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23 条记录 (耗时 0.045 秒)

    Cell lines and host nucleic acid sequences related to infectious disease
    2.
    发明申请
    Cell lines and host nucleic acid sequences related to infectious disease 有权
    与感染性疾病相关的细胞系和宿主核酸序列

    公开(公告)号：US20060257872A1

    公开(公告)日：2006-11-16

    申请号：US10535523

    申请日：2003-11-18

    申请人： Thomas Hodge ,  Natalie McDonald ,  Michael Shaw ,  Donald Rubin ,  Anthony Sanchez

    发明人： Thomas Hodge ,  Natalie McDonald ,  Michael Shaw ,  Donald Rubin ,  Anthony Sanchez

    IPC分类号： C12Q1/68 ,  C12P21/06

    CPC分类号： C07K14/47 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/18 ,  G01N33/56983 ,  G01N2500/02

    摘要： Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.

    摘要翻译： 已经鉴定了参与病毒感染的宿主核酸和宿主蛋白，例如人类免疫缺陷病毒（HIV），甲型流感和埃博拉病毒。 干扰或破坏宿主核酸或宿主蛋白与病毒或病毒蛋白质之间的相互作用赋予对感染的抑制或抗性。 因此，干扰宿主受试者中的这种相互作用可以赋予针对病毒的治疗或预防效果。 鉴定的序列可用于鉴定减少或抑制病毒感染的试剂。

    MAMMALIAN GENES INVOLVED IN INFECTION
    6.
    发明申请
    MAMMALIAN GENES INVOLVED IN INFECTION 审中-公开
    涉及感染的MAMMALIAN基因

    公开(公告)号：US20140220690A1

    公开(公告)日：2014-08-07

    申请号：US13877247

    申请日：2010-10-28

    申请人： Donald Rubin ,  Thomas Hodge ,  Robert Jeffrey Hogan

    发明人： Donald Rubin ,  Thomas Hodge ,  Robert Jeffrey Hogan

    IPC分类号： C12N15/85

    CPC分类号： A61K31/40

    摘要： The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.

    摘要翻译： 本发明涉及由这些序列编码的涉及感染或以其它方式与一种或多种病原体的生命周期相关的核酸序列和细胞蛋白质。

    Hidden document data removal
    7.
    发明申请
    Hidden document data removal 审中-公开
    隐藏的文档数据删除

    公开(公告)号：US20070174766A1

    公开(公告)日：2007-07-26

    申请号：US11336329

    申请日：2006-01-20

    申请人： Donald Rubin ,  William Neumann ,  Lauren Antonoff

    发明人： Donald Rubin ,  William Neumann ,  Lauren Antonoff

    IPC分类号： G06F17/00

    CPC分类号： G06F17/24 ,  G06F17/218

    摘要： Technology for finding and acting on hidden data contained in documents generated by a user in productivity applications is disclosed. The technology uses a user configurable document release policy file and a document inspector which parses a document file based on the configuration policy and either presents options to the user to make changes, implements changes automatically, or both, based on the policy definition. A method implemented at least in part by a computing device includes loading a user defined document policy configuration including data types identified as hidden data. A document is then parsed for the defined hidden data and a policy defined action is executed on the hidden data in the document in accordance with the document policy configuration.

    摘要翻译： 公开了用于在生产率应用中发现和执行由用户生成的文档中包含的隐藏数据的技术。 该技术使用用户可配置文档发布策略文件和文档检查器，该文档检查器根据配置策略解析文档文件，并根据策略定义向用户呈现选项以进行更改，自动实现更改或同时实现更改。 至少部分地由计算设备实现的方法包括加载用户定义的文档策略配置，包括被识别为隐藏数据的数据类型。 然后根据文档策略配置对文档中的隐藏数据进行解析，并对文档中的隐藏数据执行策略定义的操作。

    Multilevel secure database
    8.
    发明申请
    Multilevel secure database 有权

    公开(公告)号：US20060206485A1

    公开(公告)日：2006-09-14

    申请号：US11079055

    申请日：2005-03-14

    申请人： Donald Rubin ,  Arthur Rask ,  William Neumann

    发明人： Donald Rubin ,  Arthur Rask ,  William Neumann

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30286 ,  G06F21/6227 ,  G06F2221/2113 ,  Y10S707/99939

    摘要： Row level security (RLS) and cell level security (CLS) are implemented in a database to provide secure dynamic access to database data. Encryption keys are created based on either security classification meta-data tags associated with the individual fields of an incoming data stream or on the security classification of the source network. Without prior knowledge of the incoming data security classification, the present system may generate encryption keys and, if necessary, security classification meta-data on the fly.

    Dimension reduction in predictive model development
    9.
    发明申请
    Dimension reduction in predictive model development 有权
    预测模型开发中的维度减少

    公开(公告)号：US20050234762A1

    公开(公告)日：2005-10-20

    申请号：US10826949

    申请日：2004-04-16

    申请人： Stephen Pinto ,  Richard Mansfield ,  Donald Rubin

    发明人： Stephen Pinto ,  Richard Mansfield ,  Donald Rubin

    IPC分类号： G06F15/18 ,  G06Q30/00 ,  G06F17/60

    CPC分类号： G06Q30/02 ,  G06Q40/025

    摘要： Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. Historical multi-dimensional data is received representing multiple variables to be used as an input to a predictive model of a commercial system variables are pruned for which the data is sparse or missing, and the population of variables is adjusted to represent main effects exhibited by the data and interaction and non-linear effects exhibited by the data.

    摘要翻译： 使用模型生成平台的各种工具和功能生成模型。 例如，关于用户根据关于正被建模的系统的历史数据生成预测模型的项目，通过图形用户界面提供要遵循的模型生成活动的结构化序列，所述序列包括维度 减少，模型生成，模型过程验证和模型重新生成。 接收到的代表多个变量的历史多维数据被用作商业系统的预测模型的输入，修剪数据稀疏或丢失的变量，并且调节变量的总数以表示由 数据和相互作用以及数据显示的非线性效应。

    Predictive model validation
    10.
    发明申请
    Predictive model validation 有权
    预测模型验证

    公开(公告)号：US20050234753A1

    公开(公告)日：2005-10-20

    申请号：US10826947

    申请日：2004-04-16

    申请人： Stephen Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

    发明人： Stephen Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

    IPC分类号： G06F19/00 ,  G06Q10/00 ,  G06Q30/00 ,  G06F17/60

    CPC分类号： G06Q10/04 ,  G06Q30/02 ,  G06Q40/025

    摘要： Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. In connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is enabled to validate the model development process with cross-validation between at least two subsets of the historical data; the validated model development process is enabled to be reapplied.

    摘要翻译： 使用模型生成平台的各种工具和功能生成模型。 例如，关于用户根据关于正被建模的系统的历史数据生成预测模型的项目，通过图形用户界面提供要遵循的模型生成活动的结构化序列，所述序列包括维度 减少，模型生成，模型过程验证和模型重新生成。 关于用户根据关于正在建模的系统的历史数据生成预测模型的项目，用户能够通过历史数据的至少两个子集之间的交叉验证来验证模型开发过程; 验证的模型开发过程能够被重新应用。