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公开(公告)号：US20120101137A1
公开(公告)日：2012-04-26
申请号：US13380664
申请日：2010-06-26
申请人： Tokuyuki Yamashita , Kaori Chikamatsu , Naoki Takahashi , Hisakazu Iwai , Masakazu Kogami , Masao Sakairi , Nobuhide Watanabe , Hiroki Fujieda , Daisuke Kataoka , Mitsuhiro Makino , Noriyasu Kato , Toshiyuki Miyazawa , Kazushige Nagai , Nobuyoshi Kasugai , Hiroyo Kataoka , Naoki Hiramatsu , Nobuaki Tsuruta , Yurie Yamada , Mika Miyoshi , Sei Murakami , Izumi Goto , Tohru Izuchi , Kimie Suzuki , Satoko Harada , Martin Lang , Markus Hans-Juergen Seifert , Kristina Kaarina Wolf
发明人： Tokuyuki Yamashita , Kaori Chikamatsu , Naoki Takahashi , Hisakazu Iwai , Masakazu Kogami , Masao Sakairi , Nobuhide Watanabe , Hiroki Fujieda , Daisuke Kataoka , Mitsuhiro Makino , Noriyasu Kato , Toshiyuki Miyazawa , Kazushige Nagai , Nobuyoshi Kasugai , Hiroyo Kataoka , Naoki Hiramatsu , Nobuaki Tsuruta , Yurie Yamada , Mika Miyoshi , Sei Murakami , Izumi Goto , Tohru Izuchi , Kimie Suzuki , Satoko Harada , Martin Lang , Markus Hans-Juergen Seifert , Kristina Kaarina Wolf
IPC分类号： A61K31/433 , A61P3/10 , C07D409/04 , C07D333/38 , A61K31/427 , C07D417/14
CPC分类号： A61K31/427 , A61K31/433 , C07D333/40 , C07D409/04 , C07D417/14
摘要： The object of the present invention is to provide a compound having a glucokinase-activating effect.A pharmaceutical composition comprising a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein X means a nitrogen atom or CR6, wherein R6 means a hydrogen atom or a halogen atom; R1 means a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 alkylthio group; R2 means a hydrogen atom or a fluorine atom; R3 means a hydrogen atom or a C1-C6 alkyl group; and one of R4 and R5 means a hydrogen atom or a C1-C6 alkyl group, and the other means a C1-C6 alkylenecarboxylic acid, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, or CONH2.
摘要翻译： 本发明的目的是提供具有葡糖激酶活化作用的化合物。 一种药物组合物，其包含由通式（I）表示的化合物或其药学上可接受的盐作为活性成分：其中X表示氮原子或CR 6，其中R 6表示氢原子或卤素原子; R1表示氢原子，C1-C6烷基，C1-C6烷氧基或C1-C6烷硫基; R2表示氢原子或氟原子; R3表示氢原子或C1-C6烷基; R4和R5之一表示氢原子或C1-C6烷基，另一个表示C1-C6亚烷基羧酸，C1-C6烷基磺酰基，C1-C6烷基羰基或CONH2。
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公开(公告)号：US08025037B2
公开(公告)日：2011-09-27
申请号：US12292935
申请日：2008-12-01
申请人： Naoki Hiramatsu
发明人： Naoki Hiramatsu
IPC分类号： F01L1/18
CPC分类号： F01L1/185 , F01L1/18 , F01L1/2405 , F01L1/46 , F01L2001/187 , Y10T29/49295 , Y10T74/20882
摘要： A valve gear comprises a cylinder head, a supporting member fixed to the cylinder head, a rocker arm which is mounted on the supporting member so as to be placed on the latter, a substantially plate-shaped clip mountable to the rocker arm, the clip having a fitting hole in which an outer periphery of the supporting member is fitted so that the clip is prevented from falling off, a pair of walls which is formed on the rocker arm so as to be opposed to each other with the supporting member being located therebetween, and a pair of locking portions formed in inner faces of the walls so that outer edges of the clip are elastically engaged with the locking portions thereby to be locked, respectively.
摘要翻译： 阀门齿轮包括气缸盖，固定到气缸盖的支撑构件，安装在支撑构件上以便放置在气缸盖上的摇臂，安装到摇臂的基本上为板状的夹子，夹子 具有装配孔，支撑构件的外周嵌合在该嵌合孔中，以防止夹子脱落;一对壁，其形成在摇臂上以支撑构件位于彼此相对的方式 以及形成在壁的内表面中的一对锁定部分，使得夹子的外边缘分别与锁定部分弹性接合，从而被锁定。
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公开(公告)号：US20070175428A1
公开(公告)日：2007-08-02
申请号：US11700110
申请日：2007-01-31
CPC分类号： F01L1/185 , B21K1/205 , F01L1/181 , Y10T29/49295 , Y10T74/20882
摘要： A rocker arm 6 that is rockably attached to a cylinder head 1 actuates a valve 4 by means of a guide groove 73b that is formed at an end thereof engaging with an upper end of a valve stem 41, and a roller 8 that is mounted in a roller housing portion 72 of the arm main unit 7 contacting against a cam 31 and rocking. The guide groove 73b is formed by press working ends of the arm main unit 7 in the thickness direction of the plate material to form a pair of walls 73d, and thereafter applying sandwiching pressure in the lateral direction to the walls 73d to increase the height thereof.
摘要翻译： 可摇动地附接到气缸盖1的摇臂6通过形成在其与阀杆41的上端接合的端部处的引导槽73b来驱动阀4，并且安装有辊8 在臂主体单元7的与凸轮31接触并摆动的滚筒收纳部分72中。 引导槽73b通过臂主体7的板材的厚度方向的冲压加工端形成，形成一对壁73d，然后向侧壁73d施加横向夹持压力以增加 其高度。
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公开(公告)号：US08240284B2
公开(公告)日：2012-08-14
申请号：US12216030
申请日：2008-06-27
申请人： Masahide Sakurai , Naoki Hiramatsu
发明人： Masahide Sakurai , Naoki Hiramatsu
IPC分类号： F01L1/18
摘要： A rocker arm includes a roller rotatably mounted between two sidewalls thereof. The roller is pressed by a cam. The rocker arm also includes two washers that reduce a wobbling motion of the roller with respect to the cam. The washers guiding mechanism the rocking movement of the rocker arm in the up-and-down direction, thereby reducing wobbling motion of the rocker arm when an engine runs.
摘要翻译： 摇臂包括可旋转地安装在其两个侧壁之间的辊。 滚轮被凸轮按压。 摇臂还包括两个垫圈，其减少了辊相对于凸轮的摆动运动。 垫圈引导机构使摇臂在上下方向上的摇摆运动，从而减少发动机运转时摇臂的摆动运动。
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公开(公告)号：US07779803B2
公开(公告)日：2010-08-24
申请号：US11948598
申请日：2007-11-30
IPC分类号： F01L1/18
CPC分类号： F01L1/185 , Y10T74/2107
摘要： A rocker arm installed module 1 is constructed by installing the cam shaft 3, the rocker arm 4 and the pivot 5 to the housing 2. The housing 2 is provided with a drop-off preventing means 21 for supporting and preventing the rocker arm 4, which is disposed on the pivot 5, from dropping off. The rocker arm installed module 1 is constructed by disposing the rocker arm 4 among the cam 31 of the cam shaft 3, the pivot 5 and the drop-off preventing means 21 in the housing 2 to form a module, the module being configured to be disposed in a concave portion 61 of the cylinder head 6 while preventing the rocker arm 4 from dropping off.
摘要翻译： 摇臂安装模块1通过将凸轮轴3，摇臂4和枢轴5安装到壳体2而构成。壳体2设置有用于支撑和防止摇臂4的防脱落装置21， 其设置在枢轴5上，从而脱落。 摇臂安装模块1通过将摇臂4设置在凸轮轴3的凸轮31中，枢轴5和防脱落装置21在壳体2中以形成模块而构成，该模块被配置为 设置在气缸盖6的凹部61中，同时防止摇臂4脱落。
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公开(公告)号：US20080127923A1
公开(公告)日：2008-06-05
申请号：US11948598
申请日：2007-11-30
IPC分类号： F01L1/18
CPC分类号： F01L1/185 , Y10T74/2107
摘要： A rocker arm installed module 1 is constructed by installing the cam shaft 3, the rocker arm 4 and the pivot 5 to the housing 2. The housing 2 is provided with a drop-off preventing means 21 for supporting and preventing the rocker arm 4, which is disposed on the pivot 5, from dropping off. The rocker arm installed module 1 is constructed by disposing the rocker arm 4 among the cam 31 of the cam shaft 3, the pivot 5 and the drop-off preventing means 21 in the housing 2 to form a module, the module being configured to be disposed in a concave portion 61 of the cylinder head 6 while preventing the rocker arm 4 from dropping off.
摘要翻译： 摇臂安装模块1通过将凸轮轴3，摇臂4和枢轴5安装到壳体2而构成。 壳体2设置有用于支撑和防止设置在枢轴5上的摇臂4脱落的防脱落装置21。 摇臂安装模块1通过将摇臂4设置在凸轮轴3的凸轮31中，枢轴5和防脱落装置21在壳体2中以形成模块而构成，该模块被配置为 设置在气缸盖6的凹部61中，同时防止摇臂4脱落。
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公开(公告)号：US08567362B2
公开(公告)日：2013-10-29
申请号：US12897024
申请日：2010-10-04
申请人： Naoki Hiramatsu , Masahide Sakurai
发明人： Naoki Hiramatsu , Masahide Sakurai
CPC分类号： F01M11/02 , F01L1/053 , F01L1/185 , F01L1/2405 , F01L2001/0476 , F01L2001/0537 , F01L2101/00 , F01L2105/00 , F01L2810/02 , F01L2820/01
摘要： A vehicle engine includes a cylinder head, a cam housing fixed to a top of the cylinder head, a cam cap fixed to a top of the cam housing, a camshaft rotatably supported between the cam housing and the cam cap, the camshaft supporting a cam, a rocker arm configured to be pushed by the cam, and a valve configured to operate by being pushed by the rocker arm. The vehicle engine has an oil pipe that is formed integrally with the cam housing.
摘要翻译： 车辆发动机包括气缸盖，固定到气缸盖顶部的凸轮壳体，固定到凸轮壳体顶部的凸轮盖，可旋转地支撑在凸轮壳体和凸轮盖之间的凸轮轴，凸轮轴支撑凸轮 构造成被凸轮推动的摇臂，以及构造成通过被摇臂推动而操作的阀。 车辆发动机具有与凸轮壳体一体形成的油管。
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公开(公告)号：US08037856B2
公开(公告)日：2011-10-18
申请号：US12343660
申请日：2008-12-24
申请人： Masahide Sakurai , Naoki Hiramatsu , Eiichi Nozaki
发明人： Masahide Sakurai , Naoki Hiramatsu , Eiichi Nozaki
IPC分类号： F01L1/18
摘要： A rocker arm includes a pair of side wall portions formed so as to face each other, an engaging portion connecting the pair of side wall portions and adapted to engage with a rocking support member arranged in an engine, and a sliding portion connecting the pair of side wall portions and being adapted to be in slidable contact with a stem front end portion of an engine valve. The engaging portion includes a board surface portion connecting the pair of side wall portions and a protruding portion protruding from the board surface portion toward the rocking support member. In the protruding portion, a spherical concave portion adapted to engage with a spherical protruding portion of the rocking support member is formed as a depression.
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公开(公告)号：US20110041791A1
公开(公告)日：2011-02-24
申请号：US12850994
申请日：2010-08-05
CPC分类号： F01L1/185 , F01L1/2405 , F01L2001/187 , F01L2105/00 , Y10T74/20882 , Y10T74/2107
摘要： A rocker arm unit constituting a valve gear of an internal combustion engine includes a support member assembled into the cylinder head, a rocker arm supported on a top of the support member so as to be swung with a supported position serving as an approximate fulcrum, and a wire member bridging the support member side and the rocker arm side with each other thereby to connect the support member and the rocker arm together.
摘要翻译： 构成内燃机的气门齿轮的摇臂单元包括：组装在气缸盖中的支撑构件，支撑在支撑构件的顶部上的摇臂，以摆动作为大致支点的支撑位置;以及 将支撑构件侧和摇臂侧彼此桥接的线构件，从而将支撑构件和摇臂连接在一起。
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公开(公告)号：US20090007869A1
公开(公告)日：2009-01-08
申请号：US12216030
申请日：2008-06-27
申请人： Masahide Sakurai , Naoki Hiramatsu
发明人： Masahide Sakurai , Naoki Hiramatsu
IPC分类号： F01L1/18
摘要： A rocker arm includes a roller rotatably mounted between two sidewalls thereof. The roller is pressed by a cam. The rocker arm also includes two washers that reduce a wobbling motion of the roller with respect to the cam. The washers guiding mechanism the rocking movement of the rocker arm in the up-and-down direction, thereby reducing wobbling motion of the rocker arm when an engine runs.
摘要翻译： 摇臂包括可旋转地安装在其两个侧壁之间的辊。 滚轮被凸轮按压。 摇臂还包括两个垫圈，其减少了辊相对于凸轮的摆动运动。 垫圈引导机构使摇臂在上下方向上的摇摆运动，从而减少发动机运转时摇臂的摆动运动。
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