摘要:
Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, halogen, trifluoromethyl, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, or nitro, and R.sup.3 is hydrogen, halogen or alkyl having 1 to 6 carbon atoms, and pharmaceutically acceptable salts thereof, processes for preparation thereof, and pharmaceutical composition containing the same. Said compounds and their salts show excellent aldose reductase inhibitory activity and are useful for the prevention and treatment of diabetic complications.
摘要:
The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof, methods for producing them and pharmaceutical compositions containing them: wherein A is a group represented by Formula (a) or the like: (wherein either R4 or R5 represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R1 or R2 represents a group: -D-(X)m-R6 or the like, and the other represents a group: -E-(Y)n-R7, hydrogen atom, aryl or the like; R3 is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent O or the like; R6 and R7 independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted. Such compounds exhibit a potent antagonistic activity on glucagon receptor and are of use as preventive and/or therapeutic agents for symptoms and diseases in which glucagon is involved.
摘要翻译:本发明提供由下述通式(I)表示的2-呋喃甲酰肼化合物及其前体药物,生理学上可接受的盐,水合物,溶剂化物,其制备方法和含有它们的药物组合物:其中A是由式 a)等:(其中R 4或R 5或R 5表示氰基,硝基等,另一个表示氢原子等); R 1或R 2 2代表基团:-D-(X)m R 6等,另一个表示一个基团: -E-(Y)nR 7,氢原子,芳基等; R 3是氢原子等; D和E独立地表示芳基; X和Y独立地表示O等; R 6和R 7独立地代表烷基,芳基,芳烷基等; 并且m和n独立地为0或1,条件是芳基任选被取代。 这些化合物对胰高血糖素受体表现出有效的拮抗活性,并且可用作涉及胰高血糖素的症状和疾病的预防和/或治疗剂。
摘要:
The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof: wherein A is a group represented by Formula (a) or the like: (wherein either R4 or R5 represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R1 or R2 represents a group: -D-(X)m-R6 or the like, and the other represents a group: -E-(Y)n-R7, hydrogen atom, aryl or the like; R3 is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent O or the like; R6 and R7 independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted.
摘要:
A warning system for conveying alerts and information relating to a vehicle blind spot and objects detected therein, is disclosed. The system conveys an assortment of information through a single light emitting indicator. Also disclosed are various methods of indicating the advisability of lane changes, and modes of configuring the indicator and an associated sensing system and controller.
摘要:
To provide a tungsten oxide photocatalyst which shows a high photocatalytic activity by irradiating with visible light even under the environment where ultraviolet light is not irradiated, the tungsten oxide photocatalyst has tungsten oxide particles and Pt particles having a primary particle size of 3 to 20 nm supported on the surface of the tungsten oxide particles in an amount of 0.03 to 5 parts by weight based on 100 parts by weight of the tungsten oxide particles.
摘要:
An information processing device includes a processing unit that recognizes an action based on sensor data output by a sensor and obtained in a same timing as a photographing timing of an image string. The processing unit associates information indicating the action as information for a selection of a reproduction position at a time of a reproduction of the image string with the image string. In addition, the processing unit extracts a plurality of features from the sensor data. The processing unit recognizes the action based on a time series of the plurality of features using a model for a recognition.
摘要:
A picture processing apparatus is disclosed which includes: an acquiring device which, apart from a first picture sequence picked up for reproduction purposes, acquires a second picture sequence picked up in synchronism with the first picture sequence, the second picture sequence being made up of pictures wider in angle than those constituting the first picture sequence; a calculating device operable to calculate degrees of similarity between scenes each made up of a predetermined number of consecutive pictures included in the second picture sequence; and a linking device which, after appropriating the degrees of similarity calculated by the calculating device for the degrees of similarity between the corresponding scenes in the first picture sequence, links together those of the corresponding scenes which have high degrees of similarity in the first picture sequence.
摘要:
In a vehicle having an electrical system including a ground circuit that provides an operative connection from the electrical system to an electrical ground and an electric power generator driven by an engine of the vehicle, the generator arranged to selectively provide electric power to an electrical load of the vehicle and to selectively charge a battery of the vehicle, a fault detection system is provided for detecting an open circuit or high resistance fault in the ground circuit. The fault detection system includes: a controller that controls a voltage output of the generator so as to at least one of restrict or suspend charging or increase or start charging of the battery by the generator for a designated test period; and, determining means for determining a current discharge from or charging current into the battery during the test period, wherein if the determined current discharge or charging current is less than a given threshold, then an open circuit or high resistance fault is deemed to be detected in the ground circuit.
摘要:
A photocatalyst dispersion liquid contains titanium oxide particles, tungsten oxide particles, a phosphoric acid (salt) and a dispersion medium, and a containing amount of the phosphoric acid (salt) is from 0.001 mol times to 0.2 mol times with respect to the titanium oxide particles. In this photocatalyst dispersion liquid, the aggregation of the particles is suppressed and thus solid-liquid separation is not easily generated. According to this process for producing a photocatalyst dispersion liquid, titanium oxide particles are dispersed in a dispersion medium containing a phosphoric acid (salt) dissolved therein to obtain a titanium oxide particle dispersion liquid, and then tungsten oxide particles are mixed in the titanium oxide particle dispersion liquid.
摘要:
An image recognition apparatus, method and program capable of discriminatively recognizing an object at an enhanced recognition rate despite an increase in the total number of reference images registered in image databases. When any individual person or public corporation for example is to be specified from the object image obtained by shooting the person or the like, one image database of the attribute corresponding to various situations, or familiarity to the object image is selected automatically, and then the person or corporation is specified from the shot image while referring to the reference images stored in the image database of the selected attribute. Therefore, even if the sum of the reference images is increased, since they are subdivided and classified corresponding to the attributes, the number of the reference images for each attribute can be reduced, and further the image database of the optimal attribute can be selected automatically in conformity to the situation of recognition such as date, time and so on. Thus, the number of the reference images can be minimized without the user's intentional manipulation, and the reference images are narrowed down due to the additional information of the situation.