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    Method of making a cartridge for a medicament respiratory delivery device
    1.
    发明授权
    Method of making a cartridge for a medicament respiratory delivery device 有权
    制造用于药物呼吸输送装置的药筒的方法

    公开(公告)号：US07644562B2

    公开(公告)日：2010-01-12

    申请号：US11083751

    申请日：2005-03-18

    申请人： Vincent J. Sullivan ,  Lawrence A. Monahan ,  Christopher J. Knors ,  Anjana Bhuta Wills ,  Michael W. Trull

    发明人： Vincent J. Sullivan ,  Lawrence A. Monahan ,  Christopher J. Knors ,  Anjana Bhuta Wills ,  Michael W. Trull

    IPC分类号： B65B7/28

    CPC分类号： B05B11/061 ,  A61M11/003 ,  A61M11/008 ,  A61M15/0028 ,  A61M15/0031 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2207/00 ,  B05B11/062

    摘要： A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet. The method of forming the cartridge includes stretching out and bending a membrane to one end of the cartridge, preferably by heat bonding, filling the cartridge with a medicament and sealing the opposed end preferably with a second burstable membrane by stretching out a membrane over a convex surface and heat bonding.

    摘要翻译： 一种药物呼吸递送装置，包括具有腔室，大体上与腔室同轴对准的入口和出口的壳体，其中所述腔室包括药剂盒，所述药剂盒具有主体，该主体包括大体上圆柱形的通道，该通道延伸穿过所述药筒的相对端， 壳体的入口和出口具有薄的可爆破的聚烯烃膜，其具有介于盒的端部之间拉伸的介于1.2和10个大气压之间的爆破压力，使得输送到入口的流体破裂膜，夹带在盒通道内的药剂 通过出口将其输送到患者的呼吸系统。 形成盒的方法包括：将膜延伸出并弯曲到盒的一端，优选通过热粘合，用药物填充盒，并优选用第二可爆膜密封相对端，通过在凸起 表面和热粘合。

    Medicament respiratory delivery device, cartridge and method of making same
    2.
    发明授权
    Medicament respiratory delivery device, cartridge and method of making same 有权
    药物呼吸装置，药筒及其制造方法

    公开(公告)号：US06929005B2

    公开(公告)日：2005-08-16

    申请号：US09879517

    申请日：2001-06-12

    申请人： Vincent J. Sullivan ,  Anjana Bhuta Wills ,  Lawrence A. Monahan ,  Michael W. Trull ,  Christopher J. Knors

    发明人： Vincent J. Sullivan ,  Anjana Bhuta Wills ,  Lawrence A. Monahan ,  Michael W. Trull ,  Christopher J. Knors

    IPC分类号： A61J1/06 ,  A61J7/00 ,  A61M11/06 ,  A61M15/00 ,  B05B11/06

    CPC分类号： A61M15/0028 ,  A61M11/002 ,  A61M11/003 ,  A61M11/02 ,  A61M15/0025 ,  A61M15/0031 ,  A61M15/0033 ,  A61M15/004 ,  A61M15/0041 ,  A61M15/0068 ,  A61M2202/064 ,  A61M2205/075 ,  A61M2207/00 ,  B05B11/061 ,  B05B11/062

    摘要： A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet. The method of forming the cartridge includes stretching out and bending a membrane to one end of the cartridge, preferably by heat bonding, filling the cartridge with a medicament and sealing the opposed end preferably with a second burstable membrane by stretching out a membrane over a convex surface and heat bonding.

    摘要翻译： 一种药物呼吸递送装置，包括具有腔室，大体上与腔室同轴对准的入口和出口的壳体，其中所述腔室包括药剂盒，所述药剂盒具有主体，该主体包括大体上圆柱形的通道，该通道延伸穿过所述药筒的相对端， 壳体的入口和出口具有薄的可爆破的聚烯烃膜，其具有介于盒的端部之间拉伸的介于1.2和10个大气压之间的爆破压力，使得输送到入口的流体破裂膜，夹带在盒通道内的药剂 通过出口将其输送到患者的呼吸系统。 形成盒的方法包括：将膜延伸出并弯曲到盒的一端，优选通过热粘合，用药物填充盒，并优选用第二可爆膜密封相对端，通过在凸起 表面和热粘合。

    Medicament respiratory delivery device
    5.
    发明授权
    Medicament respiratory delivery device 有权
    药物呼吸装置

    公开(公告)号：US07270127B2

    公开(公告)日：2007-09-18

    申请号：US10233863

    申请日：2002-09-03

    申请人： Artis R. Lockhart ,  Vincent J. Sullivan ,  Lawrence A. Monahan ,  Anjana Bhuta Wills

    发明人： Artis R. Lockhart ,  Vincent J. Sullivan ,  Lawrence A. Monahan ,  Anjana Bhuta Wills

    IPC分类号： A61M15/00

    CPC分类号： B05B11/061 ,  A61M11/003 ,  A61M11/008 ,  A61M15/0028 ,  A61M15/003 ,  A61M15/0031 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2207/00 ,  B05B11/062

    摘要： A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.

    摘要翻译： 一种药物呼吸输送装置，包括由相对的热成型聚合物片材形成的壳体，所述壳体在其间形成有腔室，所述腔室具有封装在所述片材之间的药剂盒，与通过所述药筒的通道对准的入口具有可刺穿的封闭件和与所述通道对准的出口 出口具有可爆破的膜。 该装置包括形成为片材之间的泡罩的压力致动器和具有弓形致动器部分的穿孔元件和在致动压力致动器时刺穿可刺破的封闭件的轴，将压力下的流体输送到药筒通道， 膜并表达药物。

    Catheter assemblies and injection molding processes and equipment for making the same
    10.
    发明申请
    Catheter assemblies and injection molding processes and equipment for making the same 审中-公开
    导管组件和注射成型工艺以及制造相同的设备

    公开(公告)号：US20090143767A1

    公开(公告)日：2009-06-04

    申请号：US12290448

    申请日：2008-10-30

    申请人： James Fentress ,  Scott A. O'Connor ,  Scott A. White ,  Lawrence A. Monahan ,  Frank E. Martin ,  Kevin G. Tingey ,  Craig N. Gawreluk

    发明人： James Fentress ,  Scott A. O'Connor ,  Scott A. White ,  Lawrence A. Monahan ,  Frank E. Martin ,  Kevin G. Tingey ,  Craig N. Gawreluk

    IPC分类号： A61M25/00 ,  B28B5/00

    CPC分类号： A61M25/0009 ,  A61M25/0014 ,  B29C45/0001 ,  B29C45/0003 ,  B29C45/16 ,  B29C45/261 ,  B29C45/2708 ,  B29K2075/00 ,  B29L2031/7542

    摘要： Various single-part catheter assemblies, multi-part integrated catheter assemblies, and methods for making the same are disclosed. The single-part catheter assemblies include a catheter hub integrally formed with a catheter tube for insertion into the bloodstream of a patient. The multi-part integrated catheter assemblies include a catheter hub integrally formed to a catheter tube for insertion into the bloodstream of a patient. The catheter assemblies of the invention may be injection molded in a single step or in multiple steps by injecting flows of molten plastic into a cavity of molds provided herein such that the flows converge into an even distribution about the circumference of the sleeve. The mold may have a core pin designed to fit into the cavity. Through the use of the even distribution of flows, the core pin may be seated within the cavity in an untensioned manner. The catheter assemblies of the invention may be produced of a single material or of multiple materials.

    摘要翻译： 公开了各种单一部件导管组件，多部分集成导管组件及其制造方法。 单组件导管组件包括与用于插入患者血流中的导管管一体形成的导管座。 多部分集成导管组件包括与导管管一体形成的用于插入患者血流的导管套管。 本发明的导管组件可以在单个步骤或多个步骤中通过将熔融塑料流注入本文提供的模具的空腔中而注射模制，使得流体围绕套筒的圆周收敛成均匀分布。 模具可以具有设计成适合于空腔的芯销。 通过使用均匀的流动分布，芯销可以以未张紧的方式安置在空腔内。 本发明的导管组件可以由单一材料或多种材料制成。