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公开(公告)号：US4312728A
公开(公告)日：1982-01-26
申请号：US206181
申请日：1980-11-12
IPC分类号： G01N21/17 , G01N21/59 , G01N27/26 , G01N27/447 , G01N33/483 , G01N33/16
CPC分类号： G01N27/44721
摘要： A method for determining boundary points on electrophoretic densitograms comprising a bounding point judging step for locating boundary points on electrophoretic densitograms, a normal fraction judging step for judging whether or not the boundary points located by said boundary point judging step are normal, and a standard position computing step for determining standard positions on the basis of data having been judged as normal by said normal fraction judging step, said method being so adapted as to determine boundary points taking reference to the standard positions located by said standard position computing step by utilizing unknown samples for locating the standard positions and perform data processing without using standard samples.
摘要翻译： 一种用于确定电泳密度图上的边界点的方法，包括用于定位电泳密度图上的边界点的边界点判断步骤，用于判断由所述边界点判断步骤定位的边界点是否正常的正常分数判断步骤，以及标准位置 基于通过所述正常分数判断步骤判断为正常的数据来确定标准位置的计算步骤，所述方法适于通过利用未知样本来参考由所述标准位置计算步骤定位的标准位置来确定边界点 用于定位标准位置并执行数据处理，而不使用标准样品。
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公开(公告)号：US4429996A
公开(公告)日：1984-02-07
申请号：US256591
申请日：1981-04-22
IPC分类号： G01N27/26 , G01N27/447 , G01N27/28
CPC分类号： G01N27/44721
摘要： To facilitate fractionation of an electrophoretogram, the disclosed process differentiates signals representing the electrophoretogram so as to obtain the differential of the first order and to generate a first series of pulses representing changes of sign of the differential of the first order. The process differentiates again the differential of the first order so as to obtain the differential of the second order and generates a second series of pulses representing changes of sign of the differential of the second order. Output pulses are generated by logically processing the first and second series of pulses, whereby the electrophoretogram is fractionated on the basis of the timing of the output pulses.
摘要翻译： 为了促进电泳图的分离，所公开的处理区分表示电泳图的信号，以获得第一阶的差分，并产生表示第一阶微分的符号变化的第一序列脉冲。 该过程再次区分第一级的差分，以获得二阶微分，并产生表示二阶微分的符号变化的第二脉冲序列。 通过对第一和第二脉冲序列进行逻辑处理产生输出脉冲，由此基于输出脉冲的定时对电泳图进行分馏。
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公开(公告)号：US4420383A
公开(公告)日：1983-12-13
申请号：US281495
申请日：1981-07-08
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44721
摘要： A fractionating method in electrophoresis wherein, in order to make it possible to automatically and accurately fractionate a pattern obtained by the electrophoresis of a sample to be measured, respective peak tops or minimum points of the pattern obtained by electrophoresizing the sample to be measured are made to correspond to respective peak tops or minimum points to be obtained by electrophoresizing a normal sample by making the basic positions coincide with each other and the minimum points in the sample to be measured located in the positions nearest to the minimum points on the normal sample are made boundary points or the boundary points are determined on the basis of the ratios of the lengths from the basic position to the respective peak tops or minimum points in the sample to be meaured nearest to the values of the above mentioned ratios in the normal sample.
摘要翻译： 电泳中的分馏方法，其中为了使得可以自动和准确地分级通过待测样品的电泳获得的图案，可以制备通过对待测样品进行电泳获得的图案的各个峰顶或最小点 对应于通过使基本位置彼此重合而使正常样品电泳而获得的相应峰顶或最小点，并且待测样品中位于最接近正常样品上最小点的位置的最小点为 根据在正常样品中最接近上述比例值的待测试样品中从基本位置到相应峰顶或最小点的长度的比率来确定边界点或边界点。
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4.发明授权Method for determining boundary points on electrophoretic patterns and means therefor 失效用于确定电泳图案上边界点的方法及其方法
公开(公告)号：US4420384A
公开(公告)日：1983-12-13
申请号：US292537
申请日：1981-08-13
申请人： Toshihide Fujiwara
发明人： Toshihide Fujiwara
IPC分类号： G01N21/17 , G01N27/26 , G01N27/447
CPC分类号： G01N27/44721
摘要： A method for determining boundary points on electrophoretic patterns whereby boundary points can be easily and accurately added onto or erased from fractionated patterns or analogue patterns by utilizing a densitometer for obtaining fractionated patterns of serums formed by an electrophoresis, a computer for making necessary operations and data treatments, an input terminal device for putting boundary point position informations or the like into the computer and an output terminal device which can record and digitally type analogue patterns with the output of the computer and means for working the method. Any input error by the input terminal device can be corrected.
摘要翻译： 一种用于确定电泳图案上边界点的方法，其中通过利用密度计获得通过电泳形成的血清分离图谱，可以容易且准确地将边界点加入或从分级图案或模拟图案中擦除边界点，用于进行必要操作和数据的计算机 处理，用于将边界点位置信息等放入计算机的输入终端装置以及可以用计算机的输出记录和数字地类型模拟模式的输出终端装置和用于工作方法的装置。 可以校正输入端子装置的输入错误。
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公开(公告)号：US4343991A
公开(公告)日：1982-08-10
申请号：US151888
申请日：1980-05-21
CPC分类号： G01N27/44721 , G01D5/34723 , G01N21/86 , G01V8/24
摘要： A sample detector is comprised of a first group of optical fibers having exit end surfaces arranged in the direction perpendicular to the shifting direction of the carrier, a second group of optical fibers having entrance end surfaces arranged opposite said exit end surfaces of the first group of optical fibers, a plural number of light emitting diodes arranged in the vicinity of the entrance end surfaces of the first group of optical fibers, a single photo detector element arranged in the vicinity of the exit end surfaces of the second group of optical fibers and a preamplifier connected to the output side of said photo detector element. Said sample detector is adapted in such a manner that the light emitting diodes are caused to glow consecutively, the light, having passed through the first group of optical fibers the carrier and the second group of optical fibers, is received by said photo-detector element, subjected to photoelectric conversion and amplified by said preamplifier. The presence of samples on the carrier is detected based on the outputs thus obtained.
摘要翻译： 样品检测器由具有沿着与载体的移动方向垂直的方向排列的出射端面的第一组光纤组成，第二组光纤具有与第一组的出口端面相对的入口端面 布置在第一组光纤的入射端面附近的多个发光二极管，布置在第二组光纤的出射端表面附近的单个光检测器元件，以及 前置放大器连接到所述光电检测器元件的输出侧。 所述样品检测器以使得发光二极管连续发光的方式适配，已经通过第一组光纤的载体和第二组光纤的光被所述光检测器元件 经过光电转换并由所述前置放大器放大。 基于这样获得的输出，检测载体上样本的存在。
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公开(公告)号：US4295949A
公开(公告)日：1981-10-20
申请号：US151889
申请日：1980-05-21
申请人： Toshihide Fujiwara , Ryo Fujimori
发明人： Toshihide Fujiwara , Ryo Fujimori
IPC分类号： G01N21/17 , G01N21/59 , G01N27/26 , G01N27/447
CPC分类号： G01N27/44721
摘要： A method for determining boundary points in electrophoresis comprising a step to determine points on the abscissa corresponding to peak tops on a densitogram traced on the basis of electrophoresis of a standard sample as standard positions, a step to locate positions corresponding to said standard positions on a densitogram traced on the basis of electrophoresis of an unknown sample, a step to determine the point corresponding to the lowest concentration among points having minimum values between each pair of neighboring standard positions as the normal boundary point and a step to calculate an integral or a value proportional to the integral of each fraction delimited by the boundary points thus determined.
摘要翻译： 一种用于确定电泳中边界点的方法，其中包括确定与基于标准样品的电泳作为标准位置追踪的浓度图上的峰顶相对应的横坐标上的点的步骤，将与所述标准位置相对应的位置定位在 在未知样品的电泳的基础上跟踪密度图，确定对应于在每对相邻标准位置之间具有最小值的点之间的最低浓度的点作为正常边界点的步骤和计算积分值或值的步骤 与由如此确定的边界点分界的每个分数的积分成比例。
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公开(公告)号：US4329591A
公开(公告)日：1982-05-11
申请号：US155384
申请日：1980-06-02
CPC分类号： G01N35/00009 , G01N21/86 , G01N27/44721
摘要： A method for detecting samples by comparing outputs corresponding to a carrier portion free from sample with those corresponding to a carrier portion onto which a sample is applied while detecting said outputs with a plural number of sample detectors arranged in the direction perpendicular to the shifting direction of a carrier, selecting a sample detector showing the highest output reduction ratio as the one to be utilized for sample detection and detecting the end edge of a sample as a time at which output of said sample detector changes from a level darker than a preset value to another level brighter than said preset value.
摘要翻译： 一种检测样本的方法，该方法通过将与样本的载体部分相对应的输出与对应于其上施加样本的载体部分的输出进行比较，同时检测所述输出的多个样本检测器沿垂直于移位方向的方向排列 载体，选择显示最高输出降低率的样品检测器作为样品检测的检测器，并且检测样品的末端边缘，作为所述样品检测器的输出从比预设值更暗的水平变化的时间到 另一个级别比所述预设值更亮。
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公开(公告)号：US4301116A
公开(公告)日：1981-11-17
申请号：US146368
申请日：1980-05-02
申请人： Hideaki Ida , Toshihide Fujiwara
发明人： Hideaki Ida , Toshihide Fujiwara
IPC分类号： G01N1/00 , G01N1/28 , G01N27/26 , G01N27/447 , G01N33/48 , G01N35/00 , G01N35/04 , G01N1/10 , G01N35/06
CPC分类号： G01N35/00 , G01N27/44704 , G01N27/44743 , G01N2035/0425 , G01N2035/0465 , G01N35/026 , Y10T436/114998
摘要： A sample tray feeding apparatus comprising a sample tray accommodating container having an opening for inserting sample trays and another opening at the lower end thereof, and a sample tray feeding mechanism for shifting said sample trays from said opening located at the lower end, said sample tray feeding apparatus being so adapted as to accommodate a large number of sample trays in said accommodating container in piled up condition and feed said sample trays consecutively from the lower ones to a sample adhering position through the opening located at the lower end by operating said sample tray feeding mechanism.
摘要翻译： 一种样品托盘进给装置，包括：样品托盘容纳容器，其具有用于插入样品托盘的开口和在其下端的另一个开口;以及样品托盘进给机构，用于从位于下端的所述开口移动所述样品托盘，所述样品托盘 进料装置适于在堆积状态下容纳所述容纳容器中的大量样品托盘，并通过操作所述样品托盘将所述样品盘从下部样品连续地供给到位于下端的开口的样品粘合位置 喂养机制。
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公开(公告)号：US4224529A
公开(公告)日：1980-09-23
申请号：US907283
申请日：1978-05-18
申请人： Toshihide Fujiwara
发明人： Toshihide Fujiwara
IPC分类号： G01R1/28 , G01N27/26 , G01N27/447 , H01H47/00 , H01H43/32
CPC分类号： G01N27/44773 , Y10T307/839
摘要： A device for automatically changing the polarity of a direct current supply source for use in a cataphoresis apparatus comprises a switch for changing the polarity of migration current, a device for generating a functional signal in response to a detection of the finish or the beginning of the migration current, a signal processing device connected to the functional signal generator for processing the functional signal to drive the polarity change switch and a polarity changing device connected between the signal processing device and the polarity change switch for instructing polarity change of the migration current to the polarity change switch and for memorizing the changed polarity of the migration current in spite of switching on or off of a power supply source. The polarity changing device always changes the polarity of the migration current to a polarity opposite to the just before polarity every detection of the finishing or the beginning of the migration current.
摘要翻译： 用于自动改变用于电泳装置的直流电源的极性的装置包括用于改变迁移电流的极性的开关，用于响应于完成的检测或开始的检测而产生功能信号的装置 迁移电流，连接到功能信号发生器的信号处理装置，用于处理功能信号以驱动极性改变开关;以及极性改变装置，连接在信号处理装置和极性改变开关之间，用于指示迁移电流的极性变化 极性变化开关，并且用于存储迁移电流的改变的极性，尽管电源的接通或断开。 极性改变装置始终将迁移电流的极性改变为刚好在刚刚完成的极性之前的极性，每次检测完成或开始迁移电流。
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公开(公告)号：US4395125A
公开(公告)日：1983-07-26
申请号：US175415
申请日：1980-08-05
IPC分类号： G01N21/17 , G01N21/88 , G01N27/26 , G01N27/447 , G01N35/00 , G01N35/04 , G01N35/10 , G01B11/00 , G01N21/86
CPC分类号： G01N21/88 , G01N35/00009 , G01N2035/0493 , G01N2035/1025
摘要： A sample centering system comprising a photometric system for colorimetrically measuring samples applied onto a carrier shifted in a definite direction, a detection system arranged at a definite interval apart from said photometric system, a sample detection signal generating means for generating a signal on the basis of the output from said detection system, and a shifting timer which is operated on the basis of said sample detection signal or at a definite time after shifting of said carrier is started, said sample centering system being so adapted as to stop said carrier when said shifting timer is turned off after a definite time, thereby making it possible to stop said carrier always at a time when a sample is located on the optical axis of said photometric system regardless of sample conditions.
摘要翻译： 一种采样定心系统，包括用于对应用于沿一定方向移位的载波上的样本进行比色测量的测光系统，与所述测光系统隔开一定距离的检测系统;采样检测信号发生装置，用于基于 来自所述检测系统的输出和基于所述采样检测信号操作或在所述载波移位之后的确定时间开始的移位定时器开始，所述采样定心系统适于在所述移位时停止所述载体 定时器在一定时间后关闭，从而使得可以在样品位于所述测光系统的光轴上时无论采样情况如何，始终停止所述载体。
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