-
公开(公告)号:US08541544B2
公开(公告)日:2013-09-24
申请号:US13126039
申请日:2009-10-27
申请人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
CPC分类号: A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译: 用于检测作为感兴趣对象的细胞团中的癌干细胞的分子标记,其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记,但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒,其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。
-
公开(公告)号:US20110262358A1
公开(公告)日:2011-10-27
申请号:US13126039
申请日:2009-10-27
申请人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
发明人: Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号: A61K49/00 , C12Q1/48 , C12Q1/68 , G01N33/566 , C12Q1/02 , C12N5/095 , C07K7/00 , C07K16/18 , A61K38/02 , A61K39/395 , C07H21/00 , A61K39/00 , C07H21/04 , C07H21/02 , A61K31/7088 , A61P35/00 , A61P43/00 , C12Q1/04
CPC分类号: A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要: A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译: 用于检测作为感兴趣对象的细胞团中的癌干细胞的分子标记,其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记,但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒,其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。
-
公开(公告)号:US08915223B2
公开(公告)日:2014-12-23
申请号:US13880913
申请日:2011-10-14
CPC分类号: F01L1/34 , F01L1/3442 , F01L2001/0476 , F01L2001/34423 , F01L2001/34469 , F01L2001/34479 , F01L2001/34483 , F01L2250/02
摘要: Provided is a valve timing control apparatus that allows relaxation of manufacturing precision of a driving-side rotary member and a driven-side rotary member and that achieves space saving at the same time. An urging member includes at least one trough-folded portion and at least one crest-folded portion, one end side contact portion formed between one terminal end of the urging member and the trough-folded portion and coming into contact with a sealing element, and other end side contact portion formed between the other terminal end of the urging member and the crest-folded portion and coming into contact with a partitioning portion. In association with urging of the urging member, the distance between the one end side contact portion and the other end side contact portion along the urging direction is decreased and the angles of the trough-folded portion and the crest-folded portion are decreased.
摘要翻译: 提供一种允许驱动侧旋转部件和从动侧旋转部件的制造精度松弛的气门正时控制装置,同时实现节省空间。 推动构件包括至少一个槽折叠部分和至少一个折曲部分,形成在推动构件的一个末端和槽折叠部分之间并与密封元件接触的一个端侧接触部分,以及 形成在推压构件的另一端部与顶部折曲部分之间并与分隔部分接触的另一端侧接触部分。 伴随着推动部件的推压,沿着推压方向的一端侧接触部和另一端侧接触部之间的距离减小,并且槽折部和折边部的角度减小。
-
4.
公开(公告)号:US08965948B2
公开(公告)日:2015-02-24
申请号:US10576048
申请日:2004-10-14
申请人: Koichi Shimamura , Takenori Sekiya , Satoshi Nishizawa , Hideaki Suga , Jota Nakatsuma , Hisashi Kato , Yoshimi Saito
发明人: Koichi Shimamura , Takenori Sekiya , Satoshi Nishizawa , Hideaki Suga , Jota Nakatsuma , Hisashi Kato , Yoshimi Saito
CPC分类号: H04M3/42374 , H04L51/043 , H04L51/32 , H04M1/72547 , H04M1/72572 , H04M3/42093 , H04M3/42357 , H04M3/42365 , H04M2201/38 , H04W4/02
摘要: The presence display system of the present invention displays presences and distances between buddies.The mobile station 11 performs poling to the user data section 26 at predetermined time intervals, transmits location information of the mobile station 11 to the presence server 27, receives buddies state information and information indicating the proximity between the user and the buddies, and displays the presence of the buddies by means of an icon with a size that corresponds with the proximity. The buddy list server 28 calculates the distance between the user and the buddies from the location information of the mobile station 11 and the location information of the requested buddies in accordance with the poling by the mobile station 11, determines the proximity by comparing the distance with a threshold value that is set by the user, and transmits the proximity to the mobile station 11.
摘要翻译: 本发明的存在显示系统显示了朋友之间的存在和距离。 移动台11以规定的时间间隔对用户数据部26进行极化,向存在服务器27发送移动台11的位置信息,接收与状态信息以及指示用户和好友之间的接近度的信息,并显示 通过具有与接近度相对应的大小的图标来存在好友。 好友列表服务器28根据移动台11的偏移量,根据移动台11的位置信息和所请求的好友的位置信息,计算用户与好友之间的距离,通过将距离与 由用户设置的阈值,并且发送与移动台11的接近。
-
公开(公告)号:US20130213327A1
公开(公告)日:2013-08-22
申请号:US13880913
申请日:2011-10-14
IPC分类号: F01L1/34
CPC分类号: F01L1/34 , F01L1/3442 , F01L2001/0476 , F01L2001/34423 , F01L2001/34469 , F01L2001/34479 , F01L2001/34483 , F01L2250/02
摘要: Provided is a valve timing control apparatus that allows relaxation of manufacturing precision of a driving-side rotary member and a driven-side rotary member and that achieves space saving at the same time. An urging member includes at least one trough-folded portion and at least one crest-folded portion, one end side contact portion formed between one terminal end of the urging member and the trough-folded portion and coming into contact with a sealing element, and other end side contact portion formed between the other terminal end of the urging member and the crest-folded portion and coming into contact with a partitioning portion. In association with urging of the urging member, the distance between the one end side contact portion and the other end side contact portion along the urging direction is decreased and the angles of the trough-folded portion and the crest-folded portion are decreased.
摘要翻译: 提供一种允许驱动侧旋转部件和从动侧旋转部件的制造精度松弛的气门正时控制装置,同时实现节省空间。 推动构件包括至少一个槽折叠部分和至少一个折曲部分,形成在推动构件的一个末端和槽折叠部分之间并与密封元件接触的一个端侧接触部分,以及 形成在推压构件的另一端部与顶部折曲部分之间并与分隔部分接触的另一端侧接触部分。 伴随着推动部件的推压,沿着推压方向的一端侧接触部和另一端侧接触部之间的距离减小,并且槽折部和折边部的角度减小。
-
6.
公开(公告)号:US20070078965A1
公开(公告)日:2007-04-05
申请号:US10576048
申请日:2004-10-14
申请人: Koichi Shimamura , Takenori Sekiya , Satoshi Nishizawa , Hideaki Suga , Jota Nakatsuma , Hisashi Kato , Yoshimi Saito
发明人: Koichi Shimamura , Takenori Sekiya , Satoshi Nishizawa , Hideaki Suga , Jota Nakatsuma , Hisashi Kato , Yoshimi Saito
IPC分类号: G06F15/173
CPC分类号: H04M3/42374 , H04L51/043 , H04L51/32 , H04M1/72547 , H04M1/72572 , H04M3/42093 , H04M3/42357 , H04M3/42365 , H04M2201/38 , H04W4/02
摘要: The presence display system of the present invention displays presences and distances between buddies. The mobile station 11 performs poling to the user data section 26 at predetermined time intervals, transmits location information of the mobile station 11 to the presence server 27, receives buddies state information and information indicating the proximity between the user and the buddies, and displays the presence of the buddies by means of an icon with a size that corresponds with the proximity. The buddy list server 28 calculates the distance between the user and the buddies from the location information of the mobile station 11 and the location information of the requested buddies in accordance with the poling by the mobile station 11, determines the proximity by comparing the distance with a threshold value that is set by the user, and transmits the proximity to the mobile station 11.
摘要翻译: 本发明的存在显示系统显示了朋友之间的存在和距离。 移动台11以规定的时间间隔对用户数据部26进行极化,向存在服务器27发送移动台11的位置信息,接收与状态信息以及指示用户和好友之间的接近度的信息,并且显示 通过具有与接近度相对应的大小的图标来存在好友。 好友列表服务器28根据移动台11的偏移量,根据移动台11的位置信息和所请求的好友的位置信息,计算用户与好友之间的距离,通过将距离与 由用户设置的阈值,并且发送与移动台11的接近。
-
公开(公告)号:US06854699B2
公开(公告)日:2005-02-15
申请号:US10440357
申请日:2003-05-19
申请人: Satoshi Nishizawa
发明人: Satoshi Nishizawa
CPC分类号: B60N3/102 , B60N3/106 , B60N3/108 , Y10S224/926
摘要: A cup holder device includes an attachment base, a holder main member, and a holder arm formed of first to third arms. The first arm has one end part rotatably supported to the holder main member, and the other end part with a first placement portion where the container bottom can be placed. The second arm has one end part rotatably supported to the other end part of the first arm through a first link portion, and a second placement portion at the one end part. In an unfolded state, the second placement portion continues from the first placement portion to support the container bottom. The third arm includes one end part rotatably supported to the other end part of the second arm, and the other end part rotatably supported to the holder main member through a second link portion. Thus, the cup holder device can be made compact and stably hold a container.
摘要翻译: 杯保持器装置包括附接基座,保持器主构件和由第一至第三臂形成的保持臂。 第一臂具有可旋转地支撑在保持器主构件上的一个端部,另一个端部具有可以放置容器底部的第一放置部分。 第二臂具有通过第一连杆部可旋转地支撑在第一臂的另一端部的一端部,以及在一端部的第二放置部。 在展开状态下,第二放置部分从第一放置部分继续以支撑容器底部。 第三臂包括可旋转地支撑在第二臂的另一端部的一端部,另一端部通过第二连杆部可旋转地支撑在保持器主构件上。 因此,可以使杯架装置紧凑并稳定地保持容器。
-
-
-
-
-
-