公开(公告)号：US4352374A

公开(公告)日：1982-10-05

申请号：US121873

申请日：1980-02-15

申请人： Ulf T. G. Nylen

发明人： Ulf T. G. Nylen

IPC分类号： B01J19/00 ,  A61M1/36 ,  G01N1/10 ,  G01N33/487 ,  G05D11/00 ,  E03B7/07

CPC分类号： G05D11/008 ,  A61M1/3672 ,  Y10S128/13 ,  Y10T137/2526 ,  Y10T137/3112 ,  Y10T137/8597

摘要： An apparatus and method are provided for diluting a concentrated solution to be analyzed which includes a Y-coupling for combining a diluent and the concentrated solution to form a mixture. The mixture is then divided into first and second parts, such as by a pumping arrangement, with the second part of the mixture being proportional in quantity to the quantity of concentrated solution. The first part of the mixture is then supplied to an analytical device for analyzing the mixture. A chamber including a movable wall element is provided which divides the chamber into two subchambers. The first part of the mixture is supplied to the subchamber on one side of the movable wall element, which causes the movable wall element to force a proportional quantity of diluent out of the subchamber on the other side of the movable wall element. The dispensed diluent is then conveyed to mix with the concentrated solution.

摘要翻译： 提供了用于稀释待分析的浓缩溶液的装置和方法，其包括用于将稀释剂和浓缩溶液组合的Y-偶联剂以形成混合物。 然后将混合物分成第一和第二部分，例如通过泵送装置，混合物的第二部分与浓缩溶液的量成比例。 然后将混合物的第一部分提供给用于分析混合物的分析装置。 提供了包括可移动壁元件的室，其将室分成两个子室。 混合物的第一部分被供应到可移动壁元件的一侧上的子室，这导致可移动壁元件在可移动壁元件的另一侧上迫使比例数量的稀释剂从子室中排出。 然后输送分配的稀释剂以与浓缩溶液混合。

公开(公告)号：US4311789A

公开(公告)日：1982-01-19

申请号：US69698

申请日：1979-08-27

申请人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

发明人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

IPC分类号： A61B5/00 ,  A61M5/172 ,  B01D61/24 ,  B01D63/02 ,  C12N11/14 ,  C12Q1/26 ,  C12Q1/54 ,  C12Q1/58 ,  C12Q1/60 ,  C12Q1/62 ,  G01N33/487

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/14546 ,  A61B5/686 ,  A61M5/1723 ,  B01D61/243 ,  B01D63/02 ,  B01D63/024 ,  B01D63/043 ,  C12N11/14 ,  C12Q1/26 ,  C12Q1/54 ,  C12Q1/58 ,  C12Q1/60 ,  C12Q1/62 ,  Y10T436/255

摘要： A method is provided for sampling and measuring the content of a low-molecular weight compound, such as glucose, cholesterol, or urea, in a complex fluid medium to be sampled, such as blood. A dialyzer is placed in contact with the complex fluid medium so that it passes through the dialyzer. One or more semipermeable membranes are disposed within the complex fluid medium to form one or more passageways for the passage of dialysis fluid, with the passageways being substantially smaller in volume than the volume of the surrounding complex fluid medium. A fractional portion of the complex fluid medium is acted on by the dialysis fluid and dialyzed so that only a fractional portion of the low-molecular weight compound diffuses into the passageways containing the dialysis fluid to produce a dialysate in the passageways. The dialysate is then measured to determine the content of the low-molecular weight compound in the complex fluid medium.

摘要翻译： 提供了在待采样的复杂流体介质如血液中对低分子量化合物如葡萄糖，胆固醇或尿素的含量进行取样和测量的方法。 透析器与复合流体介质接触，使其透过透析器。 一个或多个半透膜设置在复合流体介质内以形成用于透析流体通过的一个或多个通道，其中通道的体积比周围的复合流体介质的体积小得多。 复合流体介质的分数部分由透析液体作用并进行透析，使得仅低分子量化合物的分数部分扩散到含有透析液的通道中，以在通道中产生透析液。 然后测量透析液以确定复合流体介质中低分子量化合物的含量。

公开(公告)号：US4361484A

公开(公告)日：1982-11-30

申请号：US232037

申请日：1981-02-11

申请人： Lars-Ake L. Larsson ,  Lars O. V. Naucler ,  Ulf T. G. Nylen

发明人： Lars-Ake L. Larsson ,  Lars O. V. Naucler ,  Ulf T. G. Nylen

IPC分类号： A61M1/00 ,  A61K35/14 ,  A61M1/16 ,  A61M1/22 ,  A61M1/36 ,  B01D61/00 ,  B01D61/14 ,  B01D63/00 ,  B01D63/02 ,  B01D67/00 ,  B01D69/02 ,  B01D71/76 ,  B01J20/32 ,  B01D13/00 ,  B01D31/00

CPC分类号： B01D61/142 ,  A61K35/14 ,  A61M1/3679 ,  B01D61/18 ,  B01D69/02 ,  B01J20/28014 ,  B01J20/3242

摘要： A process for the treating of and/or removal of substances from a liquid, especially whole blood, via a semipermeable microporous membrane (13, 14, 15) through adsorption and/or biological reaction by means of a biologically active material. Said whole blood is exposed to pressure variations at the membrane surface in a way such that a penetrating fraction of said whole blood is flowing in an alternating flow path through the membrane walls for contacting said biologically active material.Said biologically active material is asymmetrically immobilized in and on the surface of the side of said membrane that faces away from said whole blood. Alternatively, said biologically active material may be bound to an unsoluble matrix behind said membrane.Said membrane is for example provided within a casing (7, 8, 9) comprising inlet (10) and outlet (11) for said whole blood. The space between said casing and said membrane is via a connecting nipple (12) in communication with for example an expansion chamber for the provision of pressure variations.By means of the device (3) it is possible to perform said process in one and the same step and by means of one and the same pumping system.

摘要翻译： PCT No.PCT / SE79 / 00132 Sec。 371日期1981年2月11日 102（e）日期1981年1月9日PCT提交1979年6月11日PCT公布。 出版物WO80 / 02805 日期为1980年12月24日。一种通过吸附和/或生物反应通过半透膜微孔膜（13,14,15）从液体，特别是全血中处理和/或去除物质的方法， 生物活性物质。 所述全血暴露于膜表面的压力变化，使得所述全血的穿透部分在交替流动路径中流过膜壁以接触所述生物活性物质。 所述生物活性材料不对称地固定在所述膜的面向远离所述全血的一侧的表面上。 或者，所述生物活性材料可以结合到所述膜后面的不溶性基质。 所述膜例如设置在包括用于所述全血的入口（10）和出口（11））的壳体（7,8,9）内。 所述壳体和所述膜之间的空间经由与例如用于提供压力变化的膨胀室连通的连接接头（12）。 借助于装置（3），可以在同一个步骤中并且通过同一个泵送系统来执行所述处理。

公开(公告)号：US4229542A

公开(公告)日：1980-10-21

申请号：US755977

申请日：1976-12-30

申请人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

发明人： Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

IPC分类号： G01N33/48 ,  A61B5/00 ,  B01D61/24 ,  B01D63/02 ,  C12N11/14 ,  G01N33/483 ,  G01N33/487 ,  G01N33/66 ,  C12M1/34

CPC分类号： A61B5/14865 ,  A61B5/14528 ,  A61B5/686 ,  B01D61/243 ,  B01D63/02 ,  B01D63/024 ,  B01D63/043 ,  C12N11/14

摘要： A method and apparatus is provided which measures the content of a low-molecular compound, such as glucose, cholesterol, or urea, in a complex medium, such as blood. A dialyzer is placed in contact with the complex medium so that the complex medium may pass therethrough. In addition, dialysis fluid is supplied through the dialyzer to produce a dialysate having a property which can be measured. In the preferred embodiment, an enzyme is added to the dialysate to chemically react with the low-molecular compound to produce a chemical change which can be measured.

摘要翻译： 提供了在复合介质如血液中测量低分子化合物如葡萄糖，胆固醇或尿素的含量的方法和装置。 将透析器放置成与复合介质接触，使复合介质通过。 此外，通过透析器供应透析液以产生具有可测量性质的透析液。 在优选的实施方案中，向透析液中加入酶以与低分子化合物发生化学反应以产生可测量的化学变化。

公开(公告)号：US4123353A

公开(公告)日：1978-10-31

申请号：US855604

申请日：1977-11-29

申请人： Bo H. Hakansson ,  Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

发明人： Bo H. Hakansson ,  Ulf T. G. Nylen ,  Lars A. G. Qvarnstrom

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  A61M39/28 ,  G01N27/416 ,  G01N33/483 ,  G01N33/487 ,  D01D13/00

CPC分类号： A61M39/28 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/3437

摘要： A method and apparatus is provided for measuring the content of a low-molecular weight compound in a complex medium which includes a dialyzer, conduits for conveying the complex medium through the dialyzer and conduits for supplying dialysis fluid to the dialyzer to receive by diffusion a portion of the low-molecular weight compound in the complex medium to produce a dialysate. Apparatus is also provided for conducting the dialysate produced from the dialyzer to a measuring unit, wherein the conducting apparatus includes a main flow line having an enzyme bed and a shunt flow line. A control device is provided for directing the flow of dialysate through the main flow line and the enzyme bed or the shunt flow line, so that the flow of dialysate bypasses the enzyme bed. Apparatus is also provided for comparing the dialysates in the main and shunt flow lines.

摘要翻译： 提供了一种用于测量复合介质中低分子量化合物含量的方法和装置，所述复合介质包括透析器，用于通过透析器输送复合介质的导管和用于向透析器供应透析液的导管，用于通过扩散接收部分 的复合介质中的低分子量化合物以产生透析液。 还提供了用于将从透析器产生的透析液导入测量单元的装置，其中导电装置包括具有酶床和分流管线的主流线。 提供控制装置，用于引导透析液的流动通过主流线和酶床或分流管线，使得透析液的流动绕过酶床。 还提供了用于比较主和分流流线中的透析液的装置。

公开(公告)号：US4971833A

公开(公告)日：1990-11-20

申请号：US116020

申请日：1987-11-02

申请人： Per-Olof Larsson ,  Kersti B. Johnson ,  Ulf T. G. Nylen ,  Per I. O. Wikstrom ,  Ingrid K. Zetterstrand

发明人： Per-Olof Larsson ,  Kersti B. Johnson ,  Ulf T. G. Nylen ,  Per I. O. Wikstrom ,  Ingrid K. Zetterstrand

IPC分类号： B01J20/281 ,  B01J13/04 ,  B01J20/285 ,  B01J20/32 ,  G01N30/88 ,  G01N33/548

CPC分类号： B01J20/328 ,  B01J20/3274 ,  B01J20/3282 ,  B01J20/3293 ,  G01N33/548

摘要： Methods for coating hydrophilic gels onto the surface of solid particles are disclosed which include utilizing hydrophilic solid particles, intimately admixing these hydrophilic solid particles with a hydrophilic gel-forming substance at a temperature above the gelling temperature so as to coat the solid hydrophilic particles, and then separating these coated particles from each other and cooling them to a temperature below the gelling temperature. The use of these coated particles is also disclosed in connection with various separation processes, such as an ion exchanger, in those cases where the gel-forming substance contains charged groups, or providing the particles with suitable adsorbent groups.

摘要翻译： 公开了将亲水性凝胶涂布在固体颗粒表面上的方法，其包括使用亲水性固体颗粒，在高于胶凝温度的温度下将这些亲水性固体颗粒与亲水性凝胶形成物质密切混合以涂覆固体亲水性颗粒，以及 然后将这些涂覆的颗粒彼此分离并将其冷却至低于胶凝温度的温度。 在凝胶形成物质含有带电基团的那些情况下或者为颗粒提供合适的吸附剂基团的情况下，也公开了与各种分离方法有关的使用，例如离子交换剂。

公开(公告)号：US4783264A

公开(公告)日：1988-11-08

申请号：US129935

申请日：1987-12-03

申请人： Ulf T. G. Nylen ,  Bo G. Mattiasson

发明人： Ulf T. G. Nylen ,  Bo G. Mattiasson

IPC分类号： C07K14/42 ,  B01D15/08 ,  B01D61/14 ,  B01D61/16 ,  B01D61/20 ,  B01D61/58 ,  C07K1/14 ,  C07K1/22 ,  C07K1/34 ,  C07K1/36 ,  B01D13/00

CPC分类号： C07K1/36 ,  B01D15/1871 ,  B01D15/3804 ,  B01D61/147 ,  B01D63/02 ,  B01D63/046 ,  C07K1/34 ,  B01D15/3809 ,  B01D2313/32

摘要： A process is disclosed for the recovery of a compound, for example, a peptide-containing compound, from a solution containing contaminants through combined affinity-chromatographic purification and ultrafiltration. The process comprises contacting the solution containing the compound and impurities with a first complex of ligand bound to a carrier so as to form a second complex of the compound, the ligand and the carrier, wherein the carrier is comprised of a macromolecular solid material; subsequently splitting off of the compound from the second complex to reform the compound and first complex; and separating of the compound from the first complex. An arrangement for the recovery of a compound from such a solution containing impurities is also disclosed.

摘要翻译： 公开了通过组合亲和层析纯化和超滤从含有污染物的溶液中回收化合物，例如含肽化合物的方法。 该方法包括使含有化合物和杂质的溶液与结合到载体的第一配位体配位体接触，以形成化合物，配体和载体的第二配合物，其中载体由大分子固体材料组成; 随后将化合物从第二配合物中分离出来，以改造化合物和第一配合物; 并将化合物与第一配合物分离。 还公开了从这种含有杂质的溶液中回收化合物的装置。

公开(公告)号：US4266021A

公开(公告)日：1981-05-05

申请号：US968202

申请日：1978-12-11

申请人： Ulf T. G. Nylen ,  Lars-Goran Olsson ,  Bengt G. Paulsson ,  Lars A. G. Qvarnstrom ,  Rolf H. L. Wichers

发明人： Ulf T. G. Nylen ,  Lars-Goran Olsson ,  Bengt G. Paulsson ,  Lars A. G. Qvarnstrom ,  Rolf H. L. Wichers

IPC分类号： G01N33/48 ,  A61B5/00 ,  A61M1/16 ,  A61M1/34 ,  C12Q1/00 ,  G01N33/487 ,  C12M1/34 ,  C12Q1/54 ,  G01N31/14

CPC分类号： C12Q1/00 ,  A61B5/14525 ,  A61B5/14865 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/3437 ,  Y10T436/255

摘要： A method and apparatus is provided for measuring the content of a compound in a liquid medium, and which is particularly useful for measuring the concentration of a low molecular weight compound in a complex medium in which there is provided a dialyzer in contact with the complex fluid medium and through which dialysis fluid is conducted to receive by diffusion a portion of the low molecular weight compound to produce a dialysate. The dialysate with the low molecular weight commpound to be examined is first conducted through a venting device for removal of gaseous particles therefrom before conduction through a reaction chamber containing enzymes for promoting the conversion of the low molecular weight compound in the dialysate into a converted reaction product. The dialysate is then conducted from the reaction chamber to a measuring unit for measuring the concentration of the converted reaction product in the dialysate conducted from the reaction chamber, the concentration of the converted reaction product being representative of the content of the low molecular weight compound in the complex fluid medium.

摘要翻译： 提供了一种用于测量液体介质中化合物含量的方法和装置，其特别可用于测量复合介质中的低分子量化合物的浓度，其中提供了与复合流体接触的透析器 通过透析液进行渗透以通过扩散一部分低分子量化合物以产生透析液。 首先通过排气装置进行待检查的低分子量通气的透析液，以便在通过含有促进透析液中低分子量化合物转化为转化反应产物的酶的反应室之前从其中除去气态颗粒 。 然后将透析液从反应室传导到测量单元，用于测量从反应室进行的透析液中转化的反应产物的浓度，转化反应产物的浓度代表低分子量化合物的含量 复合流体介质。