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41 条记录 (耗时 0.039 秒)

    Heterocycles as potassium channel modulators
    1.
    发明授权
    Heterocycles as potassium channel modulators 有权
    杂环作为钾通道调节剂

    公开(公告)号：US08058274B2

    公开(公告)日：2011-11-15

    申请号：US12193639

    申请日：2008-08-18

    申请人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Ann Wolf-Gouveia ,  Mark J. Suto

    发明人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Ann Wolf-Gouveia ,  Mark J. Suto

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D487/00

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

    摘要翻译： 提供了通过电压依赖钾通道调节钾离子通量可用于治疗疾病的化合物，组合物和方法。 更具体地说，本发明提供了可用于治疗中枢性或周围神经系统疾病（例如偏头痛，共济失调，帕金森病，双相情感障碍，三叉神经痛，痉挛状态，情绪障碍，脑肿瘤，精神病症）的杂环，组合物和方法 ，癫痫，癫痫，癫痫，癫痫发作，视网膜变性，听力和视力丧失，阿尔茨海默病，年龄相关记忆丧失，学习缺陷，焦虑，神经元变性和运动神经元疾病，维持膀胱控制或治疗尿失禁）和神经保护剂 （例如，为了预防中风等）通过调节与指示的病症的发作或复发相关的钾通道。

    Heterocycles as potassium channel modulators
    2.
    发明授权
    Heterocycles as potassium channel modulators 失效
    杂环作为钾通道调节剂

    公开(公告)号：US08431608B2

    公开(公告)日：2013-04-30

    申请号：US12706574

    申请日：2010-02-16

    申请人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Ann Wolf-Gouveia ,  Mark J. Suto

    发明人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Ann Wolf-Gouveia ,  Mark J. Suto

    IPC分类号： A61K31/4188 ,  C07D235/00

    CPC分类号： C07D487/04 ,  A61K31/5025 ,  C07D471/04

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

    摘要翻译： 提供了通过电压依赖钾通道调节钾离子通量可用于治疗疾病的化合物，组合物和方法。 更具体地说，本发明提供了可用于治疗中枢性或周围神经系统疾病（例如偏头痛，共济失调，帕金森病，双相情感障碍，三叉神经痛，痉挛状态，情绪障碍，脑肿瘤，精神病症）的杂环，组合物和方法 ，癫痫，癫痫，癫痫，癫痫发作，视网膜变性，听力和视力丧失，阿尔茨海默病，年龄相关记忆丧失，学习缺陷，焦虑，神经元变性和运动神经元疾病，维持膀胱控制或治疗尿失禁）和神经保护剂 （例如，为了预防中风等）通过调节与指示的病症的发作或复发相关的钾通道。

    HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS
    3.
    发明申请
    HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS 失效
    杂质作为钾通道调节剂

    公开(公告)号：US20100240663A1

    公开(公告)日：2010-09-23

    申请号：US12706574

    申请日：2010-02-16

    申请人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Ann Wolf-Gouveia ,  Mark J. Suto

    发明人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Ann Wolf-Gouveia ,  Mark J. Suto

    IPC分类号： A61K31/5025 ,  C07D471/04 ,  A61K31/437 ,  C07D487/04 ,  A61P25/28 ,  A61P25/16 ,  A61P25/22 ,  A61P25/18 ,  A61P25/08 ,  A61P27/00 ,  C12N5/02

    CPC分类号： C07D487/04 ,  A61K31/5025 ,  C07D471/04

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

    摘要翻译： 提供了通过电压依赖钾通道调节钾离子通量可用于治疗疾病的化合物，组合物和方法。 更具体地说，本发明提供了可用于治疗中枢性或周围神经系统疾病（例如偏头痛，共济失调，帕金森病，双相情感障碍，三叉神经痛，痉挛状态，情绪障碍，脑肿瘤，精神病症）的杂环，组合物和方法 ，癫痫，癫痫，癫痫，癫痫发作，视网膜变性，听力和视力丧失，阿尔茨海默病，年龄相关记忆丧失，学习缺陷，焦虑，神经元变性和运动神经元疾病，维持膀胱控制或治疗尿失禁）和神经保护剂 （例如，为了预防中风等）通过调节与指示的病症的发作或复发相关的钾通道。

    HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS
    4.
    发明申请
    HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS 有权
    杂质作为钾通道调节剂

    公开(公告)号：US20090062290A1

    公开(公告)日：2009-03-05

    申请号：US12193639

    申请日：2008-08-18

    申请人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Wolf-Gouveia ,  Mark J. Suto

    发明人： Thomas Eugene Christos ,  George S. Amato ,  Robert N. Atkinson ,  Maria Graciela Barolli ,  Lilli Wolf-Gouveia ,  Mark J. Suto

    IPC分类号： A61K31/5025 ,  A61K31/437 ,  C07D471/04 ,  A61K31/519 ,  C12N5/06 ,  A61P25/28 ,  C07D487/04

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

    摘要翻译： 提供了通过电压依赖钾通道调节钾离子通量可用于治疗疾病的化合物，组合物和方法。 更具体地说，本发明提供了可用于治疗中枢性或周围神经系统疾病（例如偏头痛，共济失调，帕金森病，双相情感障碍，三叉神经痛，痉挛状态，情绪障碍，脑肿瘤，精神病症）的杂环，组合物和方法 ，癫痫，癫痫，癫痫，癫痫发作，视网膜变性，听力和视力丧失，阿尔茨海默病，年龄相关记忆丧失，学习缺陷，焦虑，神经元变性和运动神经元疾病，维持膀胱控制或治疗尿失禁）和神经保护剂 （例如，为了预防中风等）通过调节与指示的病症的发作或复发相关的钾通道。

    INHIBITORS OF ION CHANNELS
    5.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20100041707A1

    公开(公告)日：2010-02-18

    申请号：US12561002

    申请日：2009-09-16

    申请人： Alan Fulp ,  Brian Marron ,  Mark J. Suto ,  Xiaodong Wang

    发明人： Alan Fulp ,  Brian Marron ,  Mark J. Suto ,  Xiaodong Wang

    IPC分类号： A61K31/427 ,  C07D277/22 ,  C07D417/02 ,  A61K31/4439 ,  A61P25/00

    CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供了可用于治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的杂环芳基磺酰胺，组合物和方法，其通过阻断与所述病症的发作或复发相关的钠通道。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。