公开(公告)号：US07241608B2

公开(公告)日：2007-07-10

申请号：US11227614

申请日：2005-09-15

申请人： Tetsuro Yamashita ,  Masao Miyazaki

发明人： Tetsuro Yamashita ,  Masao Miyazaki

IPC分类号： C12N9/16 ,  C12N1/20 ,  C12N15/00 ,  C12Q1/44 ,  C07H21/04

CPC分类号： C12N9/18 ,  G01N33/573

摘要： In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

摘要翻译： 鉴于猫科老年动物肾病病例数的增加，本发明提供了一种早期诊断猫肾病的标志物，可用于替代传统复杂的肾病诊断方法，如血液检查，肾摄影，使用 造影剂和超声波图像分析。 发现具有肾病的猫显示分子量为70K的新型蛋白质（命名为cauxin）的排泄水平显着降低，其在没有临床异常的正常成年猫中以高浓度排出尿液。 当蛋白质用作诊断猫肾病的标记物时，可以以简单且准确的方式检测猫肾病。

公开(公告)号：US20060094863A1

公开(公告)日：2006-05-04

申请号：US11227614

申请日：2005-09-15

申请人： Tetsuro Yamashita ,  Masao Miyazaki

发明人： Tetsuro Yamashita ,  Masao Miyazaki

IPC分类号： C07K14/705 ,  C07K16/28 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06

CPC分类号： C12N9/18 ,  G01N33/573

摘要： In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

摘要翻译： 鉴于猫科老年动物肾病病例数量的增加，本发明提供了一种早期诊断猫肾病的标记物，可用于替代传统复杂的肾病诊断方法，如血液检查，肾摄影，使用 造影剂，超声波图像分析。 发现具有肾病的猫显示出具有70K分子量的新型蛋白质（称为cauxin）的排泄水平显着降低，其在没有临床异常的正常成年猫中以高浓度排出尿液。 当蛋白质用作诊断猫肾病的标记物时，可以以简单且准确的方式检测猫肾病。

公开(公告)号：US07026151B2

公开(公告)日：2006-04-11

申请号：US10233933

申请日：2002-09-03

申请人： Tetsuro Yamashita ,  Masao Miyazaki

发明人： Tetsuro Yamashita ,  Masao Miyazaki

IPC分类号： C12N9/11 ,  C12N15/54 ,  C12Q1/44

CPC分类号： C12N9/18 ,  G01N33/573

摘要： In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such as blood examination, kidney radiography using a contrast medium, and ultrasonic image analysis. It was found that cats with nephropathy show markedly lowered levels of excretion of a novel protein (named cauxin) with a molecular weight of 70 K, which is excreted into urine in high concentrations in normal adult cats showing no clinical abnormality. When the protein is used as a marker in diagnosing feline nephropathy, feline nephropathy can be detected in a simple and exact manner.

公开(公告)号：US20100203584A1

公开(公告)日：2010-08-12

申请号：US12067404

申请日：2006-09-20

申请人： Hideharu Taira ,  Tetsuro Yamashita ,  Masao Miyazaki

发明人： Hideharu Taira ,  Tetsuro Yamashita ,  Masao Miyazaki

IPC分类号： C12P21/00 ,  C12N5/06 ,  C07K2/00

CPC分类号： C12N5/0686 ,  C12N2500/92 ,  C12N2510/02

摘要： It is an object of the present invention to provide host cells, which are able to proliferate in a serum free medium, which are able to synthesize and secrete a large amount of protein of interest, and which are able to produce a glycoprotein having a sugar chain structure. The present invention provides an established cell line, which is established from distal tubular epithelial cells derived from a mammal.

摘要翻译： 本发明的目的是提供能够在无血清培养基中增殖的宿主细胞，其能够合成和分泌大量感兴趣的蛋白质，并且能够产生具有糖的糖蛋白 链结构。 本发明提供从源自哺乳动物的远端肾小管上皮细胞建立的已建立的细胞系。

公开(公告)号：US20100190262A1

公开(公告)日：2010-07-29

申请号：US12452687

申请日：2007-07-20

申请人： Tetsuro Yamashita ,  Yasuyuki Suzuta

发明人： Tetsuro Yamashita ,  Yasuyuki Suzuta

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/4724 ,  G01N2333/918 ,  G01N2800/347

摘要： A method for diagnosing a kidney disease in a cat by detecting a cat urinary protein without being affected by cauxin, and a diagnostic agent therefor are provided. A method of detecting a urinary protein derived from renal dysfunction in a cat according to claim 1, wherein cauxin is removed from cat urine by bringing the cat urine into contact with a lectin or an anti-cauxin antibody that specifically binds to cauxin.

摘要翻译： 提供了一种通过检测猫尿蛋白而不受cauxin的影响来诊断猫的肾脏疾病的方法及其诊断剂。 2.根据权利要求1所述的猫的肾功能障碍的尿蛋白质检测方法，其特征在于，通过使猫尿与特异性结合cauxin的凝集素或抗Cauxin抗体接触，从猫尿中除去cauxin。

公开(公告)号：US06174371B1

公开(公告)日：2001-01-16

申请号：US09153957

申请日：1998-09-16

申请人： Izuru Iseki ,  Tetsuro Yamashita

发明人： Izuru Iseki ,  Tetsuro Yamashita

IPC分类号： C23C1600

CPC分类号： H01L21/02

摘要： A substrate treating method and apparatus are disclosed which are capable of heating a substrate in a stable atmosphere including the vapor of a treating liquid, without permitting the vapor of the treating liquid to condense on the substrate. The vapor of the treating liquid is mixed with a diluting gas to form a treating vapor mixture. At this time, the flow rate of the diluting gas is adjusted so that the partial pressure ratio of the vapor of the treating liquid in the treating vapor mixture increases with the passage of time. This treating vapor mixture is transmitted to a treating chamber. The treating chamber includes a substrate support table heated to a predetermined temperature. When the substrate is lowered from a separate position away from the support table to a position resting on the support table, downward displacements of the substrate are controlled so that the vapor of the treating liquid in the treating vapor mixture present adjacent the substrate surface under treatment is maintained substantially at a saturation pressure. In another method disclosed, the partial pressure ratio of the vapor of the treating liquid in the treating vapor mixture is adjusted according to the downward displacements of the substrate.

摘要翻译： 公开了一种基板处理方法和装置，其能够在包括处理液体的蒸气的稳定气氛中加热基板，而不允许处理液体的蒸气冷凝在基板上。 将处理液体的蒸气与稀释气体混合以形成处理蒸汽混合物。 此时，调节稀释气体的流量，使得处理蒸气混合物中的处理液体的蒸气的分压比随着时间的推移而增加。 该处理蒸汽混合物被传送到处理室。 处理室包括加热到预定温度的基板支撑台。 当基板从离开支撑台的分离位置降低到搁置在支撑台上的位置时，基板的向下位移被控制，使得处理蒸汽混合物中的处理液体的蒸气在处理下与基板表面相邻地存在 基本上保持在饱和压力。 在所公开的另一种方法中，处理蒸汽混合物中的处理液体的蒸气的分压比根据衬底的向下位移来调节。

公开(公告)号：US5779928A

公开(公告)日：1998-07-14

申请号：US799478

申请日：1997-02-12

申请人： Tetsuro Yamashita ,  Tsuyoshi Mitsuhashi ,  Manabu Yabe

发明人： Tetsuro Yamashita ,  Tsuyoshi Mitsuhashi ,  Manabu Yabe

IPC分类号： B05C11/08 ,  B05D3/10 ,  B08B3/08 ,  C11D7/50 ,  C11D11/00 ,  H01L21/00 ,  H01L21/311 ,  B44C1/22 ,  B08B6/00

CPC分类号： H01L21/6715 ,  B08B3/08 ,  C11D11/0047 ,  C11D7/5022 ,  H01L21/31133

摘要： A film dissolving liquid is ejected from a needle-shaped nozzle onto a peripheral edge portion of a substrate surface of a SOG film, while being subjected to the film dissolving liquid. The substrate is rotated in order to dissolve and remove the SOG film from the peripheral edge portion of the substrate. The film dissolving liquid is a solvent or mixture of two or more solvents selected from the group cyclohexanone, .gamma.-butyrolactone, ethyl lactate or ethyl pyruvate. As a result, a swelling of the SOG film is not created at the edge portion of the substrate. A crack is not therefore created at the edge portion of the SOG film, and generation of particles due to a damage at the film swelling portion thereof is prevented.

摘要翻译： 将薄膜溶解液从针状喷嘴喷射到SOG膜的基板表面的周边部分上，同时进行溶解液体。 旋转基板以从基板的周边部分溶解并除去SOG膜。 膜溶解液是选自环己酮，γ-丁内酯，乳酸乙酯或丙酮酸乙酯的两种或更多种溶剂的溶剂或混合物。 结果，在基板的边缘部分处不产生SOG膜的膨胀。 因此，在SOG膜的边缘部分处不产生裂纹，并且防止了由于其在膜膨胀部分处的损坏而产生的颗粒。

公开(公告)号：US08268639B2

公开(公告)日：2012-09-18

申请号：US12452687

申请日：2007-07-20

申请人： Tetsuro Yamashita ,  Yasuyuki Suzuta

发明人： Tetsuro Yamashita ,  Yasuyuki Suzuta

IPC分类号： G01N33/545 ,  G01N33/548

CPC分类号： G01N33/6893 ,  G01N2333/4724 ,  G01N2333/918 ,  G01N2800/347

摘要： A method for diagnosing a kidney disease in a cat by detecting a cat urinary protein without being affected by cauxin, and a diagnostic agent therefor are provided. A method of detecting a urinary protein derived from renal dysfunction in a cat according to claim 1, wherein cauxin is removed from cat urine by bringing the cat urine into contact with a lectin or an anti-cauxin antibody that specifically binds to cauxin.

摘要翻译： 提供了一种通过检测猫尿蛋白而不受cauxin的影响来诊断猫的肾脏疾病的方法及其诊断剂。 2.根据权利要求1所述的猫的肾功能障碍的尿蛋白质检测方法，其特征在于，通过使猫尿与特异性结合cauxin的凝集素或抗Cauxin抗体接触，从猫尿中除去cauxin。

公开(公告)号：US4953199A

公开(公告)日：1990-08-28

申请号：US197193

申请日：1988-05-23

申请人： Takashi Hoshi ,  Yoichi Sakai ,  Masaaki Tanabe ,  Tatsuo Inoue ,  Takeshi Kamakura ,  Teruaki Iijima ,  Hiroshi Nishinaga ,  Tetsuro Yamashita

发明人： Takashi Hoshi ,  Yoichi Sakai ,  Masaaki Tanabe ,  Tatsuo Inoue ,  Takeshi Kamakura ,  Teruaki Iijima ,  Hiroshi Nishinaga ,  Tetsuro Yamashita

IPC分类号： H04M11/06 ,  H04N1/327

CPC分类号： H04N1/32708 ,  H04M11/06 ,  H04N1/32704 ,  H04N1/32717 ,  H04N1/32726 ,  H04N1/32728 ,  H04N1/32732 ,  H04N1/32741 ,  H04N1/32743 ,  Y10S379/902

摘要： An interface apparatus connects one of a plurality of communication terminal equipment units to a single telephone line on the basis of a selection signal supplied via the telephone line. The telephone line is disconnected when there is no answer from the selected communication terminal equipment unit within a predetermined time period.

摘要翻译： 接口装置根据通过电话线提供的选择信号将多个通信终端设备单元之一连接到单个电话线。 当在预定时间段内没有来自所选择的通信终端设备单元的应答时，电话线路断开。

公开(公告)号：US08962705B2

公开(公告)日：2015-02-24

申请号：US13579897

申请日：2011-02-17

申请人： Shinya Matsuno ,  Kyoichi Saito ,  Tetsuro Yamashita ,  Ayako Ito ,  Yasuyuki Suzuta

发明人： Shinya Matsuno ,  Kyoichi Saito ,  Tetsuro Yamashita ,  Ayako Ito ,  Yasuyuki Suzuta

IPC分类号： C08F255/02 ,  C08F257/02 ,  C08F259/00 ,  C08F263/04 ,  C08F283/04 ,  C08J9/36 ,  G01N33/68 ,  C12Q1/44

CPC分类号： G01N33/6893 ,  C12Q1/44 ,  G01N2333/918 ,  G01N2800/347

摘要： A method for removing cauxin in cat urine and a material for removing cauxin are provided. The material for removing cauxin in cat urine comprises a polymer substrate on which surface a trifluoroketone derivative is immobilized via dithiol.

摘要翻译： 提供了一种去除猫尿中的cauxin的方法和用于去除cauxin的材料。 用于除去猫尿中的cauxin的材料包括通过二硫醇固定有三氟酮衍生物的表面的聚合物基材。