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公开(公告)号：US12065510B2
公开(公告)日：2024-08-20
申请号：US16937286
申请日：2020-07-23
发明人： Han Altae-Tran , Linyi Gao , Feng Zhang
IPC分类号： C07K19/00 , C07K14/47 , C07K14/705
CPC分类号： C07K19/00 , C07K14/47 , C07K14/705 , C07K2319/02
摘要： Novel programmable targeting sequences and applications thereof. The targeting sequences can be engineered for binding to proteins, polypeptides, and other macromolecules.
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公开(公告)号：US20190010471A1
公开(公告)日：2019-01-10
申请号：US15844528
申请日：2017-12-16
发明人： Feng Zhang , Linyi Gao , Bernd Zetsche , Ian Slaymaker
摘要： Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.
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公开(公告)号：US20240035006A1
公开(公告)日：2024-02-01
申请号：US17986277
申请日：2022-11-14
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , University of Tokyo , The United States of America, as Represented by the Secretary Dept of Health and Human Services
发明人： Takashi Yamano , Hiroshi Nishimasu , Bernd Zetsche , Ian Slaymaker , Yinqing Li , Iana Fedorova , Kira Makarova , Linyi Gao , Eugene Koonin , Feng Zhang , Osamu Nureki
IPC分类号： C12N9/22 , A61P35/00 , G16B15/00 , G16C20/30 , G16C60/00 , G16C20/50 , G16C20/70 , C07K1/30 , C12N15/10
CPC分类号： C12N9/22 , A61P35/00 , G16B15/00 , G16C20/30 , C07K2299/00 , G16C20/50 , G16C20/70 , C07K1/306 , C12N15/102 , G16C60/00
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20230287370A1
公开(公告)日：2023-09-14
申请号：US17910497
申请日：2021-03-11
发明人： Feng Zhang , Jonathan Leo Schmid-Burgk , Linyi Gao , David Li
CPC分类号： C12N9/22 , C12N15/11 , C12N15/907 , C12N2310/20 , C12N2310/315 , C12N2800/80
摘要： A method of identifying and characterizing novel Cas protein and guide RNAs with desired activity and specificity. The disclosure further comprises compositions and systems comprising engineered Cas protein and guide RNAs with desired activity and specificity.
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公开(公告)号：US20210024655A1
公开(公告)日：2021-01-28
申请号：US16937286
申请日：2020-07-23
发明人： Han Altae-Tran , Linyi Gao , Feng Zhang
IPC分类号： C07K19/00 , C07K14/705 , C07K14/47
摘要： Novel programmable targeting sequences and applications thereof. The targeting sequences can be engineered for binding to proteins, polypeptides, and other macromolecules.
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公开(公告)号：US20190264186A1
公开(公告)日：2019-08-29
申请号：US16071896
申请日：2017-01-23
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , University of Tokyo , The USA, As Represented by The Secretary Department of Health and Human Services
发明人： Takashi Yamano , Hiroshi Nishimasu , Bernd Zetsche , Ian Slaymaker , Yinqing Li , Iana Fedorova , Kira Makarova , Linyi Gao , Eugene Koonin , Feng Zhang , Osamu Nureki
IPC分类号： C12N9/22 , C12N15/10 , G16C20/50 , G16C20/70 , G16C20/30 , G16C60/00 , G16B15/00 , C07K1/30 , A61P35/00
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20210130833A1
公开(公告)日：2021-05-06
申请号：US17085937
申请日：2020-10-30
发明人： Feng Zhang , Linyi Gao
摘要： Engineered systems comprising components of defense systems identified in prokaryotes are provided.
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公开(公告)号：US12123032B2
公开(公告)日：2024-10-22
申请号：US16697018
申请日：2019-11-26
发明人： Feng Zhang , Linyi Gao , Bernd Zetsche , Ian Slaymaker
CPC分类号： C12N9/22 , C12N15/111 , C12N15/902 , C12Y301/00 , C07K2319/09 , C12N2310/20
摘要： Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.
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公开(公告)号：US20240174818A1
公开(公告)日：2024-05-30
申请号：US18523580
申请日：2023-11-29
发明人： Ruixuan Gao , Linyi Gao , Chih-Chieh Yu , Edward Stuart Boyden
IPC分类号： C08J3/075 , C08F8/00 , C08F8/12 , C08F8/30 , C08F8/44 , C08F222/10 , C08G65/26 , C08G65/32 , C08G81/02 , C08J3/24 , C12Q1/68 , C12Q1/6834 , C12Q1/6841 , C12Q1/6869 , G01N1/30 , G01N33/545 , C08F220/04 , C08F220/30 , C08F220/34 , G01N1/36 , G01N15/0205
CPC分类号： C08J3/075 , C08F8/00 , C08F8/12 , C08F8/30 , C08F8/44 , C08F222/104 , C08G65/2624 , C08G65/32 , C08G81/025 , C08J3/246 , C12Q1/68 , C12Q1/6834 , C12Q1/6841 , C12Q1/6869 , G01N1/30 , G01N33/545 , C08F220/04 , C08F220/303 , C08F220/346 , C08F2438/01 , C08G2210/00 , C08J2300/206 , C08J2400/206 , C12Q2523/101 , G01N1/36 , G01N15/0205
摘要： The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
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公开(公告)号：US11873374B2
公开(公告)日：2024-01-16
申请号：US16267849
申请日：2019-02-05
发明人： Ruixuan Gao , Linyi Gao , Chih-Chieh Yu , Edward Stuart Boyden
IPC分类号： C08J3/075 , C08G65/26 , C12Q1/6834 , C12Q1/6841 , G01N33/545 , C08G81/02 , C08F8/12 , G01N1/30 , C08J3/24 , C12Q1/68 , C08F8/30 , C08G65/32 , C12Q1/6869 , C08F8/44 , C08F8/00 , C08F222/10 , C08F220/04 , G01N15/02 , G01N1/36 , C08F220/30 , C08F220/34
CPC分类号： C08J3/075 , C08F8/00 , C08F8/12 , C08F8/30 , C08F8/44 , C08F222/104 , C08G65/2624 , C08G65/32 , C08G81/025 , C08J3/246 , C12Q1/68 , C12Q1/6834 , C12Q1/6841 , C12Q1/6869 , G01N1/30 , G01N33/545 , C08F220/04 , C08F220/303 , C08F220/346 , C08F2438/01 , C08G2210/00 , C08J2300/206 , C08J2400/206 , C12Q2523/101 , G01N1/36 , G01N15/0205 , C08F8/12 , C08F8/30 , C08F20/18 , C08F8/12 , C08F8/00 , C08F8/04 , C08F8/30 , C08F20/18 , C08F8/44 , C08F8/30 , C08F20/18 , C08F8/44 , C08F8/00 , C08F8/04 , C08F8/30 , C08F20/18 , C12Q1/6869 , C12Q2521/107 , C12Q2525/191 , C12Q2527/125 , C12Q2543/101
摘要： The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
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