公开(公告)号：US5051349A

公开(公告)日：1991-09-24

申请号：US490199

申请日：1990-03-08

申请人： Toshiki Taguchi ,  Hiroyuki Hirai

发明人： Toshiki Taguchi ,  Hiroyuki Hirai

IPC分类号： G03C1/498

CPC分类号： G03C1/49863

摘要： A heat developable color photographic material is disclosed, comprising a support having thereon at least a photosensitive silver halide, a binder, and a dye providing compound capable of releasing or forming a diffusible dye in correspondence or counter-correspondence to reduction of the silver halide to silver, said heat developable color photosensitive material further comprising a compound represented by formula (I):C.sub.6n (H.sub.2 O).sub.5n+1 (I)wherein n represents an integer of 1 or more. The material exhibits excellent raw preservability and provides a stain-free color image having a high maximum density.

公开(公告)号：US5139919A

公开(公告)日：1992-08-18

申请号：US657937

申请日：1991-02-21

申请人： Toshiki Taguchi ,  Takeshi Nakamine ,  Ken Kawata ,  Hiroyuki Hirai

发明人： Toshiki Taguchi ,  Takeshi Nakamine ,  Ken Kawata ,  Hiroyuki Hirai

IPC分类号： G03C8/08 ,  G03C8/40

CPC分类号： G03C8/408 ,  G03C8/08 ,  G03C8/4033 ,  Y10S430/16

摘要： A heat-developable color photographic material comprising a support having thereon at least a light-sensitive silver halide, a binder, at least one of an electron-donating agent and a precursor thereof, a reducible dye-forming compound which releases a diffusible dye by reduction and an electron-transferring agent, wherein an electron-transferring agent precursor co-exists together with the electron-transferring agent.

摘要翻译： 一种可热显影的彩色照相材料，包括其上至少含有感光卤化银，粘合剂，给电子剂及其前体中的至少一种的载体，可释放的染料形成化合物，其通过 还原和电子转移剂，其中电子转移剂前体与电子转移剂一起共存。

公开(公告)号：US09580689B2

公开(公告)日：2017-02-28

申请号：US13811572

申请日：2011-07-22

申请人： Nobuaki Kikyo ,  Hiroyuki Hirai

发明人： Nobuaki Kikyo ,  Hiroyuki Hirai

IPC分类号： C12N5/00 ,  C12N5/074 ,  C07K14/47 ,  C12N15/85

CPC分类号： C12N5/0696 ,  A01K2207/12 ,  A01K2227/105 ,  C07K14/4702 ,  C07K2319/71 ,  C12N15/8509 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2506/1307 ,  C12N2510/00 ,  C12N2740/15041

摘要： Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.

摘要翻译： 这里描述的是核重新编程和诱导多能干细胞（iPSC）技术的重大突破。 将MyoD强大的转录激活结构域（TAD）融合到Oct4蛋白质中，使得iPSC生成更快，更有效，更纯净，更安全，更无饲料。 此外，本文公开的是使用与转录因子融合的TAD作为制备iPSC的方法的第一个报告。 通过组合转录因子和TAD，这种核重新编程方法可以具有诱导多能性诱导转分化而不通过iPSC过渡的应用范围。

公开(公告)号：US20130195812A1

公开(公告)日：2013-08-01

申请号：US13811572

申请日：2011-07-22

申请人： Nobuaki Kikyo ,  Hiroyuki Hirai

发明人： Nobuaki Kikyo ,  Hiroyuki Hirai

IPC分类号： C12N5/071

CPC分类号： C12N5/0696 ,  A01K2207/12 ,  A01K2227/105 ,  C07K14/4702 ,  C07K2319/71 ,  C12N15/8509 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2506/1307 ,  C12N2510/00 ,  C12N2740/15041

摘要： Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.

摘要翻译： 这里描述的是核重新编程和诱导多能干细胞（iPSC）技术的重大突破。 将MyoD强大的转录激活结构域（TAD）融合到Oct4蛋白质中，使得iPSC生成更快，更有效，更纯净，更安全，更无饲料。 此外，本文公开的是使用与转录因子融合的TAD作为制备iPSC的方法的第一个报告。 通过组合转录因子和TAD，这种核重新编程方法可以具有诱导多能性诱导转分化而不通过iPSC过渡的应用范围。

公开(公告)号：US20090130022A1

公开(公告)日：2009-05-21

申请号：US11916391

申请日：2006-06-06

申请人： Junji Nishigaki ,  Hiroyuki Hirai ,  Masayoshi Kojima ,  Kazuhiro Aikawa

发明人： Junji Nishigaki ,  Hiroyuki Hirai ,  Masayoshi Kojima ,  Kazuhiro Aikawa

IPC分类号： A61B5/055 ,  A61K9/127

CPC分类号： A61K49/1812

摘要： A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.

摘要翻译： 含有磷脂酰胆碱和磷脂酰丝氨酸的磷脂酰丝氨酸组合为磷脂酰胆碱的膜组分：磷脂酰丝氨酸摩尔比为3:1至1:2，所述脂质体含有平均粒度不小于1nm且不大于50的超顺磁性颗粒 nm。 用于选择性地累积由血管平滑肌细胞的异常增殖引起的血管疾病的病变中的MRI造影剂的手段，所述血管病变由PTCA提供之后的动脉硬化和再狭窄引起。

公开(公告)号：US07462300B2

公开(公告)日：2008-12-09

申请号：US10982876

申请日：2004-11-08

申请人： Hiroyuki Hirai ,  Keiko Sugihara ,  Junji Nishigaki

发明人： Hiroyuki Hirai ,  Keiko Sugihara ,  Junji Nishigaki

IPC分类号： C09K11/56 ,  B82B1/00 ,  C01G9/08

CPC分类号： C09K11/574 ,  B82Y15/00 ,  C09K11/584 ,  G01N33/582 ,  G01N33/588 ,  Y10S977/773 ,  Y10S977/786 ,  Y10S977/813 ,  Y10S977/824 ,  Y10S977/834 ,  Y10T428/2991

摘要： A doped-type metal sulfide phosphor nanoparticle, whose surface is modified with a surface modifier, the surface modifier being a compound of formula [I]: HS-L-W  Formula [I] wherein L is a divalent linking group; and W is COOM or NH2, in which M is a hydrogen atom, an alkali metal atom, or NX4, in which X is a hydrogen atom or an alkyl group; a dispersion containing the nanoparticle; and a method of producing the nanoparticle or the dispersion.

摘要翻译： 掺杂型金属硫化物荧光体纳米颗粒，其表面用表面改性剂改性，表面改性剂为式[I]的化合物：<？in-line-formula description =“In-line Formulas”end =“lead” α> HS-LW式[I] <？in-line-formula description =“In-line formula”end =“tail”？>其中L是二价连接基团; W为COOM或NH 2，其中M为氢原子，碱金属原子或NX4，其中X为氢原子或烷基; 含有纳米颗粒的分散体; 以及制备纳米颗粒或分散体的方法。

公开(公告)号：US20080156736A1

公开(公告)日：2008-07-03

申请号：US11883742

申请日：2006-02-08

申请人： Hiroyuki Hirai ,  Masayoshi Kojima

发明人： Hiroyuki Hirai ,  Masayoshi Kojima

IPC分类号： B03C1/02 ,  H01F1/42

CPC分类号： B03C1/01 ,  B82Y25/00 ,  H01F1/0054

摘要： A magnetic composite body comprising magnetic nanoparticles having a number average particle diameter of 1 to 50 nm and having a compound represented by formula (I) fixed on their surfaces, and a method comprising bringing the magnetic composite body into contact with a test piece followed by magnetic separation: R1O—(CH(R2)CH2O)n-L-X   Formula (I) wherein R1 represents a hydrogen atom, an alkyl or alkenyl group having a carbon chain length of 1 to 20, or a substituted or unsubstituted, aryl or heterocyclic group; R2 represents a hydrogen atom or a methyl group; L may be present or not present, and, when L is present, L represents an alkylene or alkenylene group having a carbon chain length of 1 to 10 which may have a branched chain or a substituent; X represents a hydrogen atom, a carboxylic acid group, a phosphoric acid group, or a sulfonic acid group; and n represents an integer of 1 to 10

摘要翻译： 一种磁性复合体，其包含数均粒径为1〜50nm的磁性纳米颗粒，并且具有固定在其表面上的式（I）表示的化合物，以及包括使磁性复合体与试验片接触的方法， 磁分离：<？in-line-formula description =“In-line Formulas”end =“lead”？> R O-（CH（R 2）2 CH 式（I）<？in-line-formula description =“In-line formula”end =“tail”？>其中R ^{1 表示氢原子，碳链长度为1-20的烷基或烯基，或取代或未取代的芳基或杂环基; R 2表示氢原子或甲基; L可以存在或不存在，并且当存在L时，L表示碳链长度为1至10的亚烷基或亚烯基，其可以具有支链或取代基; X表示氢原子，羧酸基，磷酸基或磺酸基; n表示1〜10的整数}

公开(公告)号：US07242591B2

公开(公告)日：2007-07-10

申请号：US10530518

申请日：2003-10-06

申请人： Tatsuro Imamura ,  Yuji Yamaguchi ,  Kazuhiro Shinozaki ,  Satoshi Shibazaki ,  Yoshitaka Fukuoka ,  Hiroyuki Hirai ,  Osamu Shimada ,  Kenji Sasaoka ,  Kenichi Matsumura

发明人： Tatsuro Imamura ,  Yuji Yamaguchi ,  Kazuhiro Shinozaki ,  Satoshi Shibazaki ,  Yoshitaka Fukuoka ,  Hiroyuki Hirai ,  Osamu Shimada ,  Kenji Sasaoka ,  Kenichi Matsumura

IPC分类号： H05K1/18

CPC分类号： H05K1/184 ,  H05K1/023 ,  H05K1/186 ,  H05K3/3442 ,  H05K3/4602 ,  H05K2201/10636 ,  Y02P70/611 ,  Y10T29/49126 ,  Y10T29/4913 ,  Y10T29/49146 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49165 ,  Y10T29/49789 ,  Y10T29/49798

摘要： To provide a component built-in wiring board and a manufacturing method thereof capable of further improving component mounting density without deteriorating reliability. The component built-in wiring board includes: a conductive layer (34, 35) extending in a thickness direction of the board and buried in the board without being exposed from an upper and a lower surface of the board; an electrical/electronic component (33) having a terminal and buried in the board with the terminal facing the buried conductive layer; a connecting member (36, 37) provided in a gap between the terminal of the buried electrical/electronic component and the conductive layer to electrically/mechanically connect the terminal and the conductive layer; and two upper and lower insulating layers (11, 15) which cover an outer surface of the buried electrical/electronic component excluding a portion connected to the connecting member and which are in close contact with a top and a bottom in the board thickness direction of the electrical/electronic component.

摘要翻译： 提供一种组件内置布线板及其制造方法，其能够进一步提高部件安装密度而不劣化可靠性。 所述部件内置布线板包括：导电层（34,35），其在所述板的厚度方向上延伸并埋设在所述板中而不暴露于所述板的上表面和下表面; 一个电子/电子部件（33），具有一个终端并埋设在该电路板中，该端子面向该掩埋的导电层; 设置在掩埋电气/电子部件的端子与导电层之间的间隙中的电连接/机械连接端子和导电层的连接件（36,37）; 以及两个覆盖所述埋入的电气/电子部件的外表面的绝缘层（11,15），除了连接到所述连接构件的部分之外，所述外部表面与所述电气/电子部件的板厚方向上的顶部和底部紧密接触 电气/电子部件。

公开(公告)号：US20070125985A1

公开(公告)日：2007-06-07

申请号：US11647368

申请日：2006-12-29

申请人： Hiroyuki Hirai ,  Keiko Sugihara ,  Junji Nishigaki

发明人： Hiroyuki Hirai ,  Keiko Sugihara ,  Junji Nishigaki

IPC分类号： C09K11/54 ,  C09K11/56

CPC分类号： C09K11/574 ,  B82Y15/00 ,  C09K11/584 ,  G01N33/582 ,  G01N33/588 ,  Y10S977/773 ,  Y10S977/786 ,  Y10S977/813 ,  Y10S977/824 ,  Y10S977/834 ,  Y10T428/2991

摘要： A doped-type metal sulfide phosphor nanoparticle dispersion, comprising a doped-type metal sulfide phosphor nanoparticle dispersed in water and/or a hydrophilic solvent, wherein the doped-type metal sulfide phosphor nanoparticle comprises a surface that is modified with a surface modifier, the surface modifier being a compound represented by formula [I]: HS-L-W   Formula [I] wherein L represents a divalent linking group; and W represents COOM or NH2, in which M represents a hydrogen atom, an alkali metal atom, or NX4, in which X represents a hydrogen atom or an alkyl group.

摘要翻译： 掺杂型金属硫化物荧光体纳米颗粒分散体，其包含分散在水中的掺杂型金属硫化物荧光体纳米颗粒和/或亲水性溶剂，其中所述掺杂型金属硫化物荧光体纳米颗粒包括用表面改性剂改性的表面， 表面改性剂是由式[I]表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> HS-LW Formula [I] <？in-line-formula description = “In-line Formulas”end =“tail”？>其中L表示二价连接基团; W表示COOM或NH 2，其中M表示氢原子，碱金属原子或NX 4，其中X表示氢原子或烷基 。

公开(公告)号：US20070108415A1

公开(公告)日：2007-05-17

申请号：US11647369

申请日：2006-12-29

申请人： Hiroyuki Hirai ,  Keiko Sugihara ,  Junji Nishigaki

发明人： Hiroyuki Hirai ,  Keiko Sugihara ,  Junji Nishigaki

IPC分类号： C09K11/08

CPC分类号： C09K11/574 ,  B82Y15/00 ,  C09K11/584 ,  G01N33/582 ,  G01N33/588 ,  Y10S977/773 ,  Y10S977/786 ,  Y10S977/813 ,  Y10S977/824 ,  Y10S977/834 ,  Y10T428/2991

摘要： A doped-type metal sulfide phosphor nanoparticle dispersion, comprising a doped-type metal sulfide phosphor nanoparticle dispersed in a hydrophobic organic solvent, wherein the doped-type metal sulfide phosphor nanoparticle comprises a surface that is modified with a surface modifier, the surface modifier being a compound represented by formula [I]: HS-L-W  Formula [I] wherein L represents a divalent linking group; and W represents COOM or NH2, in which M represents a hydrogen atom, an alkali metal atom, or NX4, in which X represents a hydrogen atom or an alkyl group.

摘要翻译： 1.一种掺杂型金属硫化物荧光体纳米颗粒分散体，其包含分散在疏水性有机溶剂中的掺杂型金属硫化物荧光体纳米粒子，其中所述掺杂型金属硫化物荧光体纳米粒子包含用表面改性剂改性的表面，所述表面改性剂为 由式[I]表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> HS-LW Formula [I] <？in-line-formula description =“In- 线式“end =”tail“？>其中L表示二价连接基团; W表示COOM或NH 2，其中M表示氢原子，碱金属原子或NX 4，其中X表示氢原子或烷基 。