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1.发明授权Detection of circulating tumor cells in peripheral blood with an automated scanning fluorescence microscope 有权用自动扫描荧光显微镜检测外周血中的循环肿瘤细胞公开(公告)号：US08445411B2
公开(公告)日：2013-05-21
申请号：US13337823
申请日：2011-12-27
申请人： Sir Walter Bodmer , Triantafyllos P. Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
发明人： Sir Walter Bodmer , Triantafyllos P. Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
IPC分类号： C40B30/04
CPC分类号： G06K9/00127 , G01N21/6458
摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
摘要翻译： 一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。
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公开(公告)号：US20080206774A1
公开(公告)日：2008-08-28
申请号：US12051032
申请日：2008-03-19
申请人： Triantafyllos P. Tafas , Michael Kilpatrick , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Petros Tsipouras
发明人： Triantafyllos P. Tafas , Michael Kilpatrick , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Petros Tsipouras
IPC分类号： C12Q1/68
CPC分类号： G01N33/5005 , G01N21/6458 , G01N2021/6439 , G06K9/0014 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
摘要： In various embodiments methods for automated screening for gene amplification in biological tissue samples using an automated fluorescence microscope to analyze fluorescence in situ hybridized samples are provided. Various additional embodiments provide methods of high throughput screening for gene amplification.
摘要翻译： 在各种实施方案中，提供了使用自动荧光显微镜自动筛选生物组织样品中基因扩增以分析荧光原位杂交样品的方法。 各种另外的实施方案提供了用于基因扩增的高通量筛选方法。
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公开(公告)号：US07901887B2
公开(公告)日：2011-03-08
申请号：US12051032
申请日：2008-03-19
申请人： Triantafyllos P. Tafas , Michael Kilpatrick , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Petros Tsipouras
发明人： Triantafyllos P. Tafas , Michael Kilpatrick , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Petros Tsipouras
CPC分类号： G01N33/5005 , G01N21/6458 , G01N2021/6439 , G06K9/0014 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
摘要： In various embodiments methods for automated screening for gene amplification in biological tissue samples using an automated fluorescence microscope to analyze fluorescence in situ hybridized samples are provided. Various additional embodiments provide methods of high throughput screening for gene amplification.
摘要翻译： 在各种实施方案中，提供了使用自动荧光显微镜自动筛选生物组织样品中基因扩增以分析荧光原位杂交样品的方法。 各种另外的实施方案提供了用于基因扩增的高通量筛选方法。
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公开(公告)号：US20090111101A1
公开(公告)日：2009-04-30
申请号：US12013944
申请日：2008-01-14
申请人： Triantafyllos P. Tafas , Michael Kilpatrick , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Petros Tsipouras
发明人： Triantafyllos P. Tafas , Michael Kilpatrick , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Petros Tsipouras
CPC分类号： C12Q1/6841 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2021/6439 , G01N2035/1034 , G06K9/00127 , G06K9/0014 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
摘要： In various embodiments methods for automated screening for gene amplification in biological tissue samples using an automated fluorescence microscope to analyze fluorescence in situ hybridized samples are provided. Various additional embodiments provide methods of high throughput screening for gene amplification.
摘要翻译： 在各种实施方案中，提供了使用自动荧光显微镜自动筛选生物组织样品中基因扩增以分析荧光原位杂交样品的方法。 各种另外的实施方案提供了用于基因扩增的高通量筛选方法。
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公开(公告)号：US20160025755A1
公开(公告)日：2016-01-28
申请号：US14446130
申请日：2014-07-29
申请人： Youngmin Kim , Yanning ZHU , Yash AGARWAL , Xiuzhong WANG , Aaron ARMSTRONG , Robert BORGERDING , Andrew MACGINITIE , Antti SEPPO , Ilia JCHETOVKIN , Michael KILPATRICK , Petros TSIPOURAS , Triantafyllos P. TAFAS
发明人： Youngmin Kim , Yanning ZHU , Yash AGARWAL , Xiuzhong WANG , Aaron ARMSTRONG , Robert BORGERDING , Andrew MACGINITIE , Antti SEPPO , Ilia JCHETOVKIN , Michael KILPATRICK , Petros TSIPOURAS , Triantafyllos P. TAFAS
CPC分类号： G01N35/00732 , G01J3/2803 , G01J3/4406 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00851 , G01N2201/06113 , G01N2201/12
摘要： A method for automated microscopic analysis wherein the test protocol is obtained from interrogatable data affixed to each microscope slide. The method further comprises the algorithms that implement the test protocol.
摘要翻译： 一种用于自动显微镜分析的方法，其中从每个显微镜载片上的可询问数据获得测试方案。 该方法还包括实现测试协议的算法。
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6.发明授权Detection of circulating tumor cells in peripheral blood with an automated scanning fluorescence microscope 有权用自动扫描荧光显微镜检测外周血中的循环肿瘤细胞公开(公告)号：US08088715B2
公开(公告)日：2012-01-03
申请号：US12270820
申请日：2008-11-13
申请人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
发明人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
IPC分类号： C40B30/04
CPC分类号： G06K9/00127 , G01N21/6458
摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
摘要翻译： 一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。
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7.发明申请公开(公告)号：US20090123054A1
公开(公告)日：2009-05-14
申请号：US12270820
申请日：2008-11-13
申请人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
发明人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
IPC分类号： G06K9/00
CPC分类号： G06K9/00127 , G01N21/6458
摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
摘要翻译： 一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。
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8.发明申请公开(公告)号：US20120094868A1
公开(公告)日：2012-04-19
申请号：US13337823
申请日：2011-12-27
申请人： Sir Walter BODMER , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
发明人： Sir Walter BODMER , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
IPC分类号： C40B30/10
CPC分类号： G06K9/00127 , G01N21/6458
摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
摘要翻译： 一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。
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公开(公告)号：US07902814B2
公开(公告)日：2011-03-08
申请号：US12330104
申请日：2008-12-08
申请人： Triantafyllos Tafas , Yash Agarwal , Youngmin Kim , Wei Guo , Richard Eberle , Joseph Turgeon , Michael Kilpatrick , Petros Tsipouras
发明人： Triantafyllos Tafas , Yash Agarwal , Youngmin Kim , Wei Guo , Richard Eberle , Joseph Turgeon , Michael Kilpatrick , Petros Tsipouras
IPC分类号： G01R31/302
CPC分类号： G02B21/24
摘要： A displaceable light-tight enclosure system housing an automated robotic microscope having electronically controllable components and an image capture device. The enclosure system includes a device(s) for displacement, an externally viewable monitor, and a plurality of electrical power receptacles. The light-tight enclosure system also incorporates an anti-fall support leg that may be extended from the enclosure.
摘要翻译： 容纳具有电子可控组件和图像捕获装置的自动机器人显微镜的可置换的不透光外壳系统。 外壳系统包括用于移动的装置，外部可观察的监视器和多个电力插座。 不透光的外壳系统还包括可从外壳延伸的防跌落支撑腿。
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10.发明授权公开(公告)号：US07948676B2
公开(公告)日：2011-05-24
申请号：US11833517
申请日：2007-08-03
申请人： Tibor Virag , Yash Agarwal , Wei Guo , Richard Eberle , Youngmin Kim , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
发明人： Tibor Virag , Yash Agarwal , Wei Guo , Richard Eberle , Youngmin Kim , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G02B21/26
CPC分类号： G02B21/34 , G01N35/026 , G01N35/04 , G01N2035/0425 , G01N2035/0427 , Y10S359/90
摘要： An automated cassette and slide handling system is disclosed which organizes microscope slides in cassettes, automatically and sequentially removes individual slides from their respective cassettes, positioned each slide under the microscope as provided by the protocol, and after examination returns the slide to its proper cassette.
摘要翻译： 公开了一种自动化的盒式磁带和幻灯片处理系统，其在盒中组织显微镜幻灯片，自动地并且顺序地从其各自的盒中移除各个幻灯片，每个幻灯片根据协议设置在显微镜下放置，并且在检查后将幻灯片返回到其正确的盒。
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