking out analytical implements, dipping them in the sample solution, optical measurement, calculation, and disposal of the used sample solution are performed automatically.The dip stage, in particular, is automated by use of an analytical-implement automatic supply device and an analytical implement automatic handling device which, holding an analytical implement, dips it in the sample solution, and sets it ona reaction turntable. A number of analytical implements are put in a storage section comprising a bottom section provided with an analytical implement groove and at least one inside surface which is parallel with the groove, are taken out one by one by the relative movement of the groove and in normal and reverse direction and by stopping in a specified position after confirming by a detector that an implement has been caught in the groove.

摘要翻译： 一种使用Dip和Read型分析仪器的自主连续分析方法和装置。 自动执行一系列取出分析工具，浸渍在样品溶液中，进行光学测量，计算和处理的操作。 特别地，浸渍阶段通过使用分析工具自动供应装置和分析工具自动处理装置来自动化，其分离工具自动处理装置，其保持分析工具，将其浸入样品溶液中，并将其设置在反应转台上。 许多分析用具被放入存储部分中，该存储部分包括设置有分析用具槽的底部部分和与槽平行的至少一个内表面，通过槽的相对运动逐个取出并且在正常情况下 并且在由检测器确认工具已经被捕获在凹槽中之后停止在指定位置。

公开(公告)号：US5589045A

公开(公告)日：1996-12-31

申请号：US331813

申请日：1994-10-31

申请人： Hiroshi Hyodo

发明人： Hiroshi Hyodo

IPC分类号： G01N33/50 ,  G01N27/416 ,  G01N33/487 ,  G01N33/66 ,  G01N27/26

CPC分类号： G01N33/48792 ,  Y10S435/817

摘要： A managing method includes steps of selecting a function according to the type of an electrode mounted on the portable blood sugar value-measuring apparatus; executing a process of clocking a predetermined period of time; deciding whether or not the clocking process has been switched over to a different process while the predetermined period of time is being clocked; and reading out data of measured blood sugar values stored in a storing device from a termination point of the first predetermined period of time when the first predetermined period of time has terminated without the switch-over from the first clocking process to the blood sugar value-measuring process being decided in the deciding process.

摘要翻译： 管理方法包括根据安装在便携式血糖值测量装置上的电极的类型选择功能的步骤; 执行计时预定时间段的处理; 在所述预定时间段被计时的情况下，判断所述计时过程是否切换到不同的进程; 并且从第一预定时间段终止的第一预定时间段的终止点读出存储在存储装置中的测量血糖值的数据，而不从第一计时过程切换到血糖值 - 测量过程在决定过程中决定。

公开(公告)号：US5781455A

公开(公告)日：1998-07-14

申请号：US696742

申请日：1996-08-14

申请人： Hiroshi Hyodo

发明人： Hiroshi Hyodo

IPC分类号： G01N33/487 ,  G05B23/02

CPC分类号： G01N27/3274

摘要： An article of manufacture includes a computer usable medium, including computer-readable program code instructions embodied therein, for causing a computer to manage data in a measuring apparatus. The instructions include a detecting portion utilized for causing the computer to detect whether an electrode has been mounted on the measuring apparatus. A characteristic measuring portion is utilized for causing the computer to measure a characteristic of the electrode to determine what type of electrode has been mounted on the measuring apparatus. A clocking portion is utilized for causing the computer to clock a first period of time after the computer has measured the characteristic of the electrode. A determining portion is utilized for causing the computer to determine whether to measure density of an element included in a biological body fluid or whether to read out measured density data. A density measuring portion is utilized for causing the computer to measure density of the element included in the biological body fluid which has been placed on the electrode. A density storing portion is utilized for causing the computer to store a measured density of the element included in the biological body fluid in a storing device. A read out portion is utilized for causing the computer to read out measured density data stored in the storing device.

摘要翻译： 一种制品包括计算机可用介质，包括其中包含的计算机可读程序代码指令，用于使计算机管理测量装置中的数据。 指示包括用于使计算机检测电极是否已经安装在测量装置上的检测部分。 使用特征测量部分来使计算机测量电极的特性，以确定在测量装置上安装了哪种类型的电极。 时钟部分被用于使计算机在计算机测量电极的特性之后的第一时间段内进行计时。 使用确定部分来使计算机确定是否测量包括在生物体液中的元素的密度或是否读出测量的密度数据。 密度测量部分用于使计算机测量已经放置在电极上的生物体液中包含的元素的密度。 密度存储部分用于使计算机将包含在生物体液中的元素的测量密度存储在存储装置中。 读出部分用于使计算机读出存储在存储装置中的测量密度数据。

公开(公告)号：US4585007A

公开(公告)日：1986-04-29

申请号：US493415

申请日：1983-05-10

申请人： Takatoshi Uchigaki ,  Hiroshi Hyodo ,  Teijiro Iwase

发明人： Takatoshi Uchigaki ,  Hiroshi Hyodo ,  Teijiro Iwase

IPC分类号： A61B5/145 ,  A61B5/1473 ,  A61B5/1495 ,  A61M1/10 ,  A61M1/36 ,  A61B5/00

CPC分类号： A61M1/3672

摘要： A method for accurately performing concentration measurements while compensating the dilution ratio as needed during continuous measurement of specified ingredient in the liquid to be tested. The liquid to be tested is diluted by a diluent, wherein the liquid to be tested and the diluent or the mixture of the two and the diluent is transferred by means of the respective tube pumps to a measuring section. Either or both of the quantities of liquid-feeding of those two liquids are changed at the beginning of measuring or in an optional stage during the time of the measurement, diluted and mixed at two or more dilution ratios. Then the real dilution ratio at the time of changing the quantities of the said liquids is found on the basis of the measured value of the substance to be measured at the respective dilution ratios, and the concentration of the substance contained in the liquid to be tested is determined by using the real dilution ratio.

摘要翻译： 一种准确地进行浓度测量的方法，同时在连续测量待测液体中的特定成分时根据需要补偿稀释比。 待测试的液体被稀释剂稀释，其中待测试的液体和稀释剂或二者和稀释剂的混合物通过相应的管式泵转移到测量部分。 在测量开始时或在测量期间的任选阶段，这两种液体的液体供给量中的任一种或两者都发生变化，以两种或多种稀释比稀释和混合。 然后根据待测物质的测定值以各自的稀释比例和所测液体中含有的物质的浓度，求出改变上述液体量时的实际稀释倍数 通过使用实际稀释比来确定。

公开(公告)号：US06730046B1

公开(公告)日：2004-05-04

申请号：US10089296

申请日：2002-03-27

申请人： Katsumi Hamamoto ,  Atsushi Murakami ,  Hiroshi Hyodo

发明人： Katsumi Hamamoto ,  Atsushi Murakami ,  Hiroshi Hyodo

IPC分类号： A61B515

CPC分类号： A61B5/15144 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150412 ,  A61B5/15113 ,  A61B5/15117

摘要： A body fluid sampling apparatus (A), comprising a piston (11) provided in a tubular main case (10), a first plunger rod (12) extending into the piston (11) integrally with each other; a first spring (13) elastically energzing the piston (11) toward the upper end side, a second plunger rod (15) installed in the first plunger rod (12) through a second spring (14), a lancet mounted body (16) provided on the second plunger rod (15) and having a lancet (B) mounted therein, a third spring (17) elastically energizing the lancet mounted body (16) toward the upper end side, latch mechanisms (20, 30) suppressing the second plunger rod (15) and first plunger rod (12) when the first plunger rod (12) is moved to the lower end side by he push-down of the piston (11), and a release mechanism (40) for releasing the locked state of the first plunger rod (12) and the second plunger rod (15).

摘要翻译： 一种体液取样装置（A），包括设置在管状主壳体（10）中的活塞（11），彼此一体地延伸到所述活塞（11）中的第一柱塞杆（12） 第一弹簧（13）朝向上端侧弹性地激励活塞（11），通过第二弹簧（14）安装在第一柱塞杆（12）中的第二柱塞杆（15），刺血针安装体（16） 设置在所述第二柱塞杆（15）上并且具有安装在其中的刺血针（B）的第三弹簧（17）朝向所述上端侧弹性激励所述刺血针安装体（16），所述闩锁机构（20,30） 当第一活塞杆（12）通过活塞（11）的下推移动到下端侧时，柱塞杆（15）和第一柱塞杆（12）以及用于释放锁定的释放机构 第一柱塞杆（12）和第二柱塞杆（15）的状态。

公开(公告)号：US5266179A

公开(公告)日：1993-11-30

申请号：US733130

申请日：1991-07-19

申请人： Shiro Nankai ,  Mariko Kawaguri ,  Toshihiko Yoshioka ,  Haruhiro Tsutsumi ,  Kyozo Terao ,  Naoki Tanimoto ,  Masahiro Yoshioka ,  Hiroshi Hyodo ,  Takatoshi Uchigaki

发明人： Shiro Nankai ,  Mariko Kawaguri ,  Toshihiko Yoshioka ,  Haruhiro Tsutsumi ,  Kyozo Terao ,  Naoki Tanimoto ,  Masahiro Yoshioka ,  Hiroshi Hyodo ,  Takatoshi Uchigaki

IPC分类号： G01N27/26 ,  G01N27/28 ,  G01N27/416 ,  G01N27/49

CPC分类号： G01N33/48771 ,  G01N2035/009

摘要： A sensor 13 is inserted into a connector 14. A constant voltage required to obtain a response current is applied across the connector 14 by a voltage applying source 15 at timings required. A response current of the sensor 13 inserted into the connector 14 is converted into a voltage by a current-to-voltage converter 16, and the amount thereof is determined by a microcomputer, the analysis results being displayed onto a display unit.

公开(公告)号：US4697925A

公开(公告)日：1987-10-06

申请号：US665623

申请日：1984-10-29

申请人： Hiroshi Hyodo ,  Naoki Yamada ,  Kenichi Iwase ,  Shinichi Kishimoto

发明人： Hiroshi Hyodo ,  Naoki Yamada ,  Kenichi Iwase ,  Shinichi Kishimoto

IPC分类号： G01N21/17 ,  G01N21/49 ,  G01N21/51 ,  G01N21/59 ,  G01N21/75 ,  G01N21/82 ,  G01N33/86 ,  G01N21/00

CPC分类号： G01N21/51 ,  G01N2021/5969 ,  G01N2201/08

摘要： The test solution in the measuring cell is regarded to be divided into a plurality of sections, and the quantity of scattered light from each section is continuously measured to give a plurality of independent series of signal. This measurement is carried out by scanning the measuring cell with a minute light flux periodically to obtain a plurality of measurements in a period. Out of the series of signals obtained, those containing abnormal scattered light signal are eliminated to determine accurate concentration and reaction process.

摘要翻译： 认为测量单元中的测试溶液被分成多个部分，并且连续地测量来自每个部分的散射光的量，以产生多个独立的信号序列。 该测量是通过周期性地以微小的光通量扫描测量单元以在一段时间内获得多个测量来进行的。 在获得的一系列信号中，消除了包含异常散射光信号的信号，以确定准确的浓度和反应过程。