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1.发明授权Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein disorders 有权用于治疗阿尔茨海默氏病和其他β-淀粉样蛋白病症的小肽公开(公告)号：US08003612B2
公开(公告)日：2011-08-23
申请号：US12323944
申请日：2008-11-26
申请人： Thomas Lake , Alan D. Snow , Gerardo Castillo , Beth Nguyen , Virginia Sanders , Qubai Hu , Judy A. Cam
发明人： Thomas Lake , Alan D. Snow , Gerardo Castillo , Beth Nguyen , Virginia Sanders , Qubai Hu , Judy A. Cam
IPC分类号： A61K38/08
CPC分类号： A61K38/08
摘要： Use of a peptide or pharmaceutical composition comprising Leu-Ala-Phe-Val-Leu-Arg-Lys-amide having at least one D amino acid for the reduction of beta-amyloid protein, modulating APP processing, modulating activity of APP secretases, treatment of beta-amyloid protein diseases and the treatment of Alzheimer's disease.
摘要翻译： 使用包含具有至少一个D氨基酸的Leu-Ala-Phe-Val-Leu-Arg-Lys-酰胺的肽或药物组合物用于还原β-淀粉样蛋白，调节APP处理，调节APP分泌酶的活性，治疗 的β-淀粉样蛋白病和阿尔茨海默病的治疗。
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2.发明申请SMALL PEPTIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER BETA-AMYLOID PROTEIN DISORDERS 有权用于治疗阿尔茨海默病和其他β-淀粉样蛋白病毒的小细胞公开(公告)号：US20090253637A1
公开(公告)日：2009-10-08
申请号：US12323944
申请日：2008-11-26
申请人： Thomas Lake , Alan D. Snow , Gerrado Castillo , Beth Nguyen , Virginia Sanders , Qubai Hu , Judy A. Cam
发明人： Thomas Lake , Alan D. Snow , Gerrado Castillo , Beth Nguyen , Virginia Sanders , Qubai Hu , Judy A. Cam
CPC分类号： A61K38/08
摘要： Use of a peptide or pharmaceutical composition comprising Leu-Ala-Phe-Val-Leu-Arg-Lys-amide having at least one D amino acid for the reduction of beta-amyloid protein, modulating APP processing, modulating activity of APP secretases, treatment of beta-amyloid protein diseases and the treatment of Alzheimer's disease.
摘要翻译： 使用包含具有至少一个D氨基酸的Leu-Ala-Phe-Val-Leu-Arg-Lys-酰胺的肽或药物组合物用于还原β-淀粉样蛋白，调节APP处理，调节APP分泌酶的活性，治疗 的β-淀粉样蛋白病和阿尔茨海默病的治疗。
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3.发明授权Small peptides for the treatment of alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders 失效用于治疗阿尔茨海默病和其他β-淀粉样蛋白原纤维发生障碍的小肽公开(公告)号：US07759311B2
公开(公告)日：2010-07-20
申请号：US11732226
申请日：2007-04-02
申请人： Gerardo Castillo , Thomas Lake , Beth Nguyen , Virginia Sanders , Alan D. Snow
发明人： Gerardo Castillo , Thomas Lake , Beth Nguyen , Virginia Sanders , Alan D. Snow
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K38/10 , C07K7/08 , G01N33/6896 , G01N2800/2821
摘要： A pharmaceutical composition comprising a peptide consisting of Arg-Val-Ala-Val-Ile-Met-Gly-amide-having at least one D-amino acid.
摘要翻译： 包含由具有至少一个D-氨基酸的Arg-Val-Ala-Val-Ile-Met-Gly-酰胺组成的肽的药物组合物。
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4.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's 有权用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US09051253B2
公开(公告)日：2015-06-09
申请号：US13887762
申请日：2013-05-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen
IPC分类号： A61K31/047 , A61K31/05 , C07C49/248 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： The use of 3,4,3′,4′-tetrahydroxychalcone in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease.
摘要翻译： 3,4,3'，4'-四羟基查耳酮在治疗淀粉样变性疾病方面的应用，特别是A＆BGR; 淀粉样变性，例如在阿尔茨海默病中观察到，IAPP淀粉样变性，例如在2型糖尿病中观察到的，以及突触核蛋白病，例如在帕金森病中观察到的。
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5.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE 有权用于治疗阿尔茨海默病，类型2糖尿病和帕金森病的淀粉样变性和合并症的化合物，组合物和方法公开(公告)号：US20140038980A1
公开(公告)日：2014-02-06
申请号：US14042891
申请日：2013-10-01
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake
IPC分类号： C07D213/30 , C07D213/69 , C07D295/096
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。
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6.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes and parkinson's disease 有权用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US08163957B2
公开(公告)日：2012-04-24
申请号：US12837721
申请日：2010-07-16
申请人： Alan D Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T Weavers , Stephen Lorimer , David Larsen , David L Coffen , Charlotte Coffen, legal representative
发明人： Alan D Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T Weavers , Stephen Lorimer , David Larsen , David L Coffen
IPC分类号： C07C237/14 , C07C237/20 , A61K31/16
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆ 诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。
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7.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease 失效用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US08586585B2
公开(公告)日：2013-11-19
申请号：US13413417
申请日：2012-03-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , Charlotte Coffen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen
IPC分类号： A01N43/58 , A61K31/50 , A61K31/497 , A01N43/40 , A61K31/435
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。
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8.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE 有权用于治疗阿尔茨海默病，类型2糖尿病和帕金森病的淀粉样变性和合并症的化合物，组合物和方法公开(公告)号：US20130245128A1
公开(公告)日：2013-09-19
申请号：US13887762
申请日：2013-05-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen
IPC分类号： C07C49/248
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： The use of 3,4,3′,4′-tetrahydroxychalcone in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease.
摘要翻译： 3,4,3'，4'-四羟基查耳酮用于治疗淀粉样蛋白病，特别是Aβ型淀粉样变性，例如阿尔茨海默病，IAPP淀粉样变性，如2型糖尿病观察到的突触核蛋白病，以及突触核蛋白病，如 帕金森病
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9.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES AND PARKINSON'S DISEASE 失效化合物，组合物和治疗淀粉样变性疾病和合并症的方法，如阿尔茨海默病，2型糖尿病和帕金森病公开(公告)号：US20120225890A1
公开(公告)日：2012-09-06
申请号：US13413417
申请日：2012-03-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
IPC分类号： A61K31/495 , C07D211/44 , A61K31/45 , C07D295/10 , C07D241/04 , A61P25/16 , A61K31/44 , C07D213/69 , A61P25/28 , A61P3/10 , A61P29/00 , A61P35/00 , C07D295/096 , C07D213/30
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆ 诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。
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10.发明申请Small peptides for the treatment of alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders 失效用于治疗阿尔茨海默病和其他β-淀粉样蛋白原纤维发生障碍的小肽公开(公告)号：US20080227721A1
公开(公告)日：2008-09-18
申请号：US11732226
申请日：2007-04-02
申请人： Gerardo Castillo , Thomas Lake , Beth Nguyen , Virginia Sanders , Alan D. Snow
发明人： Gerardo Castillo , Thomas Lake , Beth Nguyen , Virginia Sanders , Alan D. Snow
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K38/10 , C07K7/08 , G01N33/6896 , G01N2800/2821
摘要： A pharmaceutical composition comprising a peptide consisting of Arg-Val-Ala-Val-Ile-Met-Gly-amide-having at least one D-amino acid.
摘要翻译： 包含由具有至少一个D-氨基酸的Arg-Val-Ala-Val-Ile-Met-Gly-酰胺组成的肽的药物组合物。
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