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1.发明授权Reagent and process for the determination of the activity of the enzyme gamma-glutamyl transferase 失效用于测定γ-谷氨酰转移酶酶活性的试剂和方法
公开(公告)号：US4603107A
公开(公告)日：1986-07-29
申请号：US532907
申请日：1983-09-16
申请人： Ulfert Deneke , Rolf Nagel , Walter Rittersdorf
发明人： Ulfert Deneke , Rolf Nagel , Walter Rittersdorf
CPC分类号： C12Q1/48 , Y10S435/805 , Y10S435/81
摘要： The present invention provides a process for the kinetic determination of .gamma.-glutamyl transferase activity by the reaction of a .gamma.-glutamylarylamide with the formation of an arylamine at a pH value of from 6 to 10, wherein the arylamine is simultaneously reacted with an aromatic amine or phenol appropriate as a coupling component and an appropriate oxidation agent to give a colored compound with an absorption maximum above 565 nm, the rate of formation of which is monitored photometrically and is used as a measure for the .gamma.-glutamyl transferase activity.The present invention also provides a reagent for the kinetic determination of .gamma.-GT activity, wherein it contains the following reagents:.gamma.-GT-arylamide:1-100 mmol/l..gamma.-glutamyl acceptor (glycylglycine):10-500 mmol/l.coupling component:1-500 mmol/l.oxidation agent:0.1-500 mmol/l.buffer:10-1000 mmol/l.
摘要翻译： 本发明提供了一种通过γ-谷氨酰基芳基酰胺与pH6至10的芳胺形成反应来动态测定γ-谷氨酰转移酶活性的方法，其中芳胺与芳族胺同时反应 或苯酚作为偶联组分和适当的氧化剂，得到最大吸收峰值高于565nm的着色化合物，其形成速率通过光度法监测并用作γ-谷氨酰转移酶活性的量度。 本发明还提供用于γ-GT活性的动力学测定的试剂，其中它含有以下试剂：γ-GT-芳基酰胺：1-100mmol / l。 γ-谷氨酰受体（甘氨酰甘氨酸）：10-500mmol / l。 偶联组分：1-500 mmol / l。 氧化剂：0.1-500mmol / l。 缓冲液：10-1000mmol / l。
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2.发明授权
公开(公告)号：US4563422A
公开(公告)日：1986-01-07
申请号：US380804
申请日：1982-05-21
申请人： Ulfert Deneke , Hans Lange , Walter Rittersdorf
发明人： Ulfert Deneke , Hans Lange , Walter Rittersdorf
IPC分类号： C02F3/34 , A23L2/70 , C02F3/00 , C12P1/00 , C12Q1/26 , C12Q1/54 , G01N33/493 , C12Q1/30 , C12Q1/28
CPC分类号： C12Q1/54 , C12Q1/26 , Y10S435/805 , Y10S435/81 , Y10T436/142222 , Y10T436/25125
摘要： The present invention provides a process for removing ascorbic acid from aqueous solutions by the addition of ascorbate oxidase, wherein catalase and hydrogen peroxide are also added to the solution.The present invention also provides an agent for the removal of ascorbic acid from aqueous solutions, based on a solid carrier material impregnated with ascorbate oxidase, wherein the carrier material also contains catalase and hydrogen peroxide and optionally also a stabilizer and/or buffer substance.
摘要翻译： 本发明提供了通过加入抗坏血酸氧化酶从水溶液中除去抗坏血酸的方法，其中还向溶液中加入过氧化氢酶和过氧化氢。 本发明还提供了一种基于浸渍有抗坏血酸氧化酶的固体载体材料从水溶液中除去抗坏血酸的试剂，其中载体材料还含有过氧化氢酶和过氧化氢以及任选的稳定剂和/或缓冲物质。
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3.发明授权Method for separating non-high density lipoproteins from lipoprotein containing body fluid samples 失效从含有脂蛋白的体液样品中分离非高密度脂蛋白的方法
公开(公告)号：US5786164A
公开(公告)日：1998-07-28
申请号：US661833
申请日：1996-06-11
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDL-s are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译： 本发明涉及从含有它们的生物液体中分离非高密度脂蛋白（称为“非HDL”）的方法。 提供含有非HDL沉淀剂的多孔载体。 只需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL-不再存在于待测样品中。 该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。
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4.发明授权Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step 有权通过具有综合分馏步骤的快速诊断剂测定HDL胆固醇的方法公开(公告)号：US06171849B2
公开(公告)日：2001-01-09
申请号：US09481664
申请日：2000-01-12
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12M100
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein (HDL) cholesterol in a HDL and non high density lipoprotein (non-HDL) in a body sample.
摘要翻译： 公开了一种包括用于评估生物流体样品的第一多孔载体和第二多孔载体的装置。 该装置用于从身体样品中的脂蛋白分离非高密度脂蛋白（非HDL），并用于测定身体样品中HDL和非高密度脂蛋白（非HDL）中的高密度脂蛋白（HDL）胆固醇。
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公开(公告)号：US5426030A
公开(公告)日：1995-06-20
申请号：US572875
申请日：1990-08-24
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to an apparatus and a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译： 本发明涉及一种用于从含有它们的生物液体中分离非高密度脂蛋白（被称为“非HDL”）的装置和方法。 提供含有非HDL沉淀剂的多孔载体。 仅需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL不再存在于待测样品中。 该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。
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6.再颁专利Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step 失效通过具有综合分馏步骤的快速诊断剂测定HDL胆固醇的方法公开(公告)号：USRE39915E1
公开(公告)日：2007-11-06
申请号：US10644617
申请日：2003-08-20
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92
摘要： An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein (HDL) cholesterol in a HDL and non high density lipoprotein (non-HDL) in a body sample.
摘要翻译： 公开了一种包括用于评估生物流体样品的第一多孔载体和第二多孔载体的装置。 该装置用于从身体样品中的脂蛋白分离非高密度脂蛋白（非HDL），并用于测定身体样品中HDL和非高密度脂蛋白（非HDL）中的高密度脂蛋白（HDL）胆固醇。
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7.发明授权Method for separating non-HDLs from HDLs, and determining, HDL cholesterol 失效从HDL中分离非HDL和测定HDL胆固醇的方法公开(公告)号：US06214570B1
公开(公告)日：2001-04-10
申请号：US09114361
申请日：1998-07-14
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
IPC分类号： C12Q160
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The subject matter of the application is a method for the separation of non-HDL lipoproteins from biological fluids in a carrier through which liquids can flow. The carrier contains a precipitating agent for non-high density lipoproteins (non-HDLs).
摘要翻译： 本申请的主题是用于从液体可以流过的载体中的生物流体分离非HDL脂蛋白的方法。 载体含有用于非高密度脂蛋白（非HDL）的沉淀剂。
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8.发明授权Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step 失效通过具有综合分馏步骤的快速诊断剂测定HDL胆固醇的方法
公开(公告)号：US5580743A
公开(公告)日：1996-12-03
申请号：US384046
申请日：1995-02-06
申请人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
发明人： Walter Rittersdorf , Ulfert Deneke , Gerhard Hiller , Hartmut Merdes , Klaus Buecker , Uwe Goebbert
CPC分类号： C12Q1/60 , G01N33/526 , G01N33/92 , Y10T436/104165 , Y10T436/25125 , Y10T436/255
摘要： The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.
摘要翻译： 本发明涉及从含有它们的生物液体中分离非高密度脂蛋白（称为“非HDL”）的方法。 提供含有非HDL沉淀剂的多孔载体。 仅需要将感兴趣的样品与载体接触一分钟或更短时间，之后沉淀的非HDL不再存在于待测样品中。 该方法的应用包括测定样品中高密度脂蛋白而不受非HDL干扰的能力。
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公开(公告)号：US4582684A
公开(公告)日：1986-04-15
申请号：US531439
申请日：1983-09-12
申请人： Peter Vogel , Walter Rittersdorf
发明人： Peter Vogel , Walter Rittersdorf
CPC分类号： G01N33/525 , G01N21/03 , G01N31/22
摘要： A cuvette for the determination of a chemical component of a fluid by photo evaluation has two planar-shaped parts parallel to one another at least one of which is transparent in the spectral range used for the evaluation. A planar distance piece of a filamentary reticulation for receiving the fluid therein spaces the planar-shaped parts apart to set the length of the light path through the cuvette for the photo evaluation.
摘要翻译： 用于通过光学评估测定流体的化学成分的比色皿具有彼此平行的两个平面形部分，其中至少一个在用于评估的光谱范围中是透明的。 用于接收流体的丝状网状物的平面距离片将平面形部分分开，以将通过比色杯的光路的长度设定为照相评估。
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10.发明授权
公开(公告)号：US4219336A
公开(公告)日：1980-08-26
申请号：US892359
申请日：1978-03-31
CPC分类号： C12Q1/28 , G01N33/725 , C12Q2326/00 , Y10S436/904
摘要： A diagnostic agent for the detection of occult blood in feces comprising hydrogen peroxide and, as a chromogen, guaiaconic acid A, optionally with a stabilizer. The invention provides, as a novel substance, guaiaconic acid A having a specific extinction E.sub.1 cm.sup.1% at 600 nm of at least 200, determined by the reaction with peroxidase and hydrogen peroxide, having infra-red bands at1600 cm.sup.-1 (m);1505 cm.sup.-1 (v.s.);1260 cm.sup.-1 (s;b);1115 cm.sup.-1 (m);1025 cm.sup.-1 (m); and1200 cm.sup.-1 (s;b)and having an R.sub.F value of 0.45 (toluene/dioxan/glacial acetic acid; 90:25:10 v/v/v).
摘要翻译： 用于检测粪便中的潜血的诊断剂，其包含过氧化氢和任选地与稳定剂作为色原，愈创木酸A。 本发明提供作为新物质，通过与过氧化物酶和过氧化氢的反应确定在600nm处具有600nm以上的具有特定消光度E1cm1％的愈创木酸A至少为200，在1600cm -1处具有红外线
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