公开(公告)号：US4266021A

公开(公告)日：1981-05-05

申请号：US968202

申请日：1978-12-11

申请人： Ulf T. G. Nylen ,  Lars-Goran Olsson ,  Bengt G. Paulsson ,  Lars A. G. Qvarnstrom ,  Rolf H. L. Wichers

发明人： Ulf T. G. Nylen ,  Lars-Goran Olsson ,  Bengt G. Paulsson ,  Lars A. G. Qvarnstrom ,  Rolf H. L. Wichers

IPC分类号： G01N33/48 ,  A61B5/00 ,  A61M1/16 ,  A61M1/34 ,  C12Q1/00 ,  G01N33/487 ,  C12M1/34 ,  C12Q1/54 ,  G01N31/14

CPC分类号： C12Q1/00 ,  A61B5/14525 ,  A61B5/14865 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/3437 ,  Y10T436/255

摘要： A method and apparatus is provided for measuring the content of a compound in a liquid medium, and which is particularly useful for measuring the concentration of a low molecular weight compound in a complex medium in which there is provided a dialyzer in contact with the complex fluid medium and through which dialysis fluid is conducted to receive by diffusion a portion of the low molecular weight compound to produce a dialysate. The dialysate with the low molecular weight commpound to be examined is first conducted through a venting device for removal of gaseous particles therefrom before conduction through a reaction chamber containing enzymes for promoting the conversion of the low molecular weight compound in the dialysate into a converted reaction product. The dialysate is then conducted from the reaction chamber to a measuring unit for measuring the concentration of the converted reaction product in the dialysate conducted from the reaction chamber, the concentration of the converted reaction product being representative of the content of the low molecular weight compound in the complex fluid medium.

摘要翻译： 提供了一种用于测量液体介质中化合物含量的方法和装置，其特别可用于测量复合介质中的低分子量化合物的浓度，其中提供了与复合流体接触的透析器 通过透析液进行渗透以通过扩散一部分低分子量化合物以产生透析液。 首先通过排气装置进行待检查的低分子量通气的透析液，以便在通过含有促进透析液中低分子量化合物转化为转化反应产物的酶的反应室之前从其中除去气态颗粒 。 然后将透析液从反应室传导到测量单元，用于测量从反应室进行的透析液中转化的反应产物的浓度，转化反应产物的浓度代表低分子量化合物的含量 复合流体介质。

公开(公告)号：US4123353A

公开(公告)日：1978-10-31

申请号：US855604

申请日：1977-11-29

申请人： Bo H. Hakansson ,  Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

发明人： Bo H. Hakansson ,  Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  A61M39/28 ,  G01N27/416 ,  G01N33/483 ,  G01N33/487 ,  D01D13/00

CPC分类号： A61M39/28 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/3437

摘要： A method and apparatus is provided for measuring the content of a low-molecular weight compound in a complex medium which includes a dialyzer, conduits for conveying the complex medium through the dialyzer and conduits for supplying dialysis fluid to the dialyzer to receive by diffusion a portion of the low-molecular weight compound in the complex medium to produce a dialysate. Apparatus is also provided for conducting the dialysate produced from the dialyzer to a measuring unit, wherein the conducting apparatus includes a main flow line having an enzyme bed and a shunt flow line. A control device is provided for directing the flow of dialysate through the main flow line and the enzyme bed or the shunt flow line, so that the flow of dialysate bypasses the enzyme bed. Apparatus is also provided for comparing the dialysates in the main and shunt flow lines.

摘要翻译： 提供了一种用于测量复合介质中低分子量化合物含量的方法和装置，所述复合介质包括透析器，用于通过透析器输送复合介质的导管和用于向透析器供应透析液的导管，用于通过扩散接收部分 的复合介质中的低分子量化合物以产生透析液。 还提供了用于将从透析器产生的透析液导入测量单元的装置，其中导电装置包括具有酶床和分流管线的主流线。 提供控制装置，用于引导透析液的流动通过主流线和酶床或分流管线，使得透析液的流动绕过酶床。 还提供了用于比较主和分流流线中的透析液的装置。

公开(公告)号：US4311789A

公开(公告)日：1982-01-19

申请号：US69698

申请日：1979-08-27

申请人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

发明人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

IPC分类号： A61B5/00 ,  A61M5/172 ,  B01D61/24 ,  B01D63/02 ,  C12N11/14 ,  C12Q1/26 ,  C12Q1/54 ,  C12Q1/58 ,  C12Q1/60 ,  C12Q1/62 ,  G01N33/487

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/14546 ,  A61B5/686 ,  A61M5/1723 ,  B01D61/243 ,  B01D63/02 ,  B01D63/024 ,  B01D63/043 ,  C12N11/14 ,  C12Q1/26 ,  C12Q1/54 ,  C12Q1/58 ,  C12Q1/60 ,  C12Q1/62 ,  Y10T436/255

摘要： A method is provided for sampling and measuring the content of a low-molecular weight compound, such as glucose, cholesterol, or urea, in a complex fluid medium to be sampled, such as blood. A dialyzer is placed in contact with the complex fluid medium so that it passes through the dialyzer. One or more semipermeable membranes are disposed within the complex fluid medium to form one or more passageways for the passage of dialysis fluid, with the passageways being substantially smaller in volume than the volume of the surrounding complex fluid medium. A fractional portion of the complex fluid medium is acted on by the dialysis fluid and dialyzed so that only a fractional portion of the low-molecular weight compound diffuses into the passageways containing the dialysis fluid to produce a dialysate in the passageways. The dialysate is then measured to determine the content of the low-molecular weight compound in the complex fluid medium.

摘要翻译： 提供了在待采样的复杂流体介质如血液中对低分子量化合物如葡萄糖，胆固醇或尿素的含量进行取样和测量的方法。 透析器与复合流体介质接触，使其透过透析器。 一个或多个半透膜设置在复合流体介质内以形成用于透析流体通过的一个或多个通道，其中通道的体积比周围的复合流体介质的体积小得多。 复合流体介质的分数部分由透析液体作用并进行透析，使得仅低分子量化合物的分数部分扩散到含有透析液的通道中，以在通道中产生透析液。 然后测量透析液以确定复合流体介质中低分子量化合物的含量。

公开(公告)号：US4229542A

公开(公告)日：1980-10-21

申请号：US755977

申请日：1976-12-30

申请人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

发明人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

IPC分类号： G01N33/48 ,  A61B5/00 ,  B01D61/24 ,  B01D63/02 ,  C12N11/14 ,  G01N33/483 ,  G01N33/487 ,  G01N33/66 ,  C12M1/34

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/686 ,  B01D61/243 ,  B01D63/02 ,  B01D63/024 ,  B01D63/043 ,  C12N11/14

摘要： A method and apparatus is provided which measures the content of a low-molecular compound, such as glucose, cholesterol, or urea, in a complex medium, such as blood. A dialyzer is placed in contact with the complex medium so that the complex medium may pass therethrough. In addition, dialysis fluid is supplied through the dialyzer to produce a dialysate having a property which can be measured. In the preferred embodiment, an enzyme is added to the dialysate to chemically react with the low-molecular compound to produce a chemical change which can be measured.

摘要翻译： 提供了在复合介质如血液中测量低分子化合物如葡萄糖，胆固醇或尿素的含量的方法和装置。 将透析器放置成与复合介质接触，使复合介质通过。 此外，通过透析器供应透析液以产生具有可测量性质的透析液。 在优选的实施方案中，向透析液中加入酶以与低分子化合物发生化学反应以产生可测量的化学变化。