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公开(公告)号：US08499613B2
公开(公告)日：2013-08-06
申请号：US13016086
申请日：2011-01-28
申请人： Federico Giovanni Ziglioli , Amedeo Maierna , Flavio Francesco Villa , Ubaldo Mastromatteo , Gabriele Barlocchi
发明人： Federico Giovanni Ziglioli , Amedeo Maierna , Flavio Francesco Villa , Ubaldo Mastromatteo , Gabriele Barlocchi
IPC分类号： G01N7/04
CPC分类号： G01N33/0009
摘要： A cartridge-like chemical sensor is formed by a housing having a base and a cover fixed to the base and provided with an input opening, an output hole and a channel for a gas to be analyzed. The channel extends in the cover between the input opening and the output hole and faces a printed circuit board carrying an integrated circuit having a sensitive region open toward the channel and of a material capable to bind with target chemicals in the gas to be analyzed. A fan is arranged in the housing, downstream of the integrated device, for sucking the gas after being analyzed, and is part of a thermal control system for the integrated circuit.
摘要翻译： 盒式化学传感器由壳体形成，壳体具有固定到基座的基部和盖，并且设置有用于待分析气体的输入开口，输出孔和通道。 通道在输入开口和输出孔之间的盖中延伸，并且面向承载具有朝向通道开口的敏感区域的集成电路的印刷电路板和能够与要分析的气体中的目标化学物质结合的材料。 在集成装置的下游的壳体内设置风扇，用于在分析后吸入气体，并且是集成电路的热控制系统的一部分。
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公开(公告)号：US09170183B2
公开(公告)日：2015-10-27
申请号：US13621176
申请日：2012-09-15
CPC分类号： B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/0684 , B01L2300/0645 , B01L2300/087 , B01L2400/049 , G01N5/02 , G01N29/022 , G01N33/54366 , G01N33/5438 , G01N33/76 , G01N2035/00237
摘要： A device for detecting the concentration of biological materials, is formed in a body having a plurality of fluidic paths connectable to a multi-microbalance structure carrying a plurality of microbalances, each microbalance having a sensitive portion facing a reaction chamber. The body and the multi-microbalance structure are configured to be mechanically coupled together and each microbalance is configured to be coupled to a respective fluidic path. Each fluidic path includes an inlet, a duct and a liquid waste, each duct being configured to be coupled with a respective reaction chamber. The plurality of fluidic paths and microbalances form at least one first and one second reference cells and one first sample cell.
摘要翻译： 用于检测生物材料浓度的装置形成在具有可连接到多微量平衡结构的多个微量平衡结构的多个流体路径的主体中，每个微量天平具有面向反应室的敏感部分。 主体和多微平衡结构被配置为机械耦合在一起，并且每个微量天平被配置为耦合到相应的流体路径。 每个流体路径包括入口，管道和液体废物，每个管道被配置为与相应的反应室联接。 多个流体路径和微量平衡形成至少一个第一和第二参考单元和一个第一样品池。
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3.发明授权Integrated chemical microreactor with large area channels and manufacturing process thereof 有权具有大面积通道的集成化学微反应器及其制造工艺公开(公告)号：US07732192B2
公开(公告)日：2010-06-08
申请号：US11743062
申请日：2007-05-01
IPC分类号： C12N1/10
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , Y10T436/114998
摘要： The microreactor has a body of semiconductor material; a large area buried channel extending in the body and having walls; a coating layer of insulating material coating the walls of the channel; a diaphragm extending on top of the body and upwardly closing the channel. The diaphragm is formed by a semiconductor layer completely encircling mask portions of insulating material.
摘要翻译： 微反应器具有半导体材料体; 一个大面积的埋藏通道延伸到身体并具有墙壁; 覆盖通道壁的绝缘材料的涂层; 一个在主体顶部延伸并向上关闭通道的隔膜。 隔膜由完全环绕绝缘材料的掩模部分的半导体层形成。
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公开(公告)号：US08586351B2
公开(公告)日：2013-11-19
申请号：US12649019
申请日：2009-12-29
IPC分类号： C12M1/34
CPC分类号： G01N29/022 , C12Q1/6825 , G01N2291/02466 , G01N2291/0426 , C12Q2565/629 , C12Q2563/131
摘要： A hybridization detecting device, wherein a probe cell has a body of semiconductor material forming a diaphragm, a first electrode on the diaphragm, a piezoelectric region on the first electrode, a second electrode on the piezoelectric region and a detection layer on the second electrode. The body accommodates a buried cavity downwardly delimiting the diaphragm.
摘要翻译： 一种杂交检测装置，其中探针单元具有形成隔膜的半导体材料体，隔膜上的第一电极，第一电极上的压电区域，压电区域上的第二电极和第二电极上的检测层。 主体容纳向下限定隔膜的掩埋腔。
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5.发明申请FLUIDIC CARTRIDGE FOR DETECTING CHEMICALS IN SAMPLES, IN PARTICULAR FOR PERFORMING BIOCHEMICAL ANALYSES 有权用于检测样品中化学品的流体盒，特别是用于生物化学分析公开(公告)号：US20110318840A1
公开(公告)日：2011-12-29
申请号：US13170058
申请日：2011-06-27
申请人： Federico Giovanni Ziglioli , Amedeo Maierna , Ubaldo Mastromatteo , Gabriele Barlocchi , Flavio Francesco Villa
发明人： Federico Giovanni Ziglioli , Amedeo Maierna , Ubaldo Mastromatteo , Gabriele Barlocchi , Flavio Francesco Villa
IPC分类号： G01N30/00
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0645 , B01L2300/0672 , B01L2300/0816 , B01L2300/0867 , B01L2300/1827 , B01L2400/0439 , Y10T436/11
摘要： A fluidic cartridge for detecting chemicals, formed by a casing, hermetically housing an integrated device having a plurality of detecting regions to bind with target chemicals; part of a supporting element, bearing the integrated device; a reaction chamber, facing the detecting regions; a sample feeding hole and a washing feeding hole, self-sealingly closed; fluidic paths, which connect the sample feeding and washing feeding holes to the reaction chamber; and a waste reservoir, which may be fluidically connected to the reaction chamber by valve elements that may be controlled from outside. The integrated device is moreover connected to an interface unit carried by the supporting element, electrically connected to the integrated device and including at least one signal processing stage and external contact regions.
摘要翻译： 一种用于检测由壳体形成的化学品的流体盒，其气密地容纳具有多个检测区域以与目标化学品结合的集成装置; 支撑元件的一部分，承载集成装置; 反应室，面对检测区域; 样品供给孔和洗涤进料孔，自密封; 流体路径，其将样品进料和洗涤进料孔连接到反应室; 以及可以通过可从外部控制的阀元件流体地连接到反应室的废物储存器。 此外，集成装置还连接到由支撑元件承载的接口单元，电连接到集成装置并且包括至少一个信号处理级和外部接触区域。
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公开(公告)号：US20100170324A1
公开(公告)日：2010-07-08
申请号：US12648996
申请日：2009-12-29
CPC分类号： G01G3/13 , G01G3/16 , G01N29/036 , G01N2291/0256 , Y10T29/42
摘要： An electronic microbalance made in a semiconductor body accommodating an oscillating circuit adjacent to a diaphragm. A stack formed by a first electrode, a second electrode, and a piezoelectric region arranged between the first and the second electrode extends above the diaphragm. Any substance that deposits on the stack causes a change in the mass of the microbalance and thus in the resonance frequency of a resonator formed by the microbalance and by the oscillating circuit and can thus be detected electronically. A chemical sensor is obtained by forming a sensitive layer of a material suitable for binding to target chemicals on the stack. The sensitivity of the microbalance can be increased by making the first electrode of molybdenum so as to increase the piezoelectric characteristics of the piezoelectric region.
摘要翻译： 一种电子微量天平，其制造在容纳与隔膜相邻的振荡电路的半导体主体中。 由第一电极，第二电极和布置在第一和第二电极之间的压电区形成的堆叠在隔膜的上方延伸。 沉积在堆叠上的任何物质都会导致微量天平的质量的变化，从而导致由微量天平形成的谐振器和振荡电路的共振频率的变化，并且因此可以被电子地检测。 通过形成适合于与堆叠上的目标化学物质结合的材料的敏感层来获得化学传感器。 可以通过使钼的第一电极增加压电区域的压电特性来增加微量天平的灵敏度。
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公开(公告)号：US07635454B2
公开(公告)日：2009-12-22
申请号：US10997235
申请日：2004-11-24
IPC分类号： B01J19/00
CPC分类号： B01L3/502715 , B01L3/5025 , B01L3/502707 , B01L7/52 , B01L2200/027 , B01L2200/12 , B01L2300/044 , B01L2300/0816 , B01L2300/1827
摘要： The microreactor is formed by a sandwich including a first body, an intermediate sealing layer and a second body. A buried channel extends in the first body and communicates with the surface of the first body through a first and a second apertures. A first and a second reservoirs are formed in the second body and are at least partially aligned with the first and second apertures. The sealing layer separates the first aperture from the first reservoir and the second aperture from the second reservoir, thereby avoiding contamination of liquids contained in the buried channel from the outside and from any adjacent buried channels. The sealing layer is perforated during use of the device, but a resilient plug can be used to reseal the device.
摘要翻译： 微反应器由包括第一主体，中间密封层和第二主体的夹层形成。 掩埋通道在第一主体中延伸并且通过第一和第二孔与第一主体的表面连通。 第一和第二储存器形成在第二主体中并且至少部分地与第一和第二孔对准。 密封层将第一孔与第一储存器和第二孔分隔开来自第二储存器，从而避免了从外部和任何相邻的埋入通道污染包含在掩埋通道中的液体。 在使用该装置期间密封层是穿孔的，但是可以使用弹性塞来重新密封装置。
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公开(公告)号：US08448494B2
公开(公告)日：2013-05-28
申请号：US12648996
申请日：2009-12-29
IPC分类号： G01H11/08
CPC分类号： G01G3/13 , G01G3/16 , G01N29/036 , G01N2291/0256 , Y10T29/42
摘要： An electronic microbalance made in a semiconductor body accommodating an oscillating circuit adjacent to a diaphragm. A stack formed by a first electrode, a second electrode, and a piezoelectric region arranged between the first and the second electrode extends above the diaphragm. Any substance that deposits on the stack causes a change in the mass of the microbalance and thus in the resonance frequency of a resonator formed by the microbalance and by the oscillating circuit and can thus be detected electronically. A chemical sensor is obtained by forming a sensitive layer of a material suitable for binding to target chemicals on the stack. The sensitivity of the microbalance can be increased by making the first electrode of molybdenum so as to increase the piezoelectric characteristics of the piezoelectric region.
摘要翻译： 一种电子微量天平，其制造在容纳与隔膜相邻的振荡电路的半导体主体中。 由第一电极，第二电极和布置在第一和第二电极之间的压电区形成的堆叠在隔膜的上方延伸。 沉积在堆叠上的任何物质都会导致微量天平的质量的变化，从而导致由微量天平形成的谐振器和振荡电路的共振频率的变化，并且因此可以被电子地检测。 通过形成适合于与堆叠上的目标化学物质结合的材料的敏感层来获得化学传感器。 可以通过使钼的第一电极增加压电区域的压电特性来增加微量天平的灵敏度。
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公开(公告)号：US20130078643A1
公开(公告)日：2013-03-28
申请号：US13621176
申请日：2012-09-15
CPC分类号： B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/0684 , B01L2300/0645 , B01L2300/087 , B01L2400/049 , G01N5/02 , G01N29/022 , G01N33/54366 , G01N33/5438 , G01N33/76 , G01N2035/00237
摘要： A device for detecting the concentration of biological materials, is formed in a body having a plurality of fluidic paths connectable to a multi-microbalance structure carrying a plurality of microbalances, each microbalance having a sensitive portion facing a reaction chamber. The body and the multi-microbalance structure are configured to be mechanically coupled together and each microbalance is configured to be coupled to a respective fluidic path. Each fluidic path includes an inlet, a duct and a liquid waste, each duct being configured to be coupled with a respective reaction chamber. The plurality of fluidic paths and microbalances form at least one first and one second reference cells and one first sample cell.
摘要翻译： 用于检测生物材料浓度的装置形成在具有可连接到多微量平衡结构的多个微量平衡结构的多个流体路径的主体中，每个微量天平具有面向反应室的敏感部分。 主体和多微平衡结构被配置为机械耦合在一起，并且每个微量天平被配置为耦合到相应的流体路径。 每个流体路径包括入口，管道和液体废物，每个管道被配置为与相应的反应室联接。 多个流体路径和微量平衡形成至少一个第一和第二参考单元和一个第一样品池。
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公开(公告)号：US20110209524A1
公开(公告)日：2011-09-01
申请号：US13016086
申请日：2011-01-28
申请人： Federico Giovanni Ziglioli , Amedeo Maierna , Flavio Francesco Villa , Ubaldo Mastromatteo , Gabriele Barlocchi
发明人： Federico Giovanni Ziglioli , Amedeo Maierna , Flavio Francesco Villa , Ubaldo Mastromatteo , Gabriele Barlocchi
IPC分类号： G01N33/00
CPC分类号： G01N33/0009
摘要： A cartridge-like chemical sensor is formed by a housing having a base and a cover fixed to the base and provided with an input opening, an output hole and a channel for a gas to be analyzed. The channel extends in the cover between the input opening and the output hole and faces a printed circuit board carrying an integrated circuit having a sensitive region open toward the channel and of a material capable to bind with target chemicals in the gas to be analyzed. A fan is arranged in the housing, downstream of the integrated device, for sucking the gas after being analyzed, and is part of a thermal control system for the integrated circuit.
摘要翻译： 盒式化学传感器由壳体形成，壳体具有固定到基座的基部和盖，并且设置有用于待分析气体的输入开口，输出孔和通道。 通道在输入开口和输出孔之间的盖中延伸，并且面向承载具有朝向通道开口的敏感区域的集成电路的印刷电路板和能够与要分析的气体中的目标化学物质结合的材料。 在集成装置的下游的壳体内设置风扇，用于在分析后吸入气体，并且是集成电路的热控制系统的一部分。
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