公开(公告)号：US5231005A

公开(公告)日：1993-07-27

申请号：US849481

申请日：1992-03-10

申请人： Thomas Russell ,  Kenneth H. Kortright ,  Wallace H. Coulter ,  Carlos M. Rodriguez ,  Ronald Paul ,  Constance M. Hajek ,  James C. Hudson

发明人： Thomas Russell ,  Kenneth H. Kortright ,  Wallace H. Coulter ,  Carlos M. Rodriguez ,  Ronald Paul ,  Constance M. Hajek ,  James C. Hudson

IPC分类号： G01N15/00 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00

CPC分类号： G01N15/12 ,  G01N33/5002 ,  G01N33/5094 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/56972 ,  G01N15/14 ,  G01N2015/008 ,  G01N2015/1037 ,  G01N2015/1062 ,  G01N2015/1081 ,  G01N35/0098 ,  Y10T436/101666 ,  Y10T436/117497 ,  Y10T436/24

摘要： A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected population of cells or formed bodies, such as a white blood cell population and at least one subset thereof of a whole blood sample or portion thereof. A volume of a biological medium containing the white blood cells is prepared and at least one reactant specific or preferential at least to some selected biological cells is introduced thereto and rapidly mixed for a short period of time. The opacity and/or volume parameter of the cells can be modified and the mixture is then counted and analyzed in one or more steps to obtain the desired white blood cell population and subset analysis. The biological sample can be a whole blood sample and the reactant can include or be a lyse or a monoclonal antibody bound to microspheres, which will bind to specific ones of the cells or a combination of lyse and microspheres with antibody bound thereto. The microspheres can be magnetic and the bound cells can be magnetically removed for retrieving and analyzing the remaining blood cell population.

摘要翻译： 一种用于自动并快速地检索，计数和/或分析全血样本或其部分的至少一个选定细胞群体或形成体，例如白细胞群体及其至少一个子集的方法和装置。 制备含有白细胞的体积的生物培养基，并将至少一种至少一种选择的生物细胞特异性或优先选择的反应物引入其中并在短时间内快速混合。 可以修改细胞的不透明度和/或体积参数，然后在一个或多个步骤中对混合物进行计数和分析，以获得所需的白细胞群体和子集分析。 生物样品可以是全血样品，并且反应物可以包括结合微球的裂解液或单克隆抗体，其将与特定细胞结合，或与结合抗体的溶血和微球体的组合。 微球可以是磁性的，并且结合的细胞可被磁性去除，用于检索和分析剩余的血细胞群体。

公开(公告)号：US06774144B1

公开(公告)日：2004-08-10

申请号：US09703804

申请日：2000-11-01

申请人： Christine C. Dykstra ,  James C. Hudson ,  Sandra Ewald ,  Richard R. Tidwell ,  David W. Boykin

发明人： Christine C. Dykstra ,  James C. Hudson ,  Sandra Ewald ,  Richard R. Tidwell ,  David W. Boykin

IPC分类号： A61K3134

CPC分类号： A61K31/138 ,  A61K31/19 ,  A61K31/34 ,  A61K31/366 ,  A61K31/56 ,  A61K31/573

摘要： In one aspect, the invention relates to a method of treating infectious bursal disease (IBD) in an avian subject in need of such treatment. The method comprises administering to the subject a compound of the formulas (I) through (IV) or a pharmaceutically acceptable salt thereof in an amount sufficient to treat IBD. In another aspect, the invention relates to a method of producing active immunity against infectious bursal virus disease (IBD) in an avian subject. The method comprises administering to a subject an immunogenic-amount of an IBDV vaccine and a compound selected from the compounds of formulas (I) through (IV) described herein. The compound represented by formulas (I) through (IV) is administered in an amount sufficient to induce an immune response in the avian subject.

摘要翻译： 一方面，本发明涉及在需要这种治疗的禽类受试者中治疗传染性法氏囊病（IBD）的方法。 该方法包括向受试者施用足以治疗IBD的量的式（I）至（IV）化合物或其药学上可接受的盐。 另一方面，本发明涉及在禽类受试者中产生针对传染性法氏囊病毒病（IBD）的主动免疫的方法。 该方法包括向受试者施用免疫原性量的IBDV疫苗和选自本文所述的式（I）至（IV）的化合物的化合物。 由式（I）至（IV）表示的化合物以足以在禽类受试者中诱导免疫应答的量施用。

公开(公告)号：US4128029A

公开(公告)日：1978-12-05

申请号：US859963

申请日：1977-12-12

申请人： Danny Gay ,  James Horine ,  James C. Hudson ,  Joseph P. Sallee ,  Hershel R. Wininger

发明人： Danny Gay ,  James Horine ,  James C. Hudson ,  Joseph P. Sallee ,  Hershel R. Wininger

IPC分类号： B23D47/02 ,  B27B5/22 ,  B27B25/10 ,  B27B27/06

CPC分类号： B23D47/025 ,  B27B5/222 ,  Y10T83/6584 ,  Y10T83/6612 ,  Y10T83/727 ,  Y10T83/773 ,  Y10T83/7734

摘要： A table for a saw has three equal table segments supported on foldable legs. The three segments are spaced from one another by spacer elements and held in position by front and back longitudinal rails and nut and bolt combinations through the spacer elements. The spacer elements hold the table segments spaced from one another thereby defining first and second lateral slots within which the rail of a mitre gauge can ride. Four spacer elements are integral parts of a spacer bar. Each spacer bar has laterally spaced spacer elements and vertically spaced spacer elements thereby providing numerous accurately dimensioned spacing locations between adjacent table segments. The spacer elements and longitudinal rails in combination establish table element positioning and rigidity with respect to one another as well as established two longitudinal slots having a uniform predetermined width.

摘要翻译： 锯的桌子在可折叠的腿上支撑有三个相等的桌子片段。 三个部分通过间隔元件彼此间隔开，并通过前后纵向导轨和通过间隔元件的螺母和螺栓组合保持在适当位置。 间隔元件保持工作台部分彼此间隔开，从而限定第一和第二横向狭槽，斜面计的导轨可以在该槽内骑行。 四个间隔元件是间隔杆的组成部分。 每个间隔杆具有横向隔开的间隔元件和垂直间隔的间隔元件，从而在相邻的工作台段之间提供许多精确尺寸的间隔位置。 间隔元件和纵向轨道组合地建立相对于彼此的台面元件定位和刚性，以及具有均匀的预定宽度的已建立的两个纵向狭槽。