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    Derivatives of uridine phosphate and their uses in protein binding assays
    3.
    发明授权
    Derivatives of uridine phosphate and their uses in protein binding assays 有权
    磷酸尿苷的衍生物及其在蛋白质结合测定中的用途

    公开(公告)号：US09018370B2

    公开(公告)日：2015-04-28

    申请号：US13504997

    申请日：2010-11-01

    申请人： Gerd Wagner ,  Thomas Pesnot

    发明人： Gerd Wagner ,  Thomas Pesnot

    IPC分类号： C07H19/10 ,  C12M1/34 ,  C12N9/12 ,  G01N33/573

    CPC分类号： C07H19/10

    摘要： The present invention relates to compounds and their use in competitive protein binding assays, for example for use with glycosyl transferase and/or glycoprocessing proteins. The present application also provides kits and apparatuses for use in the assays. In particular, the present invention provides a compound of the formula (I): wherein n is 1, 2 or 3; R1 is selected from —OH, —OPO3H, —OR4, —NHR4, R6; R2 and R3 are each independently selected from —H, —OH, optionally substituted —O-alkyl and —O-alkanoyl; R4 is selected from an optionally substituted mono or polysaccharide, -alkyl, -alkenyl, -alkynyl, and L-Z, where L is a linking agent and Z is a binding agent; R6 is an optionally substituted hydrocarbon group; A is either (i) a substituted heteroaryl group, the substituent on the heteroaryl group having a double bond conjugated to the heteroaryl group, or (ii) a substituted aryl group, the substituent on the aryl group having a double bond conjugated to the aryl group.

    摘要翻译： 本发明涉及化合物及其在竞争性蛋白结合测定中的用途，例如用于糖基转移酶和/或糖苷加工蛋白。 本申请还提供了用于测定中的试剂盒和装置。 特别地，本发明提供式（I）化合物：其中n为1,2或3; R 1选自-OH，-OPO 3 H，-OR 4，-NHR 4，R 6; R2和R3各自独立地选自-H，-OH，任选取代的-O-烷基和-O-烷酰基; R4选自任选取代的单或多糖 - 烷基， - 烯基， - 炔基和L-Z，其中L是连接剂，Z是结合剂; R6是任选取代的烃基; A是（i）取代的杂芳基，具有与杂芳基结合的双键的杂芳基上的取代基，或（ii）取代的芳基，具有与芳基共轭的双键的芳基上的取代基 组。

    DERIVATIVES OF URIDINE PHOSPHATE AND THEIR USES IN PROTEIN BINDING ASSAYS
    4.
    发明申请
    DERIVATIVES OF URIDINE PHOSPHATE AND THEIR USES IN PROTEIN BINDING ASSAYS 有权
    磷酸氢钙的衍生物及其在蛋白质结合测定中的应用

    公开(公告)号：US20120219963A1

    公开(公告)日：2012-08-30

    申请号：US13504997

    申请日：2010-11-01

    申请人： Gerd Wagner ,  Thomas Pesnot

    发明人： Gerd Wagner ,  Thomas Pesnot

    IPC分类号： G01N33/573 ,  C07H19/10 ,  C12M1/34 ,  C12N9/12 ,  C12N9/90

    CPC分类号： C07H19/10

    摘要： The present invention relates to compounds and their use in competitive protein binding assays, for example for use with glycosyl transferase and/or glycoprocessing proteins. The present application also provides kits and apparatuses for use in the assays. In particular, the present invention provides a compound of the formula (I): wherein n is 1, 2 or 3; R1 is selected from —OH, —OPO3H, —OR4, —NHR4, R6; R2 and R3 are each independently selected from —H, —OH, optionally substituted —O-alkyl and —O-alkanoyl; R4 is selected from an optionally substituted mono or polysaccharide, -alkyl, -alkenyl, -alkynyl, and L-Z, where L is a linking agent and Z is a binding agent; R6 is an optionally substituted hydrocarbon group; A is either (i) a substituted heteroaryl group, the substituent on the heteroaryl group having a double bond conjugated to the heteroaryl group, or (ii) a substituted aryl group, the substituent on the aryl group having a double bond conjugated to the aryl group.

    摘要翻译： 本发明涉及化合物及其在竞争性蛋白结合测定中的用途，例如用于糖基转移酶和/或糖苷加工蛋白。 本申请还提供了用于测定中的试剂盒和装置。 特别地，本发明提供式（I）化合物：其中n为1,2或3; R 1选自-OH，-OPO 3 H，-OR 4，-NHR 4，R 6; R2和R3各自独立地选自-H，-OH，任选取代的-O-烷基和-O-烷酰基; R4选自任选取代的单或多糖 - 烷基， - 烯基， - 炔基和L-Z，其中L是连接剂，Z是结合剂; R6是任选取代的烃基; A是（i）取代的杂芳基，具有与杂芳基结合的双键的杂芳基上的取代基，或（ii）取代的芳基，具有与芳基共轭的双键的芳基上的取代基 组。

    Method For Geno-And Pathotyping Pseudomonas Aeruginosa
    5.
    发明申请
    Method For Geno-And Pathotyping Pseudomonas Aeruginosa 审中-公开
    Geno和Pathotyping铜绿假单胞菌的方法

    公开(公告)号：US20080026370A1

    公开(公告)日：2008-01-31

    申请号：US10587180

    申请日：2005-01-26

    申请人： Gerd Wagner ,  Lutz Wiehlmann ,  Burkhard Tuemmler

    发明人： Gerd Wagner ,  Lutz Wiehlmann ,  Burkhard Tuemmler

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C40B40/06

    CPC分类号： C12Q1/689 ,  C12Q2600/16

    摘要： The invention relates to a method for genotyping and pathotyping bacteria of the species Pseudomonas aeruginosa by means of hybridization assays on a biochip or microarray. The invention further relates to specific oligonucleotide probes, which can be employed within the scope of the detection method, as well as to biochips having such oligonucleotide probes.

    摘要翻译： 本发明涉及通过在生物芯片或微阵列上进行杂交测定来对铜绿假单胞菌进行基因分型和病原性鉴定的方法。 本发明还涉及可以在检测方法的范围内使用的特异性寡核苷酸探针以及具有这种寡核苷酸探针的生物芯片。