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公开(公告)号：US5496824A
公开(公告)日：1996-03-05
申请号：US327851
申请日：1994-10-21
申请人： Tomoyuki Onishi , Chika Mukai , Takaaki Sekiyama , Takashi Tsuji , Satoshi Iwayama , Masahiko Okunishi
发明人： Tomoyuki Onishi , Chika Mukai , Takaaki Sekiyama , Takashi Tsuji , Satoshi Iwayama , Masahiko Okunishi
IPC分类号： C07D239/54 , C07D239/553 , A61K31/505
CPC分类号： C07D239/54 , C07D239/553 , Y02P20/55
摘要： The present invention provides a pharmaceutical agent having a high pharmaceutical potency against varicella-zoster viruses and herpes simplex viruses, compositions containing the same, and methods for treating varicella-zoster viruses using the same.
摘要翻译： 本发明提供了对水痘带状疱疹病毒和单纯疱疹病毒具有高药用效力的药剂，以及含有该药物的组合物，以及使用该药剂治疗水痘带状疱疹病毒的方法。
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公开(公告)号：US5449840A
公开(公告)日：1995-09-12
申请号：US357927
申请日：1994-12-16
IPC分类号： A61K31/505 , A61K31/00 , A61K31/52 , A61K31/522 , A61P31/00 , A61P31/12 , A61P31/22 , C07C309/73 , C07D239/47 , C07D239/54 , C07D473/00 , C07D473/16 , C07D473/18 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/40 , C07C35/04
CPC分类号： C07D473/00 , Y02P20/55
摘要： A cyclopropane derivative of formula (I) ##STR1## wherein B.sup.1 is a purine or pyrimidine residue, R.sup.1 and R.sup.2 are, independently, hydrogen or a protecting group for hydroxyl and each of k, m and n represents, independently, an integer of 1 or 2 is useful for its antiviral effect.
摘要翻译： 式（I）的环丙烷衍生物其中B1是嘌呤或嘧啶残基，R1和R2独立地是氢或羟基的保护基，并且k，m和n中的每一个独立地表示 1或2的整数对其抗病毒作用是有用的。
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公开(公告)号：US5342840A
公开(公告)日：1994-08-30
申请号：US846615
申请日：1992-03-05
IPC分类号： A61K31/505 , A61K31/00 , A61K31/52 , A61K31/522 , A61P31/00 , A61P31/12 , A61P31/22 , C07C309/73 , C07D239/47 , C07D239/54 , C07D473/00 , C07D473/16 , C07D473/18 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/40
CPC分类号： C07D473/00 , Y02P20/55
摘要： A cyclopropane derivative of formula (I) ##STR1## wherein B.sup.1 is a purine or pyrimidine residue, R.sup.1 and R.sup.2 are, independently, hydrogen or a protecting group for hydroxyl and each of k, m and n represents, independently, an integer of 1 or 2 is useful for its antiviral effect.
摘要翻译： 式（I）的环丙烷衍生物其中B1是嘌呤或嘧啶残基，R1和R2独立地是氢或羟基的保护基，并且k，m和n中的每一个独立地表示 1或2的整数对其抗病毒作用是有用的。
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公开(公告)号：US20060194850A1
公开(公告)日：2006-08-31
申请号：US11346426
申请日：2006-02-03
申请人： Takashi Yamamoto , Akira Chiba , Kouichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oohmuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi Yamamoto , Akira Chiba , Kouichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oohmuta , Yuko Iida , Satoshi Iwayama
IPC分类号： A61K31/433 , A61K31/4245 , A61K31/42 , A61K31/425
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要翻译： 由式I表示的唑类化合物：其中环A是异恶唑等，R 1是取代或未取代的芳基等，R 2是氢原子等，R 3是取代或未取代的烷基等， 和其药学上可接受的盐抑制溶血磷脂酸（LPA）的生理活性，并且可用于预防或治疗其中抑制LPA的生理活性用于预防或治疗其的疾病，例如涉及 LPA受体。
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5.发明申请Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist 失效含有加巴喷丁或普瑞巴林和N型钙通道拮抗剂的药物组合物公开(公告)号：US20050009814A1
公开(公告)日：2005-01-13
申请号：US10911633
申请日：2004-08-05
申请人： Satoshi Iwayama , Hajime Koganei , Shinichi Fujita , Tomoko Takeda , Hiroshi Yamamoto , Seiji Niwa
发明人： Satoshi Iwayama , Hajime Koganei , Shinichi Fujita , Tomoko Takeda , Hiroshi Yamamoto , Seiji Niwa
IPC分类号： A61K31/195 , A61K31/451 , A61K45/06 , A61P25/04 , A61P43/00 , C07D211/70 , A61K31/5415 , A61K31/498
CPC分类号： C07D211/70 , A61K31/195 , A61K31/451 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.
摘要翻译： 本发明涉及用于预防/治疗疼痛的药物组合物，其包含加巴喷丁或普瑞巴林或其药学上可接受的盐和N-型钙通道拮抗剂或其药学上可接受的盐的组合，例如具有以下结构的化合物。
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公开(公告)号：US20080070903A1
公开(公告)日：2008-03-20
申请号：US11856339
申请日：2007-09-17
申请人： Seiji OHNO , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
发明人： Seiji OHNO , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
IPC分类号： A61K31/55 , A61K31/44 , A61K31/445 , A61K31/496 , A61P9/00 , C07D221/00 , C07D239/24 , C07D295/00 , C07D223/02 , C07D213/02 , A61P25/00 , A61K31/505 , A61K31/506
CPC分类号： C07D213/80 , A61K31/455 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要： Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.
摘要翻译： 下列通式或其类似物的手性嘧啶衍生物和吡啶衍生物具有选择性的N型钙通道拮抗活性，口服时显示镇痛作用。 它们可用作与N型钙通道相关的疼痛和各种疾病的治疗剂。
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公开(公告)号：US07288544B2
公开(公告)日：2007-10-30
申请号：US10387543
申请日：2003-03-14
申请人： Seiji Ohno , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
发明人： Seiji Ohno , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
IPC分类号： C07D239/338 , C07D403/04 , A61K31/505
CPC分类号： C07D213/80 , A61K31/455 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要： Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels
摘要翻译： 下列通式或其类似物的手性嘧啶衍生物和吡啶衍生物具有选择性的N型钙通道拮抗活性，口服时显示镇痛作用。 它们可用作与N型钙通道相关的疼痛和各种疾病的治疗剂
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公开(公告)号：US08278329B2
公开(公告)日：2012-10-02
申请号：US11924997
申请日：2007-10-26
申请人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
发明人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
IPC分类号： A61K31/445 , C07D211/18
CPC分类号： C07D295/205 , C07C237/06 , C07C271/20 , C07C271/22 , C07D211/70 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D417/06
摘要： The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
摘要翻译： 本发明涉及由以下通式（1）表示的化合物或其类似物，其选择性地抑制N-型钙通道或其类似物，以及涉及治疗疼痛等的方法，其包含由以下通式表示的化合物 1）或其与需要这种治疗的患者的类似物：其中A表示CH = CH等，a，b，c和d表示CH等，R 1，R 2，R 3，R 4，R 5和R 6表示H 等等，V-W表示C = C等，n表示0〜3，Y 1表示O等，B表示 - （CH 2）v CHR 21，其中v为0〜3，R 21表示H，低级烷基或 G等表示-CO-，共价键等，m为0〜6，R7和R8表示H，低级烷基，-COR18a，-COOR20，其中R18a和R20各自表示低级烷基 或类似物等
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公开(公告)号：US07517996B2
公开(公告)日：2009-04-14
申请号：US11346426
申请日：2006-02-03
申请人： Takashi Yamamoto , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi Yamamoto , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
IPC分类号： C07D261/04 , A01N43/80
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要翻译： 由式I表示的唑类化合物：其中环A是异恶唑等，R 1是取代或未取代的芳基等，R 2是氢原子等，R 3是取代或未取代的烷基等， 和其药学上可接受的盐抑制溶血磷脂酸（LPA）的生理活性，并且可用于预防或治疗其中抑制LPA的生理活性用于预防或治疗其的疾病，例如涉及 LPA受体。
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公开(公告)号：US07494989B2
公开(公告)日：2009-02-24
申请号：US11856339
申请日：2007-09-17
申请人： Seiji Ohno , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
发明人： Seiji Ohno , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
IPC分类号： C07D213/82 , C07D213/80 , C07D401/06 , A61K31/455 , A61K31/496
CPC分类号： C07D213/80 , A61K31/455 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要： Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.
摘要翻译： 下列通式或其类似物的手性嘧啶衍生物和吡啶衍生物具有选择性的N型钙通道拮抗活性，口服时显示镇痛作用。 它们可用作与N型钙通道相关的疼痛和各种疾病的治疗剂。
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