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公开(公告)号：US20230077385A1
公开(公告)日：2023-03-16
申请号：US18058530
申请日：2022-11-23
Applicant: University of Washington , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US12270067B2
公开(公告)日：2025-04-08
申请号：US18058530
申请日：2022-11-23
Applicant: University of Washington , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US20230159979A1
公开(公告)日：2023-05-25
申请号：US17904916
申请日：2021-04-15
Applicant: UNIVERSITY OF WASHINGTON , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Haobin Chen , Jiangbo Yu
CPC classification number: C12Q1/32 , C12Q1/008 , C09K11/06 , C09K11/025 , B82Y20/00
Abstract: Transducers, kits, systems, and methods for determining a concentration of an analyte are described. In an embodiment, the transducers include a chromophore; and an enzyme physically associated with the chromophore. In an embodiment, the transducer is configured to catalyze a reaction comprising a plurality of reaction elements. In an embodiment, the plurality of reaction elements comprises one or more reactants including the analyte and one or more products. In an embodiment, an amount of fluorescence emitted from the chromophore is determined by a concentration of a reaction element of the plurality of reaction elements.
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公开(公告)号：US11542539B2
公开(公告)日：2023-01-03
申请号：US16307363
申请日：2017-06-05
Applicant: UNIVERSITY OF WASHINGTON , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US20190284601A1
公开(公告)日：2019-09-19
申请号：US16307363
申请日：2017-06-05
Applicant: UNIVERSITY OF WASHINGTON , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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Patent Agency Ranking
公开(公告)号：US12272468B2
公开(公告)日：2025-04-08
申请号：US18484587
申请日：2023-10-11
Applicant: University of Washington
Inventor： Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号：US11823809B2
公开(公告)日：2023-11-21
申请号：US17368078
申请日：2021-07-06
Applicant: University of Washington
Inventor： Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
CPC classification number: H01B1/18 , C07K14/00 , C07K16/00 , C08K3/36 , C08L83/04 , G02F1/015 , C08K2201/001 , C08L2203/20
Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号：US10770197B2
公开(公告)日：2020-09-08
申请号：US16309795
申请日：2017-06-13
Applicant: University of Washington
Inventor： Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号：US10514381B2
公开(公告)日：2019-12-24
申请号：US14774971
申请日：2014-03-14
Inventor： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC: G01N33/58 , C09K11/02 , G01N33/543 , C08G61/02 , C08G73/00 , C08G75/32 , G01N33/533
Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
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公开(公告)号：US09810693B2
公开(公告)日：2017-11-07
申请号：US13865942
申请日：2013-04-18
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , C09K11/06 , B82Y30/00 , B82Y40/00 , H01L51/00 , B82Y15/00 , C08G61/12 , C08J3/11 , C09K11/02
CPC classification number: G01N33/588 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/126 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J3/11 , C08J2327/22 , C09K11/025 , C09K11/06 , C09K2211/1425 , H01L51/0039
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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