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    SYSTEMS AND METHODS FOR IMAGING AND ABLATING A SAMPLE
    1.
    发明申请
    SYSTEMS AND METHODS FOR IMAGING AND ABLATING A SAMPLE 有权

    公开(公告)号：US20230011590A1

    公开(公告)日：2023-01-12

    申请号：US17751506

    申请日：2022-05-23

    申请人： Thermo Fisher Scientific (Bremen) GmbH ,  LIFE TECHNOLOGIES CORPORATION ,  FEI DEUTSCHLAND GmbH

    发明人： Alexander MAKAROV ,  Michael WARD ,  Rainer DAUM

    IPC分类号： G01N1/28 ,  G01N21/65 ,  G01N21/64 ,  G01N30/72

    摘要： Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device includes an optical assembly, a sample stage, and a receiver. The optical assembly enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume toward the receiver. A laser focus detection unit including at least one reference laser and photodetector generates at least one real-time detection signal indicative of one or more characteristics of the sample during ablation and/or of a distance from the objective to the sample stage or a surface of the sample. A controller coupled with the laser focus detection unit dynamically controls in real-time one or more parameters of the ablation laser and/or a position of the objective and/or a position of the receiver relative to the sample to improve MS imaging quality.

    SYSTEMS AND METHODS FOR IMAGING AND ABLATING A SAMPLE
    2.
    发明申请
    SYSTEMS AND METHODS FOR IMAGING AND ABLATING A SAMPLE 有权

    公开(公告)号：US20220399197A1

    公开(公告)日：2022-12-15

    申请号：US17755179

    申请日：2020-11-10

    申请人： Thermo Fisher Scientific (Bremen) GmbH ,  Life Technologies Corporation ,  FEI Deutschland GmbH

    发明人： Alexander Makarov ,  Michael WARD ,  Rainer DAUM

    IPC分类号： H01J49/00 ,  H01J49/16 ,  G01N21/64

    摘要： Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device (110) includes an optical assembly (112), a sample stage (114), and a receiver (116). The optical assembly (112) is disposed in an inverted position below the sample stage (114) and the receiver (116) is positioned above the sample stage (112). The optical assembly enables imaging of a sample disposed on the sample stage (114). The optical assembly (112) also enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume (20) toward the receiver (116).

    Systems, Methods, and Apparatuses for Optical Systems in Flow Cytometers
    9.
    发明申请
    Systems, Methods, and Apparatuses for Optical Systems in Flow Cytometers 有权
    流式细胞术中光学系统的系统，方法和装置

    公开(公告)号：US20150247789A1

    公开(公告)日：2015-09-03

    申请号：US14607677

    申请日：2015-01-28

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Gregory KADUCHAK ,  Wesley SMITH ,  Michael WARD

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1459 ,  G01N15/1434

    摘要： The present set of embodiments relate to a system, method, and apparatus for an optical configuration in a flow cytometer that allows for independent adjustment of focusing for each light source. Such systems, methods, and apparatuses require a final focusing element to be moved near the beginning of the optical train and for each optical element coming after the final focusing element to be configured to accommodate converging light beams while minimizing the introduction of aberrations into those beams.

    摘要翻译： 本组实施例涉及用于流式细胞仪中的光学配置的系统，方法和装置，其允许独立调整每个光源的聚焦。 这样的系统，方法和装置需要最终的聚焦元件在光学列车的开始附近移动，并且对于在最终聚焦元件之后的每个光学元件被配置成适应会聚的光束，同时最小化将像差引入到那些光束中 。