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公开(公告)号：US09580461B2
公开(公告)日：2017-02-28
申请号：US13813083
申请日：2011-07-27
申请人： Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
发明人： Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
IPC分类号： A61K49/00 , A61K39/395 , A61K39/00 , C07K1/18 , B01D15/16 , B01D15/36 , B01J41/14 , B01J41/20 , C07K17/02 , A61K47/48 , C07K16/28
CPC分类号： C07K16/2851 , A61K39/3955 , A61K47/02 , A61K47/6829 , A61K47/6849 , A61K2039/505 , B01D15/166 , B01D15/363 , B01J41/14 , B01J41/20 , C07K1/18 , C07K16/2803 , C07K17/02 , C07K2317/56 , C07K2317/94 , C07K2319/35 , C07K2319/55
摘要： The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.
摘要翻译： 本发明提供了通过使用阴离子交换层析纯化含有活性多肽或免疫偶联物及其酸性变体例如脱酰胺化变体的溶液来分离活性多肽或免疫缀合物的方法。
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公开(公告)号：US20130202626A1
公开(公告)日：2013-08-08
申请号：US13813083
申请日：2011-07-27
申请人： Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
发明人： Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
CPC分类号： C07K16/2851 , A61K39/3955 , A61K47/02 , A61K47/6829 , A61K47/6849 , A61K2039/505 , B01D15/166 , B01D15/363 , B01J41/14 , B01J41/20 , C07K1/18 , C07K16/2803 , C07K17/02 , C07K2317/56 , C07K2317/94 , C07K2319/35 , C07K2319/55
摘要： The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.
摘要翻译： 本发明提供了通过使用阴离子交换层析纯化含有活性多肽或免疫偶联物及其酸性变体例如脱酰胺化变体的溶液来分离活性多肽或免疫缀合物的方法。
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公开(公告)号：US09657776B2
公开(公告)日：2017-05-23
申请号：US13929560
申请日：2013-06-27
IPC分类号： F16C33/10 , C10M119/02 , C10M169/02
CPC分类号： F16C33/10 , C10M119/02 , C10M169/02 , C10M2203/10 , C10M2203/102 , C10M2203/106 , C10M2205/028 , C10M2205/0285 , C10M2205/166 , C10M2207/026 , C10M2207/281 , C10M2207/285 , C10M2219/00 , C10N2220/022 , C10N2230/10 , C10N2230/40 , C10N2240/02 , C10N2240/20 , C10N2250/10 , F16C33/102
摘要： A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.
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公开(公告)号：US09598687B2
公开(公告)日：2017-03-21
申请号：US14342017
申请日：2012-08-31
申请人： Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
发明人： Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/647
摘要： The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
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公开(公告)号：US08820001B1
公开(公告)日：2014-09-02
申请号：US14084525
申请日：2013-11-19
申请人： Alan Hunter , Oleksandr Goshko
发明人： Alan Hunter , Oleksandr Goshko
IPC分类号： E04D13/00 , E04D13/147 , E04D13/04
CPC分类号： E04D13/0445 , E04D13/0481 , E04D2013/0454
摘要： A roof valley water diverter is provided herein for changing direction of rain water flowing through a roof valley. The diverter includes at least first and second side plates joined together to form a trough extending along a longitudinal axis and configured to channel a flow of rain water therethrough. A deflector plate, having opposing first and second faces, is secured to at least the first and second side plates such that the first face intersects the longitudinal axis. At least one gap is defined between the first face and at least one of the first and second side plates. Advantageously, the diverter of the subject invention allows for re-direction of flow of rain water from a roof valley.
摘要翻译： 本文提供了一种屋顶谷分水器，用于改变流过屋顶谷的雨水的方向。 分流器包括至少连接在一起的第一和第二侧板，以形成沿着纵向轴线延伸并构造成将雨水流过其中的通道。 具有相对的第一和第二面的偏转板固定到至少第一和第二侧板，使得第一面与纵向轴线相交。 在第一面和第一和第二侧板中的至少一个之间限定至少一个间隙。 有利地，本发明的转向器允许来自屋顶谷的雨水的流动方向。
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公开(公告)号：US20090257694A1
公开(公告)日：2009-10-15
申请号：US12421299
申请日：2009-04-09
IPC分类号： F16C33/10
CPC分类号： F16C33/10 , C10M119/02 , C10M169/02 , C10M2203/10 , C10M2203/102 , C10M2203/106 , C10M2205/028 , C10M2205/0285 , C10M2205/166 , C10M2207/026 , C10M2207/281 , C10M2207/285 , C10M2219/00 , C10N2220/022 , C10N2230/10 , C10N2230/40 , C10N2240/02 , C10N2240/20 , C10N2250/10 , F16C33/102
摘要： A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.
摘要翻译： 轴承包括具有构造成接合轴的通道的第一构件，所述第一构件具有金属材料; 以及设置在所述第一构件的至少一部分周围的第二构件，所述第二构件具有金属材料和至少一个能够限制所述第一构件的轴向运动的径向和向内弯曲部分。 第一和第二构件可相对于彼此移动。
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公开(公告)号：US20140303353A1
公开(公告)日：2014-10-09
申请号：US14342017
申请日：2012-08-31
申请人： Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
发明人： Alan Hunter , Xiangyang Wang , Timothy Pabst , Michaela Wendeler , Jihong Wang , Kendall Carey , Robert Strouse , Johnson Varghese
IPC分类号： C12N9/74 , C07K14/745
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/647
摘要： The present application relates to methods for purifying recombinant coagulation factor proteins, including for example, prothrombin (Factor II). In embodiments, the methods provide purified prothrombin that exhibit increased bioactivity and reduced levels of thrombin, thereby increasing the safety of the prothrombin. Also provided are purified recombinant coagulation factor proteins.
摘要翻译： 本申请涉及用于纯化重组凝血因子蛋白的方法，包括例如凝血酶原（凝血因子）（因子II）。 在实施方案中，所述方法提供显示增加的生物活性和降低凝血酶水平的纯化凝血酶原，从而增加凝血酶原的安全性。 还提供了纯化的重组凝血因子蛋白。
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公开(公告)号：US20140003749A1
公开(公告)日：2014-01-02
申请号：US13929560
申请日：2013-06-27
IPC分类号： F16C33/10
CPC分类号： F16C33/10 , C10M119/02 , C10M169/02 , C10M2203/10 , C10M2203/102 , C10M2203/106 , C10M2205/028 , C10M2205/0285 , C10M2205/166 , C10M2207/026 , C10M2207/281 , C10M2207/285 , C10M2219/00 , C10N2220/022 , C10N2230/10 , C10N2230/40 , C10N2240/02 , C10N2240/20 , C10N2250/10 , F16C33/102
摘要： A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.
摘要翻译： 轴承包括具有构造成接合轴的通道的第一构件，所述第一构件具有金属材料; 以及设置在所述第一构件的至少一部分周围的第二构件，所述第二构件具有金属材料和至少一个能够限制所述第一构件的轴向运动的径向和向内弯曲部分。 第一和第二构件可相对于彼此移动。
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公开(公告)号：US08496381B2
公开(公告)日：2013-07-30
申请号：US12421299
申请日：2009-04-09
CPC分类号： F16C33/10 , C10M119/02 , C10M169/02 , C10M2203/10 , C10M2203/102 , C10M2203/106 , C10M2205/028 , C10M2205/0285 , C10M2205/166 , C10M2207/026 , C10M2207/281 , C10M2207/285 , C10M2219/00 , C10N2220/022 , C10N2230/10 , C10N2230/40 , C10N2240/02 , C10N2240/20 , C10N2250/10 , F16C33/102
摘要： A bearing includes a first member having a passageway configured to engage a shaft, the first member having a metallic material; and a second member disposed around at least a portion of the first member, the second member having a metallic material and at least one radially and inwardly bent portion capable of restricting axial movement of the first member. The first and second members are movable relative to each other.
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