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    Markers, Antibodies and Recombinant scFvs for Mesenchymal Stem Cell Sub-populations and Osteoclasts
    2.
    发明申请
    Markers, Antibodies and Recombinant scFvs for Mesenchymal Stem Cell Sub-populations and Osteoclasts 审中-公开
    标记，抗体和重组scFv用于间充质干细胞亚群和破骨细胞

    公开(公告)号：US20100062038A1

    公开(公告)日：2010-03-11

    申请号：US12529789

    申请日：2008-03-12

    申请人： Tyrone Villalard Bowes ,  Udo Greiser ,  William James Johnathan Finlay ,  Timothy O'Brien ,  Frank Barry

    发明人： Tyrone Villalard Bowes ,  Udo Greiser ,  William James Johnathan Finlay ,  Timothy O'Brien ,  Frank Barry

    IPC分类号： A61F2/00 ,  C07K7/06 ,  C07H21/04 ,  C07K16/00 ,  C12N15/63 ,  G01N33/566 ,  C12N5/00 ,  A61K35/12

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： Abstract Markers, antibodies and recombinant scFvs for Mesenchymal Stem Cell sub-populations and osteoclasts. The present invention relates to specific epitopes of surface membrane bound glycoproteins expressed by mesenchymal stem cells and pre-osteoclasts and relates to antibodies such as monoclonal antibodies and recombinant scFv or fragments thereof, raised to the particular epitope and their use in identifying, isolating, and characterization of mesenchymal stem cell sub-populations such as that termed “Stromal Progenitor Cells” (SPCs) in bone marrow and identifying, isolating, and characterization of pre-osteoclasts in peripheral blood. By binding to a specific epitope on the cell surface, limbin/EVC-2 detection and separation by conventional cell sorting methodologies are facilitated.

    摘要翻译： 摘要标记，抗体和重组scFvs用于间充质干细胞亚群和破骨细胞。 本发明涉及由间充质干细胞和破骨细胞表达的表面膜结合的糖蛋白的特异性表位，涉及产生特定表位的抗体如单克隆抗体和重组scFv或其片段，以及它们在鉴定，分离和 间质干细胞亚群的表征，如骨髓中称为“间质祖细胞”（SPCs），并鉴定，分离和表征外周血中破骨细胞。 通过结合细胞表面上的特异性表位，促进了常规细胞分选方法的limbin / EVC-2检测和分离。

    Autonomous Filter Element
    3.
    发明申请
    Autonomous Filter Element 审中-公开

    公开(公告)号：US20130008838A1

    公开(公告)日：2013-01-10

    申请号：US13584023

    申请日：2012-08-13

    申请人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    发明人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    IPC分类号： B01D35/14

    CPC分类号： B01D53/22 ,  B01D61/22 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/103 ,  B01D2311/16 ,  B01D2313/22 ,  B01D2321/40 ,  G01F1/6888 ,  G01F1/69 ,  G01F15/125

    摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

    Autonomous Filter Element
    4.
    发明申请
    Autonomous Filter Element 审中-公开
    自动过滤元件

    公开(公告)号：US20120318738A1

    公开(公告)日：2012-12-20

    申请号：US13584032

    申请日：2012-08-13

    申请人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    发明人： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

    IPC分类号： B01D65/08 ,  B01D35/18 ,  G08B21/00 ,  B01D35/14

    CPC分类号： B01D53/22 ,  B01D61/22 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/103 ,  B01D2311/16 ,  B01D2313/22 ,  B01D2321/40 ,  G01F1/6888 ,  G01F1/69 ,  G01F15/125

    摘要： An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

    摘要翻译： 公开了一种自主的过滤装置和改善过滤器寿命和性能的方法。 过滤器元件配备有适于测量一个或多个特性的一个或多个传感器。 响应于测量的特性，滤波器元件内的控制逻辑能够确定适当的响应。 例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。 作为响应，控制逻辑可以启动旨在减轻阻塞的特定响应。 然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。 基于此，控制逻辑可以警告操作者必须更换过滤元件。 或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。

    CA125 gene and its use for diagnostic and therapeutic interventions
    6.
    发明授权
    CA125 gene and its use for diagnostic and therapeutic interventions 有权
    CA125基因及其在诊断和治疗干预中的应用

    公开(公告)号：US08124728B2

    公开(公告)日：2012-02-28

    申请号：US10475117

    申请日：2003-10-17

    申请人： Timothy O'Brien ,  John Beard ,  Lowell Underwood

    发明人： Timothy O'Brien ,  John Beard ,  Lowell Underwood

    IPC分类号： C07K14/00 ,  C07K14/435

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The CA125 gene has been cloned. The CA125 molecule comprises three major domains: an extracellular amino terminal domain; a large multiple repeat domain; and a carboxy terminal domain which includes a transmembrane anchor with a short cytoplasmic domain. Additionally, an amino terminal extension is present. The molecular structure is dominated by a repeat domain comprising more than sixty 156-amino-acid repeat units The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The structure has potential for use as a new gold standard for detecting the CA125 antigen, and can provide a basis for the development of a vaccine useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

    摘要翻译： 已经克隆了CA125基因。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域; 一个大的多重重复域; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域。 此外，存在氨基末端延伸。 分子结构由包含多于六十六个156个氨基酸重复单元的重复结构域所支配。重复单元包含交互式二硫键桥接的C-封闭物和OC125和M11结合位点。 CA125分子在其羧基末端通过跨膜结构域和短的胞质尾部锚定。 该结构有可能用作检测CA125抗原的新金标准，可为开发可用于治疗CA125升高的卵巢癌和其他癌症的疫苗提供依据。

    Enhanced Performance Dehumidifier
    8.
    发明申请
    Enhanced Performance Dehumidifier 失效
    增强性能除湿机

    公开(公告)号：US20080028776A1

    公开(公告)日：2008-02-07

    申请号：US11872106

    申请日：2007-10-15

    申请人： Timothy O'Brien ,  Steve Dingle

    发明人： Timothy O'Brien ,  Steve Dingle

    IPC分类号： F24F3/14 ,  F25B39/02

    CPC分类号： F24F3/153 ,  F24F1/04

    摘要： A dehumidifier includes an air flow path with first, second and third segments in series from upstream to downstream and passing ambient air respectively to an evaporator coil then to a condenser coil and then discharging same. The air flow path has a fourth segment passing ambient air to the condenser coil in parallel with the noted second air flow path segment.

    摘要翻译： 除湿器包括具有从上游到下游串联的第一，第二和第三段的空气流动路径，并将环境空气分别传递到蒸发器线圈，然后到冷凝器盘管，然后将其排出。 空气流动路径具有第四段，其将环境空气与所述第二气流通道段平行地传递到冷凝器盘管。

    Closing Package for a Mortgage Loan
    9.
    发明申请
    Closing Package for a Mortgage Loan 审中-公开
    抵押贷款的封闭包

    公开(公告)号：US20080027845A1

    公开(公告)日：2008-01-31

    申请号：US11870519

    申请日：2007-10-11

    申请人： Geoffery Dreyer ,  Mark Oman ,  Robert Caruso ,  Steven Bulmer ,  Eric Malchodi ,  Michael DeVito ,  Nancy Brennan ,  Michael Heid ,  Timothy O'Brien

    发明人： Geoffery Dreyer ,  Mark Oman ,  Robert Caruso ,  Steven Bulmer ,  Eric Malchodi ,  Michael DeVito ,  Nancy Brennan ,  Michael Heid ,  Timothy O'Brien

    IPC分类号： G06Q40/00 ,  G06Q90/00

    CPC分类号： G06Q40/08 ,  G06Q40/00 ,  G06Q40/025

    摘要： A method of refinancing a mortgage loan is provided. The method of refinancing a mortgage loan comprises pre-approving a customer for refinancing of a mortgage loan. This customer is sent a pre-screened offer. The offer comprises materials setting forth the terms of the refinanced mortgage loan, materials providing all required pre-acceptance disclosures, and instructions describing how the customer may accept the offer. Upon receiving an indication of acceptance of the offer from the customer, a closing package is sent to the customer to be executed by the customer. The execution of the closing package by the customer creates a refinancing loan agreement. Also provided is a closing package for a mortgage loan comprising closing documents and a format and instructions providing specific guidance to the customer for completion and execution of the closing documents.

    摘要翻译： 提供了贷款抵押贷款的方法。 贷款抵押贷款的方法包括预先批准客户再融资抵押贷款。 这个客户被发送了一个预先筛选的报价。 该提议包括提供贷款抵押贷款条款的材料，提供所有必要的预接受披露的材料以及描述客户如何接受要约的说明。 在收到客户接受要约的指示后，向客户发送关闭包以由客户执行。 客户关闭包的执行创建了再融资贷款协议。 还提供了一种用于抵押贷款的结算包，其中包括关闭文件以及为客户完成和执行关闭文件提供具体指导的格式和指令。