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公开(公告)号：US20060211931A1
公开(公告)日：2006-09-21
申请号：US11359700
申请日：2006-02-21
申请人： Thomas Blank , Mutua Mattu , James Henderson , Kevin Hazen , Roxanne Abul-Haj
发明人： Thomas Blank , Mutua Mattu , James Henderson , Kevin Hazen , Roxanne Abul-Haj
IPC分类号： A61B5/00
CPC分类号： A61B5/6842 , A61B5/14532 , A61B5/6841 , A61B2562/187
摘要： The invention provides an adaptive mount for use in coupling a noninvasive analyte property analyzer to a living tissue sample site. The adaptive mount increases precision and accuracy of sampling by relieving stress and strain on a sample prior to and/or during sampling, which results in noninvasive analyte property estimations with corresponding performance enhancement.
摘要翻译： 本发明提供了一种用于将非侵入性分析物质分析仪与生物体组织样品位点连接的自适应装置。 自适应底座通过在采样之前和/或采样期间减轻样品的应力和应变来增加采样的精度和精度，这导致具有相应性能增强的非侵入性分析物质估计。
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公开(公告)号：US20050203359A1
公开(公告)日：2005-09-15
申请号：US11008001
申请日：2004-12-08
申请人： Thomas Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen Monfre , Alexander Lorenz , Timothy Ruchti , Kevin Hazen , Donovan Berry , Roxanne Abul-Haj
发明人： Thomas Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen Monfre , Alexander Lorenz , Timothy Ruchti , Kevin Hazen , Donovan Berry , Roxanne Abul-Haj
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6833
摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
摘要翻译： 公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。 本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导 控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。 可选组件包括闭塞元件和耦合流体。
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3.发明申请Sampling interface system for in-vivo estimation of tissue analyte concentration 审中-公开用于体内估计组织分析物浓度的采样界面系统公开(公告)号：US20050187439A1
公开(公告)日：2005-08-25
申请号：US11031103
申请日：2005-01-06
申请人： Thomas Blank , George Acosta , Stephen Monfre , Roxanne Abul-Haj , Kevin Hazen , Sedar Brown , Benjamin Richie , James Henderson , Barry Elliott , Josh Hope
发明人： Thomas Blank , George Acosta , Stephen Monfre , Roxanne Abul-Haj , Kevin Hazen , Sedar Brown , Benjamin Richie , James Henderson , Barry Elliott , Josh Hope
CPC分类号： G01N21/359 , A61B5/0075 , A61B5/14532 , A61B5/1455 , A61B2562/146
摘要： Sampling is controlled to enhance analyte concentration estimation derived from noninvasive sampling. Means of assuring that the same tissue sample volume is repeatably sampled are presented, thus minimizing sampling errors due to mechanical tissue distortion, specular reflectance, and probe placement. In a first embodiment of the invention, sampling is controlled using automated delivery of a coupling fluid to a region between a tip of a sample probe and a tissue measurement site in a manner requiring minimal user interaction. In a second embodiment of the invention, sampling is controlled by controlling temperature variations, preferably with a coupling fluid, at a region about the tip of a sample probe and a sample site. In a third embodiment, sampling is procedurally controlled via timing and location of coupling fluid delivery to a sample site.
摘要翻译： 控制采样以增强从无创采样得到的分析物浓度估计。 呈现确保相同组织样本体积被重复采样的方法，从而最小化由于机械组织变形，镜面反射率和探针放置引起的采样误差。 在本发明的第一实施例中，采用自动化方式将耦合流体以需要最少用户相互作用的方式自动传送到样品探针的尖端和组织测量部位之间的区域进行控制。 在本发明的第二实施例中，通过在围绕样品探针的尖端的区域和样品位置处控制温度变化来控制采样，优选地通过耦合流体进行控制。 在第三实施例中，通过将流体输送到样品位置的定时和位置程序地控制采样。
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公开(公告)号：US20060200017A1
公开(公告)日：2006-09-07
申请号：US11361143
申请日：2006-02-23
申请人： Stephen Monfre , Thomas Blank , Kevin Hazen , Alan Abul-Haj , Tim Ruchti , James Henderson , Tim Stippick , Roxanne Abul-Haj
发明人： Stephen Monfre , Thomas Blank , Kevin Hazen , Alan Abul-Haj , Tim Ruchti , James Henderson , Tim Stippick , Roxanne Abul-Haj
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/061 , A61B5/1455 , A61B5/1495 , A61B5/489 , A61B5/7264 , A61B2562/0242 , A61B2562/146
摘要： The invention provides a targeting system used to direct a measuring system to a targeted sample site or volume. The targeting system increases analyte estimation performance by increasing precision and accuracy of sampling and/or by targeting an analyte rich tissue volume.
摘要翻译： 本发明提供了一种用于将测量系统引导到目标样品位点或体积的靶向系统。 靶向系统通过提高采样的精度和准确度和/或通过靶向富含分析物的组织体积来增加分析物估计性能。
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公开(公告)号：US11678819B2
公开(公告)日：2023-06-20
申请号：US16667020
申请日：2019-10-29
IPC分类号： A61B5/145 , G01N21/359 , A61B5/1455 , A61B5/00 , G01N21/47 , G01N21/17 , G01N21/49
CPC分类号： A61B5/14532 , A61B5/0051 , A61B5/1455 , A61B5/6841 , G01N21/1717 , G01N21/359 , G01N21/474 , G01N21/49 , G01N2021/1729
摘要： The invention comprises an applied force-optic analyzer used to determine a sample constituent concentration, a physical measure of the sample, and/or a state of the sample. The analyzer comprises: an electro-mechanical transducer affixed to skin of a subject; a controller, the controller providing a voltage waveform to the electro-mechanical transducer driving displacement of the skin and inducing a pressure wave into the skin; and a spectrometer interfaced to a sample site of the skin, the spectrometer comprising a set of sources and a set of detectors, where the controller is configured to collect signal from the set of detectors as a function of timing of the voltage waveform and apply a calibration model to the signal to determine the analyte concentration.
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6.发明申请公开(公告)号：US20200163596A1
公开(公告)日：2020-05-28
申请号：US16691615
申请日：2019-11-22
申请人： Alodeep Sanyal , Benjamin Mbouombouo , Roxanne Abul-Haj , Alan Abul-Haj , Christopher Slawinski , Kevin Hazen
发明人： Alodeep Sanyal , Benjamin Mbouombouo , Roxanne Abul-Haj , Alan Abul-Haj , Christopher Slawinski , Kevin Hazen
摘要： The invention comprises a method for noninvasively determining a sample property, comprising controlling photon generation from a source and analyzing signal from a set of detectors; irradiating an illumination zone of skin with the photons; and detecting diffusely reflected photons from the skin, the set of detectors respectively optically coupled to a set of detection zones of the skin positioned along a spiral path between a first and second radial distance from the illumination zone, where a first detection zone of a first detector of the set of detectors extends radially outward from the illumination zone to at least an inward radial distance, from the illumination zone, of a second detection zone of a second detector of the set of detectors, where at least one detection zone of the set of detection zones has a central radial distance from the illumination zone between the first and second radial distances.
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公开(公告)号：US11690541B2
公开(公告)日：2023-07-04
申请号：US16777846
申请日：2020-01-30
申请人： Kevin Hazen , Benjamin Mbouombouo , Alan Abul-Haj , Roxanne Abul-Haj , Christopher Slawinski , Alodeep Sanyal
发明人： Kevin Hazen , Benjamin Mbouombouo , Alan Abul-Haj , Roxanne Abul-Haj , Christopher Slawinski , Alodeep Sanyal
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/145 , G01N33/49 , G01J3/10
CPC分类号： A61B5/1455 , A61B5/0022 , A61B5/0051 , A61B5/0053 , A61B5/14532 , A61B5/6824 , A61B5/6832 , G01J3/10 , G01N33/49 , A61B5/0004 , A61B5/7264 , A61B2562/0233 , A61B2562/0238 , A61B2562/046 , G01J2003/102 , G01J2003/106
摘要： The invention comprises a method and apparatus for sampling skin of a person as a part of noninvasive analyte property determination system, comprising the steps of: providing an analyzer, comprising: sources and at least three detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including: a range of differing radial distances from a first illumination zone; repetitively illuminating an illumination zone of the skin with photons in a range of 1200 to 2500 nm; detecting portions of the first photons with the at least three detectors; and using signals from the at least three detectors and a metric, respectively classifying the skin into a first, second, and third tissue state, the radial distances of the at least three detectors differing from each other by greater than ten percent.
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公开(公告)号：US11547329B2
公开(公告)日：2023-01-10
申请号：US16691615
申请日：2019-11-22
申请人： Alodeep Sanyal , Benjamin Mbouombouo , Roxanne Abul-Haj , Alan Abul-Haj , Christopher Slawinski , Kevin Hazen
发明人： Alodeep Sanyal , Benjamin Mbouombouo , Roxanne Abul-Haj , Alan Abul-Haj , Christopher Slawinski , Kevin Hazen
IPC分类号： A61B5/1455 , A61B5/145 , A61B5/00 , G01J3/10
摘要： The invention comprises a method for noninvasively determining a sample property, comprising controlling photon generation from a source and analyzing signal from a set of detectors; irradiating an illumination zone of skin with the photons; and detecting diffusely reflected photons from the skin, the set of detectors respectively optically coupled to a set of detection zones of the skin positioned along a spiral path between a first and second radial distance from the illumination zone, where a first detection zone of a first detector of the set of detectors extends radially outward from the illumination zone to at least an inward radial distance, from the illumination zone, of a second detection zone of a second detector of the set of detectors, where at least one detection zone of the set of detection zones has a central radial distance from the illumination zone between the first and second radial distances.
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9.发明申请公开(公告)号：US20200337609A1
公开(公告)日：2020-10-29
申请号：US16667020
申请日：2019-10-29
IPC分类号： A61B5/145 , G01N21/359 , G01N21/47 , A61B5/00 , A61B5/1455
摘要： The invention comprises an applied force-optic analyzer used to determine a sample constituent concentration, a physical measure of the sample, and/or a state of the sample. The analyzer comprises: an electro-mechanical transducer affixed to skin of a subject; a controller, the controller providing a voltage waveform to the electro-mechanical transducer driving displacement of the skin and inducing a pressure wave into the skin; and a spectrometer interfaced to a sample site of the skin, the spectrometer comprising a set of sources and a set of detectors, where the controller is configured to collect signal from the set of detectors as a function of timing of the voltage waveform and apply a calibration model to the signal to determine the analyte concentration.
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10.发明申请公开(公告)号：US20200337606A1
公开(公告)日：2020-10-29
申请号：US16777842
申请日：2020-01-30
申请人： Kevin Hazen , Benjamin Mbouombouo , Alodeep Sanyal , Alan Abul-Haj , Roxanne Abul-Haj , Christopher Slawinski
发明人： Kevin Hazen , Benjamin Mbouombouo , Alodeep Sanyal , Alan Abul-Haj , Roxanne Abul-Haj , Christopher Slawinski
IPC分类号： A61B5/1477 , A61B5/00 , A61B5/1455 , A61B5/145
摘要： The invention comprises a method and apparatus for sampling optical pathways having a common tissue depth, such as a maximum mean depth of penetration in the dermis, with a common sample position of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges and detecting, using a set of detectors, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection. Optionally, given illumination zone-to-detection zone distances are dynamically selected based upon a measure of state of the skin of the person.
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