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公开(公告)号：US20080282765A1
公开(公告)日：2008-11-20
申请号：US11803968
申请日：2007-05-16
CPC分类号： G01N33/0006
摘要： Embodiments of the present invention relate to a gas sensor comprising a flow channel, a concentration modulator positioned in the flow channel, a gas generator in contact with the flow channel, one or more gas detectors positioned downstream of the concentration modulator and gas generator and a pump.
摘要翻译： 本发明的实施例涉及一种气体传感器，其包括流动通道，位于流动通道中的浓度调节器，与流动通道接触的气体发生器，位于浓缩调节器和气体发生器下游的一个或多个气体检测器和 泵。
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公开(公告)号：US07975525B2
公开(公告)日：2011-07-12
申请号：US11803968
申请日：2007-05-16
IPC分类号： G01N21/00
CPC分类号： G01N33/0006
摘要： Embodiments of the present invention relate to a gas sensor comprising a flow channel, a concentration modulator positioned in the flow channel, a gas generator in contact with the flow channel, one or more gas detectors positioned downstream of the concentration modulator and gas generator and a pump.
摘要翻译： 本发明的实施例涉及一种气体传感器，其包括流动通道，位于流动通道中的浓度调节器，与流动通道接触的气体发生器，位于浓缩调节器和气体发生器下游的一个或多个气体检测器和 泵。
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公开(公告)号：US20060174683A1
公开(公告)日：2006-08-10
申请号：US11241591
申请日：2005-09-30
申请人： Ulrich Bonne , James Detry , Richard Kirkpatrick , Peter Tobias
发明人： Ulrich Bonne , James Detry , Richard Kirkpatrick , Peter Tobias
IPC分类号： G01N35/00
CPC分类号： G01N27/4141
摘要： A self-calibration device and method for a FFET sensor having a thin functional film positioned to detect the presence of at least one specific component in a fluid, a current driven source, a gate and a voltage source applied to said gate, a tub and a drain. An input signal is applied to the gate to produce a measured output signal that is compared to an expected output reference signal. The input signal is selected from controlled voltage pulses to the gate, or the source bias current can be changed. Alternatively, the signal can be a known concentration pulse of the specific component applied to the FFET or a heat source pulse for changing the temperature of the FFET by a small amount.
摘要翻译： 一种用于FFET传感器的自校准装置和方法，其具有薄功能膜，其被定位成检测施加到所述门的流体，电流驱动源，栅极和电压源中的至少一个特定部件的存在， 排水 将输入信号施加到栅极以产生与预期输出参考信号相比较的测量输出信号。 输入信号从对栅极的受控电压脉冲中选择，或者可以改变源极偏置电流。 或者，信号可以是施加到FFET的特定分量的已知浓度脉冲或用于将FFET的温度改变少量的热源脉冲。
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公开(公告)号：US20080156074A1
公开(公告)日：2008-07-03
申请号：US11618404
申请日：2006-12-29
申请人： Peter Tobias
发明人： Peter Tobias
CPC分类号： G01N33/0006 , G01N27/16 , G01N2033/0072
摘要： Embodiments of the present invention relate a gas sensor system comprising a gas generating device adapted to generate a test gas, a target gas sensor positioned near the gas generating device, a test gas sensor positioned near the gas generating device and in communication with the target gas sensor and wherein the test gas sensor is sensitive to the test gas.
摘要翻译： 本发明的实施例涉及一种气体传感器系统，包括适于产生测试气体的气体发生装置，位于气体发生装置附近的目标气体传感器，位于气体发生装置附近并与目标气体连通的测试气体传感器 传感器，其中测试气体传感器对测试气体敏感。
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公开(公告)号：US20060073145A1
公开(公告)日：2006-04-06
申请号：US10236051
申请日：2002-09-03
申请人： Didier Leturcq , Ann Moriarty , Richard Ulevitch , Peter Tobias , John Mathison
发明人： Didier Leturcq , Ann Moriarty , Richard Ulevitch , Peter Tobias , John Mathison
IPC分类号： A61K39/395 , C12N5/06
CPC分类号： B82Y15/00 , C07K16/2896 , C07K2319/00 , C07K2319/033 , C07K2319/32 , G01N33/6872 , G01N2333/70596 , G01N2400/50 , G01N2800/26
摘要： This invention provides hybridoma cell lines producing monoclonal antibodies which inhibit CD14 mediated cell activation. Monoclonal antibodies produced by these cell lines also are provided. The antibodies are useful for the detection of the presence of cell surface and soluble CD14 in a sample. Chimeric and CDR grafted antibodies generated from the above monoclonal antibodies are further provided. Pharmaceutical compositions containing the above biological compositions are provided. These are useful to treat and prevent disorders with CD14 mediated cell activation, such as sepsis.
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6.发明授权Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides 失效急性期蛋白调节脂多糖的内毒素活性，测定方法和多肽
公开(公告)号：US5245013A
公开(公告)日：1993-09-14
申请号：US367454
申请日：1989-06-16
申请人： Richard Ulevitch , Peter Tobias
发明人： Richard Ulevitch , Peter Tobias
IPC分类号： A61K38/00 , C07K14/47 , G01N33/569
CPC分类号： C07K14/47 , G01N33/56916 , A61K38/00 , G01N2400/50
摘要： A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute phase serum, but is substantially absent from normal serum; (b) binds to Gram-negative bacterially secreted lipopolysaccharide in vitro in the serum of the animal treated; (c) retards in vitro binding of the lipopolysaccharide to high density lipoprotein present in the normal serum of the animal host; and (d) immunoreacts with antibodies raised to a polypeptide having the amino acid residue sequence, from left to right and in the direction from amino-terminus to carboxy-terminus, or ##STR1## wherein each of said parenthesized amino acid residues in an alternative to the immediately preceding residue in said sequence.
摘要翻译： 公开了与该结合蛋白相关的测定方法，多肽和抗体的脂多糖结合蛋白。 结合蛋白：（a）以不纯形式存在于急性期血清中，但在正常血清中基本不存在; （b）在动物处理的血清中体外结合革兰阴性细菌分泌的脂多糖; （c）阻止脂多糖与动物宿主正常血清中存在的高密度脂蛋白的体外结合; 和（d）从产生于具有从左至右和从氨基末端至羧基末端的方向的氨基酸残基序列的多肽产生的抗体的免疫反应，或Thr-Asn-Pro-Gly-Leu-Ile-Thr- Arg-Ile-Thr-Asp-Lys-Gly-Leu-Glu-Tyr-Ala-Ala-Arg-Glu-Gly-Leu-Leu-Ala-Leu-Gln-Arg-Lys-Leu-Asn（Leu） -Val-Thr-Leu-Pro-Asp-Phe（Ser）-Asp-Gly; 其中每个所述括号中的氨基酸残基与所述序列中紧邻的前一个残基相替。
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公开(公告)号：US08616205B2
公开(公告)日：2013-12-31
申请号：US12899075
申请日：2010-10-06
申请人： Peter Tobias , Brian Krafthefer
发明人： Peter Tobias , Brian Krafthefer
CPC分类号： A61M16/107 , A61M2205/0227 , A61M2205/125 , A61M2205/17 , A61M2205/42 , A61M2205/705 , A62B9/006 , A62B19/00
摘要： The present disclosure relates to methods and apparatus for detecting when respiratory cartridges of a respirator have reached their end-of-service-life. In some instances, two or more respiratory cartridges are removably connectable to a respirator housing, where each of the two or more respiratory cartridges receives ambient air and deliver cleaned air to the respirator housing. One of the respiratory cartridges may be configured to have a lower adsorption capacity than the remaining respirator cartridges. A gas sensor may be situated downstream of the reduced capacity respirator cartridge, and may detect an increased concentration of the targeted gas in the cleaned air delivered by the reduced capacity respiratory cartridge. When detected, an end-of-service-life indication may be provided to the user.
摘要翻译： 本公开涉及用于检测呼吸器的呼吸盒何时已经达到使用寿命的方法和装置。 在一些情况下，两个或更多个呼吸盒可移除地连接到呼吸器壳体，其中两个或更多个呼吸盒中的每一个接收环境空气并将清洁的空气输送到呼吸器壳体。 其中一个呼吸盒可以被配置为具有比其余的呼吸器盒更低的吸附能力。 气体传感器可以位于容量较小的呼吸器筒的下游，并且可以检测由减小容量的呼吸筒输送的清洁空气中的目标气体的浓度增加。 当检测到时，可以向用户提供服务寿命终止指示。
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8.发明申请公开(公告)号：US20130104900A1
公开(公告)日：2013-05-02
申请号：US13287836
申请日：2011-11-02
申请人： Peter Tobias , Lynn Feiner
发明人： Peter Tobias , Lynn Feiner
CPC分类号： A62B9/006 , A61M16/105 , A61M16/107 , A62B18/088 , A62B19/00
摘要： A respirator service lift indication system comprises a breathing apparatus comprising an air purifying element; and a service life indicator arranged in a parallel flow configuration with the breathing apparatus. The service life indicator comprises a sacrificial cartridge, and a sensor disposed downstream of the sacrificial cartridge and configured to detect a contaminant concentration above a predetermined threshold in an gas stream passing through the sacrificial cartridge.
摘要翻译： 一种呼吸器服务提升指示系统，包括一个包括空气净化元件的呼吸器; 以及使用寿命指示器，其与所述呼吸装置并联布置。 使用寿命指示器包括牺牲盒和设置在牺牲盒的下游的传感器，并且被配置为在穿过牺牲盒的气流中检测到高于预定阈值的污染物浓度。
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公开(公告)号：US20090113984A1
公开(公告)日：2009-05-07
申请号：US11936546
申请日：2007-11-07
申请人： Steven Gautieri , Peter Tobias
发明人： Steven Gautieri , Peter Tobias
CPC分类号： G01N33/0006
摘要： A sensing system having a zeroing mechanism incorporating a micropump. The micropump may be connected to a gas conditioner for providing zeroing gas to a sensor downstream. The micropump and sensor may be connected to a processor or computer for pump control and receipt of information from the sensor. Upon zeroing and/or baseline correction of the sensor, the pump may be stopped and a sample gas may be fed into the sensor for detection and analysis. Alternatively, the pump may situated downstream of the sensor to draw conditioned gas through the sensor. A valve may be added having a conditioned gas input connected to the conditioner and having a sample input. The valve may have an output connected to the sensor. When the valve is open to the conditioned gas input, it will be closed to the sample input, and vice versa. The system may be for zeroing and/or calibration.
摘要翻译： 一种具有结合微型泵的调零机构的感测系统。 微型泵可以连接到气体调节器，以向下游的传感器提供归零气体。 微型泵和传感器可以连接到处理器或计算机，用于泵控制和从传感器接收信息。 在传感器的归零和/或基线校正之后，泵可以停止，并且样品气体可以被馈送到传感器中用于检测和分析。 或者，泵可以位于传感器的下游，以通过传感器吸收经调节的气体。 可以添加具有连接到调节器并具有样品输入的调节气体输入的阀。 阀可以具有连接到传感器的输出。 当阀门打开到调节气体输入口时，它将被关闭到样品输入端，反之亦然。 该系统可以用于归零和/或校准。
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公开(公告)号：USD431775S
公开(公告)日：2000-10-10
申请号：US110066
申请日：1999-08-30
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