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22 条记录 (耗时 0.04 秒)

    Micromechanical antibody sensor
    2.
    发明授权
    Micromechanical antibody sensor 失效
    微机械抗体传感器

    公开(公告)号：US06289717B1

    公开(公告)日：2001-09-18

    申请号：US09281032

    申请日：1999-03-30

    申请人： Thomas G. Thundat ,  K. Bruce Jacobson ,  Mitchel J. Doktycz ,  Stephen J. Kennel ,  Robert J. Warmack

    发明人： Thomas G. Thundat ,  K. Bruce Jacobson ,  Mitchel J. Doktycz ,  Stephen J. Kennel ,  Robert J. Warmack

    IPC分类号： G01N1910

    CPC分类号： G01N33/54373

    摘要： A sensor apparatus is provided using a microcantilevered spring element having a coating of a detector molecule such as an antibody or antigen. A sample containing a target molecule or substrate is provided to the coating. The spring element bends in response to the stress induced by the binding which occurs between the detector and target molecules. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 &mgr;m long, approximately 1 to 50 &mgr;m wide, and approximately 0.3 to 3.0 &mgr;m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers.

    摘要翻译： 使用具有检测器分子如抗体或抗原的涂层的微悬臂弹簧元件提供传感器装置。 将包含靶分子或基底的样品提供给涂层。 弹簧元件响应于由检测器和靶分子之间发生的结合引起的应力而弯曲。 通过各种检测技术检测悬臂的偏转。 该微悬臂梁的长度可以为约1至200μm，宽度大约为1至50μm，厚度为0.3至3.0μm。 检测偏转的灵敏度在0.01纳米的范围内。

    Micromechanical calorimetric sensor
    3.
    发明授权
    Micromechanical calorimetric sensor 失效
    微机械量热传感器

    公开(公告)号：US6096559A

    公开(公告)日：2000-08-01

    申请号：US39707

    申请日：1998-03-16

    申请人： Thomas G. Thundat ,  Mitchel J. Doktycz

    发明人： Thomas G. Thundat ,  Mitchel J. Doktycz

    IPC分类号： G01N13/16 ,  G01N25/20

    CPC分类号： G01N29/036 ,  G01N2291/0257

    摘要： A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers. The microcantilever is extremely sensitive to thermal changes in samples as small as 30 microliters.

    摘要翻译： 利用微悬臂弹簧元件开发用于检测含有经历化学和生物化学反应的生物分子的样品内的热变化的热量传感器装置。 弹簧元件包括在微悬臂梁的至少一个表面上的涂覆区域上的化学品的双层材料层。 由于放置在涂覆区域上的样品中的化学反应的热量，化学品与样品中的分析物或生物分子发生反应时，化学物质会在整个表面产生不同的热应力。 弹簧元件表面的热应力产生了微型悬臂梁的机械弯曲。 弹簧元件具有低热质量，以允许检测和测量与放置在涂覆区域上或附近的样品内的化学和生化反应相关的热传递。 第二表面可以具有不同的材料，或者微型悬臂梁的第二表面和主体可以是惰性组合物。 微悬臂梁表面之间的差热应力产生了悬臂的弯曲。 通过各种检测技术检测悬臂的偏转。 该微悬臂梁的长度可以为1〜200μm，宽度为1〜50μm左右，厚度为0.3〜3.0μm左右。 检测偏转的灵敏度在0.01纳米的范围内。 微型悬臂梁对样品的热变化非常敏感，只有30微升。

    ACTIVE MATERIALS FOR PREVENTION AND TREATMENT OF FOULED SURFACES
    4.
    发明申请
    ACTIVE MATERIALS FOR PREVENTION AND TREATMENT OF FOULED SURFACES 审中-公开
    用于预防和处理磨损表面的活性材料

    公开(公告)号：US20140093572A1

    公开(公告)日：2014-04-03

    申请号：US14114797

    申请日：2012-05-04

    申请人： Mitchel J. Doktycz ,  David P. Allison ,  Charles F. Barnett ,  Scott T. Retterer

    发明人： Mitchel J. Doktycz ,  David P. Allison ,  Charles F. Barnett ,  Scott T. Retterer

    IPC分类号： A61K41/00

    CPC分类号： A61K41/0057 ,  A61K41/0052 ,  A61L27/446 ,  A61L27/54 ,  A61L29/126 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2400/12 ,  B82Y30/00

    摘要： A method, composition and structure to treat fouling. In one embodiment, the method of treating fouling includes providing a structure including a first component of a base material and a second component of an energetically activated nanostructure, and applying a stimuli to the structure that effectuates an increase or decrease in the temperature of the energetically activated nanostructure. The increase or decrease in the temperature of the energetically activated nanostructure modifies the chemical and/or mechanical properties of the base material. The modifications to the chemical and/or mechanical properties of the base material obstruct fouling of the structure.

    摘要翻译： 一种治疗结垢的方法，组成和结构。 在一个实施方案中，处理结垢的方法包括提供包括基材的第一组分和能量活化的纳米结构的第二组分的结构，以及向结构施加刺激以实现能量的升高或降低的结构 活性纳米结构。 能量活化的纳米结构的温度的增加或减少改变了基材的化学和/或机械性能。 对基材的化学和/或机械性能的改变阻碍了结构的结垢。

    MICRO FLUIDICS MANIFOLD APPARATUS
    6.
    发明申请
    MICRO FLUIDICS MANIFOLD APPARATUS 审中-公开
    微型流体显示装置

    公开(公告)号：US20090074625A1

    公开(公告)日：2009-03-19

    申请号：US12326723

    申请日：2008-12-02

    申请人： James E. Johnson ,  Neil R. Picha ,  Mitchel J. Doktycz

    发明人： James E. Johnson ,  Neil R. Picha ,  Mitchel J. Doktycz

    IPC分类号： B01L3/02

    CPC分类号： G01N35/1097 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00394 ,  B01J2219/00412 ,  B01J2219/00605 ,  B01J2219/00659 ,  C40B60/14 ,  F16K11/0743 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0028 ,  F16K2099/0084 ,  G01N1/14 ,  G01N2035/1041 ,  Y10T137/86863 ,  Y10T137/87249 ,  Y10T436/2575

    摘要： A manifold device is provided for use with a valve assembly, an aspiration source and a dispensing source to transfer fluid from at least one of a plurality of fluid reservoirs to at least one test site on a substrate surface. The manifold device includes a manifold body that defines a plurality of fluid aspiration conduits, for fluid aspiration in an aspiration position, and a plurality of fluid dispensing conduits to selectively dispense at least one droplet of the corresponding liquid sample slug, in a dispensing position. In the aspiration position, the respective sample paths are out of fluid communication with the dispensing source and, in the dispensing position, the respective sample paths are out of fluid communication with the aspiration source.

    摘要翻译： 提供歧管装置，用于与阀组件，抽吸源和分配源一起使用以将流体从多个流体储存器中的至少一个流体传送到基底表面上的至少一个测试部位。 歧管装置包括歧管主体，其限定多个流体抽吸导管，用于在抽吸位置中的流体抽吸，以及多个流体分配管道，用于在分配位置中选择性地分配相应液体样品块的至少一个液滴。 在抽吸位置中，各个样品路径不与分配源流体连通，并且在分配位置中，各个样品路径不与抽吸源流体连通。

    Dual manifold system and method for fluid transfer
    10.
    发明授权
    Dual manifold system and method for fluid transfer 失效
    双歧管系统和流体传输方法

    公开(公告)号：US06627157B1

    公开(公告)日：2003-09-30

    申请号：US09262455

    申请日：1999-03-04

    申请人： Mitchel J. Doktycz ,  William Louis Bryan ,  Reid Kress

    发明人： Mitchel J. Doktycz ,  William Louis Bryan ,  Reid Kress

    IPC分类号： B01L302

    CPC分类号： B01L3/0241 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00378 ,  B01J2219/00659 ,  C40B60/14 ,  G01N35/028 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

    摘要翻译： 提供了一种双歧管组件，用于将液体试剂从微量滴定板快速平行转移到具有集成在其上的生物传感器的固态微电子器件。 组件包括通过多个管道连接的抽吸和分配歧管。 在操作中，抽吸歧管被致动，使得吸入歧管被置于微量滴定板的试剂填充孔的阵列上。 孔被加压以迫使试剂通过导管朝向分配歧管。 由标准喷墨打印头提供的压力脉冲通过打印头孔阵列和微电子器件表面上的测试位置喷射纳升至微升的试剂液滴。