Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors
    7.
    发明申请
    Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors 有权
    可用作丙二酰辅酶A脱羧酶抑制剂的哌啶化合物

    公开(公告)号:US20090124660A1

    公开(公告)日:2009-05-14

    申请号:US12245558

    申请日:2008-10-03

    IPC分类号: A61K31/454 C07D417/12

    摘要: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

    摘要翻译: 本发明提供了使用结构I所示化合物的方法,含有该化合物的药物组合物,以及预防,治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防,管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地,这些化合物和含有它们的药物组合物在心血管疾病,糖尿病,癌症和肥胖症的预防,治疗和治疗中被指出。

    Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors
    8.
    发明授权
    Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors 有权
    可用作丙二酰辅酶A脱羧酶抑制剂的哌啶化合物

    公开(公告)号:US08080665B2

    公开(公告)日:2011-12-20

    申请号:US12245558

    申请日:2008-10-03

    IPC分类号: A61K31/4468 C07D211/58

    摘要: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

    摘要翻译: 本发明提供了使用结构I所示化合物的方法,含有该化合物的药物组合物,以及预防,治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防,管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地,这些化合物和含有它们的药物组合物在心血管疾病,糖尿病,癌症和肥胖症的预防,治疗和治疗中被指出。

    Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors
    9.
    发明授权
    Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors 失效
    可用作丙二酰辅酶A脱羧酶抑制剂的哌啶化合物

    公开(公告)号:US07449482B2

    公开(公告)日:2008-11-11

    申请号:US10900705

    申请日:2004-07-28

    IPC分类号: A61K31/4468

    摘要: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

    摘要翻译: 本发明提供了使用结构I所示化合物的方法,含有该化合物的药物组合物,以及预防,治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防,管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地,这些化合物和含有它们的药物组合物在心血管疾病,糖尿病,癌症和肥胖症的预防,治疗和治疗中被指出。