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    Multi-compartment pharmaceutical vials
    1.
    发明授权
    Multi-compartment pharmaceutical vials 有权
    多间隔药瓶

    公开(公告)号：US09237985B2

    公开(公告)日：2016-01-19

    申请号：US13945499

    申请日：2013-07-18

    申请人： Tokitae LLC

    发明人： Philip A. Eckhoff ,  Muriel Y. Ishikawa ,  Orin Levine ,  Nels R. Peterson ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

    IPC分类号： A61J1/06 ,  A61J1/14 ,  A61J1/20

    CPC分类号： A61J1/1425 ,  A61J1/05 ,  A61J1/1406

    摘要： Multi-compartment pharmaceutical vials are described. In some embodiments, a multi-compartment pharmaceutical vial includes: a multi-compartment pharmaceutical storage region including a bottom wall, at least one outer wall and at least one interior wall, the bottom wall, the at least one outer wall and the at least one interior wall forming a plurality of pharmaceutical storage compartments, each pharmaceutical storage compartment including an aperture positioned opposite to the bottom wall of the pharmaceutical storage region; and an access region attached to the pharmaceutical storage region, the access region including a plurality of conduits, each with a first end and a second end, wherein the first end of each conduit is connected to one aperture in a pharmaceutical storage compartment, and the second end of each conduit circumscribes an aperture positioned opposite to the bottom wall.

    摘要翻译： 描述了多室药物小瓶。 在一些实施方案中，多隔室药物瓶包括：多室药物储存区域，包括底壁，至少一个外壁和至少一个内壁，底壁，至少一个外壁和至少 一个内壁形成多个药物储存室，每个药物储存室包括与药物储存区域的底壁相对定位的孔口; 以及附接到所述药物储存区域的进入区域，所述进入区域包括多个导管，每个导管具有第一端和第二端，其中每个导管的第一端连接到药物储存室中的一个孔，并且 每个导管的第二端围绕与底壁相对定位的孔。

    REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS
    2.
    发明申请
    REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 有权
    包括温度控制容器系统的制冷装置

    公开(公告)号：US20150233617A1

    公开(公告)日：2015-08-20

    申请号：US14704107

    申请日：2015-05-05

    申请人： Tokitae LLC

    发明人： Fong-Li Chou ,  Philip A. Eckhoff ,  Lawrence Morgan Fowler ,  William Gates ,  Jennifer Ezu Hu ,  Muriel Y. Ishikawa ,  Fridrik Larusson ,  Shieng Liu ,  Nathan P. Myhrvold ,  Brian L. Pal ,  Nels R. Peterson ,  David Keith Piech ,  Maurizio Vecchione ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood ,  David J. Yager

    IPC分类号： F25B39/02 ,  F25B49/02

    CPC分类号： F25B39/028 ,  F25B49/00 ,  F25B49/02 ,  F25B2339/02 ,  F25D11/006 ,  F25D11/025

    摘要： In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

    摘要翻译： 在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成在制冷装置内部保持相变材料; 至少一个主动制冷单元，其包括位于所述液体不可渗透容器内部的一组蒸发器盘管; 基本上形成存储区域的壁; 以及传热系统，其包括具有中空内部的第一组不透气结构，以形成基本上形成液体不可渗透容器的与所述壁热接触的冷凝器，具有中空内部连接的第二组蒸气不可渗透结构 以形成与基本上形成存储区域的壁热接触的蒸发器，以及具有固定到冷凝器和蒸发器两者的中空内部的连接器，所述连接器在冷凝器的中空内部和 中空的蒸发器内部。

    METHODS, SYSTEMS, AND DEVICES FOR POSITIVE PRESSURE PHARMACEUTICAL VIALS
    4.
    发明申请
    METHODS, SYSTEMS, AND DEVICES FOR POSITIVE PRESSURE PHARMACEUTICAL VIALS 审中-公开
    方法，系统和用于积极压力药用植物的装置

    公开(公告)号：US20150211950A1

    公开(公告)日：2015-07-30

    申请号：US14167854

    申请日：2014-01-29

    申请人： TOKITAE LLC

    发明人： Philip A. Eckhoff ,  Muriel Y. Ishikawa ,  Nels R. Peterson ,  Lowell L. Wood, JR. ,  Victoria Y. H. Wood

    IPC分类号： G01L19/08 ,  B65B7/16 ,  B65C3/06 ,  B65D41/00 ,  A61J1/06 ,  A61J1/14 ,  A61J1/18 ,  B65D25/20 ,  B65B3/00 ,  B65B31/08

    CPC分类号： G01L19/08 ,  A61J1/065 ,  A61J1/1406 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2096 ,  A61J2200/70 ,  B65B3/003 ,  B65B7/2821 ,  B65B31/042 ,  B65B31/08 ,  B65B51/10 ,  B65B57/00

    摘要： Methods, systems, and devices are described for calculating a push pressure for a pharmaceutical vial with a syringe, the method including accepting data regarding at least one parameter of the pharmaceutical vial, at least one parameter of a vial cap with a seal, at least one parameter of the syringe, and a single dose volume of a liquid pharmaceutical; calculating a volume of headspace over the liquid pharmaceutical with a computing device; calculating an ejection pressure based on the single dose volume of the liquid pharmaceutical and the volume of headspace; calculating a motive pressure based on a static force and a cross-sectional area of the syringe; defining the push pressure as the greater of the ejection pressure or the motive pressure; and reporting the push pressure to a user. The method further includes calculating a molar amount of inert gas needed in the pharmaceutical vial to generate the calculated push pressure.

    摘要翻译： 描述了用于计算具有注射器的药物瓶的推压的方法，系统和装置，所述方法包括至少接收关于药瓶的至少一个参数的数据，至少具有密封的小瓶盖的参数 注射器的一个参数和单剂量的液体药物; 用计算装置计算液体药物上的顶空体积; 基于液体药物的单剂量体积和顶部空间体积来计算喷射压力; 基于注射器的静力和横截面面积来计算运动压力; 将推压力定义为喷射压力或动力压力的较大值; 并向用户报告推压。 该方法还包括计算药物小瓶中所需的惰性气体的摩尔量以产生计算出的推压。

    Temperature-controlled container systems for use within a refrigeration device
    6.
    发明授权
    Temperature-controlled container systems for use within a refrigeration device 有权
    用于制冷装置内的温度控制容器系统

    公开(公告)号：US09366483B2

    公开(公告)日：2016-06-14

    申请号：US14091831

    申请日：2013-11-27

    申请人： Tokitae LLC

    发明人： Philip A. Eckhoff ,  Lawrence Morgan Fowler ,  William Gates ,  Jennifer Ezu Hu ,  Muriel Y. Ishikawa ,  Nathan P. Myhrvold ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Maurizio Vecchione ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

    IPC分类号： F25D11/00 ,  F25B21/02 ,  F28D15/02 ,  F25B23/00

    CPC分类号： F28D15/02 ,  F25B21/02 ,  F25B23/006 ,  F25B2600/07 ,  F25D11/006 ,  F25D2700/12 ,  F28D15/0275 ,  F28D15/04 ,  F28D20/02 ,  Y02E60/145

    摘要： In some embodiments, a temperature-controlled container for use within a refrigeration device includes: one or more sections of insulation material substantially defining one or more walls of a temperature-controlled container, the temperature-controlled container including an internal region; a thermally-insulated partition dividing the internal region to form a storage region and a phase change material region internal to the container, the thermally-insulated partition including a conduit between the storage region and the phase change material region; a thermal control device within the conduit; an aperture within a section of the insulation material substantially defining the container, the aperture between the phase change material region internal to the container and an external surface of the container; and a unidirectional thermal conductor positioned within the aperture, the unidirectional thermal conductor configured to transmit heat in a direction from the phase change material region to the external surface of the container.

    摘要翻译： 在一些实施例中，用于制冷装置内的温度控制容器包括：绝热材料的一个或多个部分，基本上限定温度控制容器的一个或多个壁，所述温度控制容器包括内部区域; 分隔所述内部区域以形成容器内部的存储区域和相变材料区域的绝热隔板，所述绝热隔板包括在所述存储区域和所述相变材料区域之间的导管; 管道内的热控制装置; 基本上限定容器的绝缘材料的一部分内的孔，容器内部的相变材料区域和容器的外表面之间的孔; 以及定位在所述孔内的单向热导体，所述单向热导体构造成在从所述相变材料区域到所述容器的外表面的方向上传递热量。

    MULTI-COMPARTMENT PHARMACEUTICAL VIALS
    7.
    发明申请
    MULTI-COMPARTMENT PHARMACEUTICAL VIALS 有权
    多层药水

    公开(公告)号：US20150021288A1

    公开(公告)日：2015-01-22

    申请号：US13945499

    申请日：2013-07-18

    申请人： Tokitae LLC

    发明人： Philip A. Eckhoff ,  Muriel Y. Ishikawa ,  Orin Levine ,  Nels R. Peterson ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    IPC分类号： A61J1/06

    CPC分类号： A61J1/1425 ,  A61J1/05 ,  A61J1/1406

    摘要： Multi-compartment pharmaceutical vials are described. In some embodiments, a multi-compartment pharmaceutical vial includes: a multi-compartment pharmaceutical storage region including a bottom wall, at least one outer wall and at least one interior wall, the bottom wall, the at least one outer wall and the at least one interior wall forming a plurality of pharmaceutical storage compartments, each pharmaceutical storage compartment including an aperture positioned opposite to the bottom wall of the pharmaceutical storage region; and an access region attached to the pharmaceutical storage region, the access region including a plurality of conduits, each with a first end and a second end, wherein the first end of each conduit is connected to one aperture in a pharmaceutical storage compartment, and the second end of each conduit circumscribes an aperture positioned opposite to the bottom wall.

    摘要翻译： 描述了多室药物小瓶。 在一些实施方案中，多隔室药物瓶包括：多室药物储存区域，包括底壁，至少一个外壁和至少一个内壁，底壁，至少一个外壁和至少 一个内壁形成多个药物储存室，每个药物储存室包括与药物储存区域的底壁相对定位的孔口; 以及附接到所述药物储存区域的进入区域，所述进入区域包括多个导管，每个导管具有第一端和第二端，其中每个导管的第一端连接到药物储存室中的一个孔，并且 每个导管的第二端围绕与底壁相对定位的孔。

    TEMPERATURE-CONTROLLED CONTAINER SYSTEMS FOR USE WITHIN A REFRIGERATION DEVICE
    8.
    发明申请
    TEMPERATURE-CONTROLLED CONTAINER SYSTEMS FOR USE WITHIN A REFRIGERATION DEVICE 有权
    在制冷装置中使用的温度控制容器系统

    公开(公告)号：US20150143818A1

    公开(公告)日：2015-05-28

    申请号：US14091831

    申请日：2013-11-27

    申请人： Tokitae LLC

    发明人： Philip A. Eckhoff ,  Lawrence Morgan Fowler ,  William Gates ,  Jennifer Ezu Hu ,  Muriel Y. Ishikawa ,  Nathan P. Myhrvold ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Maurizio Vecchione ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    IPC分类号： F25D11/00 ,  F28D15/02 ,  F25B21/02

    CPC分类号： F28D15/02 ,  F25B21/02 ,  F25B23/006 ,  F25B2600/07 ,  F25D11/006 ,  F25D2700/12 ,  F28D15/0275 ,  F28D15/04 ,  F28D20/02 ,  Y02E60/145

    摘要： In some embodiments, a temperature-controlled container for use within a refrigeration device includes: one or more sections of insulation material substantially defining one or more walls of a temperature-controlled container, the temperature-controlled container including an internal region; a thermally-insulated partition dividing the internal region to form a storage region and a phase change material region internal to the container, the thermally-insulated partition including a conduit between the storage region and the phase change material region; a thermal control device within the conduit; an aperture within a section of the insulation material substantially defining the container, the aperture between the phase change material region internal to the container and an external surface of the container; and a unidirectional thermal conductor positioned within the aperture, the unidirectional thermal conductor configured to transmit heat in a direction from the phase change material region to the external surface of the container.

    摘要翻译： 在一些实施例中，用于制冷装置内的温度控制容器包括：绝热材料的一个或多个部分，基本上限定温度控制容器的一个或多个壁，所述温度控制容器包括内部区域; 分隔所述内部区域以形成容器内部的存储区域和相变材料区域的绝热隔板，所述绝热隔板包括在所述存储区域和所述相变材料区域之间的导管; 管道内的热控制装置; 基本上限定容器的绝缘材料的一部分内的孔，容器内部的相变材料区域和容器的外表面之间的孔; 以及定位在所述孔内的单向热导体，所述单向热导体构造成在从所述相变材料区域到所述容器的外表面的方向上传递热量。

    Refrigeration devices including temperature-controlled container systems
    10.
    发明授权
    Refrigeration devices including temperature-controlled container systems 有权
    制冷装置包括温度控制的容器系统

    公开(公告)号：US09523522B2

    公开(公告)日：2016-12-20

    申请号：US14704107

    申请日：2015-05-05

    申请人： Tokitae LLC

    发明人： Fong-Li Chou ,  Philip A. Eckhoff ,  Lawrence Morgan Fowler ,  William Gates ,  Jennifer Ezu Hu ,  Muriel Y. Ishikawa ,  Fridrik Larusson ,  Shieng Liu ,  Nathan P. Myhrvold ,  Brian L. Pal ,  Nels R. Peterson ,  David Keith Piech ,  Maurizio Vecchione ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  David J. Yager

    IPC分类号： F25B39/02 ,  F25B49/02

    CPC分类号： F25B39/028 ,  F25B49/00 ,  F25B49/02 ,  F25B2339/02 ,  F25D11/006 ,  F25D11/025

    摘要： In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

    摘要翻译： 在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成在制冷装置内部保持相变材料; 至少一个主动制冷单元，其包括位于所述液体不可渗透容器内部的一组蒸发器盘管; 基本上形成存储区域的壁; 以及传热系统，其包括具有中空内部的第一组不透气结构，以形成基本上形成液体不可渗透容器的与所述壁热接触的冷凝器，具有中空内部连接的第二组蒸气不可渗透结构 以形成与基本上形成存储区域的壁热接触的蒸发器，以及具有固定到冷凝器和蒸发器两者的中空内部的连接器，所述连接器在冷凝器的中空内部和 中空的蒸发器内部。