公开(公告)号：US20240241028A1

公开(公告)日：2024-07-18

申请号：US18559013

申请日：2022-05-04

申请人： SBT Instruments A/S

发明人： Gustav Skands ,  Sara Paulsen ,  Peter Jordal

IPC分类号： G01N15/1031 ,  G01N15/10

CPC分类号： G01N15/1031 ,  G01N15/1023 ,  G01N2015/1006

摘要： The present invention relates to a method of detecting a target microparticle in a fluid in a microfluidic particle analysis device comprising a measuring channel with a first electrode and a second electrode defining an operating space between and being in electrical connection with an electric current source and a device for monitoring an electrical signal from the first and/or the second electrode. A sample fluid suspected of containing a target microparticle exposing an identification binding partner is mixed with a recognition binding partner component to provide a complex of the recognition binding partner and the identification binding partner, and the complex is labelled with electrically conducting nanoparticles; before optionally adjusting the conductivity to be in the range of 5,000 μS/cm to 50,000 μS/cm and applying a flow of the suspension to the measuring channel of the microfluidic particle analysis device; before applying a current to create an electric field in the operating space and monitoring an electrical signal between the first and the second electrode to detect target microparticles labelled with the electrically conducting nanoparticles. The method is suited to detect a pathogenic bacterium in a water or another fluid.

公开(公告)号：US20240191204A1

公开(公告)日：2024-06-13

申请号：US18391053

申请日：2023-12-20

申请人： Cellino Biotech, Inc.

发明人： Matthias WAGNER ,  Suvi AIVIO ,  Mariangela AMENDUNI ,  Catherine PILSMAKER ,  Arnaldo PEREIRA ,  Ananya ZUTSHI ,  Anthia TOURE ,  Steven NAGLE ,  Ozge WHITING ,  George HARB ,  Matthew SULLIVAN ,  Maya BERLIN-UDI ,  Stefanie MORGAN ,  Nick SEAY ,  Sang LEE ,  Scott LURO

IPC分类号： C12N5/074 ,  B01L3/00 ,  B01L9/00 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00 ,  C12N5/00 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1433 ,  G01N15/1434 ,  G06T7/00

CPC分类号： C12N5/0696 ,  B01L3/502715 ,  B01L3/502761 ,  B01L9/52 ,  C12M23/14 ,  C12M23/22 ,  C12M23/26 ,  C12M23/28 ,  C12M23/42 ,  C12M23/44 ,  C12M23/48 ,  C12M25/06 ,  C12M27/02 ,  C12M29/02 ,  C12M31/02 ,  C12M33/00 ,  C12M33/12 ,  C12M41/12 ,  C12M41/26 ,  C12M41/44 ,  C12M41/46 ,  C12M41/48 ,  C12M47/04 ,  C12N5/0081 ,  G01N15/1023 ,  G01N15/1429 ,  G01N15/1433 ,  G01N15/1434 ,  G06T7/0012 ,  G06T7/0016 ,  B01L2200/18 ,  B01L2300/0663 ,  B01L2300/0877 ,  C12M41/36 ,  G01N2015/1006 ,  G01N2015/1452 ,  G01N2015/1454 ,  G01N2015/1486 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/20081 ,  G06T2207/30024 ,  G06T2207/30072

摘要： Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

公开(公告)号：US12020495B2

公开(公告)日：2024-06-25

申请号：US17515924

申请日：2021-11-01

申请人： AIRAMATRIX PRIVATE LIMITED

发明人： Nitin Singhal ,  Bharathi Vijay ,  Satya Chaitanya Kondragunta

IPC分类号： G06V20/69 ,  G01N15/10 ,  G02B5/02 ,  G03B15/03 ,  G06V10/141 ,  G06V10/147 ,  H04N23/56 ,  H04N23/60 ,  H04N23/695 ,  G06N5/02

CPC分类号： G06V20/693 ,  G01N15/1023 ,  G02B5/0278 ,  G03B15/03 ,  G06V10/141 ,  G06V10/147 ,  G06V20/698 ,  H04N23/56 ,  H04N23/64 ,  H04N23/695 ,  G01N2015/1024 ,  G06N5/02

摘要： Micro-biological colony counters and more particularly, to a device and a method for lighting, conditioning and capturing image(s) of organic sample(s) such as but not limited to micro-organisms. The device (700) captures accurate image(s) of organic sample(s) and has a fixed focus imaging for repeatability in quality of images. The device (700) can capture images of organic sample in different lighting and color conditions thereby improving detection of microbiological colonies by increasing the contrast from the background medium. The color calibrated imaging device (700) provides diffused illumination by using polychromatic LED lights, light reflectors and light diffusers for optimal color reproduction of micro-biological colonies contained in organic sample(s). The device (700) is adapted for automatic capturing of images of organic sample(s) cultivated on petri dishes of different sizes.

公开(公告)号：US12011718B2

公开(公告)日：2024-06-18

申请号：US17162753

申请日：2021-01-29

申请人： GIST(Gwangju Institute of Science and Technology)

发明人： Sung Yang ,  Ji Chul Hyun ,  Yu Gyung Jung

IPC分类号： B01L3/00 ,  G01N15/10 ,  G01N15/1031 ,  G01N33/49 ,  G01N15/01

CPC分类号： B01L3/502761 ,  G01N15/1023 ,  G01N15/1031 ,  G01N33/491 ,  B01L2200/0652 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0819 ,  G01N2015/016

摘要： The present invention relates to a blood diagnostic device, which includes one or more blood input parts into which blood is injected, a deterministic lateral displacement separation part which communicates with the blood input part to form a blood flow path along which the blood flows and separates white blood cells from remaining blood components, a first microchannel which communicates with the deterministic lateral displacement separation part so that the white blood cells separated through the deterministic lateral displacement separation part flow therein, one or more second microchannels which communicate with the deterministic lateral displacement separation part so that the remaining blood components separated through the deterministic lateral displacement separation part flow therein, a first discharge part which communicates with the first microchannel so that the white blood cells flowing in the first microchannel are discharged therethrough, and a second discharge part which communicates with the second microchannel.

公开(公告)号：US20240253032A1

公开(公告)日：2024-08-01

申请号：US18391002

申请日：2023-12-20

申请人： Cellino Biotech, Inc.

发明人： Matthias WAGNER ,  Suvi AIVIO ,  Mariangela AMENDUNI ,  Catherine PILSMAKER ,  Arnaldo PEREIRA ,  Ananya ZUTSHI ,  Ozge WHITING ,  George HARB ,  Steven NAGLE ,  Anthia TOURE ,  Matthew SULLIVAN ,  Maya BERLIN-UDI ,  Lukas VASADI ,  Alexander STANGE ,  Sangkyun LEE ,  Stefanie MORGAN ,  Nick SEAY ,  Scott LURO

IPC分类号： B01L3/00 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00 ,  C12N5/00 ,  G01N15/10 ,  G06T7/00

CPC分类号： B01L3/502715 ,  C12M23/14 ,  C12M23/22 ,  C12M23/26 ,  C12M23/42 ,  C12M23/44 ,  C12M23/48 ,  C12M25/06 ,  C12M27/02 ,  C12M29/02 ,  C12M41/12 ,  C12M41/26 ,  C12M41/48 ,  C12M47/04 ,  C12N5/0081 ,  G01N15/1023 ,  G06T7/0016 ,  B01L2300/0663 ,  G01N2015/1006 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/20081 ,  G06T2207/30024 ,  G06T2207/30072

摘要： Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

公开(公告)号：US12031895B2

公开(公告)日：2024-07-09

申请号：US17081585

申请日：2020-10-27

申请人： OP-Hygiene IP GmbH

发明人： Siegfried Steltenkamp ,  Heiner Ophardt ,  Albrecht Lang

IPC分类号： G01N15/1031 ,  B01L3/00 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1433

CPC分类号： G01N15/1031 ,  B01L3/502715 ,  B01L3/502761 ,  G01N15/1023 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1433 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/087 ,  G01N2015/1006 ,  G01N2015/1024

摘要： A method of analysing and identifying particles in an input fluid by electrical field analysis preferably in combination with imaging analysis and towards establishing characterises of the particles that can be compared with characteristics of known particles, preferably biologic particles such as bacteria and viruses. Preferably in a focusing step, the particles are focused as in a microfluidic particle sorting cartridge followed by electrical field analysis to determine impedance data. Preferably, the electrical field analysis is carried out in a water and alcohol solution.

公开(公告)号：US12025549B2

公开(公告)日：2024-07-02

申请号：US17414155

申请日：2019-05-13

申请人： Hewlett-Packard Development Company, L.P.

发明人： Viktor Shkolnikov ,  Alexander Govyadinov ,  Diane R. Hammerstad

IPC分类号： G01N15/12 ,  B01L3/00 ,  B81B7/02 ,  G01N15/10 ,  G01N15/1031 ,  G01N33/543

CPC分类号： G01N15/12 ,  B01L3/502761 ,  B81B7/02 ,  G01N15/1023 ,  G01N15/1031 ,  G01N33/54386 ,  B01L2200/025 ,  B01L2200/0652 ,  B01L2200/0663 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/14 ,  B01L2400/02 ,  B01L2400/0487 ,  G01N2015/1006 ,  G01N2015/1028

摘要： A system includes a microchannel analysis region, a first fluid actuation device, a second fluid actuation device, a sensor, and a controller. The first fluid actuation device is at a first end of the microchannel analysis region. The second fluid actuation device is at a second end of the microchannel analysis region opposite to the first end. The sensor is within the microchannel analysis region between the first fluid actuation device and the second fluid actuation device. The sensor measures an impedance of a fluid within the microchannel analysis region. The controller activates the first fluid actuation device to generate a first pressure wave in the fluid and activates the second fluid actuation device to generate a second pressure wave in the fluid. The first pressure wave and the second pressure wave converge at the sensor.

公开(公告)号：US12000770B2

公开(公告)日：2024-06-04

申请号：US17432484

申请日：2020-02-21

申请人： KYOCERA Corporation

发明人： Masashi Yoneta

IPC分类号： G01N15/10 ,  G01N15/01

CPC分类号： G01N15/1023 ,  G01N2015/016 ,  G01N2015/1006 ,  G01N2015/1028

摘要： A particle separating and measuring device includes a first flow path device having a post-separation flow outlet to allow discharge of a first fluid containing target particles to be separated, and a second flow path device receiving the first flow path device and having a first flow inlet to receive the first fluid. The first flow path device having a lower surface having the post-separation flow outlet is on the second flow path device having an upper surface having the first flow inlet in a first region, with the post-separation flow outlet facing and connecting to the first flow inlet. A connection flow path vertically extends from an opening of the first flow inlet to a first flow path, and narrows from the opening of the first flow inlet toward the first flow path.

公开(公告)号：US20240302256A1

公开(公告)日：2024-09-12

申请号：US18573795

申请日：2022-06-23

申请人： BOREALIS AG

发明人： Pascal CASTRO ,  Niko HELLSTEN ,  Antti Juhani KARTTUNEN ,  Alexander REZNICHENKO ,  Anu-Leena HONGELL ,  Tarja-Tuulikki TURPEINEN ,  Erika JOENVUO ,  Vasileios KANELLOPOULOS

IPC分类号： G01N3/08 ,  C08F4/659 ,  G01N15/02 ,  G01N15/10

CPC分类号： G01N3/08 ,  C08F4/65912 ,  C08F4/65916 ,  G01N15/0255 ,  G01N15/1023 ,  C08F2420/07 ,  G01N2203/0019 ,  G01N2203/0085 ,  G01N2203/0087 ,  G01N2203/0286

摘要： The disclosure relates to a method for determining the compressive character of an olefin polymerisation catalyst, comprising subjecting particles of an olefin polymerisation catalyst to micro-compression testing to obtain crushing strength data of the particles of the olefin polymerisation catalyst to determine the compressive character of the olefin polymerisation catalyst. The disclosure further re later to a method for evaluating the quality of an olefin polymerisation catalyst, comprising determining the compressive character of the olefin polymerisation catalyst, and evaluating the quality of the olefin polymerisation from the information obtained from the determination of its compressive strength. The disclosure still further relates to a method for predicting the performance of an olefin polymerisation catalyst in an olefin polymerisation process from its compressive strength descriptors, characterized in that the compressive character of the olefin polymerisation catalyst is determined as disclosed. The disclosure furthermore re I ate rs to an olefin polymerisation catalyst, having a Weibull modulus higher than modulus higher than 2.

公开(公告)号：US12044612B2

公开(公告)日：2024-07-23

申请号：US17712888

申请日：2022-04-04

申请人： Steven H. Reichenbach

发明人： Steven H. Reichenbach

IPC分类号： B01L3/00 ,  B01D43/00 ,  G01N15/10 ,  G01N15/01

CPC分类号： G01N15/1023 ,  B01D43/00 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N15/01 ,  G01N2015/1006 ,  G01N2015/1028

摘要： An apparatus and method to segregate particles suspended in a fluid with an obstacle field in the flow path of the fluid. The particles may be dispersed after an interaction with obstacles in the obstacle field. The obstacle-particle interactions may result in an asymmetrical particle shift or bump in which the particles are differentially dispersed relative to the obstacle and the fluid flow. Individual obstacles having properties that are asymmetrical are arranged creating asymmetrical gaps between adjacent pairs of obstacles to separate particles flowing through the device.