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公开(公告)号：US06289717B1
公开(公告)日：2001-09-18
申请号：US09281032
申请日：1999-03-30
申请人： Thomas G. Thundat , K. Bruce Jacobson , Mitchel J. Doktycz , Stephen J. Kennel , Robert J. Warmack
发明人： Thomas G. Thundat , K. Bruce Jacobson , Mitchel J. Doktycz , Stephen J. Kennel , Robert J. Warmack
IPC分类号： G01N1910
CPC分类号： G01N33/54373
摘要： A sensor apparatus is provided using a microcantilevered spring element having a coating of a detector molecule such as an antibody or antigen. A sample containing a target molecule or substrate is provided to the coating. The spring element bends in response to the stress induced by the binding which occurs between the detector and target molecules. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 &mgr;m long, approximately 1 to 50 &mgr;m wide, and approximately 0.3 to 3.0 &mgr;m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers.
摘要翻译： 使用具有检测器分子如抗体或抗原的涂层的微悬臂弹簧元件提供传感器装置。 将包含靶分子或基底的样品提供给涂层。 弹簧元件响应于由检测器和靶分子之间发生的结合引起的应力而弯曲。 通过各种检测技术检测悬臂的偏转。 该微悬臂梁的长度可以为约1至200μm，宽度大约为1至50μm，厚度为0.3至3.0μm。 检测偏转的灵敏度在0.01纳米的范围内。
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公开(公告)号：US06436346B1
公开(公告)日：2002-08-20
申请号：US09395630
申请日：1999-09-14
申请人： Mitchel J. Doktycz , Charles L. Britton, Jr. , Stephen F. Smith , Patrick I. Oden , William L. Bryan , James A. Moore , Thomas G. Thundat , Robert J. Warmack
发明人： Mitchel J. Doktycz , Charles L. Britton, Jr. , Stephen F. Smith , Patrick I. Oden , William L. Bryan , James A. Moore , Thomas G. Thundat , Robert J. Warmack
IPC分类号： G01N2520
CPC分类号： G01K17/006
摘要： A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.
摘要翻译： 提供了一种用于检测和监测由分子反应引起的微量焓变的方法和装置。 微加工技术用于创建非常小的热隔离块，并结合温度敏感电路。 热隔离的质量块设置有分子层或涂层，并且当涂层的分子参与焓反应时，温度敏感电路提供指示。 可以单独地或以阵列形式提供热分离的质量，并且在后一种情况下，分子涂层可以不同以提供物质的定性和/或定量测定。
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公开(公告)号：US07243548B2
公开(公告)日：2007-07-17
申请号：US11100839
申请日：2005-04-07
CPC分类号： G01N29/022 , G01N29/2418 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： A surface wave chemical detector comprising at least one surface wave substrate, each of said substrates having a surface wave and at least one measurable surface wave parameter; means for exposing said surface wave substrate to an unknown sample of at least one chemical to be analyzed, said substrate adsorbing said at least one chemical to be sensed if present in said sample; a source of radiation for radiating said surface wave substrate with different wavelengths of said radiation, said surface wave parameter being changed by said adsorbing; and means for recording signals representative of said surface wave parameter of each of said surface wave substrates responsive to said radiation of said different wavelengths, measurable changes of said parameter due to adsorbing said chemical defining a unique signature of a detected chemical.
摘要翻译： 一种表面波化学检测器，包括至少一个表面波衬底，每个所述衬底具有表面波和至少一个可测量的表面波参数; 用于将所述表面波衬底暴露于待分析的至少一种化学物质的未知样品的装置，所述衬底在所述样品中吸附所述至少一种要被感测的化学物质; 用于辐射具有不同波长的所述辐射的所述表面波衬底的辐射源，所述表面波参数通过所述吸附而改变; 以及用于响应于所述不同波长的所述辐射记录表示每个所述表面波衬底的所述表面波参数的信号的装置，由于吸附所述化学物质而限定所检测化学物质的唯一标记，所述参数的可测量的变化。
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4.发明授权Micromechanical transient sensor for measuring viscosity and density of a fluid 失效用于测量流体的粘度和密度的微机械瞬态传感器公开(公告)号：US06311549B1
公开(公告)日：2001-11-06
申请号：US09401865
申请日：1999-09-23
IPC分类号： G01N1110
CPC分类号： G01N29/022 , G01N9/002 , G01N11/16 , G01N29/30 , G01N29/343 , G01N29/46 , G01N2009/006 , G01N2291/0256 , G01N2291/02818 , G01N2291/0427
摘要： A method and apparatus for measuring the viscosity and/or specific density of a fluid utilizes a microcantilever vibrated in the analyte fluid. The source of vibration is switched on and off and the transient behavior or decay in amplitude of the vibration is monitored. The method is particularly useful for the measurement of process conditions in remote locations in real time.
摘要翻译： 用于测量流体的粘度和/或比重密度的方法和装置利用在分析物流体中振动的微悬臂梁。 振动源开启和关闭，并监测振动振幅的瞬态特性或衰减。 该方法对于实时测量偏远地区的工艺条件特别有用。
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公开(公告)号：US06005400A
公开(公告)日：1999-12-21
申请号：US916345
申请日：1997-08-22
IPC分类号： G01R31/26 , G01R31/265 , G01R31/28 , H01L21/66 , G01R1/04
CPC分类号： G01R31/2656 , G01R31/2648 , G01R31/2831 , H01L22/14 , Y10S977/854
摘要： A semiconductor doping profiler provides a Schottky contact at one surface and an ohmic contact at the other. While the two contacts are coupled to a power source, thereby establishing an electrical bias in the semiconductor, a localized light source illuminates the semiconductor to induce a photocurrent. The photocurrent changes in accordance with the doping characteristics of the semiconductor in the illuminated region. By changing the voltage of the power source the depth of the depletion layer can be varied to provide a three dimensional view of the local properties of the semiconductor.
摘要翻译： 半导体掺杂轮廓仪在一个表面提供肖特基接触，在另一个表面提供欧姆接触。 当两个触点耦合到电源时，由此在半导体中建立电偏压，局部光源照射半导体以引起光电流。 光电流根据照明区域中的半导体的掺杂特性而变化。 通过改变电源的电压，可以改变耗尽层的深度以提供半导体的局部性质的三维视图。
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6.发明授权
公开(公告)号：US6118124A
公开(公告)日：2000-09-12
申请号：US588484
申请日：1996-01-18
IPC分类号： G01J1/00 , B81B3/00 , G01J1/04 , G01J5/00 , G01J5/10 , G01J5/40 , G01J5/44 , G01N13/16 , G01T1/02 , G01J5/34
摘要： Electromagnetic and nuclear radiation is detected by micromechanical sensors that can be coated with various interactive materials. As the micromechanical sensors absorb radiation, the sensors bend and/or undergo a shift in resonance characteristics. The bending and resonance changes are detected with high sensitivity by any of several detection methods including optical, capacitive, and piezoresistive methods. Wide bands of the electromagnetic spectrum can be imaged with picoJoule sensitivity, and specific absorptive coatings can be used for selective sensitivity in specific wavelength bands. Microcantilevers coated with optical cross-linking polymers are useful as integrating optical radiation dosimeters. Nuclear radiation dosimetry is possible by fabricating cantilevers from materials that are sensitive to various nuclear particles or radiation. Upon exposure to radiation, the cantilever bends due to stress and its resonance frequency shifts due to changes in elastic properties, based on cantilever shape and properties of the coating.
摘要翻译： 电磁和核辐射由可以用各种交互材料涂覆的微机械传感器检测。 当微机械传感器吸收辐射时，传感器弯曲和/或经历谐振特性的偏移。 通过包括光学，电容和压阻方法的几种检测方法中的任何一种，以高灵敏度检测弯曲和谐振变化。 电磁光谱的宽带可以用微微焦灵敏感度成像，并且特定吸收涂层可用于特定波长带中的选择性灵敏度。 涂有光学交联聚合物的微悬臂梁可用作整合光学辐射剂量计。 可以通过从对各种核粒子或辐射敏感的材料制造悬臂来进行核辐射剂量测定。 暴露于辐射后，基于悬臂形状和涂层性质，悬臂由于应力而引起弯曲，并且由于弹性性质的变化而引起的共振频率偏移。
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公开(公告)号：US08425596B2
公开(公告)日：2013-04-23
申请号：US12052992
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61F2/16
CPC分类号： A61F9/00736 , A61B17/205 , A61F9/007 , A61F9/00727
摘要： In one embodiment, the present invention provides a method of removing scar tissue from an eye that includes inserting a device including an array of micro-rods into an eye, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature; contacting a scar tissue with the array of micro-rods; and removing the array of micro-rods and the scar tissue from the eye. In another embodiment, the present invention provides a medical device for engaging a tissue including and an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods that is connected to the cannula, wherein the sharp feature of the at least one micro-rod is angled from a plane that is normal to a face of the base of the array of glass micro-rods.
摘要翻译： 在一个实施方案中，本发明提供了一种从眼睛去除疤痕组织的方法，包括将包括微棒阵列的装置插入到眼睛中，其中玻璃微棒阵列的至少一个玻璃微棒包括 一个尖锐的特征; 使疤痕组织与微杆阵列接触; 并从眼睛中移除微杆阵列和瘢痕组织。 在另一个实施方案中，本发明提供了一种用于接合包括玻璃微棒和玻璃微棒的阵列的组织的医疗装置，其中所述玻璃微棒阵列的至少一个玻璃微棒包括与所述玻璃微棒的基底相对的尖锐特征 连接到插管的玻璃微杆的阵列，其中所述至少一个微杆的尖锐特征从与所述玻璃微棒阵列的基部的面垂直的平面成角度。
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公开(公告)号：US20120228138A1
公开(公告)日：2012-09-13
申请号：US13046412
申请日：2011-03-11
IPC分类号： G01N27/407
CPC分类号： G01N33/0054 , G01N27/4074 , Y02A50/246
摘要： An array-type sensor that senses NH3 includes non-Nernstian sensing elements constructed from metal and/or metal-oxide electrodes on an O2 ion conducting substrate. In one example sensor, one electrode may be made of platinum, another electrode may be made of manganese (III) oxide (Mn2O3), and another electrode may be made of tungsten trioxide (WO3). Some sensing elements may further include an electrode made of La0.6Sr0.4Co0.2Fe0.8O3 and another electrode made of LaCr0.95Mg0.05O3.
摘要翻译： 感测NH3的阵列型传感器包括由O 2离子传导基底上的金属和/或金属氧化物电极构成的非仙女感测元件。 在一个示例性传感器中，一个电极可以由铂制成，另一个电极可以由氧化锰（III）（Mn 2 O 3）制成，另一个电极可以由三氧化钨（WO3）制成。 一些感测元件还可以包括由La0.6Sr0.4Co0.2Fe0.8O3制成的电极和另一个由LaCr0.95Mg0.05O3制成的电极。
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9.发明授权Capacitively readout multi-element sensor array with common-mode cancellation 有权电容式读出具有共模消除的多元件传感器阵列公开(公告)号：US06167748A
公开(公告)日：2001-01-02
申请号：US09144309
申请日：1998-08-31
申请人： Charles L. Britton, Jr. , Robert J. Warmack , William L. Bryan , Robert L. Jones , Patrick Ian Oden , Thomas Thundat
发明人： Charles L. Britton, Jr. , Robert J. Warmack , William L. Bryan , Robert L. Jones , Patrick Ian Oden , Thomas Thundat
IPC分类号： G01B716
CPC分类号： G01B7/023 , G01D5/2417 , G01N27/227 , Y10S436/806
摘要： An improved multi-element apparatus for detecting the presence of at least one chemical, biological or physical component in a monitored area comprising an array or single set of the following elements: a capacitive transducer having at least one cantilever spring element secured thereto, the cantilever element having an area thereof coated with a chemical having an affinity for the component to be detected; a pick-up plate positioned adjacent to the cantilever element at a distance such that a capacitance between the cantilever element and the pick-up plate changes as the distance between the cantilever element and the pick-up plate varies, the change in capacitance being a measurable variation; a detection means for measuring the measurable variation in the capacitance between the cantilever element and the pick-up plate that forms a measurement channel signal; and at least one feedback cantilever spring element positioned apart from the coated cantilever element, the cantilever element substantially unaffected by the component being monitored and providing a reference channel signal to the detection means that achieves a common mode cancellation between the measurement channel signal and reference channel signal.
摘要翻译： 一种用于检测被监测区域中至少一种化学，生物或物理组分的存在的改进的多元件装置，包括阵列或单组以下元件：具有固定到其上的至少一个悬臂弹簧元件的电容换能器，所述悬臂 元件，其面积涂覆有对要检测的组分具有亲和性的化学品; 一个与悬臂元件相邻的拾取板，其距离使得悬臂元件和拾取板之间的电容随着悬臂元件和拾取板之间的距离而变化，电容的变化是 可测量变化; 用于测量形成测量通道信号的悬臂元件和拾取板之间的电容的可测量变化的检测装置; 以及至少一个反向悬臂弹簧元件，其与所述涂覆的悬臂元件分开定位，所述悬臂元件基本上不受所监视的部件的影响，并且向所述检测装置提供参考通道信号，所述参考通道信号实现所述测量通道信号和参考通道之间的共模消除 信号。
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公开(公告)号：US07265686B2
公开(公告)日：2007-09-04
申请号：US10619915
申请日：2003-07-15
IPC分类号： H03K17/94
CPC分类号： G06F3/045 , G06F3/0488
摘要： A touch sensors with improved topological equivalence between an equipotential space and a Cartesian space to which the equipotential space will be mapped. The touch sensor comprises a substrate with a touch region, and a set of electrodes that are electrically coupled to the touch region. The touch sensor further comprises a plurality of resistive band segments that frames the touch region. The electrodes are located between the resistive band segments. Each resistive band segment has a resistivity that is intermediate between the resistivity of the electrodes and the resistivity of the touch region, thereby providing a transition between the low resistivity electrodes and the high resistivity touch region, and improving the topological equivalence within the corners of the touch region. At least one of the band segments has a non-uniform linear resistance to provide further improvement to the topological equivalence.
摘要翻译： 触摸传感器具有等位置空间与等位空间映射到的笛卡尔空间之间的拓扑等效性。 触摸传感器包括具有触摸区域的基板和电耦合到触摸区域的一组电极。 触摸传感器还包括多个阻挡接触区域的电阻带段。 电极位于电阻带段之间。 每个电阻带段具有在电极的电阻率和触摸区域的电阻率之间的电阻率，从而提供低电阻率电极和高电阻率接触区域之间的转变，并且改善电极的拐角内的拓扑等效性 触摸区域。 至少一个带段具有不均匀的线性电阻以提供对拓扑等效性的进一步改进。
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