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公开(公告)号：US20230077385A1
公开(公告)日：2023-03-16
申请号：US18058530
申请日：2022-11-23
Applicant: University of Washington , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US12270067B2
公开(公告)日：2025-04-08
申请号：US18058530
申请日：2022-11-23
Applicant: University of Washington , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US11542539B2
公开(公告)日：2023-01-03
申请号：US16307363
申请日：2017-06-05
Applicant: UNIVERSITY OF WASHINGTON , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US20190284601A1
公开(公告)日：2019-09-19
申请号：US16307363
申请日：2017-06-05
Applicant: UNIVERSITY OF WASHINGTON , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US20230408526A1
公开(公告)日：2023-12-21
申请号：US18058458
申请日：2022-11-23
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H10K85/10 , C09K11/06 , C08G61/12 , C08J3/11 , C09K11/02
CPC classification number: G01N33/588 , C09K2211/1425 , B82Y40/00 , B82Y15/00 , H10K85/115 , C09K11/06 , C08G61/126 , C08J3/11 , C09K11/025 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J2327/22 , B82Y30/00
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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Patent Agency Ranking
公开(公告)号：US11835526B2
公开(公告)日：2023-12-05
申请号：US17672586
申请日：2022-02-15
Inventor： Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
CPC classification number: G01N33/587 , C09K11/06 , G01N33/582
Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号：US11674964B2
公开(公告)日：2023-06-13
申请号：US17538447
申请日：2021-11-30
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
CPC classification number: G01N33/58 , C09K11/02 , C09K11/06 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US11585818B2
公开(公告)日：2023-02-21
申请号：US16989491
申请日：2020-08-10
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: C09K11/02 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , C09K11/06 , H01L51/00 , C08G61/12 , C08J3/11
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US10444243B2
公开(公告)日：2019-10-15
申请号：US15100056
申请日：2014-11-25
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US20250035636A1
公开(公告)日：2025-01-30
申请号：US18911931
申请日：2024-10-10
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/12 , C08J3/11 , C09K11/02 , C09K11/06 , H10K85/10
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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