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    Three-dimensional printing apparatus and methods of manufacture including sterilization or disinfection, for example, using ultraviolet light
    1.
    发明授权
    Three-dimensional printing apparatus and methods of manufacture including sterilization or disinfection, for example, using ultraviolet light 失效
    三维印刷装置和制造方法，包括例如使用紫外线的灭菌或消毒

    公开(公告)号：US07445441B2

    公开(公告)日：2008-11-04

    申请号：US10891440

    申请日：2004-07-14

    申请人： Thomas George West ,  Qing Liu ,  Peter A. Materna ,  Alfred Anthony Litwak ,  Christopher M. Gaylo

    发明人： Thomas George West ,  Qing Liu ,  Peter A. Materna ,  Alfred Anthony Litwak ,  Christopher M. Gaylo

    IPC分类号： B29C35/02 ,  B29C67/00 ,  B28B17/02

    CPC分类号： A61L2/208 ,  A61L2/10 ,  A61L2/206 ,  B29C64/165 ,  B29C2035/0827 ,  B29C2791/005 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00

    摘要： The invention includes a three-dimensional printing (3DP) machine that has at least one ultraviolet (UV) light source directed at powder or slurry being processed by the 3DP machine and/or directed at any of various surfaces or machine components, in a manner suitable to kill or damage microorganisms to a desired extent. The UV light sources may be either stationary or movable, and may be either pulsed or substantially continuous, and may operate in any desired sequence and timing with respect to other operations performed by the machine. The invention may include ultraviolet illumination in such a way as to interact with powder to sterilize or disinfect powder either while the powder is stationary or, alternatively, as powder is being moved from one place to another within the 3DP machine, or both. The invention also includes methods of performing three-dimensional printing using such illumination. The invention also includes the combination of other methods of sterilization or disinfection with the use of ultraviolet light. The invention also includes the use of ultraviolet light sources for a combination of polymerization/cross-linking in addition to sterilization/disinfection.

    摘要翻译： 本发明包括三维打印（3DP）机器，其具有至少一个紫外线（UV）光源，其以粉末或浆料的形式被3DP机器处理和/或以各种表面或机器部件的任何一种方式 适合杀死或损害微生物至所需程度。 UV光源可以是静止的或可移动的，并且可以是脉冲的或基本上连续的，并且可以相对于由机器执行的其它操作以任何期望的顺序和定时操作。 本发明可以包括紫外线照射，以便与粉末相互作用以在粉末静止时或者当粉末在3DP机器内从一个位置移动到另一个位置时消除粉末或二者兼而有之。 本发明还包括使用这种照明进行三维打印的方法。 本发明还包括灭菌或消毒的其它方法与紫外线的组合。 本发明还包括除灭菌/消毒之外使用紫外光源用于聚合/交联的组合。

    Apparatus and method for dispensing of powders
    5.
    发明授权
    Apparatus and method for dispensing of powders 失效
    用于分配粉末的装置和方法

    公开(公告)号：US06336480B2

    公开(公告)日：2002-01-08

    申请号：US09829533

    申请日：2001-04-09

    申请人： Christopher M. Gaylo ,  Ireneusz J. Imiolek ,  Jeffrey A. Fedor

    发明人： Christopher M. Gaylo ,  Ireneusz J. Imiolek ,  Jeffrey A. Fedor

    IPC分类号： B65B104

    CPC分类号： B29C41/36 ,  B22F3/004 ,  B22F2998/00 ,  B29C41/12 ,  B29C64/00 ,  B29C64/153 ,  B29C2791/008 ,  B33Y30/00 ,  B33Y40/00 ,  B22F3/008

    摘要： A method and apparatus for dispensing and distributing a powder is disclosed that uses a rotary dispenser to dispense the powder by gravity onto a movable platen, the platen being movable to a position adjacent to a build bed where the powder can be distributed across the build bed using a spreader. The method and apparatus are also suited to dispensing of a plurality of powders used in build beds for solid free-form fabrication and three-dimensional printing. It is preferred that a powder contacting surface of the apparatus be coated with a coating selected from the group consisting of: an anodized finish, a hardcoat anodized finish, siloxane, baked enamel, electroplated enamel, electroless nickel, coated elastomer, laminated elastomer, dipped latex, sprayed latex, polyvinyl chloride, nylon, polytetrafluoroethylene, polyurethane, an epoxy resin, or a polyester.

    摘要翻译： 公开了一种用于分配和分配粉末的方法和装置，其使用旋转分配器将重力分配到可移动压板上，所述压板可移动到与构建床相邻的位置，在所述位置处粉末可以分布在整个床上 使用吊具。 该方法和装置也适用于分配用于固化床形成和三维印刷的构建床中使用的多种粉末。 优选的是，该设备的粉末接触表面涂覆有选自以下的涂层：阳极化处理，硬涂阳极氧化处理，硅氧烷，烘烤搪瓷，电镀搪瓷，无电镀镍，涂覆弹性体，层压弹性体，浸渍 胶乳，喷雾胶乳，聚氯乙烯，尼龙，聚四氟乙烯，聚氨酯，环氧树脂或聚酯。

    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
    6.
    发明授权
    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form 有权
    药物递送装置的方法和形式，例如以口服剂型将毒性核心包封在无毒区域内

    公开(公告)号：US07276252B2

    公开(公告)日：2007-10-02

    申请号：US09861480

    申请日：2001-05-18

    申请人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    发明人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    IPC分类号： A61K9/26

    CPC分类号： A61K9/2893 ,  A61K9/209 ,  A61K9/2886 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

    摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.

    摘要翻译： 药物递送装置，例如具有由无毒区域包封的毒性或有效核心的口服剂型（ODF）。 无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对有毒或有效的核心的保护和分离。 有毒或有效的核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而被并入到剂型中。 这最小化在制造过程中产生毒性药物的空气中颗粒的可能性，从而控制和最小化制造人员对有害物质的暴露。 有毒或有效的药物的湿分配进一步提供药物对患者更大的生物利用度。

    Apparatus and method for dispensing of powders
    9.
    发明授权
    Apparatus and method for dispensing of powders 失效

    公开(公告)号：US06213168B1

    公开(公告)日：2001-04-10

    申请号：US09343239

    申请日：1999-06-30

    申请人： Christopher M. Gaylo ,  Ireneusz J. Imiolek

    发明人： Christopher M. Gaylo ,  Ireneusz J. Imiolek

    IPC分类号： B65B104

    CPC分类号： B29C41/36 ,  B22F3/004 ,  B22F2998/00 ,  B29C41/12 ,  B29C64/00 ,  B29C64/153 ,  B29C2791/008 ,  B33Y30/00 ,  B33Y40/00 ,  B22F3/008

    摘要： A method and apparatus for dispensing and distributing a powder is disclosed that uses a rotary dispenser to dispense the powder by gravity onto a movable platen, the platen being movable to a position adjacent to a build bed where the powder can be distributed across the build bed using a spreader. The method and apparatus are also suited to dispensing of a plurality of powders used in build beds for solid free-form fabrication and three-dimensional printing. It is preferred that a powder contacting surface of the apparatus be coated with a coating selected from the group consisting of: an anodized finish, a hardcoat anodized finish, siloxane, baked enamel, electroplated enamel, electroless nickel, coated elastomer, laminated elastomer, dipped latex, sprayed latex, polyvinyl chloride, nylon, polytetrafluoroethylene, polyurethane, an epoxy resin, or a polyester.

    Method for dispensing of powders
    10.
    发明授权
    Method for dispensing of powders 失效
    分配粉末的方法

    公开(公告)号：US5934343A

    公开(公告)日：1999-08-10

    申请号：US52179

    申请日：1998-03-31

    申请人： Christopher M. Gaylo ,  Ireneusz J. Imiolek

    发明人： Christopher M. Gaylo ,  Ireneusz J. Imiolek

    IPC分类号： B22F3/00 ,  B29C41/12 ,  B29C41/36 ,  B29C67/00 ,  B65B1/04

    CPC分类号： B29C67/0085 ,  B22F3/004 ,  B29C41/12 ,  B29C41/36 ,  B29C67/0077 ,  B22F2998/00 ,  B29C2791/008

    摘要： A method and apparatus for dispensing and distributing a powder is disclosed which uses a rotary dispenser to dispense the powder by gravity onto a movable platen, the platen being movable to a position adjacent to a build bed, where the powder can be distributed across the build bed using a spreader. The method and apparatus are also suited to dispensing of a plurality of powders used in build beds for solid free-form fabrication and three dimensional printing.

    摘要翻译： 公开了一种用于分配和分配粉末的方法和装置，其使用旋转分配器将重力分配到可移动的压板上，该压板可移动到与构建床相邻的位置，其中粉末可以分布在构件 使用吊具的床。 该方法和装置还适合于分配用于固化床形成和三维印刷的构建床中使用的多种粉末。