-
1.发明申请ESTRATRIENE DERIVATIVES COMPRISING HETEROCYCLIC BIOISOSTERES FOR THE PHENOLIC A-RING 审中-公开包含苯酚环的杂环生物活性成分的雌激素衍生物公开(公告)号：US20110190246A1
公开(公告)日：2011-08-04
申请号：US13055388
申请日：2009-07-14
申请人： Thorsten Blume , Dieter Heldmann , Norbert Schmees , Christiane Otto , Tim Wintermantel , Joachim Kuhnke
发明人： Thorsten Blume , Dieter Heldmann , Norbert Schmees , Christiane Otto , Tim Wintermantel , Joachim Kuhnke
IPC分类号： A61K31/58 , C07J71/00 , A61P35/00 , A61P19/08 , A61P15/02 , A61P19/10 , A61P3/06 , A61P25/00 , A61P9/00 , A61P19/02
CPC分类号： C07J71/0047
摘要： The present invention is directed to novel pyrazolo-estrien and triazolo-estrien-derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes, vaginal dryness, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, degenerative brain diseases, cardiovascular diseases, cerebrovascular diseases, hormone sensitive cancers and hyperplasia (in tissues including breast, endometrium, and cervix in women and prostate in men), endometriosis, uterine fibroids, osteoarthritis; and as contraceptive agents either alone or in combination with a progestogen or progestogen antagonist. The compounds of the invention are selective estrogen receptor modulators.
摘要翻译： 本发明涉及新颖的吡唑并雌三烯衍生物，含有它们的药物组合物及其用于治疗或预防由雌激素受体介导的疾病和疾病，例如潮热，阴道干燥，骨质减少，骨质疏松症， 高脂血症，认知功能丧失，退行性脑疾病，心血管疾病，脑血管疾病，激素敏感性癌症和增生（包括男性和女性前列腺中的乳腺，子宫内膜和子宫颈组织），子宫内膜异位症，子宫肌瘤，骨关节炎; 并且作为避孕药单独使用或与孕激素或孕激素拮抗剂组合。 本发明的化合物是选择性雌激素受体调节剂。
-
2.发明授权公开(公告)号：US07081537B2
公开(公告)日：2006-07-25
申请号：US10785627
申请日：2004-02-24
申请人： Dieter Heldmann , Jürgen Stohrer
发明人： Dieter Heldmann , Jürgen Stohrer
IPC分类号： C07D277/06 , C07D263/06
CPC分类号： C07D263/04 , C07D263/06 , C07D277/06 , Y02P20/55
摘要： A process for preparing α-functionalized thiazolidines or oxazolidines, each of which are oxycarbonyl-functionalized in the 4-position, by adding a base to a reaction mixture comprising an oxycarbonyl-functionalized thiazolidine or oxazolidine and an electrophile at a temperature of greater than −40° C.
摘要翻译： 通过向包含氧羰基官能化的噻唑烷或恶唑烷的反应混合物和亲电子试剂添加碱，制备α-官能化噻唑烷或恶唑烷的方法，其中每一个在4-位氧基羰基官能化， 40°C
-
公开(公告)号：US06667422B2
公开(公告)日：2003-12-23
申请号：US10233925
申请日：2002-09-03
申请人： Dieter Heldmann , Juergen Stohrer
发明人： Dieter Heldmann , Juergen Stohrer
IPC分类号： C07C4563
CPC分类号： C07C269/06 , C07B2200/07 , C07C45/48 , C07C319/20 , C07C271/16 , C07C271/18 , C07C323/43
摘要： A process for preparing an &agr;-haloketone of the formula (1) where R1 is an optionally heteroatom-containing and optionally substituted hydrocarbon radical, R2 is a hydrogen, alkyl, aralkyl or aryl radical, and X is a halogen radical, by reacting a carboxylic acid derivative of the general formula (2) where L is a leaving group, with a mono- or dienolate of a silyl ester of the formula (3) where R3 and R4 are identical or different alkyl, aryl, alkenyl or aralkyl radicals; and hydrolyzing the reaction product immediately afterwards by adding acid and decarboxylating to (1). The product &agr;-haloketone may be reduced to the corresponding &agr;-haloalcohol.
摘要翻译： 制备式（1）的α-卤代酮的方法，其中R 1是任选含杂原子的和任选取代的烃基，R 2是氢，烷基，芳烷基或芳基，X是卤素 自由基，其中L是离去基团的通式（2）的羧酸衍生物与式（3）的甲硅烷基酯的单或二烯醇酯反应，其中R 3和R 4相同 或不同的烷基，芳基，烯基或芳烷基;然后通过加入酸和脱羧至（1），立即水解反应产物。 产物α-卤代酮可以还原成相应的α-卤代醇。
-
4.发明授权Chelating agents as well as their tricarbonyl complexes with technetium and rhenium 失效螯合剂以及它们与锝和铼的三羰基配合物公开(公告)号：US06488909B1
公开(公告)日：2002-12-03
申请号：US09468331
申请日：1999-12-21
IPC分类号： A61K5100
CPC分类号： A61K51/0491 , A61K51/081 , A61K51/088 , A61K51/1093 , C07C323/25 , C07F13/00 , C07H21/00
摘要： New chelating agents as well as their tricarbonyl complexes with technetium and rhenium and the use of these compounds in radiodiagnosis and radiotherapy are described. The new chelating agents are coupled to substances that accumulate in the diseased tissue.
摘要翻译： 描述了新的螯合剂以及它们与锝和铼的三羰基配合物以及这些化合物在放射诊断和放射治疗中的用途。 新的螯合剂与积累在患病组织中的物质偶联。
-
公开(公告)号：US06383470B1
公开(公告)日：2002-05-07
申请号：US08897319
申请日：1997-07-21
IPC分类号： A61K4904
CPC分类号： A61K49/226 , A61K49/223
摘要： The invention relates to microparticle preparations made of biodegradable copolymers for use in treatment and diagnosis, especially ultrasonic diagnosis, as well as a process for their production.
摘要翻译： 本发明涉及由用于治疗和诊断，特别是超声波诊断的可生物降解共聚物制成的微粒制剂及其生产方法。
-
公开(公告)号：US06177062B1
公开(公告)日：2001-01-23
申请号：US08474468
申请日：1995-06-07
IPC分类号： A61B5055
CPC分类号： B82Y5/00 , A61K49/228
摘要： The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60° C., processes for the preparation thereof and their use as diagnostic and therapeutic agents.
摘要翻译： 本发明涉及包含微粒的超声造影剂，其包含合成的可生物降解聚合物和沸点低于60℃的气体和/或流体，其制备方法及其作为诊断和治疗剂的用途。
-
7.发明申请STENTS WITH A RADIOACTIVE SURFACE COATING, PROCESSES FOR THEIR PRODUCTION AND THEIR USE FOR RESTENOSIS PROPHYLAXIS 审中-公开具有放射性表面涂层的方法，其生产方法及其用于保护预防的用途公开(公告)号：US20070032694A1
公开(公告)日：2007-02-08
申请号：US10718580
申请日：2003-11-24
申请人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
发明人： Ludger Dinkelborg , Friedhelm Blume , Christoph-Stephan Hilger , Dieter Heldmann , Johannes Platzek , Ulrich Niedballa , Heribert Miklautz , Ulrich Speck , Stephan Duda , Gunnar Tepe , Bernhard Noll , Heidemarie Goerner
CPC分类号： A61K51/1282 , A61F2/82 , A61F2210/0095 , A61L31/082 , A61L31/14 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/44 , A61L2300/606 , A61N5/1002
摘要： The invention relates to radioactive stents, characterized in that the stent is coated on the surface with the radioactive isotope, as well as processes for their production.
摘要翻译： 本发明涉及放射性支架，其特征在于，用放射性同位素将支架涂覆在表面上，以及其生产方法。
-
公开(公告)号：US06436365B2
公开(公告)日：2002-08-20
申请号：US09157979
申请日：1998-09-22
IPC分类号： A61K5100
CPC分类号： A61K51/1282 , C07B59/004 , C07F13/005
摘要： The invention relates to a process for therapeutic treatment of proliferative diseases, which is characterized in that first an administration catheter is placed on the site of the lesion, and a radioactive substance is administered topically via the catheter, then the catheter is again removed, and the radioactive substance remains on the site of the lesion.
摘要翻译： 本发明涉及增殖性疾病的治疗方法，其特征在于，首先将给药导管置于病变部位，通过导管局部施用放射性物质，然后再次取出导管， 放射性物质保留在病变部位。
-
9.发明授权公开(公告)号：US06284280B1
公开(公告)日：2001-09-04
申请号：US09459578
申请日：1999-12-13
IPC分类号： B01J1304
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/1635 , A61K9/1647 , A61K49/223 , Y10S977/773 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： The invention relates to new microparticles containing active ingredients, which contain at least one gas or a gaseous phase in addition to the active ingredient(s), agents containing these particles (microparticulate systems), their use for ultrasound-controlled in vivo release of active ingredients, as well as a process for the production of particles and agents.
摘要翻译： 本发明涉及含有活性成分的新的微粒，其除了活性成分之外还含有至少一种气体或气相，含有这些颗粒的试剂（微粒体系），它们用于超声控制体内释放活性成分 成分，以及生产颗粒和试剂的方法。
-
10.发明授权Ultrasonic contrast agents, process for their preparation and their use as a diagnostic and therapeutic agent 失效超声造影剂，其制备方法及其作为诊断和治疗剂的用途公开(公告)号：US06264959B1
公开(公告)日：2001-07-24
申请号：US07536373
申请日：1990-06-11
IPC分类号： A61K900
CPC分类号： B82Y5/00 , A61K49/228
摘要： The invention relates to ultrasonic contrast agents consisting of microparticles which consist of amyloses and synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60° C., process for the preparation thereof and their use as diagnostic and therapeutic agents.
摘要翻译： 本发明涉及由由淀粉和合成可生物降解聚合物组成的微粒和沸点低于60℃的气体和/或流体组成的超声造影剂，其制备方法及其作为诊断和治疗剂的用途。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.035 秒)
