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公开(公告)号：US20070238162A1
公开(公告)日：2007-10-11
申请号：US11214948
申请日：2005-08-31
IPC分类号： C12M3/00
CPC分类号： G01N21/253 , G01N21/553 , G01N35/028 , G01N35/1095
摘要： In a measuring apparatus for biomolecule interaction, a fine particle sensor surface is dipped in a buffer solution in a reaction vessel to conduct spectral measurement by way of optical fibers. The buffer solution in the reaction vessel is made to enter an upper reaction vessel and discharged from a flow channel. Air is injected from a flow channel to inject a specimen from the discharge port to the reaction vessel. Then the specimen is sucked into the reaction vessel and brought into contact with the sensor surface where a ligand and an analyte in the specimen are bonded. Bonding is measured by a spectrophotometer through the optical fibers. A buffer solution is injected from the injection flow channel into the reaction vessel and the specimen is discharged out of the flow channel. The dissociation process in which the biomolecules are dissociated along with lowering of the concentration is measured.
摘要翻译： 在用于生物分子相互作用的测量装置中，将细颗粒传感器表面浸入反应容器中的缓冲溶液中以通过光纤进行光谱测量。 将反应容器中的缓冲溶液进入上反应容器并从流动通道排出。 空气从流动通道注入，将样品从排放口注入反应容器。 然后将样品吸入反应容器中，并与样品中的配体和分析物结合的传感器表面接触。 通过分光光度计通过光纤测量粘合。 将缓冲溶液从注射流通道注入反应容器中，并将样品从流动通道排出。 测量其中生物分子随浓度降低而解离的解离过程。
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公开(公告)号：US07629166B2
公开(公告)日：2009-12-08
申请号：US11214948
申请日：2005-08-31
IPC分类号： C12M1/34
CPC分类号： G01N21/253 , G01N21/553 , G01N35/028 , G01N35/1095
摘要： In a measuring apparatus for biomolecule interaction, a fine particle sensor surface is dipped in a buffer solution in a reaction vessel to conduct spectral measurement by way of optical fibers. The buffer solution in the reaction vessel is made to enter an upper reaction vessel and discharged from a flow channel. Air is injected from a flow channel to inject a specimen from the discharge port to the reaction vessel. Then the specimen is sucked into the reaction vessel and brought into contact with the sensor surface where a ligand and an analyte in the specimen are bonded. Bonding is measured by a spectrophotometer through the optical fibers. A buffer solution is injected from the injection flow channel into the reaction vessel and the specimen is discharged out of the flow channel. The dissociation process in which the biomolecules are dissociated along with lowering of the concentration is measured.
摘要翻译： 在用于生物分子相互作用的测量装置中，将细颗粒传感器表面浸入反应容器中的缓冲溶液中以通过光纤进行光谱测量。 将反应容器中的缓冲溶液进入上反应容器并从流动通道排出。 空气从流动通道注入，将样品从排放口注入反应容器。 然后将样品吸入反应容器中，并与样品中的配体和分析物结合的传感器表面接触。 通过分光光度计通过光纤测量粘合。 将缓冲溶液从注射流通道注入反应容器中，并将样品从流动通道排出。 测量其中生物分子随浓度降低而解离的解离过程。
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3.发明申请公开(公告)号：US20050004765A1
公开(公告)日：2005-01-06
申请号：US10859143
申请日：2004-06-03
申请人： Tetsuro Miyamoto , Shigenori Togashi , Ryo Miyake , Naoya Sasaki
发明人： Tetsuro Miyamoto , Shigenori Togashi , Ryo Miyake , Naoya Sasaki
CPC分类号： G01N33/502 , G01N33/5008 , G01N33/5082
摘要： The object of the present invention is to estimate the effect of working substances on actual living organisms such as cells and tissues. The present invention provides a method for estimation of the effect of working substance which includes the following steps (a) and (b): (a) a step of contacting a working substance with a model cell to measure a cell activity value of the model cell, and (b) a step of estimating the effect of the working substance on the target living organism when the working substance is allowed to act on the target living organism, using the cell activity value measured at the step (a) as an input value.
摘要翻译： 本发明的目的是估计工作物质对细胞和组织等实际生物体的影响。 本发明提供一种估计工作物质影响的方法，其包括以下步骤（a）和（b）：（a）使工作物质与模型细胞接触以测量模型的细胞活性值的步骤 （b）当使用步骤（a）测量的细胞活性值作为输入时，估计工作物质对目标生物体的影响的步骤，当使所述工作物质作用于所述目标生物体时， 值。
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公开(公告)号：US08287179B2
公开(公告)日：2012-10-16
申请号：US12708070
申请日：2010-02-18
IPC分类号： B01F5/04
CPC分类号： B01F5/0665 , B01F5/0679 , B01F13/0062 , B01F13/0066
摘要： A fluid mixer for mixing a first fluid and a second fluid includes an introducing component having a bore, a cylindrical component fitted into the bore of the introducing component and a mixing component having a conical recess and on which the introducing component and the cylindrical component are held. A first introducing flow path receives the first fluid and a first distributing flow path distributes the first fluid over the whole circumference of the cylindrical component. A second introducing flow path receives the second fluid. A second distributing flow path distributes the second fluid so that the first fluid and the second fluid are alternately arranged in an circumferential direction. A joining part joins together the first fluid and the second fluid fed with the fluids alternately arranged circumferentially.
摘要翻译： 用于混合第一流体和第二流体的流体混合器包括具有孔的引入部件，装配在引入部件的孔中的圆柱形部件和具有锥形凹部的混合部件，引导部件和圆柱形部件 保持。 第一引入流动路径接收第一流体，并且第一分配流动路径将第一流体分布在圆柱形部件的整个圆周上。 第二引入流路接收第二流体。 第二分配流路分配第二流体，使得第一流体和第二流体沿圆周方向交替布置。 接合部将第一流体和供给有周向交替布置的流体的第二流体连接在一起。
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公开(公告)号：US20060269966A1
公开(公告)日：2006-11-30
申请号：US11441076
申请日：2006-05-26
申请人： Tetsuro Miyamoto , Mami Hakari , Shigenori Togashi
发明人： Tetsuro Miyamoto , Mami Hakari , Shigenori Togashi
CPC分类号： G01N21/554 , G01N21/274 , G01N21/314 , G01N2021/258 , G01N2021/3148
摘要： Biomolecular and other interactions are analyzed with a simpler construction. A biotic sample is fixed to noble metal nanoparticles, and light is irradiated from a light source to the noble metal nanoparticles through an optical fiber. Light obtained after reflection of the irradiated light by the noble metal nanoparticles is introduced to one or more optical detecting units through another optical fiber. The optical detecting unit(s) separately measure the intensity of the input light in a second band including a maximum absorption wavelength, a first band covering a longer wavelength range than the range covered by the second band, and a third band covering a shorter wavelength range than the range covered by the second band.
摘要翻译： 用更简单的结构分析生物分子和其他相互作用。 将生物样品固定在贵金属纳米粒子上，通过光纤将光从光源照射到贵金属纳米粒子上。 通过贵金属纳米颗粒反射照射光后获得的光通过另一光纤被引入一个或多个光学检测单元。 光学检测单元分别测量包括最大吸收波长的第二波段中的输入光的强度，覆盖比由第二波段覆盖的范围更长的波长范围的第一波段和覆盖较短波长的第三波段 范围超过第二频带覆盖的范围。
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公开(公告)号：US20080098092A1
公开(公告)日：2008-04-24
申请号：US11755944
申请日：2007-05-31
申请人： Tadashi Sano , Yasuhiko Sasaki , Hajime Ikuta , Kazuichi Isaka , Tatsuo Sumino , Shigenori Togashi , Tetsuro Miyamoto
发明人： Tadashi Sano , Yasuhiko Sasaki , Hajime Ikuta , Kazuichi Isaka , Tatsuo Sumino , Shigenori Togashi , Tetsuro Miyamoto
摘要： A microorganism separation system comprising a sample solution container 34 containing microorganisms, a separator 1, and a receiver 47, designed to separate microorganisms from the sample solution; further comprising a microorganism detection sensor and a plate 49 which has a plurality of receivers 47 connected to each other and an identification indicator, wherein when the microorganism detection sensor judges that a microorganism has passed, supply of the sample solution is stopped, the detected microorganism is discharged together with the sample solution, and then the solution starts to be injected into the receiver; and, the number of times microorganisms are detected during the time period from the start of the injection to the end is recognized as separation quantity; and then as separation information, the separation quantity, number for a receiver 47 into which a microorganism was injected for each identification indicator, signal waveform sent from the microorganism detection sensor at the separation, date and temperature are stored.
摘要翻译： 一种微生物分离系统，包括含有微生物的样品溶液容器34，分离器1和接收器47，设计用于将微生物与样品溶液分离; 进一步包括微生物检测传感器和板49，其具有彼此连接的多个接收器47和识别指示器，其中当微生物检测传感器判断微生物已经通过时，停止供应样品溶液，检测到的微生物 与样品溶液一起放出，然后溶液开始注入接收器; 并且在从注射开始到结束的时间段期间检测到微生物的次数被识别为分离量; 然后作为分离信息，存储分离量，针对每个识别指示符注入微生物的接收器47的数量，在分离，日期和温度从微生物检测传感器发送的信号波形。
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7.发明申请Molecular interaction detector and molecule recovery device using the same 审中-公开分子相互作用检测器和分子回收装置使用相同公开(公告)号：US20060263243A1
公开(公告)日：2006-11-23
申请号：US11437701
申请日：2006-05-22
申请人： Mami Hakari , Tetsuro Miyamoto , Shigenori Togashi
发明人： Mami Hakari , Tetsuro Miyamoto , Shigenori Togashi
IPC分类号： G01N31/22
CPC分类号： G01N21/31
摘要： In a molecular interaction detector, a noble-metal free-electron thin film is formed on a substrate. Styrene-made nanoparticles are adsorbed onto the thin film surface. Another noble-metal free-electron thin film is formed on upper-half surfaces of the nanoparticles and is modified by an organic linker molecule. The organic linker molecule has a linear or branched chemical structure including a functional group capable of being fixed to the surface of the noble-metal free-electron thin film with a linear chain made of 1 to 5 atoms. A detergent is used in a mobile phase. Deposition of materials having no relation with the measurement onto a sensor can be avoided in the molecular interaction detector.
摘要翻译： 在分子相互作用检测器中，在基板上形成贵金属自由电子薄膜。 苯乙烯制造的纳米颗粒被吸附到薄膜表面上。 另外的贵金属自由电子薄膜形成在纳米颗粒的上半部表面，并被有机连接分子修饰。 有机连接分子具有直链或支链化学结构，其包括能够用1-5个原子的直链固定在贵金属自由电子薄膜的表面上的官能团。 在流动相中使用洗涤剂。 可以在分子相互作用检测器中避免将与测量无关的材料沉积到传感器上。
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公开(公告)号：US08591841B2
公开(公告)日：2013-11-26
申请号：US13318691
申请日：2009-05-14
申请人： Yukako Asano , Tetsuro Miyamoto , Shigenori Togashi , Yoshishige Endo , Hidekazu Tsudome , Hajime Kato
发明人： Yukako Asano , Tetsuro Miyamoto , Shigenori Togashi , Yoshishige Endo , Hidekazu Tsudome , Hajime Kato
CPC分类号： B01J19/0093 , B01F5/0641 , B01F13/0059 , B01J2219/00783 , B01J2219/00867 , B01J2219/00889 , B01J2219/00891
摘要： In relation to a microreactor, and also a microreactor system applying the same therein, not producing any dead volume therein, and thereby achieving a high level of mixing properties even at a low solution flow rate and having a simple structure thereof, disclosed herein are a microreactor and microreactor system, comprising a channel for mixing up at least two (2) types of fluids, and thereby conducting mixing/reacting of fluids by conducting the mixing/reacting of the fluids at least one (1) time, i.e., being suitable for so-called a multi-step reaction.
摘要翻译： 关于微反应器以及其中应用其的微反应器系统，其中不产生任何死体积，从而即使在低溶液流速下实现高水平的混合特性并且具有简单的结构，这里公开了一种 微反应器和微反应器系统，其包括用于混合至少两种（2）类型的流体的通道，从而通过使流体的混合/反应进行混合/反应，至少一次（即）适合 用于所谓的多步反应。
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公开(公告)号：US08153070B2
公开(公告)日：2012-04-10
申请号：US12431011
申请日：2009-04-28
CPC分类号： B01F5/0471 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00889
摘要： A microreactor capable of reducing a pressure drop in an entire system includes a mixer 103 having a mixing channel for mixing two kinds of raw materials 101 and 102, and a reactor 109 having a reaction channel connected to the downstream side of the mixing channel to receive the mixture flowing out from the mixing channel and cause chemical reactions of the mixture inside the reaction channel. The reactor 109 a first reactor unit 107 having a large surface-to-volume (S-V) ratio of the reaction channel at an upstream side, and a second reactor unit 108 having a small S-V ratio of the reaction channel at a downstream.
摘要翻译： 能够减少整个系统的压力降的微反应器包括具有用于混合两种原料101和102的混合通道的混合器103和具有连接到混合通道的下游侧的反应通道的反应器109以接收 混合物从混合通道流出并引起混合物在反应通道内的化学反应。 反应器109具有上游侧的反应通道的表面体积比（S-V）大的第一反应器单元107和在下游具有反应通道的S-V比小的第二反应器单元108。
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公开(公告)号：US20120045370A1
公开(公告)日：2012-02-23
申请号：US13318691
申请日：2009-05-14
申请人： Yukako Asano , Tetsuro Miyamoto , Shigenori Togashi , Yoshishige Endo , Hidekazu Tsudome , Hajime Kato
发明人： Yukako Asano , Tetsuro Miyamoto , Shigenori Togashi , Yoshishige Endo , Hidekazu Tsudome , Hajime Kato
IPC分类号： B01J14/00
CPC分类号： B01J19/0093 , B01F5/0641 , B01F13/0059 , B01J2219/00783 , B01J2219/00867 , B01J2219/00889 , B01J2219/00891
摘要： In relation to a microreactor, and also a microreactor system applying the same therein, not producing any dead volume therein, and thereby achieving a high level of mixing properties even at a low solution flow rate and having a simple structure thereof, disclosed herein are a microreactor and microreactor system, comprising a channel for mixing up at least two (2) types of fluids, and thereby conducting mixing/reacting of fluids by conducting the mixing/reacting of the fluids at least one (1) time, i.e., being suitable for so-called a multi-step reaction.
摘要翻译： 关于微反应器以及其中应用其的微反应器系统，其中不产生任何死体积，从而即使在低溶液流速下实现高水平的混合特性并且具有简单的结构，这里公开了一种 微反应器和微反应器系统，其包括用于混合至少两种（2）类型的流体的通道，从而通过使流体的混合/反应进行混合/反应，至少一次（即）适合 用于所谓的多步反应。
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